Altered α-defensin 5 expression in cervical squamocolumnar junction: Implication in the formation of a viral/tumour-permissive microenvironment

Journal of Pathology

Volumn 234, Issue 4, 2014, Pages 464-477

  Hubert, Pascale ^a   Herman, Ludivine ^a   Roncarati, Patrick ^a   Maillard, Catherine ^a   Renoux, Virginie ^a,b   Demoulin, Stéphanie ^a   Erpicum, Charlotte ^a   Foidart, Jean Michel ^a   Boniver, Jacques ^a   Noël, Agnès ^a   Delvenne, Philippe ^a   Herfs, Michael ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Cervix; Defensin; HPV

Indexed keywords

ALPHA DEFENSIN; ALPHA DEFENSIN 5; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR6; UNCLASSIFIED DRUG; ALPHA-DEFENSIN 5, HUMAN;

ADAPTIVE IMMUNITY; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PROTEIN EXPRESSION; T LYMPHOCYTE; TUMOR MICROENVIRONMENT; UTERINE CERVIX CANCER; UTERINE CERVIX EPITHELIUM; VIRION; VIRUS ENTRY; WART VIRUS; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; NONOBESE DIABETIC MOUSE; PAPILLOMAVIRUS INFECTION; PRECANCER; REAL TIME POLYMERASE CHAIN REACTION; SCID MOUSE; UTERINE CERVIX; UTERINE CERVIX CARCINOMA IN SITU; UTERUS CANCER; VIROLOGY; WESTERN BLOTTING; XENOGRAFT;

ALPHA-DEFENSINS; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CERVICAL INTRAEPITHELIAL NEOPLASIA; CERVIX UTERI; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HETEROGRAFTS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED NOD; MICE, SCID; PAPILLOMAVIRUS INFECTIONS; PRECANCEROUS CONDITIONS; REAL-TIME POLYMERASE CHAIN REACTION; UTERINE NEOPLASMS;

EID: 84910635010     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4435     Document Type: Article

References (43)

1. Herfs M, Vargas SO, Yamamoto Y, et al. A novel blueprint for 'top down' differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasia. J Pathol 2013; 229: 460-468.
2. Herfs M, Yamamoto Y, Laury A, et al. A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer. Proc Natl Acad Sci USA 2012; 109: 10516-10521.
3. Herfs M, Parra-Herran C, Howitt BE, et al. Cervical squamocolumnar junction-specific markers define distinct, clinically relevant subsets of low-grade squamous intraepithelial lesions. Am J Surg Pathol 2013; 37: 1311-1318.
4. Subramanya D, Grivas PD. HPV and cervical cancer: updates on an established relationship. Postgrad Med 2008; 120: 7-13.
5. Manickam A, Sivanandham M, Tourkova IL. Immunological role of dendritic cells in cervical cancer. Adv Exp Med Biol 2007; 601: 155-162.
6. Al-Saleh W, Giannini SL, Jacobs N, et al. Correlation of T-helper secretory differentiation and types of antigen-presenting cells in squamous intraepithelial lesions of the uterine cervix. J Pathol 1998; 184: 283-290.
7. Giannini SL, Hubert P, Doyen J, et al. Influence of the mucosal epithelium microenvironment on Langerhans cells: implications for the development of squamous intraepithelial lesions of the cervix. Int J Cancer 2002; 97: 654-659.
8. White SH, Wimley WC, Selsted ME. Structure, function, and membrane integration of defensins. Curr Opin Struct Biol 1995; 5: 521-527.
9. Jenssen H, Hamill P, Hancock RE. Peptide antimicrobial agents. Clin Microbiol Rev 2006; 19: 491-511.
10. Michaelson D, Rayner J, Couto M, et al. Cationic defensins arise from charge-neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity? J Leukoc Biol 1992; 51: 634-639.
11. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 2003; 3: 710-720.
12. Ganz T, Selsted ME, Szklarek D, et al. Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest 1985; 76: 1427-1435.
13. Rehaume LM, Hancock RE. Neutrophil-derived defensins as modulators of innate immune function. Crit Rev Immunol 2008; 28: 185-200.
14. Quayle AJ, Porter EM, Nussbaum AA, et al. Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Am J Pathol 1998; 152: 1247-1258.
15. Yang D, Liu ZH, Tewary P, et al. Defensin participation in innate and adaptive immunity. Curr Pharm Des 2007; 13: 3131-3139.
16. Caberg JH, Hubert PM, Begon DY, et al. Silencing of E7 oncogene restores functional E-cadherin expression in human papillomavirus 16-transformed keratinocytes. Carcinogenesis 2008; 29: 1441-1447.
17. + hematopoietic progenitor cells: use of interleukin-3. Exp Hematol 2012; 40: 268-278.
18. Hubert P, Greimers R, Franzen-Detrooz E, et al. In vitro propagated dendritic cells from patients with human papillomavirus-associated preneoplastic lesions of the uterine cervix: use of Flt3 ligand. Cancer Immunol Immunother 1998; 47: 81-89.
19. Renoux VM, Bisig B, Langers I, et al. Human papillomavirus entry into NK cells requires CD16 expression and triggers cytotoxic activity and cytokine secretion. Eur J Immunol 2011; 41: 3240-3252.
20. Bajou K, Noel A, Gerard RD, et al. Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization. Nat Med 1998 4: 923-928.
21. Herfs M, Hubert P, Poirrier AL, et al. Proinflammatory cytokines induce bronchial hyperplasia and squamous metaplasia in smokers: implications for chronic obstructive pulmonary disease therapy. Am J Respir Cell Mol Biol 2012; 47: 67-79.
22. Bousarghin L, Combita-Rojas AL, Touze A, et al. Detection of neutralizing antibodies against human papillomaviruses (HPV) by inhibition of gene transfer mediated by HPV pseudovirions. J Clin Microbiol 2002; 40: 926-932.
23. Masson VV, Devy L, Grignet-Debrus C, et al. Mouse aortic ring assay: a new approach of themolecular genetics of angiogenesis. Biol Proced Online 2002; 4: 24-31.
24. Bruyere F, Melen-Lamalle L, Blacher S, et al. Modeling lymphangiogenesis in a three-dimensional culture system. Nat Methods 2008; 5: 431-437.
25. Hubert P, Van Den Brule F, Giannini SL, et al. Colonization of in vitro-formed cervical human papillomavirus-associated (pre)neoplastic lesions with dendritic cells. Role of granulocyte/macrophage colony-stimulating factor. Am J Pathol 1999; 154: 775-784.
26. Dellas A, Moch H, Schultheiss E, et al. Angiogenesis in cervical neoplasia: microvessel quantitation in precancerous lesions and invasive carcinomas with clinicopathological correlations. Gynecol Oncol 1997; 67: 27-33.
27. Ravazoula P, Zolota V, Hatjicondi O, et al. Assessment of angiogenesis in human cervical lesions. Anticancer Res 1996; 16: 3861-3864.
28. Chavakis T, Cines DB, Rhee JS, et al. Regulation of neovascularization by human neutrophil peptides (α-defensins): a link between inflammation and angiogenesis. Faseb J 2004; 18: 1306-1308.
29. Suarez-Carmona M, Hubert P, Gonzalez A, et al. δNp63 isoform-mediated β-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma. Oncotarget 2014; 5: 1856-1868.
30. Banks L, Pim D, Thomas M. Human tumour viruses and the deregulation of cell polarity in cancer. Nat Rev Cancer 2012; 12: 877-886.
31. Valore EV, Park CH, Igreti SL, et al. Antimicrobial components of vaginal fluid. Am J Obstet Gynecol 2002; 187: 561-568.
32. Muller CA, Markovic-Lipkovski J, Klatt T, et al. Human α-defensins HNPs-1, -2 and -3 in renal cell carcinoma: influences on tumor cell proliferation. Am J Pathol 2002; 160: 1311-1324.
33. Holterman DA, Diaz JI, Blackmore PF, et al. Overexpression of α-defensin is associated with bladder cancer invasiveness. Urol Oncol 2006; 24: 97-108.
34. Lichtenstein A. Mechanism of mammalian cell lysis mediated by peptide defensins. Evidence for an initial alteration of the plasma membrane. J Clin Invest 1991; 88: 93-100.
35. Ghavami S, Asoodeh A, Klonisch T, et al. Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway. J Cell Mol Med 2008; 12: 1005-1022.
36. Ito T, Tanabe H, Ayabe T, et al. Paneth cells regulate both chemotaxis of immature dendritic cells and cytokine production from epithelial cells. Tohoku J Exp Med 2012; 227: 39-48.
37. Yang D, Chen Q, Chertov O, et al. Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells. J Leukoc Biol 2000; 68: 9-14.
38. Grigat J, Soruri A, Forssmann U, et al. Chemoattraction of macrophages, T lymphocytes, and mast cells is evolutionarily conserved within the human α-defensin family. J Immunol 2007; 179: 3958-3965.
39. Verreck FA, de Boer T, Langenberg DM, et al. Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria. Proc Natl Acad Sci USA 2004; 101: 4560-4565.
40. Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol 2008; 8: 533-544.
41. Sica A, Schioppa T, Mantovani A, et al. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer 2006; 42: 717-727.
42. Choi KM, Kashyap PC, Dutta N, et al. CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice. Gastroenterology 2010; 138: 2399-2409, e2391.
43. Buck CB, Day PM, Thompson CD, et al. Human α-defensins block papillomavirus infection. Proc Natl Acad Sci USA 2006; 103: 1516-1521.