High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments

Biochimica et Biophysica Acta - Biomembranes

Volumn 1838, Issue 9, 2014, Pages 2160-2172

  Wang, Guangshun ^a   Mishra, Biswajit ^a   Epand, Raquel F ^b   Epand, Richard M ^b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Antimicrobial peptide; Cathelicidin; LL 37; Membranes; NMR; Structure activity relationship

Indexed keywords

ARGININE; ARGINYLLYSYLSERYLLYSYLGLUTAMYLLYSYLISOLEUCYLGLYCYLLYSYLGLUTAMYLPHENYLALANYLLYSYLARGINYLISOLEUCYLVALYLGLUTAMINYLARGINYLISOLEUCYLLYSYLASPARTYLPHENYLALANYLLEUCYLARGINYLASPARAGINYLLEUCINE; BACTERIUM LIPOPOLYSACCHARIDE; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; GLYCYLISOLEUCYLLYSYLGLUTAMYLPHENYLALANYLLYSYLARGINYLISOLEUCYLVALYLGLUTAMINYLARGINYLISOLEUCYLLYSYLASPARTYLPHENYLALANYLLEUCYLARGINYLASPARAGINYLLEUCYLVALINE; LYSINE; LYSYLARGINYLISOLEUCYLVALYLARGINYLISOLEUCYLLYSYLASPARTYLPHENYLALANYLLEUCYLARGININE; PHENYLALANINE; PHENYLALANYLLYSYLARGINYLISOLEUCYLVALYLGLUTAMINYLARGINYLISOLEUCYLLYSYLASPARTYLPHENYLALANYLLEUCYLARGININE; PHENYLALANYLLYSYLARGINYLISOLEUCYLVALYLGLUTAMINYLARGINYLISOLEUCYLLYSYLASPARTYLPHENYLALANYLLEUCYLARGINYLASPARAGINYLLEUCYLVALINE; PHOSPHATIDYLGLYCEROL; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTIBIOFILM ACTIVITY; ANTIVIRAL ACTIVITY; BACTERIAL MEMBRANE; BINDING KINETICS; CHANNEL GATING; DRUG ACTIVITY; DRUG STRUCTURE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; MEMBRANE PERMEABILITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACID ANALYSIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN TARGETING; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVIEW;

BACTERIA (MICROORGANISMS); BOS; EQUIDAE; HUMAN IMMUNODEFICIENCY VIRUS 1; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; OVIS ARIES; RESPIRATORY SYNCYTIAL VIRUS; SUIDAE;

ANTIMICROBIAL PEPTIDE; CATHELICIDIN; LL-37; MEMBRANES; NMR; STRUCTURE-ACTIVITY RELATIONSHIP;

ANTIMICROBIAL CATIONIC PEPTIDES; ANTIVIRAL AGENTS; BIOFILMS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; HUMANS; LIPID BILAYERS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION;

EID: 84903701599     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2014.01.016     Document Type: Review

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