Antimicrobial peptides in 2014

Pharmaceuticals

Volumn 8, Issue 1, 2015, Pages 123-150

  Wang, Guangshun ^a   Mishra, Biswajit ^a   Lau, Kyle ^a   Lushnikova, Tamara ^a   Golla, Radha ^a   Wang, Xiuqing ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; AMPICILLIN; BACERIDIN; BACTERIOCIN; BETA DEFENSIN; BOVICIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; COPSIN; CROTALICIDIN; DERMCIDIN; DOUBLE STRANDED RNA; EOTAXIN; EOTAXIN 2; EOTAXIN 3; GAGEOTETRIN A; HEAT SHOCK PROTEIN; HISPIDALIN; LACTICIN; LANCOVUTIDE; LANTHIOPEPTIN; LANTIBIOTIC; LUCIFENSIN; MERSACIDIN; NISIN A; PLECTASIN; POLYPEPTIDE ANTIBIOTIC AGENT; PROLINE RICH PROTEIN; RIBONUCLEASE VI; SONORENSIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACIDITY; AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; BIFIDOBACTERIUM; BIOFILM; CANDIDA ALBICANS; CELL SURFACE; COMMENSAL; DRUG COATING; DRUG DATABASE; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG IDENTIFICATION; DRUG RELEASE; DRUG STRUCTURE; ENDOSOME; ENVIRONMENTAL FACTOR; ESCHERICHIA COLI; FUNGUS; HAEMOPHILUS INFLUENZAE; MARINE BACTERIUM; MEDICINAL PLANT; MICROORGANISM DETECTION; OLIGOMERIZATION; PH; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; PSEUDOMONAS AERUGINOSA; REVIEW; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; THREE DIMENSIONAL IMAGING;

EID: 84930209721     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph8010123     Document Type: Review

References (189)

1. Zasloff, M. Antimicrobial peptides of multicellullar organisms. Nature 2002, 415, 359-365.
2. Lai, Y.; Gallo, R.L. AMPed up immunity: How antimicrobial peptides have multiple roles in immune defense. Trends Immunol. 2009, 30, 131-141.
3. Hancock, R.E.; Lehrer, R. Cationic peptides: A new source of antibiotics. Trends Biotechnol. 1998, 16, 82-88.
4. Yeaman, M.R.; Yount, N.Y. Mechanisms of Antimicrobial Peptide Action and Resistance. Pharmacol. Rev. 2003, 55, 27-55.
5. Brogden, K.A. Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? Natl. Rev. Microbiol. 2005, 3, 238-250.
6. NCBI Resource Coordinators. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 2015, 43, D6-D17.
7. Wang, Z.; Wang, G. APD: The antimicrobial peptide database. Nucleic Acids Res. 2004, 32, D590-D592.
8. Wang, G.; Li, X.; Wang, Z. The updated antimicrobial peptide database and its application in peptide design. Nucleic Acids Res. 2009, 37, D933-D937.
9. Wang, G. Improved methods for classification, prediction, and design of antimicrobial peptides. Methods Mol. Biol. 2015, 1268, 43-66.
10. Timeline of Antimicrobial Peptide Discovery. http://aps.unmc.edu/AP/timeline.php. Accessed on 16 March 2015.
11. Chakchouk-Mtibaa, A.; Elleuch, L.; Smaoui, S.; Najah, S.; Sellem, I.; Abdelkafi, S.; Mellouli, L. An antilisterial bacteriocin BacFL31 produced by Enterococcus faecium FL31 with a novel structure containing hydroxyproline residues. Anaerobe 2014, 27C, 1-6.
12. Niggemann, J.; Bozko, P.; Bruns, N.; Wodtke, A.; Gieseler, M.T.; Thomas, K.; Jahns, C.; Nimtz, M.; Reupke, I.; Brüser, T.; et al. Baceridin, a cyclic hexapeptide from an epiphytic Bacillus strain, inhibits the proteasome. Chembiochem 2014, 15, 1021-1029.
13. Gavrish, E.; Sit, C.S.; Cao, S.; Kandror, O.; Spoering, A.; Peoples, A.; Ling, L.; Fetterman, A.; Hughes, D.; Bissell, A.; et al. Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. Chem. Biol. 2014, 21, 509-518.
14. Yamanaka, K.; Reynolds, K.A.; Kersten, R.D.; Ryan, K.S.; Gonzalez, D.J.; Nizet, V.; Dorrestein, P.C.; Moore, B.S. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 1957-1962.
15. Scholz, R.; Vater, J.; Budiharjo, A.; Wang, Z.; He, Y.; Dietel, K.; Schwecke, T.; Herfort, S.; Lasch, P.; Borriss, R. Amylocyclicin, a Novel Circular Bacteriocin Produced by Bacillus amyloliquefaciens FZB42. J. Bacteriol. 2014, 196, 1842-1852.
16. Tang, Y.Q.; Yuan, J.; Osapay, G.; Osapay, K.; Tran, D.; Miller, C.J.; Ouellette, A.J.; Selsted, M.E. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science 1999, 286, 498-502.
17. Falcao, C.B.; de La Torre, B.G.; Pérez-Peinado, C.; Barron, A.E.; Andreu, D.; Rádis-Baptista, G. Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers. Amino Acids 2014, 46, 2561-2571.
18. Conlon, J.M.; Mechkarska, M. Host-defense peptides with therapeutic potential from skin secretions of frogs from the family pipidae. Pharmaceuticals 2014, 7, 58-77.
19. Guo, C.; Hu, Y.; Li, J.; Liu, Y.; Li, S.; Yan, K.; Wang, X.; Liu, J.; Wang, H. Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. Biochimie. 2014, 105, 192-201.
20. Ryazantsev, D.Y.; Rogozhin, E.A.; Dimitrieva, T.V.; Drobyazina, P.E.; Khadeeva, N.V.; Egorov, T.A.; Grishin, E.V.; Zavriev, S.K. A novel hairpin-like antimicrobial peptide from barnyard grass (Echinochloa crusgalli L.) seeds: Structure-functional and molecular-genetics characterization. Biochimie 2014, 99, 63-70.
21. Li, M.F.; Zhang, B.C.; Li, J.; Sun, L. Sil: A Streptococcus iniae bacteriocin with dual role as an antimicrobial and an immunomodulator that inhibits innate immune response and promotes S. iniae infection. PLoS One. 2014, 9, e96222.
22. Weisshoff, H.; Hentschel, S.; Zaspel, I.; Jarling, R.; Krause, E.; Pham, T.L. PPZPMs—A novel group of cyclic lipodepsipeptides produced by the Phytophthora alni associated strain Pseudomonas sp. JX090307—The missing link between the viscosin and amphisin group. Nat. Prod. Commun. 2014, 9, 989-996.
23. Trindade, F.; Amado, F.; Pinto da Costa, J.; Ferreira, R.; Maia, C.; Henriques, I.; Colaco, B.; Vitorino, R. Salivary peptidomic as a tool to disclose new potential antimicrobial peptides. J. Proteomics 2014, 115C, 49-57.
24. Bouzid, W.; Verdenaud, M.; Klopp, C.; Ducancel, F.; Noirot, C.; Vetillard, A. de novo sequencing and transcriptome analysis for tetramorium bicarinatum: A comprehensive venom gland transcriptome analysis from an ant species. BMC Genomics 2014, 15, 987.
25. Capriotti, A.L.; Cavaliere, C.; Foglia, P.; Piovesana, S.; Samperi, R.; Zenezini Chiozzi, R.; Lagana, A. Development of an analytical strategy for the identification of potential bioactive peptides generated by in vitro tryptic digestion of fish muscle proteins. Anal. Bioanal. Chem. 2015, 407, 845-854.
26. Wang, G. Database-guided discovery of potent peptides to combat HIV-1 or superbugs. Pharmaceuticals 2013, 6, 728-758.
27. Tareq, F.S.; Lee, M.A.; Lee, H.S.; Lee, Y.J.; Lee, J.S.; Hasan, C.M.; Islam, M.T.; Shin, H.J. Gageotetrins A-C, Noncytotoxic antimicrobial linear lipopeptides from a marine bacterium Bacillus subtilis. Org. Lett. 2014, 16, 928-931.
28. Makovitzki, A.; Avrahami, D.; Shai, Y. Ultrashort antibacterial and antifungal lipopeptides. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 15997-16002.
29. First in a New Class of Antibiotics. FDA Consum. 2003, 37, 4.
30. Chopra, L.; Singh, G.; Choudhary, V.; Sahoo, D.K. Sonorensin: an antimicrobial peptide, belonging to the heterocycloanthracin subfamily of bacteriocins, from a new marine isolate, Bacillus sonorensis MT93. Appl. Environ. Microbiol. 2014, 80, 2981-2990.
31. Mygind, P.H.; Fischer, R.L.; Schnorr, K.M.; Hansen, M.T.; Sonksen, C.P.; Ludvigsen, S.; Raventos, D.; Buskov, S.; Christensen, B.; DeMaria, L.; et al. Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus. Nature 2005, 437, 975-980.
32. Oeemig, J.S.; Lynggaard, C.; Knudsen, D.H.; Hansen, F.T.; Norgaard, K.D.; Schneider, T.; Vad, B.S.; Sandvang, D.H.; Nielsen, L.A.; Neve, S.; et al. Eurocin, a new fungal defensin: structure, lipid binding, and its mode of action. J. Biol. Chem. 2012, 287, 42361-42372.
33. Essig, A.; Hofmann, D.; Munch, D.; Gayathri, S.; Kunzler, M.; Kallio, P.T.; Sahl, H.G.; Wider, G.; Schneider, T.; Aebi, M. Copsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis. J. Biol. Chem. 2014, 289, 34953-34964.
34. Sharma, S.; Verma, H.N.; Sharma, N.K. Cationic bioactive peptide from the seeds of Benincasa hispida. Int. J. Pept. 2014, 2014, 156060.
35. Kawabata, S.; Nagayama, R.; Hirata, M.; Shigenaga, T.; Agarwala, K.L.; Saito, T.; Cho, J.; Nakajima, H.; Takagi, T.; Iwanaga, S. Tachycitin, a small granular component in horseshoe crab hemocytes, is an antimicrobial protein with chitin-binding activity. J. Biochem. 1996, 120, 1253-1260.
36. Conlon, J.M.; Mechkarska, M.; Emanahmed Coquet, L.; Jouenne, T.; Jérômeleprince Vaudry, H.; Hayes, M.P; Padgett-Flohr, G. Host defense peptides in skin secretions of the Oregon spotted frog Ranapretiosa: Implications for species resistance to chytridiomycosis. Dev. Comp. Immunol. 2011, 35, 644-649.
37. Thomas, S.; Karnik, S.; Barai, R.S.; Jayaraman, V.K.; Idicula-Thomas, S. CAMP: A useful resource for research on antimicrobial peptides. Nucleic Acids Res. 2010, 38, D774-D780.
38. Lata, S.; Mishra, N.K.; Raghava, G.P. AntiBP2: Improved version of antibacterial peptide prediction. BMC Bioinformatics 2010, 11, S19.
39. Xiao, X.; Wang, P.; Lin, W.Z.; Jia, J.H.; Chou, K.C. iAMP-2L: A two-level multi-label classifier for identifying antimicrobial peptides and their functional types. Anal. Biochem. 2013, 436, 168-177.
40. Zanetti, M. the role of cathelicidins in the innate host defenses of mammals. Curr. Issues Mol. Biol. 2005, 7, 179-196.
41. Hao, X.; Yang, H.; Wei, L.; Yang, S.; Zhu, W.; Ma, D.; Yu, H.; Lai, R. Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate. Amino acids 2012, 43, 677-685.
42. Ling, G.; Gao, J.; Zhang, S.; Xie, Z.; Wei, L.; Yu, H.; Wang, Y. Cathelicidins from the bullfrog Rana catesbeiana provides novel template for peptide antibiotic design. PLoS One 2014, 9, e93216.
43. Schroeder, B.O.; Ehmann, D.; Precht, J.C.; Castillo, P.A.; Kuchler, R.; Berger, J.; Schaller, M.; Stange, E.F.; Wehkamp, J. Paneth Cell Alpha-defensin 6 (HD-6) is an antimicrobial peptide. Mucosal Immunol. 2014. doi: 10.1038/mi.2014.100.
44. Liu, H.; Yu, H.; Xin, A.; Shi, H.; Gu, Y.; Zhang, Y.; Diao, H.; Lin, D. Production and characterization of recombinant human beta-defensin DEFB120. J. Pept. Sci. 2014, 20, 251-257.
45. Gela, A.; Kasetty, G.; Jovic, S.; Ekoff, M.; Nilsson, G.; Morgelin, M.; Kjellstrom, S.; Pease, J.E.; Schmidtchen, A.; Egesten, A. Eotaxin-3 (CCL26) Exerts innate host defense activities that are modulated by mast cell proteases. Allergy 2015, 70, 161-170.
46. Becknell, B.; Eichler, T.E.; Beceiro, S.; Li, B.; Easterling, R.S.; Carpenter, A.R.; James, C.L.; McHugh, K.M.; Hains, D.S.; Partida-Sanchez, S. et al. Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract. Kidney Int. 2015, 87, 151-161.
47. Wang, G. Human antimicrobial peptides and proteins. Pharmaceuticals 2014, 7, 545-594.
48. Boman, H.G. Antibacterial peptides: Basic facts and emerging concepts. J. Inter. Med. 2003, 254, 197-215.
49. Gschwandtner, M.; Zhong, S.; Tschachler, A.; Mlitz, V.; Karner, S.; Elbe-Bürger, A.; Mildner, M. Fetal human keratinocytes produce large amounts of antimicrobial peptides: Involvement of histone-methylation processes. J. Invest Dermatol. 2014, 134, 2192-2201.
50. Zhang, L.J.; Guerrero-Juarez, C.F.; Hata, T.; Bapat, S.P.; Ramos, R.; Plikus, M.V.; Gallo, R.L. Innate immunity. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection. Science 2015, 347, 67-71.
51. Lee, P.H.; Ohtake, T.; Zaiou, M.; Murakami, M.; Rudisill, J.A.; Lin, K.H.; Gallo, R.L. Expression of an additional cathelicidin antimicrobial peptide protects against bacterial skin infection. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 3750-3755.
52. Zhao, C.; Wang, I.; Lehrer, R.I. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett. 1996, 396, 319-322.
53. Furci, L.; Baldan, R.; Bianchini, V.; Trovato, A.; Ossi, C.; Cichero, P.; Cirillo, D.M. A new role for human alpha-defensin 5 in the fight against Clostridium difficile hypervirulent strains. Infect. Immun. 2015, 83, 986-995.
54. Hubert, P.; Herman, L.; Roncarati, P.; Maillard, C.; Renoux, V.; Demoulin, S.; Erpicum, C.; Foidart, J.M.; Boniver, J.; Noel, A. et al. Altered alpha-defensin 5 expression in cervical squamocolumnar junction: implication in the formation of a viral/tumour-permissive microenvironment. J. Pathol. 2014, 234, 464-477.
55. Wiens, M.E.; Smith, J.G. Alpha-Defensin HD5 Inhibits Furin Cleavage of HPV16 L2 to Block Infection. J. Virol. 2014, 89, 2866-2874.
56. Wommack, A.J.; Ziarek, J.J.; Tomaras, J.; Chileveru, H.R.; Zhang, Y.; Wagner, G.; Nolan, E.M. Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide. J. Am. Chem. Soc. 2014, 136, 13494-13497.
57. Schroeder, B.O.; Wu, Z.; Nuding, S.; Groscurth, S.; Marcinowski, M.; Beisner, J.; Buchner, J.; Schaller, M.; Stange, E.F.; Wehkamp, J. Reduction of disulphide bonds unmasks potent antimicrobial activity of human beta-defensin 1. Nature 2011, 469, 419-423.
58. Porter, E.M.; Poles, M.A.; Lee, J.S.; Naitoh, J; Bevins, C.L.; Ganz, T. Isolation of human intestinal defensins from ileal neobladder urine. FEBS Lett. 1998, 434, 272-276.
59. Chu, H.; Pazgier, M.; Jung, G.; Nuccio, S.P.; Castillo, P.A.; de Jong, M.F.; Winter, M.G.; Winter, S.E.; Wehkamp, J.; Shen, B.; et al. Human Alpha-Defensin 6 Promotes mucosal innate immunity through self-assembled peptide nanonets. Science 2012, 337, 477-481.
60. Abou Alaiwa, M.H.; Reznikov, L.R.; Gansemer, N.D.; Sheets, K.A.; Horswill, A.R.; Stoltz, D.A.; Zabner, J.; Welsh, M.J. PH Modulates the activity and synergism of the airway surface liquid antimicrobials beta-defensin-3 and LL-37. Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 18703-18708.
61. Johansson, J.; Gudmundsson, G.H.; Rottenberg, M.E.; Berndt, K.D.; Agerberth, B. Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37. J. Biol. Chem. 1998, 273, 3718-3724.
62. Xhindoli, D.; Pacor, S.; Guida, F.; Antcheva, N.; Tossi, A. Native oligomerization determines the mode of action and biological activities of human cathelicidin LL-37. Biochem. J. 2014, 457, 263-275.
63. Wang, G. Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies; CABI: Wallingford, UK, 2010.
64. Singh, D.; Vaughan, R.; Kao, C.C. LL-37 peptide enhancement of signal transduction by toll-like receptor 3 is regulated by pH: identification of a peptide antagonist of LL-37. J. Biol. Chem. 2014, 289, 27614-27624.
65. Yamasaki, K.; Schauber, J.; Coda, A.; Lin, H.; Dorschner, R.A.; Schechter, N.M.; Bonnart, C.; Descargues, P.; Hovnanian, A.; Gallo, R.L. Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. FASEB J. 2006, 20, 2068-2080.
66. Wang, G.; Mishra, B.; Epand, R.F.; Epand, R.M. High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments. Biochim. Biophys. Acta 2014, 1838, 2160-2172.
67. Koziel, J.; Bryzek, D.; Sroka, A.; Maresz, K.; Glowczyk, I.; Bielecka, E.; Kantyka, T.; Pyrc, K.; Svoboda, P.; Pohl, J.; et al. Citrullination alters immunomodulatory function of ll-37 essential for prevention of endotoxin-induced sepsis. J. Immunol. 2014, 192, 5363-5372.
68. Picchianti, M.; Russo, C.; Castagnini, M.; Biagini, M.; Soldaini, E.; Balducci, E. NAD-Dependent ADP-ribosylation of the human antimicrobial and immune-modulatory peptide LL-37 by ADP-ribosyltransferase-1. Innate Immun. 2015, 21, 314-321.
69. S0rensen, O.E.; Gram, L.; Johnsen, A.H.; Andersson, E.; Bangsboll, S.; Tjabringa, G.S.; Hiemstra, P.S.; Malm, J.; Egesten, A.; Borregaard, N. Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: A novel mechanism of generating antimicrobial peptides in vagina. J. Biol. Chem. 2003, 278, 28540-28546.
70. Nguyen, L.T.; Haney, E.F.; Vogel, H.J. The expanding scope of antimicrobial peptide structures and their modes of action. Trends Biotechnol. 2011, 29, 464-472.
71. Gazit, E.; Miller, I.R.; Biggin, P.C.; Sansom, M.S.; Shai, Y. Structure and orientation of the mammalian antibacterial peptide cecropin p1 within phospholipid membranes. J. Mol. Biol. 1996, 258, 860-870.
72. Perrin, B.S., Jr; Tian, Y.; Fu, R.; Grant, C.V.; Chekmenev, E.Y.; Wieczorek, W.E.; Dao, A.E.; Hayden, R.M.; Burzynski, C.M.; Venable, R.M.; et al. High-resolution structures and orientations of antimicrobial peptides piscidin 1 and piscidin 3 in fluid bilayers reveal tilting, kinking, and bilayer immersion. J. Am. Chem. Soc. 2014, 136, 3491-3504.
73. Fox, R.O., Jr.; Richards, F.M. A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-Â resolution. Nature 1982, 300, 325-330.
74. Kovacs, F.; Quine, J.; Cross, T.A. Validation of the single-stranded channel conformation of gramicidin A by solid-state NMR. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 7910-7915.
75. Burian, M.; Schittek, B. The secrets of dermcidin action. Int. J. Med. Microbiol. 2015, 305, 283-286.
76. Song, C.; Weichbrodt, C.; Salnikov, E.S.; Dynowski, M.; Forsberg, B.O.; Bechinger, B.; Steinem, C.; de Groot, B.L.; Zachariae, U.; Zeth, K. Crystal structure and functional mechanism of a human antimicrobial membrane channel. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 4586-4591.
77. Mukherjee, S.; Zheng, H.; Derebe, M.G.; Callenberg, K.M.; Partch, C.L.; Rollins, D.; Propheter, D.C.; Rizo, J.; Grabe, M.; Jiang, Q.X.; et al. Antibacterial membrane attack by a pore-forming intestinal c-type lectin. Nature 2014, 505, 103-107.
78. Henzler Wildman, K.A.; Lee, D.K.; Ramamoorthy, A. Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37. Biochemistry 2003, 42, 6545-6558.
79. Oren, Z.; Lerman, J.C.; Gudmundsson, G.H.; Agerberth, B.; Shai, Y. Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: Relevance to the molecular basis for its non-cell-selective activity. Biochem. J. 1999, 341(Pt 3), 501-513.
80. Kjos, M.; Oppegard, C.; Diep, D.B.; Nes, I.F.; Veening, J.W.; Nissen-Meyer, J.; Kristensen, T. Sensitivity to the two-peptide bacteriocin lactococcin G is dependent on UppP, an enzyme involved in cell-wall synthesis. Mol. Microbiol. 2014, 92, 1177-1187.
81. Cotter, P.D. An 'Upp'-turn in bacteriocin receptor identification. Mol. Microbiol. 2014, 92, 1159-1163.
82. Wilmes, M.; Stockem, M.; Bierbaum, G.; Schlag, M.; Gotz, F.; Tran, D.Q.; Schaal, J.B.; Ouellette, A.J.; Selsted, M.E.; Sahl, H.G. Killing of staphylococci by theta-defensins involves membrane impairment and activation of autolytic enzymes. Antibiotics (Basel) 2014, 3, 617-631.
83. Mukhopadhyay, J.; Sineva, E.; Knight, J.; Levy, R.M.; Ebright, R.H. Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel. Mol. Cell 2004, 14, 739-751.
84. Krizsan, A.; Volke, D.; Weinert, S.; Strater, N.; Knappe, D.; Hoffmann, R. Insect-derived proline-rich antimicrobial peptides kill bacteria by inhibiting bacterial protein translation at the 70S ribosome. Angew. Chem. Int. Ed. Engl. 2014, 53, 12236-12239.
85. Mardirossian, M.; Grzela, R.; Giglione, C.; Meinnel, T.; Gennaro, R.; Mergaert, P.; Scocchi, M. The Host antimicrobial peptide Bac7(1-35) binds to bacterial ribosomal proteins and inhibits protein synthesis. Chem. Biol. 2014, 21, 1639-1647.
86. De Leeuw, E.; Li, C.; Zeng, P.; Li, C.; Diepeveen-de Buin, M.; Lu, W.Y.; Breukink, E.; Lu, W. Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II. FEBSLett. 2010, 584, 1543-1548.
87. Sass, V.; Schneider, T.; Wilmes, M.; Körner, C.; Tossi, A.; Novikova, N.; Shamova, O.; Sahl, H.G. Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci. Infect. Immun. 2010, 78, 2793-2800.
88. Bierbaum, G.; Sahl, H.G. Lantibiotics: Mode of action, biosynthesis and bioengineering. Curr. Pharm. Biotechnol. 2009, 10, 2-18.
89. Iwamoto, K.; Hayakawa, T.; Murate, M.; Makino, A.; Ito, K.; Fujisawa, T.; Kobayashi, T. Curvature-dependent recognition of ethanolamine phospholipids by duramycin and cinnamycin. Biophys. J. 2007, 93, 1608-1619.
90. Henriques, S.T.; Huang, Y.H.; Castanho, M.A.; Bagatolli, L.A.; Sonza, S.; Tachedjian, G.; Daly, N.L.; Craik, D.J. phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions. J. Biol. Chem. 2012, 287, 33629-33643.
91. Troeira Henriques, S.; Huang, Y.H.; Chaousis, S.; Wang, C.K.; Craik, D.J. anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. Chembiochem 2014, 15, 1956-1965.
92. Otvos, L., Jr; Insug, O.; Rogers, M.E.; Consolvo, P.J.; Condie, B.A.; Lovas, S.; Bulet, P.; Blaszczyk-Thurin, M. Interaction between heat shock proteins and antimicrobial peptides. Biochemistry 2000, 39, 14150-14159.
93. Ghosh, A.; Kar, R.K.; Jana, J.; Saha, A.; Jana, B.; Krishnamoorthy, J.; Kumar, D.; Ghosh, S.; Chatterjee, S.; Bhunia, A. Indolicidin targets duplex DNA: Structural and mechanistic insight through a combination of spectroscopy and microscopy. ChemMedChem 2014, 9, 2052-2058.
94. Wenzel, M.; Chiriac, A.I.; Otto, A.; Zweytick, D.; May, C.; Schumacher, C.; Gust, R.; Albada, H.B.; Penkova, M.; Kramer, U.; et al. Small cationic antimicrobial peptides delocalize peripheral membrane proteins. Proc. Natl. Acad. Sci. U.S.A. 2014, 111, E1409-E1418.
95. Wang, G.; Peterkofsky, A.; Clore, G.M. A novel membrane anchor function for the N-terminal amphipathic sequence of the signal-transducing protein IIAglucose of the Escherichia coli phosphotransferase system. J. Biol. Chem. 2000, 275, 39811-39814.
96. Wang, G.; Li, Y.; Li, X. Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a nontoxic bacterial membrane anchor. J. Biol. Chem. 2005, 280, 5803-5811.
97. Wang, G. Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles. J. Biol. Chem. 2008, 283, 32637-32643.
98. Epand, RF; Wang, G.; Berno, B.; Epand, R.M. Lipid segregation explains selective toxicity of a series of fragments derived from the human cathelicidin LL-37. Antimicrob. Agents Chemother. 2009, 53, 3705-3714.
99. Bals, R.; Wilson, J.M. Cathelicidins—A family of multifunctional antimicrobial peptides. Cell. Mol. Life Sci. 2003, 60, 711-720.
100. Wang, G.; Epand, R.F.; Mishra, B.; Lushnikova, T.; Thomas, V.C.; Bayles, K.W.; Epand, R.M. Decoding the functional roles of cationic side chains of the major antimicrobial region of human cathelicidin LL-37. Antimicrob. Agents Chemother. 2012, 56, 845-856.
101. Nakagawa, Y.; Gallo, R.L. Endogenous intracellular cathelicidin enhances TLR9 activation in dendritic cells and macrophages. J. Immunol. 2015, 194, 1274-1284.
102. Neumann, A.; Berends, E.T.; Nerlich, A.; Molhoek, E.M.; Gallo, R.L.; Meerloo, T.; Nizet, V.; Naim, H.Y.; von Kockritz-Blickwede, M. The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps. Biochem. J. 2014, 464, 3-11.
103. Yang, D.; Chen, Q.; Schmidt, A.P.; Anderson, G.M.; Wang, J.M.; Wooters, J.; Oppenheim, J.J.; Chertov, O. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J. Exp. Med. 2000, 192, 1069-1074.
104. Elssner, A.; Duncan, M.; Gavrilin, M.; Wewers, M.D. A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release. J. Immunol. 2004, 172, 4987-4994.
105. Wan, M.; van der Does, A.M.; Tang, X.; Lindbom, L.; Agerberth, B.; Haeggstrom, J.Z. Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages. J. Leukoc. Biol. 2014, 95, 971-981.
106. Tripathi, S.; Verma, A.; Kim, E.J.; White, M.R.; Hartshorn, K.L. LL-37 modulates human neutrophil responses to influenza a virus. J. Leukoc. Biol. 2014, 96, 931-938.
107. Lande, R.; Botti, E.; Jandus, C.; Dojcinovic, D.; Fanelli, G.; Conrad, C.; Chamilos, G.; Feldmeyer, L.; Marinari, B.; Chon, S.; et al. The antimicrobial peptide LL37 is a T-Cell autoantigen in psoriasis. Nat. Commun. 2014, 5, 5621.
108. Peschel, A. How do bacteria resist human antimicrobial peptides? Trends Microbiol. 2002, 10, 179-186.
109. Gebhard, S.; Fang, C.; Shaaly, A.; Leslie, D.J.; Weimar, M.R.; Kalamorz, F.; Carne, A.; Cook, G.M. Identification and characterization of a bacitracin resistance network in Enterococcus faecalis. Antimicrob. Agents Chemother. 2014, 58, 1425-1433.
110. Dintner, S.; Staron, A.; Berchtold, E.; Petri, T.; Mascher, T.; Gebhard, S. Coevolution of ABC transporters and two-component regulatory systems as resistance modules against antimicrobial peptides in Firmicutes Bacteria. J. Bacteriol. 2011, 193, 3851-3862.
111. Falord, M.; Karimova, G.; Hiron, A.; Msadek, T. GraXSR proteins interact with the VraFG ABC transporter to form a five-component system required for cationic antimicrobial peptide sensing and resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 2012, 56, 1047-1058.
112. Weidenmaier, C.; Peschel, A.; Kempf, V.A.; Lucindo, N.; Yeaman, M.R.; Bayer, A.S. DltABCD-and mprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model. Infect. Immun. 2005, 73, 8033-8038.
113. Li, M; Cha, D.J.; Lai, Y.; Villaruz, A.E.; Sturdevant, D.E.; Otto, M. The antimicrobial peptide-sensing system aps of Staphylococcus aureus. Mol. Microbiol. 2007, 66, 1136-1147.
114. Yang, S.-J.; Bayer, A.S.; Mishra, N.N.; Meehl, M.; Ledala, N.; Yeaman, M.R.; Xiong, Y.Q.; Cheung, A.L. The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides. Infect. Immun. 2012, 80, 74-81.
115. Cheung, A.L.; Bayer, A.S.; Yeaman, M.R.; Xiong, Y.Q.; Waring, A.J.; Memmi, G.; Donegan, N.; Chaili, S.; Yang, S.J. Site-specific mutation of the sensor kinase GraS in Staphylococcus aureus alters the adaptive response to distinct cationic antimicrobial peptides. Infect. Immun. 2014, 82, 5336-5345.
116. Velarde, J.J.; Ashbaugh, M.; Wessels, M.R. The human antimicrobial peptide LL-37 binds directly to CsrS, a sensor histidine kinase of group A Streptococcus, to activate expression of virulence factors. J. Biol. Chem. 2014, 289, 36315-36324.
117. Chen, H.D.; Groisman, E.A. The biology of the PmrA/PmrB two-component system: The major regulator of lipopolysaccharide modifications. Annu. Rev. Microbiol. 2013, 67, 83-112.
118. Henderson, J.C.; Fage, C.D.; Cannon, J.R.; Brodbelt, J.S.; Keatinge-Clay, A.T.; Trent, M.S. Antimicrobial peptide resistance of Vibrio cholerae results from an lps modification pathway related to nonribosomal peptide synthetases. ACS Chem. Biol. 2014, 9, 2382-2392.
119. Tzeng, Y.L.; Ambrose, K.D.; Zughaier, S.; Zhou, X.; Miller, Y.K.; Shafer, W.M.; Stephens, D.S. Cationic antimicrobial peptide resistance in Neisseria meningitidis. J. Bacteriol. 2005, 187, 5387-5396.
120. Balthazar, J.T.; Gusa, A.; Martin, L.E.; Choudhury, B.; Carlson, R.; Shafer, W.M. Lipooligosaccharide structure is an important determinant in the resistance of Neisseria gonorrhoeae to antimicrobial agents of innate host defense. Front. Microbiol. 2011, 2, 30.
121. Handing, J.W.; Criss, A.K. The lipooligosaccharide-modifying enzyme LptA enhances gonococcal defence against human neutrophils. Cell. Microbiol. 2014, doi: 10.1111/cmi.12411.
122. Kandler, J.L.; Joseph, S.J.; Balthazar, J.T.; Dhulipala, V.; Read, T.D.; Jerse, A.E.; Shafer, W.M. Phase-variable expression of lpta modulates the resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides. Antimicrob. Agents Chemother. 2014, 58, 4230-4233.
123. Packiam, M.; Yedery, R.D.; Begum, A.A.; Carlson, R.W.; Ganguly, J.; Sempowski, G.D.; Ventevogel, M.S.; Shafer, W.M.; Jerse, A.E. Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid a plays a dual immunostimulatory and protective role during experimental genital tract infection. Infect. Immun. 2014, 82, 2170-2179.
124. Groisman, E.A.; Parra-Lopez, C.; Salcedo, M.; Lipps, C.J.; Heffron, F. Resistance to host antimicrobial peptides is necessary for Salmonella virulence. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 11939-11943.
125. Dalebroux, Z.D.; Matamouros, S.; Whittington, D.; Bishop, R.E.; Miller, S.I. PhoPQ regulates acidic glycerophospholipid content of the Salmonella typhimurium outer membrane. Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 1963-1968.
126. Matamouros, S.; Miller, S.I. S. Typhimurium strategies to resist killing by cationic antimicrobial peptides. Biochim. Biophys. Acta 2015, doi: 10.1016/j.bbamem.2015.01.013.
127. Dalebroux, Z.D.; Miller, S.I. Salmonellae PhoPQ regulation of the outer membrane to resist innate immunity. Curr Opin Microbiol. 2014, 17, 106-113.
128. Cullen, T.W.; Schofield, W.B.; Barry, N.A.; Putnam, E.E.; Rundell, E.A.; Trent, M.S.; Degnan, P.H.; Booth, C.J.; Yu, H.; Goodman, A.L. Gut Microbiota. Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation. Science 2015, 347, 170-175.
129. Wang, G.; Hanke, M.L.; Mishra, B.; Lushnikova, T.; Heim, C.E.; Chittezham Thomas, V.; Bayles, K.W.; Kielian, T. Transformation of human cathelicidin LL-37 into selective, stable, and potent antimicrobial compounds. ACS Chem. Biol. 2014, 9, 1997-2002.
130. Li, X.; Li, Y.; Han, H.; Miller, D.W.; Wang, G. Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. J. Am. Chem. Soc. 2006, 128, 5776-5785.
131. Leake, I. IBD: cathelicidin can reverse intestinal fibrosis in models of colitis. Nat. Rev. Gastroenterol. Hepatol. 2015, 12, 3.
132. Steinstraesser, L.; Lam, M.C.; Jacobsen, F.; Porporato, P.E.; Chereddy, K.K.; Becerikli, M.; Stricker, I.; Hancock, R.E.; Lehnhardt, M.; Sonveaux, P.; et al. Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing. Mol. Ther. 2014, 22, 734-742.
133. Woo, J.I.; Kil, S.H.; Brough, D.E.; Lee, Y.J.; Lim, D.J.; Moon, S.K. Therapeutic potential of adenovirus-mediated delivery of beta-defensin 2 for experimental otitis media. Innate Immun. 2015, 21, 215-224.
134. Gonzalez-Curiel, I.; Trujillo, V.; Montoya-Rosales, A.; Rincon, K.; Rivas-Calderon, B.; deHaro-Acosta, J.; Marin-Luevano, P.; Lozano-Lopez, D.; Enciso-Moreno, J.A.; Rivas-Santiago, B. 1,25-Dihydroxyvitamin D3 induces LL-37 and HBD-2 production in keratinocytes from diabetic foot ulcers promoting wound healing: An in vitro model. PLoS One 2014, 9, e111355.
135. Mallbris, L.; Edstrom, D.W.; Sundblad, L.; Granath, F.; Stahle, M. UVB upregulates the antimicrobial protein hCAP18 mRNA in human skin. J. Invest. Dermatol. 2005, 125, 1072-1074.
136. Eda, N.; Shimizu, K.; Suzuki, S.; Tanabe, Y.; Lee, E.; Akama, T. Effects of yoga exercise on salivary beta-defensin 2. Eur. J. Appl. Physiol. 2013, 113, 2621-2627.
137. Lin, S.P.; Li, C.Y.; Suzuki, K.; Chang, C.K.; Chou, K.M.; Fang, S.H. Green tea consumption after intense taekwondo training enhances salivary defense factors and antibacterial capacity. PLoS One 2014, 9, e87580.
138. Aboye, T.L.; Ha, H.; Majumder, S.; Christ, F.; Debyser, Z.; Shekhtman, A.; Neamati, N.; Camarero, J.A. Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity. J. Med. Chem. 2012, 55, 10729-10734.
139. Gunasekera, S.; Foley, F.M.; Clark, R.J.; Sando, L.; Fabri, L.J.; Craik, D.J.; Daly, N.L. Engineering stabilized vascular endothelial growth factor-a antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides. J. Med. Chem. 2008, 51, 7697-7704.
140. Wang, C.K.; Gruber, C.W.; Cemazar, M.; Siatskas, C.; Tagore, P.; Payne, N.; Sun, G.; Wang, S.; Bernard, C.C.; Craik, D.J. Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. ACS Chem. Biol. 2014, 9, 156-163.
141. Craik, D.J.; Henriques, S.T.; Mylne, J.S.; Wang, C.K. Cyclotide isolation and characterization. Methods Enzymol. 2012, 516, 37-62.
142. Gunasekera, S.; Daly, N.L.; Anderson, M.A.; Craik, D.J. Chemical synthesis and biosynthesis of the cyclotide family of circular proteins. IUBMB Life 2006, 58, 515-524.
143. Jia, X.; Kwon, S.; Wang, C.I.; Huang, Y.H.; Chan, L.Y.; Tan, C.C.; Rosengren, K.J.; Mulvenna, J.P.; Schroeder, C.I.; Craik, D.J. Semienzymatic cyclization of disulfide-rich peptides using sortase A. J. Biol. Chem. 2014, 289, 6627-6638.
144. Stanger, K.; Maurer, T.; Kaluarachchi, H.; Coons, M.; Franke, Y.; Hannoush, R.N. backbone cyclization of a recombinant cystine-knot peptide by engineered sortase A. FEBS Lett. 2014, 588, 4487-4496.
145. Lim, K.; Chua, R.R.; Ho, B.; Tambyah, P.A.; Hadinoto, K.; Leong, S.S. Development of a catheter functionalized by a polydopamine peptide coating with antimicrobial and antibiofilm properties. ActaBiomater. 2014, 15, 127-138.
146. Godoy-Gallardo, M.; Mas-Moruno, C.; Fernandez-Calderon, M.C.; Perez-Giraldo, C.; Manero, J.M.; Albericio, F.; Gil, F.J.; Rodriguez, D. Covalent immobilization of hLf1-11 peptide on a titanium surface reduces bacterial adhesion and biofilm formation. Acta Biomater. 2014, 10, 3522-3534.
147. Lombana, A.; Raja, Z.; Casale, S.; Pradier, C.M.; Foulon, T.; Ladram, A.; Humblot, V. Temporin-SHa peptides grafted on gold surfaces display antibacterial activity. J. Pept. Sci. 2014, 20, 563-569.
148. Wang, Z.; Han, X.; He, N.; Chen, Z.; Brooks, C.L, 3rd. Molecular structures of C- and N-terminus cysteine modified cecropin P1 chemically immobilized onto maleimide-terminated self-assembled monolayers investigated by molecular dynamics simulation. J. Phys. Chem. B 2014, 118, 5670-5680.
149. Mishra, B.; Basu, A.; Chua, R.R.Y.; Saravanan, R.; Tambyah, P.P.; Ho, B.; Chang, M.W.; Leong, S.S.J. Site specific immobilization of a potent antimicrobial peptide onto silicone catheters: evaluation against urinary tract infection pathogens. J. Mater. Chem. B, 2014, 2, 1706-1716.
150. Salwiczek, M.; Qu, Y.; Gardiner, J.; Strugnell, R.A.; Lithgow, T.; McLean, K.M.; Thissen, H. Emerging rules for effective antimicrobial coatings. Trends Biotechnol. 2014, 32, 82-90.
151. Dutta, D.; Ozkan, J.; Willcox, M.D. Biocompatibility of antimicrobial melimine lenses: Rabbit and human studies. Optom. Vis. Sci. 2014, 91, 570-581.
152. Tan, X.W.; Goh, T.W.; Saraswathi, P.; Nyein, C.L.; Setiawan, M.; Riau, A.; Lakshminarayanan, R.; Liu, S.; Tan, D.; Beuerman, R.W.; et al. Effectiveness of antimicrobial peptide immobilization for preventing perioperative cornea implant-associated bacterial infection. Antimicrob. Agents Chemother. 2014, 58, 5229-5238.
153. Medeiros, K.A.; Joanitti, G.A.; Silva, L.P. Chitosan nanoparticles for dermaseptin peptide delivery toward tumor cells in vitro. Anticancer Drugs 2014, 25, 323-331.
154. Miao, D.; Jiang, M.; Liu, Z.; Gu, G.; Hu, Q.; Kang, T.; Song, Q.; Yao, L.; Li, W.; Gao, X.; et al. Co-administration of dual-targeting nanoparticles with penetration enhancement peptide for antiglioblastoma therapy. Mol. Pharm. 2014, 11, 90-101.
155. Ahmad, A.; Ranjan, S.; Zhang, W.; Zou, J.; Pyykko, I.; Kinnunen, P.K. Novel endosomolytic peptides for enhancing gene delivery in nanoparticles. Biochim. Biophys. Acta 2015, 1848, 544-553.
156. Keohane, K.; Brennan, D.; Galvin, P.; Griffin, B.T. Silicon microfluidic flow focusing devices for the production of size-controlled PLGA based drug loaded microparticles. Int. J. Pharm. 2014, 467, 60-69.
157. Chereddy, K.K.; Her, C.H.; Comune, M.; Moia, C.; Lopes, A.; Porporato, P.E.; Vanacker, J.; Lam, M.C.; Steinstraesser, L.; Sonveaux, P.; et al. PLGA Nanoparticles loaded with host defense peptide ll37 promote wound healing. J. Control. Release 2014, 194, 138-147.
158. Laverty, G.; McCloskey, A.P.; Gilmore, B.F.; Jones, D.S.; Zhou, J; Xu, B. Ultrashort cationic naphthalene-derived self-assembled peptides as antimicrobial nanomaterials. Biomacromolecules 2014, 15, 3429-3439.
159. Lillehoj, P.B.; Kaplan, C.W.; He, J.; Shi, W.; Ho, C.M. Rapid, electrical impedance detection of bacterial pathogens using immobilized antimicrobial peptides. J. Lab. Autom. 2014, 19, 42-49.
160. Etayash, H.; Jiang, K.; Thundat, T.; Kaur, K. impedimetric detection of pathogenic gram-positive bacteria using an antimicrobial peptide from class IIa bacteriocins. Anal. Chem. 2014, 86, 1693-1700.
161. Kim, H.J.; Brehm-Stecher, B.F. Design and evaluation of peptide nucleic acid probes for specific identification of Candida albicans. J. Clin. Microbiol. 2015, 53, 511-521.
162. Strauss-Grabo, M.; Atiyem S.; Le, T.; Kretschmar, M. Decade-long use of the antimicrobial peptide combination tyrothricin does not pose a major risk of acquired resistance with gram-positive bacteria and Candida spp. Pharmazie 2014, 69, 838-841.
163. Shenkarev, Z.O.; Gizatullina, A.K.; Finkina, E.I.; Alekseeva, E.A.; Balandin, S.V.; Mineev, K.S.; Arseniev, A.S.; Ovchinnikova, T.V. Heterologous expression and solution structure of defensin from lentil Lens culinaris. Biochem. Biophys. Res. Commun. 2014, 451, 252-257.
164. De Medeiros, L.N.; Angeli, R.; Sarzedas, C.G.; Barreto-Bergter, E.; Valente, A.P.; Kurtenbach, E.; Almeida, F.C. Backbone dynamics of the antifungal Psd1 pea defensin and its correlation with membrane interaction by NMR spectroscopy. Biochim. Biophys. Acta 2010, 1798, 105-113.
165. Neves de Medeiros, L.; Domitrovic, T.; Cavalcante de Andrade, P.; Faria, J.; Barreto Bergter, E.; Weissmüller, G.; Kurtenbach, E. Psd1 binding affinity toward fungal membrane components as assessed by SPR: The role of glucosylceramide in fungal recognition and entry. Biopolymers 2014, 102, 456-464.
166. De Paula, V.S.; Pomin, V.H.; Valente, A.P. Unique properties of human P-defensin 6 (hBD6) and glycosaminoglycan complex: sandwich-like dimerization and competition with the chemokine receptor 2 (CCR2) binding site. J. Biol. Chem. 2014, 289, 22969-22979.
167. Forde, E.; Humphreys, H.; Greene, C.M.; Fitzgerald-Hughes, D.; Devocelle, M. Potential of host defense peptide prodrugs as neutrophil elastase-dependent anti-infective agents for cystic fibrosis. Antimicrob. Agents Chemother. 2014, 58, 978-985.
168. Forde, E.; Devocelle, M. Pro-moieties of antimicrobial peptide prodrugs. Molecules 2015, 20, 1210-1227.
169. Neumann, A.; Völlger, L.; Berends, E.T.; Molhoek, E.M.; Stapels, D.A.; Midon, M.; Friâes, A.; Pingoud, A.; Rooijakkers, S.H.; Gallo, R.L.; et al. Novel role of the antimicrobial peptide LL-37 in the protection of neutrophil extracellular traps against degradation by bacterial nucleases. J. Innate Immun. 2014, 6, 860-868.
170. Sol, A.; Skvirsky, Y.; Nashef, R.; Zelentsova, K.; Burstyn-Cohen, T.; Blotnick, E.; Muhlrad, A.; Bachrach, G. Actin enables the antimicrobial action of LL-37 peptide in the presence of microbial proteases. J. Biol. Chem. 2014, 289, 22926-22941.
171. Sol, A.; Wang, G.; Blotnick, E.; Golla, R.; Bachrach, G. Interaction of the core fragments of the LL-37 host defense peptide with actin. RSC Adv. 2015, 5, 9361-9367.
172. Svensson, D.; Westman, J.; Wickstrom, C.; Jonsson, D.; Herwald, H.; Nilsson, B.O. Human Endogenous Peptide p33 Inhibits Detrimental Effects of LL-37 on Osteoblast Viability. J. Periodontal. Res. 2015, 50, 80-88.
173. Hiemstra, T.F.; Charles, P.D.; Gracia, T.; Hester, S.S.; Gatto, L.; Al-Lamki, R.; Floto, R.A.; Su, Y.; Skepper, J.N.; Lilley, K.S.; et al. Human Urinary Exosomes as Innate Immune Effectors. J. Am. Soc. Nephrol. 2014, 50, 80-88.
174. Carmona-Ribeiro, A.M.; de Melo Carrasco, L.D. Novel formulations for antimicrobial peptides. Int. J. Mol. Sci. 2014, 15, 18040-18083.
175. Pina, A.S.; Batalha, I.L.; Fernandes, C.S.; Aoki, M.A.; Roque, A.C. Exploring the potential of magnetic antimicrobial agents for water disinfection. Water Res. 2014, 66, 160-168.
176. Silva, R.R.; Avelino, K.Y.; Ribeiro, K.L.; Franco, O.L.; Oliveira, M.D.; Andrade, C.A. Optical and dielectric sensors based on antimicrobial peptides for microorganism diagnosis. Front. Microbiol. 2014, 5, 443.
177. Otter, J.A.; Vickery, K.; Walker, J.T.; deLancey Pulcini, E.; Stoodley, P.; Goldenberg, S.D.; Salkeld, J.A.; Chewins, J.; Yezli, S.; Edgeworth, J.D. Surface-attached cells, biofilms and biocide susceptibility: implications for hospital cleaning and disinfection. J. Hosp. Infect. 2015, 89, 16-27.
178. Pimentel-Filho Nde, J.; Martins, M.C.; Nogueira, G.B.; Mantovani, H.C.; Vanetti, M.C. Bovicin HC5 and nisin reduce Staphylococcus aureus adhesion to polystyrene and change the hydrophobicity profile and gibbs free energy of adhesion. Int. J. Food Microbiol. 2014, 190, 1-8.
179. Dong, X.; McCoy, E.; Zhang, M.; Yang, L. Inhibitory effects of nisin-coated multi-walled carbon nanotube sheet on biofilm formation from Bacillus anthracis spores. J. Environ. Sci. (China) 2014, 26, 2526-2534.
180. Singh, A.P.; Preet, S.; Rishi, P. Nisin/p-Lactam adjunct therapy against Salmonella enterica serovar Typhimurium: a mechanistic approach. J. Antimicrob. Chemother. 2014, 69, 1877-1887.
181. Dosler, S.; Karaaslan, E. Inhibition and destruction of Pseudomonas aeruginosa biofilms by antibiotics and antimicrobial peptides. Peptides 2014, 62, 32-37.
182. Maiti, S.; Patro, S.; Purohit, S.; Jain, S.; Senapati, S.; Dey, N. Effective control of Salmonella infections by employing combinations of recombinant antimicrobial human P-defensins hBD-1 and hBD-2. Antimicrob Agents Chemother. 2014, 58, 6896-6903.
183. Donelli, G.; Francolini, I.; Romoli, D.; Guaglianone, E.; Piozzi, A.; Ragunath, C.; Kaplan, J.B. Synergistic activity of dispersin B and cefamandole nafate in inhibition of staphylococcal biofilm growth on polyurethanes. Antimicrob Agents Chemother. 2007, 51, 2733-2740.
184. Tong, Z.; Zhang, L.; Ling, J.; Jian, Y.; Huang, L.; Deng, D. An in vitro study on the effect of free amino acids alone or in combination with nisin on biofilms as well as on planktonic bacteria of Streptococcus mutans. PLoS One 2014, 9, e99513.
185. De la Fuente-Nunez, C.; Reffuveille, F.; Haney, E.F.; Straus, S.K.; Hancock, R.E. Broad-Spectrum anti-biofilm peptide that targets a cellular stress response. PLoSPathog. 2014, 10, e1004152.
186. Bommarius, B.; Anyanful, A.; Izrayelit, Y.; Bhatt, S.; Cartwright, E.; Wang, W.; Swimm, A.I.; Benian, G.M.; Schroeder, F.C.; Kalman, D. A family of indoles regulate virulence and Shiga toxin production in pathogenic E. coli. PLoS One. 2013, 8, e54456.
187. Scopel, M.; Abraham, W.R.; Antunes, A.L.; Henriques, A.T.; Macedo, A.J. Mevalonolactone: an inhibitor of Staphylococcus epidermidis adherence and biofilm formation. Med. Chem. 2014, 10, 246-251.
188. Liaqat, I.; Bachmann, R.T.; Edyvean, R.G. Type 2 quorum sensing monitoring, inhibition and biofilm formation in marine microrganisms. Curr. Microbiol. 2014, 68, 342-351.
189. Pereira, U.A.; Barbosa, L.C.; Maltha, C.R.; Demuner, A.J.; Masood, M.A.; Pimenta, A.L. y-Alkylidene-y-lactones and isobutylpyrrol-2(5H)-ones analogues to rubrolides as inhibitors of biofilm formation by gram-positive and gram-negative bacteria. Bioorg. Med. Chem. Lett. 2014, 24, 1052-1056.