Molecular and evolutionary basis of the cellular stress response

Annual Review of Physiology

Volumn 67, Issue , 2005, Pages 225-257

  Kültz, Dietmar ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DNA repair; Macromolecular damage; Molecular chaperones; Molecular evolution; Redox regulation

Indexed keywords

CELL DNA; CELL PROTEIN; CHAPERONE; HEAT SHOCK PROTEIN;

APOPTOSIS; CELL CYCLE; CELL DAMAGE; CELL ENERGY; CELL FUNCTION; CELL GROWTH; CELL MEMBRANE; COLD STRESS; DNA REPAIR; DNA REPLICATION; ENERGY METABOLISM; ENVIRONMENTAL FACTOR; FATTY ACID METABOLISM; GENE ACTIVATION; GENETIC CONSERVATION; HOMEOSTASIS; HUMAN; LIPID MEMBRANE; LIPID METABOLISM; MACROMOLECULE; MEMBRANE DAMAGE; MEMBRANE STABILIZATION; MITOSIS INHIBITION; MOLECULAR EVOLUTION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEOMICS; REDUCTION; REVIEW; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; STRESS;

ANIMALS; CELLS; EVOLUTION, MOLECULAR; HUMANS; STRESS;

EID: 15544377794     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.67.040403.103635     Document Type: Review

References (205)

1. Cannon WB. 1929. Bodily Changes in Pain, Hunger, Fear and Rage. New York: Appleton-Century-Crofts
2. Selye H. 1936. A syndrome produced by diverse nocuous agents. Nature 138:32
3. Charmandari E, Tsigos C, Chrousos G. 2005. Endocrinology of the stress response. Annu. Rev. Physiol. 67:259-84
4. Kültz D. 2003. Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous function. J. Exp. Biol. 206:3119-24
5. Koonin EV. 2000. How many genes can make a cell: the minimal-gene-set concept. Annu. Rev. Genomics Hum. Genet. 1:99-116
6. Gasch AP, Spellman PT, Kao CM, Carmel-Harel O, Eisen MB, et al. 2000. Genomic expression programs in the response of yeast cells to environmental changes. Mol. Biol. Cell 11:4241-57
7. Beck FX, Grunbein R, Lugmayr K, Neuhofer W. 2000. Heat shock proteins and the cellular response to osmotic stress. Cell Physiol. Biochem. 10:303-6
8. DiRuggiero J, Brown JR, Bogert AP, Robb FT. 1999. DNA repair systems in archaea: mementos from the last universal common ancestor? J. Mol. Evol. 49:474-84
9. Tissières A, Mitchell HK, Tracy UM. 1974. Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs. J. Mol. Biol. 84:389-98
10. Pastori GM, Foyer CH. 2002. Common components, networks, and pathways of cross-tolerance to stress: the central role of "redox" and abscisic acid-mediated controls. Plant Physiol. 129:460-68
11. Reth M. 2002. Hydrogen peroxide as second messenger in lymphocyte activation. Nat. Immunol. 3:1129-34
12. Bolwell GP. 1996. The origin of the oxidative burst in plants. Biochem. Soc. Trans. 24:438-42
13. Reiser V, Raitt DC, Saito H. 2003. Yeast osmosensor Sln1 and plant cytokinin receptor Cre1 respond to changes in turgor pressure. J. Cell Biol. 161:1035-40
14. Miyakawa H, Woo SK, Dahl SC, Handler JS. Kwon HM. 1999. Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity. Proc. Natl. Acad. Sci. USA 96:2538-42
15. Lepore DA, Knight KR, Anderson RL, Morrison WA. 2001. Role of priming stresses and Hsp70 in protection from ischemia-reperfusion injury in cardiac and skeletal muscle. Cell Stress Chaperones 6:93-96
16. Sejerkilde M, Sorensen JG, Loeschcke V. 2003. Effects of cold- and heat-hardening on thermal resistance in Drosophila melanogaster. J. Insect Physiol. 49:719-26
17. Alsbury S, Papageorgiou K, Latchman DS. 2004. Heat shock proteins can protect aged human and rodent cells from different stressful stimuli. Mech. Ageing Dev. 125:201-9
18. Koga T, Sakamoto F, Yamoto A, Takumi K. 1999. Acid adaptation induces cross-protection against some environmental stresses in Vibrio parahaemolyticus. J. Gen. Appl. Microbiol. 45:155-61
19. Mary P, Sautour M, Chihib NE, Tierny Y, Hornez JP. 2003. Tolerance and starvation induced cross-protection against different stresses in Aeromonas hydrophila. Int. J. Food Microbiol. 87:121-30
20. Alexieva V, Sergiev I, Mapelli S, Karanov E. 2001. The effect of drought and ultraviolet radiation on growth and stress markers in pea and wheat. Plant Cell Environ. 24:1337-44
21. Enjalbert B, Nantel A, Whiteway M. 2003. Stress-induced gene expression in Candida albicans: absence of a general stress response. Mol. Biol. Cell 14:1460-67
22. Santos BC, Pullman JM, Chevaile A, Welch WJ, Gullans SR. 2003. Chronic hyperosmolarity mediates constitutive expression of molecular chaperones and resistance to injury. Am J. Physiol. 284: F564-74
23. Mikkelsen RB, Wardman P. 2003. Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms. Oncogene 22:5734-54
24. Fleury C, Mignotte B, Vayssiere JL. 2002. Mitochondrial reactive oxygen species in cell death signaling. Biochimie 84:131-41
25. Lee I, Bender E, Arnold S, Kadenbach B. 2001. New control of mitochondrial membrane potential and ROS formation: a hypothesis. Biol. Chem. 382:1629-36
26. Parasassi T, Sapora O, Giusti AM, Destasio G, Ravagnan G. 1991. Alterations in erythrocyte membrane lipids induced by low doses of ionizing radiation as revealed by 1,6-diphenyl-1,3,5-hexatriene fluorescence lifetime. Int. J. Radiat. Biol. 59:59-69
27. Bandurska H. 1998. Implication of ABA and proline on cell membrane injury of water deficit stressed barley seedlings. Acta Physiol. Plant. 20:375-81
28. Zeng F, An Y, Zhang HT, Zhang MF. 1999. The effects of La(III) on the peroxidation of membrane lipids in wheat seedling leaves under osmotic stress. Biol. Trace Element Res. 69:141-50
29. Steels EL, Learmonth RP, Watson K. 1994. Stress tolerance and membrane lipid unsaturation in Saccharomyces cerevisiae grown aerobically or anaerobically. Microbiology 140:569-76
30. Swan TM, Watson K. 1999. Stress tolerance in a yeast lipid mutant: membrane lipids influence tolerance to heat and ethanol independently of heat shock proteins and trehalose. Can. J. Microbiol. 45:472-79
31. Chatterjee MT, Khalawan SA, Curran BP. 2000. Cellular lipid composition influences stress activation of the yeast general stress response element (STRE). Microbiology 146:877-84
32. Knights KM, Drogemuller CJ. 2000. Xenobiotic-CoA ligases: kinetic and molecular characterization. Curr. Drug Metab. 1:49-66
33. 2s and lipid peroxidation. Biochim. Biophys. Acta 1488:167-81
34. Sevanian A, Ursini F. 2000. Lipid peroxidation in membranes and low-density lipoproteins: similarities and differences. Free Radic. Biol. Med. 29:306-11
35. Spiteller G. 2003. Are lipid peroxidation processes induced by changes in the cell wall structure and how are these processes connected with diseases? Med. Hypoth. 60:69-83
36. Leonarduzzi G, Arkan MC, Basaga H, Chiarpotto E, Sevanian A, Poli G. 2000. Lipid oxidation products in cell signaling. Free Radic. Biol. Med. 28:1370-78
37. Rosette C, Karin M. 1996. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274:1194-97
38. Rhee SG, Bae YS, Lee SR, Kwon J. 2000. Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation. Sci. STKE 2000:E1-11
39. Rhee SG, Chang TS, Bae YS, Lee SR, Kang SW. 2003. Cellular regulation by hydrogen peroxide. J. Am. Soc. Nephrol. 14:8211-15
40. Spiteller G. 2001. Lipid peroxidation in aging and age-dependent diseases. Exp. Gerontol. 36:1425-57
41. Marathe GK, Harrison KA, Murphy RC, Prescott SM, Zimmerman GA, McIntyre TM. 2000. Bioactive phospholipid oxidation products. Free Radic. Biol. Med. 28:1762-70
42. 2 as a mechanosensor. Biophys. J. 68:1888-94
43. 2 enzymes. Prostaglandins Other Lipid. Mediat. 68-69:3-58
44. Hoppe T, Matuschewski K, Rape M, Schlenker S, Ulrich HD, Jentsch S. 2000. Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing. Cell 102:577-86
45. 2+ entry through single stretch-activated cation channels. Proc. Natl. Acad. Sci. USA 99:6404-9
46. Kass GE, Orrenius S. 1999. Calcium signaling and cytotoxicity. Environ. Health Perspect. 107(Suppl. 1):25-35
47. Kültz D, Chakravarty D. 2001. Hyperosmolality in the form of elevated NaCl but not urea causes DNA damage in murine kidney cells. Proc. Natl. Acad. Sci. USA 98:1999-2004
48. Kültz D, Madhany S, Burg MB. 1998. Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2. J. Biol. Chem. 273:13645-51
49. Seno JD, Dynlacht JR. 2004. Intracellular redistribution and modification of proteins of the Mre11/Rad50/Nbs1 DNA repair complex following irradiation and heat-shock. J. Cell. Physiol. 199:157-70
50. Zhou BB, Elledge SJ. 2000. The DNA damage response: putting checkpoints in perspective. Nature 408:433-39
51. Natrajan G, Lamers MH, Enzlin JH, Winterwerp HH, Perrakis A, Sixma TK. 2003. Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates. Nucleic Acids Res. 31:4814-21
52. Eisen JA, Hanawalt PC. 1999. A phylogenomic study of DNA repair genes, proteins, and processes. Mutat. Res. 435:171-213
53. Sixma TK. 2001. DNA mismatch repair: MutS structures bound to mismatches. Curr. Opin. Struct. Biol. 11:47-52
54. Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J. 2000. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 14:927-39
55. Khil PP, Camerini-Otero RD. 2002. Over 1000 genes are involved in the DNA damage response of Escherichia coli. Mol. Microbiol. 44:89-105
56. Beaber JW, Hochhut B, Waldor MK. 2004. SOS response promotes horizontal dissemination of antibiotic resistance genes. Nature 427:72-74
57. Kitagawa J, Yamamoto K, Iba H. 2001. Computational analysis of SOS response in ultraviolet-irradiated Escherichia coli. Genome Inform. 12:280-81
58. Reich CI, McNeil LK, Brace JL, Brucker JK, Olsen GJ. 2001. Archaeal RecA homologues: different response to DNA-damaging agents in mesophilic and thermophilic archaea. Extremophiles 5:265-75
59. Aguilera A. 2001. Double-strand break repair: are Rad51/RecA-DNA joints barriers to DNA replication? Trends Genet. 17:318-21
60. Gasior SL, Olivares H, Ear U, Hari DM, Weichselbaum R, Bishop DK. 2001. Assembly of RecA-like recombinases: distinct roles for mediator proteins in mitosis and meiosis. Proc. Natl. Acad. Sci. USA 98:8411-18
61. Tsuzuki T, Fujii Y, Sakumi K, Tominaga Y, Nakao K, et al. 1996. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. Proc. Natl. Acad. Sci. USA 93:6236-40
62. Chen JJ, Silver D, Cantor S, Livingston DM, Scully R. 1999. BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway. Cancer Res. 59:1752s-56s
63. Scully R, Chen J, Plug A, Xiao Y, Weaver D, et al. 1997. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88:265-75
64. Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, et al. 2003. MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 421:952-56
65. Bradbury JM, Jackson SP. 2003. The complex matter of DNA double-strand break detection. Biochem. Soc. Trans. 31:40-44
66. Trujillo KM, Roh DH, Chen L, Van Komen S, Tomkinson A, Sung P. 2003. Yeast Xrs2 binds DNA and helps target Rad50 and Mre11 to DNA ends. J. Biol. Chem. 278:48957-64
67. Horejsi Z, Falck J, Bakkenist CJ, Kastan MB, Lukas J, Bartek J. 2004. Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. Oncogene 23:3122-27
68. Lee JH, Paull TT. 2004. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 304:93-96
69. Bakkenist CJ, Kastan MB. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421:499-506
70. Petrini JHJ, Stracker TH. 2003. The cellular response to DNA double-strand breaks: defining the sensors and mediators. Trends Cell Biol. 13:458-62
71. Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Lobrich M, Jeggo PA. 2004. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 64:2390-96
72. Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ. 2003. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421:961-66
73. Rouse J, Jackson SP. 2002. Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol. Cell 9:857-69
74. Unsal-Kacmaz K, Sancar A. 2004. Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities. Mol. Cell. Biol. 24:1292-300
75. Sekiguchi M, Tsuzuki T. 2002. Oxidative nucleotide damage: consequences and prevention. Oncogene 21:8895-904
76. Mao Y, Muller MT. 2003. Down modulation of topoisomerase I affects DNA repair efficiency. DNA Repair 2:1115-26
77. Kovalsky OI, Grossman L, Ahn B. 1996. The topodynamics of incision of UV-irradiated covalently closed DNA by the Escherichia coli Uvr(A)BC endonuclease. J. Biol. Chem. 271:33236-41
78. Chakraverty RK, Kearsey JM, Oakley TJ, Grenon M, de La Torre Ruiz MA, et al. 2001. Topoisomerase III acts upstream of Rad53p in the S-phase DNA damage checkpoint. Mol. Cell. Biol. 21:7150-62
79. Cobb JA, Bjergbaek L, Gasser SM. 2002. RecQ helicases: at the heart of genetic stability. FEBS Lett. 529:43-48
80. Bourdineaud JP, Nehme B, Tesse S, Lonvaud-Funel A. 2003. The ftsH gene of the wine bacterium Oenococcus oeni is involved in protection against environmental stress. Appl. Environ. Microbiol. 69:2512-20
81. Fischer B, Rummel G, Aldridge P, Jenal U. 2002. The FtsH protease is involved in development, stress response and heat shock control in Caulobacter crescentus. Mol. Microbiol. 44:461-78
82. Adam Z. 2000. Chloroplast proteases: Possible regulators of gene expression? Biochimie 82:647-54
83. Akiyama Y, Yoshihisa T, Ito K. 1995. FtsH, a membrane-bound ATPase, forms a complex in the cytoplasmic membrane of Escherichia coli. J. Biol. Chem. 270:23485-90
84. Fu GK, Smith MJ, Markovitz DM. 1997. Bacterial protease Lon is a site-specific DNA-binding protein. J. Biol. Chem. 272:534-38
85. Ebel W, Skinner MM, Dierksen KP, Scott JM, Trempy JE. 1999. A conserved domain in Escherichia coli Lon protease is involved in substrate discriminator activity. J. Bacteriol. 181:2236-43
86. Smith CK, Baker TA, Sauer RT. 1999. Lon and Clp family proteases and chaperones share homologous substrate-recognition domains. Proc. Natl. Acad. Sci. USA 96:6678-82
87. Karata K, Inagawa T, Wilkinson AJ, Tatsuta T, Ogura T. 1999. Dissecting the role of a conserved motif (the second region of homology) in the AAA family of ATPases: site-directed mutagenesis of the ATP-dependent protease FtsH. J. Biol. Chem. 274:26225-32
88. Hlavacek O, Vachova L. 2002. ATP-dependent proteinases in bacteria. Folia Microbiol. 47:203-12
89. Herman C, Prakash S, Lu CZ, Matouschek A, Gross CA. 2003. Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH. Mol. Cell 11:659-69
90. Akiyama Y, Kihara A, Tokuda H, Ito K. 1996. FtsH (HflB) is an ATP-dependent protease selectively acting on SecY and some other membrane proteins. J. Biol. Chem. 271:31196-201
91. Anilkumar G, Srinivasan R, Anand SP, Ajitkumar P. 2001. Bacterial cell division protein FtsZ is a specific substrate for the AAA family protease FtsH. Microbiology-UK 147:516-17
92. Bertani D, Oppenheim AB, Narberhaus F. 2001. An internal region of the RpoH heat shock transcription factor is critical for rapid degradation by the FtsH protease. FEBS Lett. 493:17-20
93. 32. EMBO J. 14:2551-60
94. 54 promoters. Mol. Microbiol. 31:261-70
95. 54-dependent systems: a common phenotype by different mechanisms. J. Bacteriol. 184:760-70
96. Nishii W, Maruyama T, Matsuoka R, Muramatsu T, Takahashi K. 2002. The unique sites in SulA protein preferentially cleaved by ATP-dependent Lon protease from Escherichia coli. Eur. J. Biochem. 269:451-57
97. G. J. Bacteriol. 176:6528-37
98. Jubete Y, Maurizi MR, Gottesman S. 1996. Role of the heat shock protein DnaJ in the Lon-dependent degradation of naturally unstable proteins. J. Biol. Chem. 71:30798-803
99. Savel'ev AS, Novikova LA, Kovaleva IE, Luzikov VN, Neupert W, Langer T. 1998. ATP-dependent proteolysis in mitochondria: m-AAA protease and PIM1 protease exert overlapping substrate specificities and cooperate with the mtHsp70 system. J. Biol. Chem. 273:20596-602
100. Bucca G, Brassington AME, Hotchkiss G, Mersinias V, Smith CP. 2003. Negative feedback regulation of dnaK, clpB and Ion expression by the DnaK chaper-one machine in Streptomyces coelicolor, identified by transcriptome and in vivo DnaK-depletion analysis. Mol. Microbiol. 50:153-66
101. Jenal U, Hengge-Aronis R. 2003. Regulation by proteolysis in bacterial cells. Curr. Opin. Microbiol. 6:163-72
102. Adam Z, Adamska I, Nakabayashi K, Ostersetzer O, Haussuhl K, et al. 2001. Chloroplast and mitochondrial proteases in Arabidopsis: a proposed nomenclature. Plant Physiol. 125:1912-18
103. Fu GK, Markovitz DM. 1998. The human Lon protease binds to mitochondrial promoters in a single-stranded, site-specific, strand-specific manner. Biochemistry 37:1905-9
104. Beam CE, Saveson CJ, Lovett ST. 2002. Role for RadA/sms in recombination intermediate processing in Escherichia coli. J. Bacteriol. 184:6836-44
105. Kikuchi M, Hatano N, Yokota S, Shimozawa N, Imanaka T, Taniguchi H. 2004. Proteomic analysis of rat liver peroxisomes: presence of peroxisome-specific isozyme of Lon protease. J. Biol. Chem. 279:421-28
106. Schnall R, Mannhaupt G, Stucka R, Tauer R, Ehnle S, et al. 1994. Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex. Yeast 10:1141-55
107. Goldberg AL. 2003. Protein degradation and protection against misfolded or damaged proteins. Nature 426:895-99
108. Orlowski M, Wilk S. 2003. Ubiquitin-independent proteolytic functions of the proteasome. Arch. Biochem. Biophys. 415:1-5
109. Yew PR. 2001. Ubiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators. J Cell. Physiol. 187:1-10
110. Gulow K, Bienert D, Haas IG. 2002. BiP is feed-back regulated by control of protein translation efficiency. J. Cell Sci. 115:2443-52
111. Hong M, Luo S, Baumeister P, Huang JM, Gogia RK, et al. RK, 2004. Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response. J. Biol. Chem. 279:11354-63
112. Welihinda AA, Tirasophon W, Kaufman RJ. 1999. The cellular response to protein misfolding in the endoplasmic reticulum. Gene Expr. 7:293-300
113. Craig KL, Tyers M. 1999. The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction. Prog. Biophys. Mol. Biol. 72:299-328
114. Wei N, Deng XW. 2003. The COP9 signalosome. Annu. Rev. Cell Dev. Biol. 19:261-86
115. Adler V, Yin ZM, Tew KD, Ronai Z. 1999. Role of redox potential and reactive oxygen species in stress signaling. Oncogene 18:6104-11
116. Martell EA. 1992. Radionuclide-induced evolution of DNA and the origin of life. J. Mol. Evol. 35:346-55
117. Martin W, Russell MJ. 2003. On the origins of cells: a hypothesis for the evolutionary transitions from abiotic geochemistry to chemoautotrophic prokaryotes, and from prokaryotes to nucleated cells. Philos. Trans. R. Soc. London Ser. B 358:59-83
118. Bilinski T. 1991. Oxygen toxicity and microbial evolution. Biosystems 24:305-12
119. Finkel T. 2003. Oxidant signals and oxidative stress. Curr. Opin. Cell Biol. 15:247-54
120. Toone WM, Morgan BA, Jones N. 2001. Redox control of AP-1-like factors in yeast and beyond. Oncogene 20:2336-46
121. Wang TL, Zhang X, Li JJ. 2002. The role of NF-kappa B in the regulation of cell stress responses. Int. Immunopharmacol. 2:1509-20
122. Fujii J, Ikeda Y. 2002. Advances in our understanding of peroxiredoxin, a multi-functional, mammalian redox protein. Redox Rep. 7:123-30
123. Dehaan JB, Cristiano F, Iannello RC, Kola I. 1995. Cu/Zn-superoxide dismutase and glutathione-peroxidase during aging. Biochem. Mol. Biol Int. 35:1281-97
124. Dickinson DA, Forman HJ. 2002. Glutathione in defense and signaling: lessons from a small thiol. Ann. NY Acad. Sci. 973:488-504
125. Arner ESJ, Holmgren A. 2000. Physiological functions of thioredoxin and thioredoxin reductase. Eur. J. Biochem. 267:6102-9
126. Yamawaki H, Haendeler J, Berk BC. 2003. Thioredoxin: a key regulator of cardiovascular homeostasis. Circ. Res. 93:1029-33
127. Stadtman ER. 2004. Cyclic oxidation and reduction of methionine residues of proteins in antioxidant defense and cellular regulation. Arch. Biochem. Biophys. 423:2-5
128. Nishiyama A, Masutani H, Nakamura H, Nishinaka Y, Yodoi J. 2001. Redox regulation by thioredoxin and thioredoxin-binding proteins. IUBMB Life 52:29-33
129. Brot N, Weissbach H. 2000. Peptide methionine sulfoxide reductase: biochemistry and physiological role. Biopolymers 55:288-96
130. Moskovitz J, Jenkins NA, Gilbert DJ, Copeland NG, Jursky F, et al. 1996. Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues. Proc. Natl. Acad. Sci. USA 93:3205-8
131. Gustavsson N, Kokke BP, Harndahl U, Silow M, Bechtold U, et al. 2002. A peptide methionine sulfoxide reductase highly expressed in photosynthetic tissue in Arabidopsis thaliana can protect the chaperone-like activity of a chloroplast-localized small heat shock protein. Plant J. 29:545-53
132. Kromayer M, Wilting R, Tormay P, Bock A. 1996. Domain structure of the prokaryotic selenocysteine-specific elongation factor Se1B. J. Mol. Biol. 262:413-20
133. Leipe DD, Wolf YI, Koonin EV, Aravind L. 2002. Classification and evolution of P-loop GTPases and related ATPases. J. Mol. Biol. 317:41-72
134. Kryukov GV, Kumar RA, Koc A, Sun ZH, Gladyshev VN. 2002. Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase. Proc. Natl. Acad. Sci. USA 99:4245-50
135. Brown KM, Arthur JR. 2001. Selenium, selenoproteins and human health: a review. Public Health Nutr. 4:593-99
136. Namy O, Rousset JP, Napthine S, Brierley I. 2004. Reprogrammed genetic decoding in cellular gene expression. Mol. Cell 13:157-68
137. Fagegaltier D, Carbon P, Krol A. 2001. Distinctive features in the Se1B family of elongation factors for selenoprotein synthesis. A glimpse of an evolutionary complexified translation apparatus. Biofactors 14:5-10
138. Driscoll DM, Copel and PR. 2003. Mechanism and regulation of selenoprotein synthesis. Ann. Rev. Nutr. 23:17-40
139. Hoch JA, Silhavy TJ. 1995. Two-Component Signal Transduction. Washington, DC: Am. Soc. Microbiol. 488 pp.
140. Gill G. 2003. Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activity. Curr. Opin. Genet. Dev. 13:108-13
141. Markstein M, Levine M. 2002. Decoding cis-regulatory DNAs in the Drosophila genome. Curr. Opin. Genet. Dev. 12:601-6
142. Cyert MS. 2001. Regulation of nuclear localization during signaling. J. Biol. Chem. 276:20805-8
143. Fischle W, Wang Y, Allis CD. 2003. Histone and chromatin cross-talk. Curr. Opin. Cell Biol. 15:172-83
144. Berger SL. 2002. Histone modifications in transcriptional regulation. Curr. Opin. Genet. Dev. 12:142-48
145. Kültz D. 1998. Phylogenetic and functional classification of mitogen- and stress-activated protein kinases. J. Mol. Evol. 46:571-88
146. Fu H, Subramanian RR, Masters SC. 2000. 14-3-3 proteins: structure, function, and regulation. Annu. Rev. Pharmacol. Toxicol 40:617-47
147. Wiens M, Diehl-Seifert B, Müller WE. 2001. Sponge Bcl-2 homologous protein (BHP2-GC) confers distinct stress resistance to human HEK-293 cells. Cell Death Differ. 8:887-98
148. Craven RJ, Greenwell PW, Dominska M, Petes TD. 2002. Regulation of genome stability by Tel1 and Mec1, yeast homologs of the mammalian ATM and ATR genes. Genetics 161:493-507
149. Skorokhod A, Gamulin V, Gundacker D, Kavsan V, Müller IM, Müller WE. 1999. Origin of insulin receptor-like tyrosine kinases in marine sponges. Biol. Bull. 197:198-206
150. Huisinga KL, Pugh BF. 2004. A genome-wide housekeeping role for TFIID and a highly regulated stress-related role for SAGA in Saccharomyces cerevisiae. Mol. Cell 13:573-85
151. S (RpoS) subunit of RNA polymerase. Microbiol. Mol. Biol. Rev. 66:373-95
152. Rahman I. 2003. Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases. J. Biochem. Mol. Biol. 36:95-109
153. Kültz D. Burg MB. 1998. Intracellular signaling in response to osmotic stress. Contrib. Nephrol. 123:94-109
154. Amundson SA, Bittner M, Fornace AJ Jr. 2003. Functional genomics as a window on radiation stress signaling. Oncogene 22:5828-33
155. Chinnusamy V, Schumaker K, Zhu JK. 2004. Molecular genetic perspectives on cross-talk and specificity in abiotic stress signalling in plants. J. Exp. Bot. 55:225-36
156. Aldsworth TG, Sharman RL, Dodd CE. 1999. Bacterial suicide through stress. Cell Mol. Life Sci. 56:378-83
157. Smith ML, Fornace AJ. 1996. Mammalian DNA damage-inducible genes associated with growth arrest and apoptosis. Mutat. Res. Rev. Genet. Toxicol. 340:109-24
158. Hartwell LH, Weinert TA. 1989. Checkpoints: controls that ensure the order of cell cycle events. Science 246:629-34
159. Autret S, Levine A, Holland IB, Seror SJ. 1997. Cell cycle checkpoints in bacteria. Biochimie 79:549-54
160. Kvint K, Nachin L, Diez A, Nystrom T. 2003. The bacterial universal stress protein: function and regulation. Curr. Opin. Microbiol. 6:140-45
161. Nystrom T. 2003. Conditional senescence in bacteria: death of the immortals. Mol. Microbiol. 48:17-23
162. Dai W, Huang X, Ruan Q. 2003. Polo-like kinases in cell cycle checkpoint control. Front. Biosci. 8:d1128-33
163. Bartek J, Lukas J. 2001. Mammalian G1- and S-phase checkpoints in response to DNA damage. Curr. Opin. Cell Biol. 13:738-47
164. Hartwell LH, Kastan MB. 1994. Cell cycle control and cancer. Science 266:1821-28
165. Shiloh Y. 2003. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3:155-68
166. Pietenpol JA, Stewart ZA. 2002. Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis. Toxicology 181:475-81
167. Taylor WR, Stark GR. 2001. Regulation of the G2/M transition by p53. Oncogene 20:1803-15
168. Chakravarty D, Cai Q, Ferraris JD, Michea L, Burg MB, Kültz D. 2002. Three GADD45 isoforms contribute to hypertonic stress phenotype of murine renal inner medullary cells. Am. J. Physiol. 283:F1020-29
169. Nyberg KA, Michelson RJ, Putnam CW, Weinert TA. 2002. Toward maintaining the genome: DNA damage and replication checkpoints. Annu. Rev. Genet. 36:617-56
170. Lindquist S. 1986. The heat-shock response. Annu. Rev. Biochem. 55:1151-91
171. Morimoto RI. 1998. Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev. 12:3788-96
172. Ellis RJ, Hard FU. 1999. Principles of protein folding in the cellular environment. Curr. Opin. Struct. Biol. 9:102-10
173. Gething MJ, Sambrook J. 1992. Protein folding in the cell. Nature 355:33-45
174. Feder ME, Hofmann GE. 1999. Heat shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. Annu. Rev. Physiol. 61:243-82
175. Macario AJ, Malz M, Conway DM. 2004. Evolution of assisted protein folding: the distribution of the main chaperoning systems within the phylogenetic domain archaea. Front. Biosci. 9:1318-32
176. Arsene F, Tomoyasu T, Bukau B. 2000. The heat shock response of Escherichia coll. Int. J. Food Microbiol. 55:3-9
177. Harrison C. 2003. GrpE, a nucleotide exchange factor for DnaK. Cell Stress Chaperones 8:218-24
178. Tavaria M, Gabriele T, Kola I, Anderson RL. 1996. A hitchhiker's guide to the human Hsp70 family. Cell Stress Chaperones 1:23-28
179. Christians ES, Yan LJ, Benjamin IJ. 2002. Heat shock factor 1 and heat shock proteins: critical partners in protection against acute cell injury. Crit. Care Med. 30:S43-50
180. Bukrinsky MI. 2002. Cyclophilins: unexpected messengers in intercellular communications. Trends Immunol. 23:323-25
181. Andreeva L, Heads R, Green CJ. 1999. Cyclophilins and their possible role in the stress response. Int. J. Exp. Pathol. 80:305-15
182. Gothel SF, Marahiel MA. 1999. Peptidylprolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. Cell Mol. Life Sci. 55:423-36
183. Waldmeier PC, Zimmermann K, Qian T, Tintelnot-Blomley M, Lemasters JJ. 2003. Cyclophilin D as a drug target. Curr. Med. Chem. 10:1485-506
184. Zou Y, Crowley DJ, Van Houten B. 1998. Involvement of molecular chaperonins in nucleotide excision repair: DnaK leads to increased thermal stability of UvrA, catalytic UvrB loading, enhanced repak, and increased UV resistance. J. Biol. Chem. 273:12887-92
185. Sweder K, Madura K. 2002. Regulation of repak by the 26S proteasome. J. Biomed. Biotechnol. 2:94-105
186. Hanawalt PC. 2001. Controlling the efficiency of excision repak. Mutat. Res. DNA Repair 485:3-13
187. van Hoffen A, Balajee AS, van Zeeland AA, Mullenders LH. 2003. Nucleotide excision repair and its interplay with transcription. Toxicology 193:79-90
188. Izumi T, Wiederhold LR, Roy G, Roy R, Jaiswal A, et al. 2003. Mammalian DNA base excision repak proteins: their interactions and role in repak of oxidative DNA damage. Toxicology 193:43-65
189. Fedier A, Fink D. 2004. Mutations in DNA mismatch repak genes: implications for DNA damage signaling and drug sensitivity. Int. J. Oncol. 24:1039-47
190. Schofield MJ, Hsieh P. 2003. DNA mismatch repak: molecular mechanisms and biological function. Annu. Rev. Microbiol. 57:579-608
191. Valerie K, Povirk LF. 2003. Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22:5792-812
192. van den Bosch M, Lohman PH, Pastink A. 2002. DNA double-strand break repak by homologous recombination. Biol. Chem. 383:873-92
193. +-dependent isocitrate dehydrogenase protects macrophages from LPS-induced nitric oxide and reactive oxygen species. Biochem. Biophys. Res. Commun. 317:558-64
194. Gupta M, Hogema BM, Grompe M, Bottiglieri TG, Concas A, et al. 2003. Murine succinate semialdehyde dehydrogenase deficiency. Ann. Neurol. 54(Suppl. 6):S81-90
195. Huang J, Zhang H, Wang J, Yang J. 2003. Molecular cloning and characterization of rice 6-phosphogluconate dehydrogenase gene that is up-regulated by salt stress. Mol. Biol. Rep. 30:223-27
196. Puskas F, Gergely P Jr, Banki K, Perl A. 2000. Stimulation of the pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C. FASEB J. 14:1352-61
197. Kuriyama H, Fukuda H. 2002. Developmental programmed cell death in plants. Curr. Opin. Plant Biol. 5:568-73
198. Zhivotovsky B. 2002. From the nematode and mammals back to the pine tree: on the diversity and evolution of programmed cell death. Cell Death Differ. 9:867-69
199. Cairns J. 2002. A DNA damage checkpoint in Escherichia coli. DNA Repair 1:699-701
200. Takayama S, Reed JC, Homma S. 2003. Heat-shock proteins as regulators of apoptosis. Oncogene 22:9041-47
201. Fridman JS, Lowe SW. 2003. Control of apoptosis by p53. Oncogene 22:9030-40
202. Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C. 2003. PI3K/Akt and apoptosis: size matters. Oncogene 22:8983-98
203. Kucharczak J, Simmons MJ, Fan Y, Gelinas C. 2003. To be, or not to be: NF-kappaB is the answer: role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 22:8961-82
204. Mak SK, Kültz D. 2004. GADD45 proteins modulate apoptosis in renal inner medullary cells exposed to hyperosmotic stress. J. Biol. Chem. 279:39075-84
205. Sheikh MS, Hollander MC, Fornance AJ Jr. 2000. Role of Gadd45 in apoptosis. Biochem. Pharmacol. 59:43-45