Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1

EMBO Journal

Volumn 20, Issue 14, 2001, Pages 3800-3810

  Holmberg, Carina I ^a   Hietakangas, Ville ^a,b   Mikhailov, Andrey ^a   Rantanen, Jouni O ^a   Kallio, Marko ^a   Meinander, Annika ^a   Hellman, Jukka ^a   Morrice, Nick ^c   MacKintosh, Carol ^c   Morimoto, Richard I ^d   Eriksson, John E ^a   Sistonen, Lea ^a,e,f  

^a UNIVERSITY OF TURKU   (Finland)

^b Department of Biochemistry and Food Chemistry ^*  (Finland)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d NORTHWESTERN UNIVERSITY   (United States)

^e ÅBO AKADEMI UNIVERSITY   (Finland)

^f TURKU CENTRE FOR BIOTECHNOLOGY   (Finland)

Author keywords

Heat shock factor 1; Heat shock response; Phosphorylation; Transcription

Indexed keywords

DNA; HEAT SHOCK FACTOR 1; HEAT SHOCK PROTEIN; PHOSPHOPEPTIDE; PHOSPHOPEPTIDE ANTIBODY; PROTEIN KINASE (CALCIUM,CALMODULIN) II; SERINE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA BINDING; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HEAT SHOCK RESPONSE; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS; TRANSACTIVATION; TRANSCRIPTION INITIATION;

ANTIBODIES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DNA-BINDING PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HEAT; HUMANS; MUTAGENESIS, SITE-DIRECTED; PHOSPHOPEPTIDES; PHOSPHORYLATION; RECOMBINANT PROTEINS; SERINE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 17844386323     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.14.3800     Document Type: Article

References (45)

1. Signaling to p53: Breaking the posttranslational modification code
2. Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1
3. Opposing actions of phosphatidylinositol 3-kinase and glycogen synthase kinase-3β in the regulation of HSF-1 activity
4. Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor 1
5. Transcriptional activity of heat shock factor I at 37°C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3α and protein kinases Cα and Cξ
6. The regulation of protein function by multisite phosphorylation - A 25 year update
7. Activation of heat shock factor I DNA binding precedes stress-induced serine phosphorylation
8. HSF1 granules: A novel stress-induced nuclear compartment of human cells
9. JNK targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity
10. Strategies to assess phosphoprotein phosphatase and protein kinase-mediated regulation of the cytoskeleton
11. Phosphorylation of Drosophila heat shock transcription factor
12. A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function
13. Glycogen synthase kinase 3β and extracellular signal-regulated kinase inactivate heat shock transcription factor I by facilitating the disappearance of transcriptionally active granules after heat shock
14. A short element required for turning off heat shock transcription factor: Evidence that phosphorylation enhances deactivation
15. Conventional and novel PKC isoenzymes modify the heat induced stress response but are not activated by heat shock
16. Formation of nuclear HSF1 granules varies depending on stress stimuli
17. Signaling - 2000 and beyond
18. The regulation of transcription by phosphorylation
19. HSF1 transcription factor concentrates in nuclear foci during heat shock: Relationship with transcription sites
20. Rapid and reversible relocalization of heat shock factor I within seconds to nuclear stress granules
21. Effect of sodium salicylate on the human heat shock response
22. Salicylate triggers heat shock factor differently than heat
23. Analysis of the phosphorylation of human heat shock transcription factor by MAP kinase family members
24. Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation
25. Repression of human heat shock factor I activity at control temperature by phosphorylation
26. Activation in vitro of sequence-specific DNA binding by a human regulatory factor
27. Oxidative stress induces heat shock factor phosphorylation and HSF-dependent activation of yeast metallothionein gene transcription
28. Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis
29. Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors molecular chaperones and negative regulators
30. Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells
31. Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1
32. The regulatory domain of human heat shock factor is sufficient to sense stress
33. Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity
34. A vector for expressing GAL4 (1-147) fusions in mammalian cells
35. Activation of heat shock gene transcription by HSF1 involves oligomerization acquisition of DNA binding activity and nuclear localization and can occur in the absence of stress
36. 2+/calmodulin-dependent protein kinases
37. The carboxy-terminal transactivation domain of heat shock factor I is negatively regulated and stress responsive
38. Yeast heat shock factor contains separable transient and sustained response transcriptional activators
39. Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation
40. Heat shock factor is regulated differently in yeast and HeLa cells
41. Phosphopeptide mapping and phosphoamino acid analysis on cellulose thin-layer plates
42. Ela transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex
43. The heat shock factors: Structure and regulation
44. Glycogen synthase kinase 3β negatively regulates both DNA-binding and transcriptional activities of heat shock factor 1
45. Multiple layers of regulation of human heat shock transcription factor 1