Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles

Journal of Biological Chemistry

Volumn 283, Issue 47, 2008, Pages 32637-32643

  Wang, Guangshun ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; ANIMAL CELL CULTURE; BACTERIOLOGY; COLLOIDS; DIFFUSERS (OPTICAL); MICELLES; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURAL ANALYSIS; THREE DIMENSIONAL;

AMPHIPATHIC HELIXES; ANIONIC LIPIDS; ANTIBACTERIAL PEPTIDES; ANTIMICROBIAL AGENTS; ANTIMICROBIAL PEPTIDES; AROMATIC RINGS; BACTERIAL MEMBRANES; CATHELICIDIN; FUNCTION RELATIONSHIPS; HIGH QUALITIES; HOST DEFENSES; HUMAN CELLS; INFECTIOUS DISEASES; INNATE IMMUNITIES; KEY COMPONENTS; LIPID MICELLES; NMR SPECTROSCOPIES; OVERHAUSER EFFECTS; PHOSPHATIDYLGLYCEROLS; POSITIVELY CHARGED; SDS MICELLES; SIDE CHAINS; STRUCTURAL BASES; SYNTHETIC PEPTIDES; TOXIC EFFECTS;

POLYPEPTIDES;

ARGININE; CARBON 13; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; DIOCTANOYLPHOSPHATIDYLGLYCEROL; GLUTAMINE; GLYCEROL DERIVATIVE; GLYCINE; KR 12 PEPTIDE; LIPID; NITROGEN 15; PHENYLALANINE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL MEMBRANE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; ISOTOPE LABELING; MICELLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; QUALITATIVE ANALYSIS; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; BACTERIAL PROTEINS; CATHELICIDINS; HUMANS; LIPIDS; MICELLES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHENYLALANINE; PHOSPHATIDYLGLYCEROLS; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM DODECYL SULFATE;

BACTERIA (MICROORGANISMS); PRIMATES;

EID: 57749088664     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M805533200     Document Type: Article

References (47)

1. Boman, H. G. (1995) Annu. Rev. Immunol. 13, 61-92
2. Sambhara, S., and Lehrer, R. I. (2007) Expert Rev Anti Infect Ther. 5, 1-5
3. Hancock, R. E. W. (2001) Lancet. Infect. Dis. 1, 156-164
4. Zasloff, M. (2002) Nature 415, 389-395
5. Wang, Z., and Wang, G. (2004) Nucleic Acids Res. 32, D590-D592
6. Zanetti, M. (2005) Curr. Issues Mol. Biol. 7, 179-196
7. Pütsep, K., Carlsson, G., Boman, H. G., and Andersson, M. (2002) Lancet 360, 1144-1149
8. Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., and Gallo, R. L. (2001) Nature 414, 454-457
9. Lee, P.H., Ohtake, T., Zaiou, M., Murakami, M., Rudisill, J. A., Lin, K. H., and Gallo, R. L. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 3750-3755
10. Cirioni, O., Giacometti, A., Ghiselli, R., Bergnach, C., Orlando, F., Silvestri, C., Mocchegiani, F., Licci, A., Skerlavaj, B., Rocchi, M., Saba, V., Zanetti, M., and Scalise, G. (2006) Antimicrob. Agents Chemother. 50, 1672-1679
11. Bucki, R., Byfield, F. J., and Janmey, P. A. (2007) Eur. Respir. J. 29, 624-632
12. Oren, Z., Lerman, J. C., Gudmundsson, G. H., Agerberth, B., and Shai, Y. (1999) Biochem. J. 341, 501-513
13. Johansson, J., Gudmundsson, G. H., Rottenberg, M. E., Berndt, K. D., and Agerberth, B. (1998) J. Biol. Chem. 273, 3718-3724
14. Henzler-Wildman, K. A., Lee, D. K., and Ramamoorthy, A. (2003) Biochemistry 42, 6545-6558
15. Neville, F., Cahuzac, M., Konovalov, O., Ishitsuka, Y., Lee, K. Y. C., Kuzmenko, I., Kale, G. M., and Gidalevitz, D. (2006) Biophy. J. 90, 1275-1287
16. Wang, G. (2008) Curr. Protein Pept. Sci. 9, 50-69
17. Hong, I. P., Lee, S. J., Kim, Y. S., and Choi, S. G. (2007) Biotechnol. Lett. 29, 73-78
18. Li, Y., Li., X., and Wang, G. (2006) Protein Expr. Purif. 47, 498-505
19. Moon, J. Y., Henzler-Wildman, K. A., and Ramamoorthy, A. (2006) Biochim. Biophys. Acta 1758, 1351-1358
20. Li, Y., Li, X., and Wang, G. (2007) Protein Expr. Purif. 54, 157-165
21. Li, X., Peterkofsky, A., and Wang, G. (2008) Amino Acids 35, 531-539
22. Bax, A., and Grzesiek, S. (1993) Acc. Chem. Res. 26, 131-138
23. Li, X., Peterkofsky, A., and Wang, G. (2003) J. Biomol NMR 27, 401-402
24. Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., and Bax, A. (1995) J. Biomol. NMR 6, 277-293
25. Garrett, D. S., Powers, R., Gronenborn, A. M., and Clore, G. M. (1991) J. Magn. Reson. 95, 214-220
26. Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, Wiley, New York
27. Cornilescu, G., Delaglio, F., and Bax, A. (1999) J. Biomol. NMR 13, 289-302
28. Schwieters, C. D., Kuszewski, J., Tjandra, N., and Clore, G. M. (2003) J. Magn. Reson. 160, 65-73
29. Laskowski, R. A., Rullmannn, J. A., MacArthur, M. W., Kaptein, R., and Thornton, J. M. (1996) J. Biomol. NMR 8, 477-486
30. Koradi, R., Billeter, M., and Wüthrich, K. (1996) J. Mol. Graphics 14, 51-55
31. Li, X., Li, Y., Han, H., Miller, D. W., and Wang, G. (2006) J. Am. Chem. Soc. 128, 5776-5785
32. Wang, G., Keifer, P. A., and Peterkofsky, A. (2003) Protein Sci. 12, 1087-1096
33. Wang, G. (2007) Biochim. Biophys. Acta 1768, 3271-3281
34. Wang, G. (2008) Open Magn. Reson. J. 1, 9-15
35. Chou, J. J., Baber, J. L., and Bax, A. (2004) J. Biomol. NMR 29, 299-308
36. Wang, G., Treleaven, W. D., and Cushley, R. J. (1996) Biochim. Biophys. Acta 1301, 174-184
37. Braff, M. H., Hawkins, M. A., Di Nardo, A., Lopez-Garcia, B., Howell, M. D., Wong, C., Lin, K., Streib, J. E., Dorschner, R., Leung, D. Y., and Gallo, R. L. (2005) J. Immunol. 174, 4271-4278
38. Wang, G. (2007) Protein Pept. Lett. 14, 57-69
39. Nell, M. J., Tjabringa, G. S., Wafelman, A. R., Verrijk, R., Hismstra, P. S., Drijfhout, J. W., and Grote, J. J. (2006) Peptides 27, 649-660
40. Sigurdardottir, T., Anderson, P., Davoudi, M., Malmsten, M., Schmidtchen, A., and Bodelsson, M. (2006) Antimicrob. Agents Chemother. 50, 2983-2989
41. Wang, G., Watson, K., and Buckheit, R., Jr. (2008) Antimicrob. Agents Chemother. 52, 3438-3440
42. Wang, G., Li, Y., and Li, X. (2005) J. Biol. Chem. 280, 5803-5811
43. Porcelli, F., Verardi, R., Shi, L., Henzler-Wildman, K. A., Ramamoorthy, A., and Veglia, G. (2008) Biochemistry 47, 5565-5572
44. Zelezetsky, I., Pontillo, A., Puzzi, L., Antcheva, N., Segat, L., Pacor, S., Crovella, S., and Tossi, A. (2006) J. Biol. Chem. 281, 19861-19871
45. Wang, G., Louis, J. M., Sondej, M., Seok, Y.-J., Peterkofsky, A., and Clore, G. M. (2000) EMBO J. 19, 5635-5649
46. Epand, R. F., Mowery, B. P., Lee, S. E., Stahl, S. S., Lehrer, R. I., Gellman, S. H., and Epand, R. M. (2008) J. Mol. Biol. 371, 38-50
47. Schmidt, D., Jiang, Q. X., and MacKinnon, R. (2006) Nature 444, 775-779