Membrane targeting by pleckstrin homology domains

Current Topics in Microbiology and Immunology

Volumn 282, Issue , 2003, Pages 49-88

  Cozier, G E ^a   Carlton, J ^a   Bouyoucef, D ^a   Cullen, P J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PLECKSTRIN;

ALPHA HELIX; CHEMOTAXIS; ENZYME SPECIFICITY; GENE TARGETING; MEMBRANE TRANSPORT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SECOND MESSENGER;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BLOOD PROTEINS; CELL MEMBRANE; CHEMOTAXIS; HUMANS; INTRACELLULAR MEMBRANES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLINOSITOLS; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 0141452257     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (166)

1. Abe, A. (1990) Primary structure of glycolipid transfer protein from pig brain. J. Biol. Chem. 265, 9634-9637
2. Alessi, D.R., James, S.R., Downes, C.P., Holmes, A.B., Gaffney, P.R., Reese, C.B. and Cohen, P. (1997) Characterisation of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr. Biol. 7, 261-269
3. Anderson, K.E., Coadwell, J.W., Stephens, L.R. and Hawkins, P.T. (1998) Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr. Biol. 8, 684-691
4. Anderson, K.E., Lipp, P., Bootman, M.D., Ridley, S.H., Coadwell, J., Ronnstrand, L., Lennartsson, J., Holmes, A.B., Painter, G.F., Thuring, J., Lim, Z.-Y., Erdjument-Bromage, H., Grewal, A., Tempst, P., Stephens, L.R. and Hawkins, P.T. (2000) DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma membrane recruitment and endocytosis upon cell stimulation. Curr. Biol. 10, 1403-1412
5. Andjelkovic, K., Alessi, D.R., Meier, R., Fernandez, A., Lamb, N.J., Frech, M., Cron, P., Cohen, P., Lucocq, J.M. and Hemmings, B.A. (1997) Role of translocation in the activation and function of protein kinase B. J. Biol. Chem. 272, 31515-31524
6. Audhya, A., Foti, M. and Emr, S.D. (2000) Distinct role for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics. Mol. Biol. Cell 11, 2673-2689
7. Baggiolini, M. (2001) Chemokines in pathology and medicine. J. Intern. Med. 250, 91-104
8. Baraldi, E., Carugo, K.D., Hyvonen, M., Surdo, P.L., Riley, A.M., Potter, B.V.L., O'Brien, R., Ladbury, J.E. and Saraste, M. (1999) Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. Structure 7, 449-460
9. Bellanger, J.M., Astier, C., Sardet, C., Ohta, Y., Stossel, T.P. and Debant, A. (2000) The Rac1- and RhoG-specific guanine nucleotide exchange factor domain of Trio targets filamin to remodel cytoskeletal actin. Nat. Cell Biol. 2, 888-892
10. Blomberg, N., Baraldi, E., Sattler, M., Saraste, M. and Nilges, M. (2000) Structure of the pleckstrin homology domain from the C. elegans muscle protein UNC-89 suggests a novel function. Structure 8, 1079-1087
11. Boshans, R.L., Szanto, S., van Aelst, L. and D'Souza-Schorey, C. (2000) ADP-ribosylation factor 6 regulates actin cytoskeleton remodelling in coordination with Rac1 and RhoA. Mol. Cell. Biol. 20, 3685-3694
12. Brazil, D.P. and Hemmings, B.A. (2001) Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem. Sci. 26, 657-664
13. Burks, D.J., Wang, J., Towery, H., Ishibashi, O., Lowe, D., Riedel, H. and White, M.F. (1998) IRS pleckstrin homology domains bind to acidic motifs in proteins. J. Biol. Chem. 273, 31061-31067
14. Cantrell, D.A. (2001) Phosphoinositide 3-kinase signaling pathways. J. Cell Sci. 114, 1439-1445
15. Chen, R.Y., Kim, O., Li, M., Xiong, X.S., Guan, J.L., Kung, H.J., Chen, H.G., Shimizu, Y. and Qiu, Y. (2001) Regulation of the PH domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Nat. Cell Biol. 3, 439-444
16. Chung, C.Y., Funamoto, S. and Firtel, R.A. (2001) Signaling pathways controlling cell polarity and chemotaxis. Trends Biochem. Sci. 26, 557-566
17. Chung, C.Y., Potikyan, G. and Firtel, R.A. (2001) Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell 7, 937-947
18. Cockcroft, S. and De Matteis, M.A. (2001) Inositol lipids as spatial regulators of membrane traffic. J. Membr. Biol. 180, 187-194
19. Comer, F.I. and Parent, C.A. (2002) PI 3-kinases and PTEN: how opposites chemoattract. Cell 109, 541-544
20. IP4BP contains a novel Group I pleckstrin homology domain that directs constitutive plasma membrane association. J. Biol. Chem. 275, 28261-28268
21. Crompton, A.M., Foley, L.H., Wood, A., Roscoe, W., Stokoe, D., McCormick, F., Symons, M. and Bollag, G. (2000) Regulation of Tiam-1 nucleotide exchange activity by pleckstrin homology domain binding ligands. J. Biol. Chem. 275, 25751-25759
22. Cullen, P.J. and Venkateswarlu, K. (1999) The potential regulation of ARF6 signalling by phosphatidylinositol 3,4,5-trisphosphate. Biochem. Soc. Trans. 27, 683-690
23. Cullen, P.J. and Chardin, P. (2000) Membrane targeting-what a difference a G makes. Curr. Biol. 10, R876-R878
24. Cullen, P.J., Cozier, G.E., Banting, G. and Mellor, H. (2001) Modular phosphoinositide-binding domains-their role in signaling and membrane traffic. Curr. Biol. 11, R882-R893
25. De Matteis, M.A. and Morrow, J.S. (1998) The role of ankyrin and spectrin in membrane transport and domain formation. Curr. Opin. Cell Biol. 10, 542-549
26. De Matteis, M.A. and Morrow, J.S. (2000) Spectrin tethers and mesh in the biosynthetic pathway. J. Cell Sci. 113, 2331-2343
27. De Matteis, M.A., Godi, A. and Corda, D. (2002) Phosphoinositides and the Golgi complex. Curr. Opin. Cell Biol. 14, 434-447
28. Dhe-Paganon, S., Ottinger, E.A., Nolte, R.T., Eck, M.J. and Shoelson, S.E. (1999) Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1. Proc. Natl. Acad. Sci. U.S.A. 96, 8378-8383
29. Dowler, S., Currie, R.A., Downes, C.P. and Alessi, D.R. (1999) DAPPI: a dual adaptor for phosphotyrosine and 3-phosphoinositides. Biochem. J. 342, 7-12
30. Dowler, S., Currie, R.A., Campbell, D.G., Deak, M., Kular, G., Downes, C.P. and Alessi, D.R. (2000) Identification of pleckstrin homology domain-containing proteins with novel phosphoinositide-binding specificities. Biochem. J. 351 19-31
31. Downing, A.K., Driscoll, P.C., Gout, I., Salim, K., Zvelebil, M.J. and Waterfield, M.D. (1994) Three-dimensional solution structure of the pleckstrin homology domain from dynamin. Curr. Biol. 4, 884-891
32. Drugan, J.K., Rogers-Graham, K., Gilmer, T., Campbell, S. and Clark, G.J. (2000) The Ras/p120 GTPase-activating protein (GAP) interaction is regulated by the p120 GAP pleckstrin homology domain. J. Biol. Chem. 275, 35021-35027
33. Farhang-Fallah, J., Yin, XH., Trentin, G., Chengm A.M. and Rozakis-Adcock, M. (2000) Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein. J. Biol. Chem. 275, 40492-40497
34. Federov, A.A., Federov, E., Gertler, F. and Almo, S.C. (1999) Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function. Nat. Struct. Biol. 6, 661-665
35. Ferguson, K.M., Lemmon, M.A., Schlessinger, J. and Sigler, P.B. (1994) Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin. Cell 79 199-209
36. Ferguson, K.M., Lemmon, M.A., Schlessinger, J. and Sigler, P.B. (1995) Structure of the high affinity complex between inositol 1,4,5-trisphosphate and a phospholipase C pleckstrin homology domain. Cell 83, 1037-1046
37. Ferguson, K.M., Kavran, J.M., Sankaran, V.G., Fournier, E., Isakoff, S.J., Skolnik, E.Y. and Lemmon, M.A. (2000) Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domain. Mol. Cell 6, 373-384
38. Fleming, I.N., Gray, A. and Downes, C.P. (2000) Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components. Biochem. J. 351, 173-182
39. Frech, M., Andjelkovic, M., Ingley, E., Reddy, K.K., Falck, J.R. and Hemmings, B.A. (1997) High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J. Biol. Chem. 272, 8474-8481
40. Franke, T.F., Kaplan, D.R., Cantley, L.C. and Toker, A. (1997) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol 3,4-bisphosphate. Science 275, 665-668
41. Fukuda, M., Kojima, T., Kabayama, H. and Mikoshiba, K. (1996) Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity. J. Biol. Chem. 271, 30303-30306
42. Funamoto, S., Milan, K., Meili, R. and Firtel, R.A. (2001) Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium. J. Cell Biol. 153, 795-810
43. Funamoto, S., Meili, R., Lee, S., Parry, L. and Firtel, R.A. (2002) Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109, 611-623
44. Fushman, D., Cahill, S., Lemmon, M.A., Schlessinger, J. and Cowburn, D. (1995) Solution structure of pleckstrin homology domain of dynamin by heteronuclear NMR spectroscopy. Proc. Natl. Acad. Sci. U.S.A. 92, 816-820
45. Fushman, D., Najmabadi-Kaske, T., Cahill, S., Zheng, J., LeVine, H. and Cowburn, D. (1998) The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (β-adrenergic receptor kinase 1): a binding partner of Gβγ subunits. J. Biol. Chem. 273, 2835-2843
46. Garcia, P., Gupta, R., Shah, S., Morris, A.J., Rudge, S.A., Scarlata, S., Petrova, V., McLaughlin, S. and Rebecchi, M.J. (1995) The pleckstrin homology domain of phospholipase Cγ1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes. Biochemistry 34, 16228-16234
47. Godi, A., Pertile, P., Meyers, R., Marra, P., DiTullio, G., Iurisci, C., Luini, A., Corda, D. and De Matteis, M.A. (1999) ARF mediates recruitment of phosphatidylinositol 4-monophosphate kinase-β and stimulates synthesis of phosphatidylinositol 4,5-bisphosphate on the Golgi complex. Nat. Cell Biol. 1, 280-287
48. Hall, A. (1998) Rho GTPases and the actin cytoskeleton. Science 279, 509-514
49. Hama, H., Schnieders, E.A., Thorner, J., Takemoto, J.Y. and DeWald, D.B. (1999) Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 274, 34294-34300
50. Han, J., Luby-Phelps, K., Das, B., Shu, X., Xia, Y., Mosteller, R.D., Krishna, U.M., Falck, J.R., White, M.A. and Broek, D. (1998) Role of substrates and products of phosphoinositide-3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279, 558-560
51. Hurley, J.H. and Misra, S. (2000) Signalling and subcellular targeting by membrane binding domains. Annu. Rev. Biophys. Biomol. Struct. 29, 49-79
52. Hurley, J.H. and Meyer, T. (2001) Subcellular targeting by membrane lipids. Curr. Opin. Cell Biol. 13, 146-152
53. Hyvonen, M., Macais, M.J., Nilges, M., Oschkinat, H., Saraste, M. and Wilmanns, M. (1995) Structure of the binding site for inositol phosphates in a pleckstrin homology domain. EMBO J. 14, 4676-4685
54. Hyvonen, M. and Saraste, M. (1997) Structure of the pleckstrin homology domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia. EMBO J. 16, 3396-3404
55. Iijima, M. and Devreotes, P. (2002) Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610
56. Itoh, T. and Takenawa, T. (2002) Phosphoinositide-binding domains-functional units for temporal and spatial regulation of intracellular signaling. Cell. Signal. 14, 733-743
57. Jackson, C.L. and Casanova, J.E. (2000) Turning on ARF: the Sec7 family of guanine nucleotide exchange factors. Trends Cell Biol. 10, 60-67
58. 12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain. Nature (London) 395, 808-813
59. Jin, T., Zhang, N., Long, Y., Parent, C.A. and Devreotes, P.N. (2000) Localization of the G protein βγ complex in living cells during chemotaxis. Science 287, 1034-1036
60. Jogl, G., Shen, Y., Gebauer, D., Li, J., Wiegmann, K., Kashkar, H., Kronke, M. and Tong, L. (2002) Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel pleckstrin homology domain. EMBO J. 21, 4785-4795
61. Katanaev, V.L. (2001) Signal transduction in neutrophil chemotaxis. Biochemistry (Mosc) 66, 351-368
62. Kavran, J.M., Klein, D.E., Lee, A., Falasca, M., Isakoff, S.J., Skolnik, E.Y. and Lemmon, M.A. (1998) Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J. Biol. Chem. 273, 30497-30506
63. Kimber, W.A., Trinkle-Mulcahy, L., Cheung, P.C.F., Deak, M., Marsden, L.J., Kieloch, A., Watt, S., Javier, R.T., Gray, A., Downes, C.P., Lucocq, J.M. and Alessi, D.R. (2002) Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with phosphatidylinositol 3,4-bisphosphate and the multi-PDZ-domain-containing protein MUPP1 in vivo. Biochem. J. 361, 525-536
64. Klarlund, J.K., Guilherme, A., Holik, J.J., Virbasius, A. and Czech, M.P. (1997) Signaling by phosphoinositide 3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science 275 1927-1930
65. Klarlund, J.K., Tsiaras, W., Holik, J.J., Chawla, A. and Czech, M.P. (2000) Distinct polyphosphoinositide binding selectivities for pleckstrin homology domains of GRP1-like proteins based on diglycine versus triglycine motifs. J. Biol. Chem. 275, 32816-32821
66. Klein, D.E., Lee, A., Frank, D.W., Marks, M.S. and Lemmon, M.A. (1998) The pleckstrin homology domain of dynamin isoforms require oligomerization for high affinity phosphoinositide binding. J. Biol. Chem. 273, 27725-27733
67. Klippel, A., Kavanaugh, W.M., Pot, D. and Williams, L.T. (1997) A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol. Cell. Biol. 17, 338-344
68. GAP. Biochem. Biophys. Res. Commun. 283, 888-895
69. Kojima, T., Fukuda, M., Watanabe, Y., Hamazato, F. and Mikoshiba, K. (1997) Characterisation of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide-binding capacity. Biochem. Biophys. Res. Commun. 236, 333-339
70. Konishi, H., Kuroda, S. and Kikkawa, U. (1994) The pleckstrin homology domain of Rac protein kinase associates with the regulatory domain of protein kinase-C zeta. Biochem. Biophy. Res. Commun. 205, 1770-1775
71. Konishi, H., Kuroda, S., Tanaka, M., Matsuzaki, H., Ono, Y., Kameyama, K., Haga, T. and Kikkawa, U. (1995) Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and βγ subunits of G proteins. Biochem. Biophys. Res. Commun. 216, 526-534
72. Koshiba, S., Kigawa, T., Kim, J.H., Shirouzu, M., Bowtell, D. and Yokoyama, S. (1997) The solution structure of the pleckstrin homology domain of mouse Son-of-Sevenless 1 (mSos1) J. Mol. Biol. 20, 579-591
73. Krugmann, S., Anderson, K.E., Ridley, S.H., Risso, N., McGregor, A., Coadwell, J., Davidson, K., Eguinoa, A., Ellson, C.D., Lipp, P., Manifava, M., Ktistakis, N., Painter, G., Thuring, J.W., Cooper, M.A., Lim, Z.Y., Holmes, A.B., Dove, S.K., Michell, R.H., Grewal, A., Nazarian, A., Erdjument-Bromage, H., Tempst, P., Stephens, L.R. and Hawkins, P.T. (2002) Identification of ARAP3, a novel phosphoinositide 3-kinase effector regulating both ARF and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol. Cell 9, 95-108
74. Lemmon, M.A., Ferguson, K.M., O'Brien, R., Sigler, P.B. and Schlessinger, J. (1995) Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proc. Natl. Acad. Sci. U.S.A. 92, 10472-10476
75. Lemmon, M.A. and Ferguson, K.M. (2000) Signal-dependent membrane targeting by pleckstrin homology domains. Biochem. J. 350, 1-18
76. Lemmon, M.A. and Ferguson, K.M. (2001) Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides. Biochem. Soc. Trans. 29, 377-384
77. Lemmon, M.A., Ferguson, K.M. and Abrams, C.S. (2002) Pleckstrin homology domains and the cytoskeleton. FEBS Lett. 513, 71-76
78. Leslie, N.R. and Downes, C.P. (2002) PTEN: The down side of PI 3-kinase signalling. Cell Signal, 14, 285-295
79. Levine, T.P. and Munro, S. (1998) The pleckstrin homology domain of oxysterol-binding protein recognizes a determinant specific to Golgi membranes. Curr. Biol. 8, 729-739
80. Levine, T.P. and Munro, S. (2001) Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both Golgi and the nucleus-vacuole junction. Mol. Biol. Cell 12, 1633-1644
81. Levine, T.P. and Munro, S. (2002) Targeting of Golgi-specific pleckstrin homology domains involves both phosphatidylinositol 4-kinase-dependent and -independent components. Curr. Biol. 12, 695-704
82. Li, X., Rivas, M.P., Fang, M., Marchena, J., Mehrotra, B., Chaudhary, A., Feng, L., Prestwich, G.D. and Bankaitis, V.A. (2002) Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex. J. Cell Biol. 157, 63-78
83. Lietzke, S.E., Bose, S., Cronin, T., Klarlund, J., Chawla, A., Czech, M.P. and Lambright, D.G. (2000) Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. Mol. Cell 6, 385-394
84. m as an in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein. Curr. Biol. 9, 265-268
85. Liu, X., Wang, H., Eberstadt, M., Schnuchel, A., Olejniczak, E.T., Meadows, R.P., Schkeryantz, J.M., Janowick, D.A., Harlan, J.E., Harris, E.A.S., Staunton, D.E. and Fesik, S.W. (1998) NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio. Cell 95, 269-277
86. Lorra, C and Huttner, W.B. (1999) The mesh hypothesis of Golgi dynamics. Nat. Cell Biol. 1, E113-E155
87. Lowry, W.E., Huang, J.Y., Lei, M., Rawlings, D. and Huang, X.Y. (2001) Role of the PHTH module in protein substrate recognition by Bruton's agammaglobulinemia tyrosine kinase. J. Biol. Chem. 276, 45276-45281
88. Ma, A.D., Metjian, A., Bagrodia, S., Taylor, S. and Abrams, C.S. (1998) Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase γ, a Rac guanosine exchange factor, and Rac. Mol. Cell. Biol. 18, 4744-4751
89. Macias, M.J., Musacchio, A., Ponstingi, H., Nigles, M., Saraste, M. and Oschkinat, H. (1994) Structure of the pleckstrin homology domain from β-spectrin. Nature (London) 369, 672-675
90. Maffucci, T. and Falasca, M. (2001) Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism. FEBS Lett. 506, 173-179
91. Marshall, A.J., Krahn, A.K., Ma, K.W., Duronio, V. and Hou, S. (2002) TAPP1 and TAPP2 are targets of phosphoinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B cell antigen receptor. Mol. Cell. Biol. 22, 5479-5491
92. Meili, R., Ellsworth, C., Lee, S., Reddy, T.B., Ma, H. and Firtel, R.A. (1999) Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J. 18 2092-2105
93. Meili, R., Ellsworth, C. and Firtel, R. A. (2000) A novel Akt/ PKB-related kinase is essential for morphogenesis in Dictyostelium. Curr. Biol. 10, 708-717
94. Miura, K., Jacques, K.M., Stauffer, S., Kubosaki, A., Zhu, K.J., Hirsch, D.S., Resau, J., Zheng, Y. and Randazzo, P.A. (2002) ARAP1: a point of convergence for ARFs and Rho signaling. Mol. Cell 9, 109-119
95. Muhlberg, A.B., Warnock, D.E. and Schmid, S.L. (1997) Domain structure and intramolecular regulation of dynamin GTPase. EMBO J. 16, 6676-6683
96. Nilges, M., Macias, M.J., O'Donoghue, S.I. and Oschkinat, H. (1997) Automated NOESY interpretation with ambiguous distance restraints: The refined NMR solution structure of the pleckstrin homology domain from β-spectrin. J. Mol. Biol. 269, 408-422
97. Nimnual, A.S., Yatsula, B.A. and Bar-Sagi, D. (1998) Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science 279, 560-563
98. 3-sensor that can bind the cytoskeletal adaptor, γ-filamin. J. Biol. Chem. Papers in Press published October 9 2002 as 10.1074/jbc.M208352200
99. Parent, C.A., Blacklock, B.J., Froehlich, W.M., Murphy, D.B. and Devreotes, P.N. (1998) G protein signaling events are activated at the leading edge of chemotactic cells. Cell. 95, 81-91
100. Parent, C.A. and Devreotes, P.N. (1999) A cell's sense of direction. Science 284, 765-770
101. Peters, P.J., Hsu, V.W., Ooi, C.E., Finazzi, D., Teal, S.B., Ooschot, V., Donaldson, J.G. and Klausner, R.D. (1995) Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbation of nonoverlapping membrane compartments. J. Cell Biol. 128, 1003-1017
102. Pitcher, J.A., Touhara, K., Payne, E.S. and Lefkowitz, R.J. (1995) Pleckstrin homology domain-mediated membrane association and activation of the β-adrenergic receptor kinase requires coordinate interaction with Gβγ subunits and lipid. J. Biol. Chem. 270, 11707-11710
103. Prehoda, K.E., Lee, D.J. and Lim, W.A. (1999) Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly. Cell 97, 471-480
104. Radhakrishna, H., Klausner, R.D. and Donaldson, J.G. (1996) Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase. J. Cell Biol. 134, 935-947
105. Radhakrishna, H., Al-Awar, O., Khachikian, Z. and Donaldson, J.G. (1999) ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. J. Cell Sci. 112, 855-866
106. Rameh, L.E. and Cantley, L.C. (1999) The role of phosphoinositide 3-kinase lipid in cell function. J. Biol. Chem. 274, 8347-8350
107. Raya, A., Revert, F., Navarro, S. and Saus, J. (1999) Characterisation of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen. J. Biol. Chem. 274, 12642-12649
108. Rodriguez, M.M., Ron, D., Touhara, K., Chen, C.-H. and Mochly-Rosen, D. (1999) RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro. Biochemistry 38, 13787-13794
109. Rossman, K.L., Worthylake, D.K., Snyder, J.T., Siderovski, D.P., Campbell, S.L. and Sondek, J. (2002) A crystallographic view of interactions between Dbs and Cdc43: PH domain-assisted guanine nucleotide exchange. EMBO J. 21, 1315-1326
110. Russo, C., Gao, Y., Mancini, P., Vanni, C., Porotto, M., Falasca, M., Torrisi, M.R., Zheng, Y. and Eva, A. (2001) Modulation of oncogenic Dbl activity by phosphoinositol phosphate binding to pleckstrin homology domain. J. Biol. Chem. 276 19524-19531
111. Saito, K., Scharenberg, A.M. and Kinet, J.P. (2001) Interaction between the Bruton's tyrosine kinase pleckstrin homology domain and phosphatidylinositol 3,4,5-trisphosphate directly regulates Btk. J. Biol. Chem. 276, 16201-16206
112. Sanchez-Madrid, F. and del Pozo, M.A. (1999) Leukocyte polarization in cell migration and immune interactions. EMBO J. 18, 501-511
113. Santy, L.C. and Casanova, J.E. (2001) Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D. J. Cell Biol. 154, 599-610
114. Servant, G., Weiner, O.D., Neptune, E.R., Sedat, J.W. and Bourne, H.R. (1999) Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol. Biol. Cell 10, 1163-1178
115. Servant, G., Weiner, O.D., Herzmark, P., Balla, T., Sedat, J.W. and Bourne, H.R. (2000) Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science 287, 1037-1040
116. Shinohara, M., Terada, Y., Iwamatsu, A., Shinohara, A., Mochizuki, N., Higuchi, M., Gotoh, Y., Ihara, S., Nagata, S., Itoh, H., Fukui, Y. and Jessberger, R. (2002) SWAP-70 is a guanine-nucleotide exchange factor that mediates signaling of membrane ruffling. Nature (London) 416, 759-763
117. Siddhanta, A., Backer, J.M. and Shields, D. (2000) Inhibition of phosphatidic acid synthesis alters the structure of the Golgi apparatus and inhibits secretion in endocrine cells. J. Biol. Chem. 275, 12023-12031
118. Siddhanta, A., Radulescu, A., Stankewich, M.C., Morrow, J.S. and Shields, D. (2002) Fragmentation of the Golgi apparatus: a role for III spectrin and synthesis of phosphatidylinositol 4,5-bisphosphate. J. Biol. Chem. Published on-line 10.1074/jbc.M209137200
119. Snyder, J.T., Rossman, K.L., Baumeister, M.A., Pruitt, W.M., Siderovski, D.P., Der, C.J., Lemmon, M.A. and Sondek, J. (2001) Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins. J. Biol. Chem. 276, 45868-45875
120. Snyder, J.T., Worthylake, D.K., Rossman, K.L., Betts, L., Pruitt, W.M., Siderovski, D.P., Der, C.J. and Sondek, J. (2002) Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat. Struct. Biol. 9, 468-475
121. Soisson, S.M., Nimual, A.S., Uy, M., Bar-Sagi, D. and Kuriyan, J. (1998) Crystal structure of the Dbl and pleckstrin homology domain from the human Son of Sevenless protein. Cell 95, 259-268
122. Stam, J.C., Sander, E.E., Michiels, F., van Leeuwen, F.N., Kain, H.E.T., van der Kammen, R.A. and Collard, J.G. (1997) Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain. J. Biol. Chem. 272, 28447-28454
123. Stephens, L.R., Anderson, K.A., Stokoe, D., Erdjument-Bromage, H., Painter, G.F., Holmes, A.B., Gaffney, P.R.J., Reese, C.B., McCormick, F., Tempst, P., Coadwell, J. and Hawkins, P.T. (1998) Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 279, 710-714
124. Stephens, L.R., Ellson, C. and Hawkins, P.T. (2002) Roles of PI3Ks in leukocyte chemotaxis and phagocytosis. Curr. Opin. Cell Biol. 14 203-213
125. Stites, J., Wessels, D., Uhl, A., Egelhoff, T., Shutt, D. and Soll, D.R. (1998) Phosphorylation of the Dictyosteliummyosin II heavy chain is necessary for maintaining cellular polarity and suppressing turning during chemotaxis. Cell Motil. Cytoskeleton 39, 31-51
126. Sweeney, D.A., Siddhanta, A. and Shields, D. (2002) Fragmentation and re-assembly of the Golgi apparatus in vitro. A requirement for phosphatidic acid and phosphatidylinositol 4,5-bisphosphate synthesis. J. Biol. Chem. 277, 3030-3039
127. Teruel, M.N. and Meyer, T. (2000) Reversible localization of signaling proteins: a dynamic future for signal transduction. Cell 103, 181-184
128. Thomas, C.C., Dowler, S., Deak, M., Alessi, D.R. and van Aalten, D.M.F. (2001) Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity. Biochem. J. 358, 287-294
129. Thomas, C.C., Deak, M., Alessi, D.R. and van Aalten, D.M.F. (2002) High-resolution structure of the pleckstrin homology domain of protein kinase B/Akt bound to phosphatidylinositol 3,4,5-trisphosphate. Curr. Biol. 12, 1256-1262
130. Timm, D., Salim, K., Gout, I., Gurupresad, L., Waterfield, M. and Blundell, T. (1994) Crystal structure of the pleckstrin homology domain from dynamin. Nature (London) Struct. Biol. 1, 782-788
131. Toker, A. (2002) Phosphoinositides and signal transduction. Cell. Mol. Life Sci. 59, 761-779
132. Touhara, K., Inglese, J., Pitcher, J.A., Shaw, G. and Lefkowitz, R.J. (1994) Binding of G-protein βγ subunits to pleckstrin homology domains. J. Biol. Chem. 269, 10217-10220
133. Tsujishita, Y. and Hurley, J.H. (2000) Structure and lipid transport mechanism of a StAR-related domain. Nat. Struct. Biol. 7, 408-414
134. Tsukuda, S., Simon, M.I., Witte, O.N. and Katz, A. (1994) Binding of βγ subunits of heterotrimeric G-proteins to the pleckstrin homology domain of Bruton's tyrosine kinase. Proc. Natl. Acad. Sci. U.S.A. 91, 11256-11260
135. Vanhaesebroeck, B. and Alessi, D.R. (2000) The phosphoinositide 3-kinase-3-phosphoinositide-dependent kinase 1 connection: more than just a road to protein kinase B. Biochem. J. 346, 561-576
136. Vanhaesebroeck, B., Leevers, S.J., Ahmadi, K., Timms, J., Katso, R., Driscoll, R.C., Woscholski, R., Parker, P.J. and Waterfield, M.D. (2001) Synthesis and function of 3-phosphorylated inositol lipids. Annu. Rev. Biochem. 70, 535-602
137. Varnai, P., Rother, K.I. and Balla, T. (1999) Phosphatidylinositol 3-kinase-dependent membrane association of Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells. J. Biol. Chem. 274, 10983-10989
138. Venkateswarlu, K., Oatey, P.B., Tavaré, J.M. and Cullen, P.J. (1998a) Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires PI 3-kinase. Curr. Biol. 8, 463-466
139. Venkateswarlu, K., Gunn-Moore, F., Oatey, P.B., Tavaré, J.M. and Cullen, P.J. (1998b) NGF- and EGF-stimulated translocation of the ARF-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of PI 3-kinase and the GRP1 PH domain. Biochem. J. 335, 139-146
140. 1 as an in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ARF GTPase-activating protein Gcs1. Biochem. J. 340, 359-363
141. Venkateswarlu, K., Gunn-Moore, F., Tavaré, J.M. and Cullen, P.J. (1999b) EGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain. J. Cell Sci. 112 1957-1965
142. Vetter, I.R., Nowak, C., Nishimotot, T., Kuhlmann, J. and Wittinghofer, A. (1999) Structure of the Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. Nature (London) 398, 39-46
143. Walch-Solimena, C. and Novick, P. (1999) The yeast phosphatidylinositol 4-kinase pik1 regulates secretion at the Golgi. Nat. Cell Biol. 1, 523-525
144. Waldron, R.T., Iglesias, T. and Rozengurt, E. (1999) The pleckstrin homology domain of protein kinase D interacts preferentially with the eta isoform of protein kinase C. J. Biol. Chem. 274, 9224-9230
145. Wardlaw, A.J., Brightling, C., Green, R., Woltmann, G. and Pavord, I. (2000) Eosinophils in asthma and other allergic diseases. Br. Med. Bull. 56, 985-1003
146. Wang, D.S., Shaw, R., Winkelmann, J.C. and Shaw, G. (1994) Binding of pleckstrin homology domains of β-adrenergic receptor kinase and β-spectrin to WD40/β-transducin repeat containing regions of the β-subunit of trimeric G-proteins. Biochem. Biophys. Res. Commun. 203, 29-35
147. Wang, D.S., Shaw, R., Hattori, M., Arai, H., Inoue, K. and Shaw, G. (1995) Binding of pleckstrin homology domains to WD40/β-transducin repeat containing segments of the protein product of the Lis-1 gene. Biochem. Biophys. Res. Commun. 209, 622-629
148. Watt, S.A., Kular, G., Fleming, I.N., Downes, C.P. and Lucocq, J.M. (2002) Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase Cδ1. Biochem. J. 363, 657-666
149. Watton, S.J. and Downward, J. (1999) Akt/PKB localisation and 3-phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction. Curr. Biol. 9, 433-436
150. Weiner, O.D., Servant, G., Welch, M.D., Mitchison, T.J., Sedat, J.W. and Bourne, H.R. (1999) Spatial control of actin polymerization during neutrophil chemotaxis. Nat. Cell Biol. 1, 75-81
151. Weiner, O.D. (2002) Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. Curr. Opin. Cell Biol. 14 196-202
152. 3 and Gβγ? Curr. Biol. 12, R429-431
153. Welch, H.C.E., Coadwell, W.J., Ellson, C.D., Ferguson, G.J., Andrews, S.R., Erdjument-Bromage, H., Tempst, P., Hawkins, P.T. and Stephens, L.R. (2002) P-Rex, a phosphatidylinositol 3,4,5-trisphosphate- and Gβγ -regulated guanine nucleotide exchange factor for Rac. Cell 108, 809-821
154. Wherlock, M. and Mellor, H. (2002) The Rho GTPase family: a Racs to Wrchs story. J. Cell Sci. 115, 239-240
155. Worthylake, D.K., Rossman, K.L. and Sondek, J. (2000) Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature (London) 408, 682-688
156. Wyles, J.P., McMaster, C.R. and Ridgway, N.D. (2002) Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein to modify export from the endoplasmic reticulum. J. Biol. Chem. 277, 29908-29918
157. Xiao, Z., Zhang, N., Murphy, D.B. and Devreotes, P.N. (1997) Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation. J. Cell Biol. 139, 365-374
158. Xu, Y.Q., Liu, Y.L., Ridgway, N.D. and McMaster, C.R. (2001) Novel members of the human oxysterol-binding protein family bind phospholipids and
159. Yang, W. and Desiderio, S. (1997) BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. Proc. Natl. Acad. Sci. U.S.A. 94, 604-609
160. Yao, L., Kawakami, Y. and Kawakami, T. (1994) The pleckstrin homology domain of Bruton's tyrosine kinase interacts with protein kinase C. Proc. Natl. Acad. Sci. U.S.A. 91, 9175-9179
161. Yao, L., Suzuki, H., Ozawa, K., Deng, J., Lehel, C., Fukamachi, H., Anderson, W.B., Kawakami, Y. and Kawakami, T. (1997) Interactions between protein kinase C and pleckstrin homology domains. Inhibition by phosphatidylinositol 4,5-bis-phosphate and phorbol 12-myristate 13-acetate. J. Biol. Chem. 272, 13033-13039
162. Yao, L., Janmey, P., Frigeri, L.G., Han, W., Fujita, J., Kawakami, Y., Apgar, J.R. and Kawakami, T. (1999) Pleckstrin homology domains interact with filamentous actin. J. Biol. Chem. 274 19752-19761
163. Yoon, H.S., Hajduk, P.J., Petros, A.M., Olejniczak, E.T., Meadows, R.P. and Fesik, S.W. (1994) Solution structure of a pleckstrin homology domain. Nature (London) 369, 672-675
164. Zhang, P., Talluri, S., Deng, H., Branton, D. and Wagner, G. (1995) Solution structure of the pleckstrin homology domain of Drosophilaβ -spectrin. Structure 3, 1185-1195
165. Zheng, J., Chen, R.-H., Corbalan-Garcia, S., Cahill, S.M., Bar-Sagi, D. and Cowburn, D. (1997) The solution structure of the pleckstrin homology domain of human SOS1: a possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains. J. Biol. Chem. 272, 30340-30344
166. Zhou, M.-M., Ravichandran, K.S., Olejniczak, E.T., Petros, A.M., Meadows, R.P., Sattler, M., Harlan, J.E., Wade, W.S., Burakoff, S.J. and Fesik, S.W. (1995) Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Nature (London) 378, 548-592