BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase

Biochemical Pharmacology

Volumn 59, Issue 8, 2000, Pages 937-945

  Szabados, Eszter ^a   Literati Nagy, Peter ^b   Farkas, Beatrix ^a   Sumegi, Balazs ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b N Gene Research Laboratories   (Hungary)

Author keywords

BGP 15; Cell damage; Chaperone; Free radicals; GRP78; Heart perfusion; Ischemia reperfusion; Lipid peroxidation; Poly(ADP ribose) polymerase; Reactive oxygen species; Signal

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINE DERIVATIVE; NICOTINIC AMIDOXIME; O (2 HYDROXY 3 PIPERIDINOPROPYL)NICOTINIC AMIDOXIME; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL DAMAGE; DRUG MECHANISM; ENZYME ACTIVITY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

ADENOSINE DIPHOSPHATE; ADP RIBOSE TRANSFERASES; ANIMALS; CARRIER PROTEINS; CELL NUCLEUS; CYTOPLASM; DNA DAMAGE; HEAT-SHOCK PROTEINS; LIPID PEROXIDATION; MALE; MOLECULAR CHAPERONES; NAD; OXIMES; PERFUSION; PIPERIDINES; POLY(ADP-RIBOSE) POLYMERASES; PROTECTIVE AGENTS; PROTEINS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY;

EID: 0033954867     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00418-9     Document Type: Article

References (51)

1. Halliwell B., Gutteridge J.M. Role of free radicals and catalytic metal ions in human disease An overview . Methods Enzymol. 186:1990;1-85.
2. Pan N., Hori H. The interaction of acteoside with mitochondrial lipid peroxidation as an ischemia/reperfusion injury model. Adv Exp Med Biol. 361:1994;319-325.
3. Packer L., Valenza M., Serbinova E., Starke-Reed P., Frost K., Kagan V. Free radical scavenging is involved in the protective effect of L-propionyl-carnitine against ischemia-reperfusion injury of heart. Arch Biochem Biophys. 288:1991;533-537.
4. Takeda N., Ota Y., Tanaka Y., Shikata C., Hayashi Y., Nemoto S., Tanamura A., Iwai T., Nakamura I. Myocardial adaptive changes and damage in ischemic heart disease. Ann N Y Acad Sci. 793:1996;282-288.
5. Kajstura J., Cheng W., Reiss K., Clark W.A., Sonenblick E.H., Krajewski S., Reed J.C., Olivetti G., Anversa P. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest. 74:1996;86-107.
6. Heller B., Wang Z.Q., Wagner E.F., Radons J., Burkle A., Fehsel F., Burkart V., Kolb H. Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J Biol Chem. 270:1995;11176-11180.
7. Simpson P.J., Lucchesi B.R. Free radicals and myocardial ischemia and reperfusion injury. J Lab Clin Med. 110:1987;13-30.
8. Lindahl T., Satoh M.S., Poirier G.G., Klungland A. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem Sci. 20:1995;405-411.
9. + depletion. Biochem Biophys Res Commun. 199:1994;1270-1277.
10. Janero D.R., Hreniuk D., Sharif H.M., Prout K.C. Hydroperoxide-induced oxidative stress alters pyridine nucleotide metabolism in neonatal heart muscle cells. Am J Physiol. 264:1993;1401-1410.
11. Thiemermann C., Bowes J., Myint F.P., Vane J.R. Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc Natl Acad Sci USA. 94:1997;679-683.
12. Mizumoto K., Glascott P.A. Jr, Farber J.L. Roles for oxidative stress and poly(ADP-ribosyl)ation in the killing of cultured hepatocytes by methyl methanesulfonate. Biochem Pharmacol. 46:1993;1811-1818.
13. Said S.I., Berisha H.I., Pakbaz H. Excitotoxicity in the lung N-Methyl-D-asparate-induced, nitric oxide-dependent, pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase . Proc Natl Acad Sci USA. 93:1996;4688-4692.
14. Turrens J.F., Beconi M., Barilla J., Chavez U.B., McCord J.M. Mitochondrial generation of oxygen radicals during reoxygenation of ischemic tissues. Free Radic Res Commun. 12-13:1991;681-689.
15. Ambrosio G., Zweier J.L., Duilio C., Kuppusamy P., Santoro G., Elia P.P., Tritto I., Cirillo P., Condorelli M., Chiariello M. Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow. J Biol Chem. 268:1993;18532-18541.
16. Vanden Hoek T.L., Becker L.B., Shao Z., Li C., Schumacker P.T. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J Biol Chem. 273:1998;18092-18098.
17. 2+-dependent inner-membrane permeability transition. Biochem J. 294:1993;719-725.
18. Halestrap A.P., Kerr P.M., Javadov S., Woodfield K.Y. Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. Biochim Biophys Acta. 1366:1998;79-94.
19. Lemasters J.J., Nieminen A.L., Qian T., Trost L.C., Elmore S.P., Nishimura Y., Crowe R.A., Cascio W.E., Bradham C.A., Brenner D.A., Herman B. The mitochondrial permeability transition in cell death A common mechanism in necrosis, apoptosis and autophagy . Biochim Biophys Acta. 1366:1998;177-196.
20. Cuzzocrea S., Zingarelli B., Caputi A.P. Peroxynitrate-mediated DNA strand breakage activates poly(ADP-ribose) synthetase and causes cellular energy depletion in a nonseptic shock model induced by zymosan in the rat. Shock. 9:1998;336-340.
21. Szabo C., Virag L., Cuzzocrea S., Scott G.S., Hake P., O'Connor M.P., Zingarelli B., Salzman A., Kun E. Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase. Proc Natl Acad Sci USA. 95:1998;3867-3872.
22. Horwitz L.D., Fennessey P.V., Shikes R.H., Kong Y. Marked reduction in myocardial infarct size due to prolonged infusion of an antioxidant during reperfusion. Circulation. 89:1994;1792-1801.
23. Abadie C., Ben Baouali A., Maupoil V., Rochette L. An alpha-tocopherol analogue with antioxidant activity improves myocardial function during ischemia reperfusion in isolated working rat hearts. Free Radic Biol Med. 15:1993;209-215.
24. Serbinova E., Khwaja S., Reznick A.Z., Packer L. Thioctic acid protects against ischemia-reperfusion injury in the isolated perfused Langendorff heart. Free Radic Res Commun. 17:1992;49-58.
25. Virag L., Salzman A.L., Szabo C. Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death. J Immunol. 161:1998;3753-3759.
26. Fu L.X., Kirkeboen K.A., Liang Q.M., Sjogren K.G., Hjalmarson A., Ilebekk A. Free radical scavenging enzymes and G protein mediated receptor signalling systems in ischaemically preconditioned porcine myocardium. Cardiovasc Res. 27:1993;612-616.
27. Sumegi B., Butwell N.B., Malloy C.R., Sherry A.D. Lipoamide influences substrate selection in post-ischaemic perfused rat hearts. Biochem J. 297:1994;109-113.
28. 13C]propionate in normal and ischaemic rat heart in vivo 1H- and 13C-NMR studies . Biochem J. 312:1995;75-81.
29. Brent E., Bergmeyer H.U., Mollering H. Creatine. Bergmeyer H.U. Methods of Enzymatic Analysis. 1974;1772-1776 Academic Press, New York.
30. Miles A.M., Bohlt D.S., Glassbrenner P.H., Hansert B., Winks D.A., Grisham M.B. Modulation of superoxide-dependent oxidation and hydroxylation reactions by nitric oxide. J Biol Chem. 271:1996;40-47.
31. Summerhayes I.C., Lampidis T.J., Bernal S.D., Nadakavukaren J.J., Nadakavukaren K.K., Shepherd E.L., Chen L.B. Unusual retention of rhodamine123 by mitochondria in muscle and carcinoma cells. Proc Natl Acad Sci USA. 79:1982;5292-5296.
32. Birnboim H.C., Jevcak J.J. Fluorimetric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation. Cancer Res. 41:1981;1889-1892.
33. Sumegi B., Melegh B., Adamovich K., Trombitas K. Cytochrome oxidase deficiency affecting the structure of the myofibre and the shape of mitochondrial cristae membrane. Clin Chim Acta. 192:1990;9-18.
34. Inoue A., Yamamoto N., Morisawa Y., Uchimoto T., Yukioka M., Morisawa S. Unesterified long-chain fatty acids inhibit thyroid hormone binding to the nuclear receptor. Solubilized receptor and the receptor in cultured cells. Eur J Biochem. 183:1989;565-572.
35. Shah G.M., Poirier D., Duchaine C., Brochu G., Desnoyers S., Lagueux J., Verreault A., Hoflack J.C., Kirkland J.B., Poirier G.G. Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo. Anal Biochem. 227:1995;1-13.
36. Tzeng W.F., Lee J.L., Chiou T.J. The role of lipid peroxidation in menadione-mediated toxicity in cardiomyocytes. J Mol Cell Cardiol. 27:1995;1999-2008.
37. Bergmeyer H.U., Bernt E. Lactate dehydrogenase. Bergmeyer H.U. Methods of Enzymatic Analysis. 1974;574-579 Academic Press, New York.
38. Bergmeyer H.U., Bernt E. Glutamate-oxaloacetate transaminase. Bergmeyer H.U. Methods of Enzymatic Analysis. 1974;727-733 Academic Press, New York.
39. Forster G., Bernt E., Bergmeyer H.U. Creatine kinase. Bergmeyer H.U. Methods of Enzymatic Analysis. 1974;784-793 Academic Press, New York.
40. Haramaki N., Stewart D.B., Aggarwal S., Kawabata T., Packer L. Role of ascorbate in protection by nitecapone against cardiac ischemia-reperfusion injury. Biochem Pharmacol. 50:1995;839-843.
41. Latocha G., Bernauer W. Effect of antiarrhythmic drugs on the postischaemic metabolic recovery of isolated rat hearts. Arch Int Pharmacodyn Ther. 312:1991;39-54.
42. Ledford B.E., Leno G.H. ADP-ribosylation of the molecular chaperone GRP78/BiP. Mol Cell Biochem. 138:1994;141-148.
43. Piron K.J., McMahon K.K. Localization and partial characterization of ADP-ribosylation products in hearts from adult and neonatal rats. Biochem J. 270:1990;591-597.
44. Leno G.H., Ledford B.E. ADP-ribosylation of the 78 kDa glucose-regulated protein. FEBS Lett. 276:1990;29-33.
45. Eliasson M.J., Sampei K., Mandir A.S., Hurn P.D., Traystman R.J., Bao J., Pieper A., Wang Z.Q., Dawson T.M., Snyder S.H., Dawson V.L. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischaemia. Nat Med. 3:1997;1089-1095.
46. + depletion. Biochem Biophys Res Commun. 199:1994;1270-1277.
47. Szabo C., Zingarelli B., O'Connor M., Salzman A.L. DNA strand breakage activation of poly(ADP-ribose) synthetase and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci USA. 93:1996;1753-1758.
48. Wang Z.Q., Auer B., Stingl L., Berghammer H., Haidacher D., Schweiger M., Wagner E.F. Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev. 9:1995;509-520.
49. Szabo C., Dawson V.L. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci. 19:1998;287-298.
50. Szabo C., Zingarelli B., Salzman A.L. Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circ Res. 78:1996;1051-1063.
51. Zingarelli B., Cuzzocrea S., Zsengeller Z., Salzman A.L., Szabo C. Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthetase. Cardiovasc Res. 36:1997;205-215.