Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response

PLoS Pathogens

Volumn 10, Issue 5, 2014, Pages

  de la Fuente Núñez, César ^a   Reffuveille, Fany ^a   Haney, Evan F ^a   Straus, Suzana K ^a   Hancock, Robert E W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOFILM PEPTIDE; PEPTIDE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; GUANOSINE 3',5'-POLYPHOSPHATE SYNTHETASES; LIGASE; PEPTIDE FRAGMENT;

ACINETOBACTER BAUMANNII; ARTICLE; BACTERIAL GROWTH; BIOFILM; BURKHOLDERIA CENOCEPACIA; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; MICROSCOPY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PEPTIDE SYNTHESIS; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERICA; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS AUREUS; THIN LAYER CHROMATOGRAPHY; CHEMISTRY; DRUG EFFECTS; GENETIC COMPLEMENTATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TEST; PHYSIOLOGICAL STRESS; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM;

ACINETOBACTER BAUMANNII; ANTI-BACTERIAL AGENTS; BIOFILMS; BURKHOLDERIA CENOCEPACIA; ESCHERICHIA COLI; GENETIC COMPLEMENTATION TEST; KLEBSIELLA PNEUMONIAE; LIGASES; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; PEPTIDE FRAGMENTS; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHIMURIUM; STRESS, PHYSIOLOGICAL;

EID: 84901654690     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004152     Document Type: Article

References (37)

1. Costerton JW, Stewart PS, Greenberg EP, (1999) Bacterial biofilms: a common cause of persistent infections. Science 284: 1318-22.
2. de la Fuente-Núñez C, Reffuveille F, Fernández L, Hancock REW, (2013) Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies. Curr Opin Microbiol 16: 580-9.
3. Potrykus K, Cashel M, (2008) (p)ppGpp: still magical? Annu Rev Microbiol 62: 35-51.
4. Magnusson LU, Farewell A, Nyström T, (2005) ppGpp: a global regulator in Escherichia coli. Trends Microbiol 13: 236-42.
5. Aberg A, Shingler V, Balsalobre C, (2006) (p)ppGpp regulates type 1 fimbriation of Escherichia coli by modulating the expression of the site-specific recombinase FimB. Mol Microbiol 60: 1520-33.
6. Balzer GJ, McLean RJ, (2002) The stringent response genes relA and spoT are important for Escherichia coli biofilms under slow-growth conditions. Can J Microbiol 48: 675-80.
7. Chávez de Paz LE, Lemos JA, Wickström C, Sedgley CM, (2012) Role of (p)ppGpp in biofilm formation by Enterococcus faecalis. Appl Environ Microbiol 78: 1627-30.
8. He H, Cooper JN, Mishra A, Raskin DM, (2012) Stringent response regulation of biofilm formation in Vibrio cholerae. J Bacteriol 194: 2962-72.
9. Lemos JA, Brown TA Jr, Burne RA, (2004) Effects of RelA on key virulence properties of planktonic and biofilm populations of Streptococcus mutans. Infect Immun 72: 1431-40.
10. Sugisaki K, Hanawa T, Yonezawa H, Osaki T, Fukutomi T, et al. (2013) Role of (p)ppGpp in biofilm formation and expression of filamentous structures in Bordetella pertussis. Microbiology 159: 1379-89.
11. Taylor CM, Beresford M, Epton HA, Sigee DC, Shama G, et al. (2002) Listeria monocytogenes relA and hpt mutants are impaired in surface-attached growth and virulence. J Bacteriol 184: 621-8.
12. Nguyen D, Joshi-Datar A, Lepine F, Bauerle E, Olakanmi O, et al. (2011) Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Science 334: 982-6.
13. Overhage J, Campisano A, Bains M, Torfs EC, Rehm BH, et al. (2008) Human host defense peptide LL-37 prevents bacterial biofilm formation. Infect Immun 76: 4176-82.
14. de la Fuente-Núñez C, Korolik V, Bains M, Nguyen U, Breidenstein EB, et al. (2012) Inhibition of bacterial biofilm formation and swarming motility by a small synthetic cationic peptide. Antimicrob Agents Chemother 56: 2696-704.
15. Rivas-Santiago B, Castañeda-Delgado JE, Rivas Santiago CE, Waldbrook M, González-Curiel I, et al. (2013) Ability of innate defence regulator peptides IDR-1002, IDR-HH2 and IDR-1018 to protect against Mycobacterium tuberculosis infections in animal models. PLoS One 8: e59119.
16. Tosa T, Pizer LI, (1971) Biochemical bases for the antimetabolite action of L-serine hydroxamate. J Bacteriol 106: 972-82.
17. Yan H, Hancock REW, (2001) Synergistic interactions between mammalian antimicrobial defense peptides. Antimicrob Agents Chemother 45: 1558-60.
18. Dahl JL, Kraus CN, Boshoff HI, Doan B, Foley K, et al. (2003) The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice. Proc Natl Acad Sci U S A 100: 10026-31.
19. Vogt SL, Green C, Stevens KM, Day B, Erickson DL, et al. (2011) The stringent response is essential for Pseudomonas aeruginosa virulence in the rat lung agar bead and Drosophila melanogaster feeding models of infection. Infect Immun 79: 4094-104.
20. Erlich H, Laffler T, Gallant J, (1971) ppGpp formation in Escherichia coli treated with rifampicin. J Biol Chem 246: 6121-3.
21. Khan SR, Yamazaki H, (1972) Trimethoprim-induced accumulation of guanosine tetraphosphate (ppGpp) in Escherichia coli. Biochem Biophys Res Commun 48: 169-74.
22. Cortay JC, Cozzone AJ, (1983) Accumulation of guanosine tetraphosphate induced by polymixin and gramicidin in Escherichia coli. Biochim Biophys Acta 755: 467-73.
23. Ikehara K, Kamitani E, Koarata C, Ogura A, (1985) Induction of stringent response by streptomycin in Bacillus subtilis cells. J Biochem 97: 697-700.
24. Gilbert P, Collier PJ, Brown MR, (1990) Influence of growth rate on susceptibility to antimicrobial agents: biofilms, cell cycle, dormancy, and stringent response. Antimicrob Agents Chemother 34: 1865-8.
25. Wexselblatt E, Oppenheimer-Shaanan Y, Kaspy I, London N, Schueler-Furman O, et al. (2012) Relacin, a novel antibacterial agent targeting the Stringent Response. PLoS Pathog 8: e1002925.
26. Pompilio A, Scocchi M, Pomponio S, Guida F, Di Primio A, et al. (2011) Antibacterial and anti-biofilm effects of cathelicidin peptides against pathogens isolated from cystic fibrosis patients. Peptides 32: 1807-14.
27. Fjell CD, Hiss JA, Hancock REW, Schneider G, (2011) Designing antimicrobial peptides: form follows function. Nat Rev Drug Discov 11: 37-51.
28. Friedrich CL, Moyles D, Beveridge TJ, Hancock REW, (2000) Antibacterial action of structurally diverse cationic peptides on Gram-positive bacteria. Antimicrob Agents Chemother 44: 2086-92.
29. Betzner AS, Ferreira LC, Höltje JV, Keck W, (1990) Control of the activity of the soluble lytic transglycosylase by the stringent response in Escherichia coli. FEMS Microbiol Lett 55: 161-4.
30. Geiger T, Goerke C, Fritz M, Schäfer T, Ohlsen K, et al. (2010) Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus. Infect Immun 78: 1873-83.
31. Tedin K, Norel F, (2001) Comparison of DeltarelA strains of Escherichia coli and Salmonella enterica serovar Typhimurium suggests a role for ppGpp in attenuation regulation of branched-chain amino acid biosynthesis. J Bacteriol 183: 6184-96.
32. Svitil AL, Cashel M, Zyskind JW, (1993) Guanosine tetraphosphate inhibits protein synthesis in vivo. A possible protective mechanism for starvation stress in Escherichia coli. J Biol Chem 268: 2307-11.
33. Xiao H, Kalman M, Ikehara K, Zemel S, Glaser G, et al. (1991) Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations. J Biol Chem 266: 5980-90.
34. Qiu D, Damron FH, Mima T, Schweizer HP, Yu HD, (2008) PBAD-based shuttle vectors for functional analysis of toxic and highly regulated genes in Pseudomonas and Burkholderia spp. and other bacteria. Appl Environ Microbiol 74: 7422-6.
35. Wiegand I, Hilpert K, Hancock REW, (2008) Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Nat Protoc 3: 163-75.
36. Sun S, Kjelleberg S, McDougald D, (2013) Relative contributions of Vibrio polysaccharide and quorum sensing to the resistance of Vibrio cholerae to predation by heterotrophic protists. PLoS One 8: e56338.
37. Hilpert K, McLeod B, Yu J, Elliott MR, Rautenbach M, et al. (2010) Short cationic antimicrobial peptides interact with ATP. Antimicrob Agents Chemother 54: 4480-3.