Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin

FASEB Journal

Volumn 20, Issue 12, 2006, Pages 2068-2080

  Yamasaki, Kenshi ^a   Schauber, Jürgen ^a   Coda, Alvin ^a   Lin, Henry ^a   Dorschner, Robert A ^a   Schechter, Norman M ^b   Bonnart, Chrystelle ^c,d   Descargues, Pascal ^c,d   Hovnanian, Alain ^c,d,e   Gallo, Richard L ^a,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c INSERM   (France)

^d UNIVERSITÉ DE TOULOUSE   (France)

^e CHU PURPAN   (France)

^f MC 9111B ^*  (United States)

Author keywords

Antimicrobial peptide; Lympho epithelial Kazal type related inhibitor; SELDI TOF MS; Stratum corneum chymotryptic protease; Stratum corneum tryptic enzyme

Indexed keywords

CATHELICIDIN; KALLIKREIN; PROTEIN KALLIKREIN 5; PROTEIN KALLIKREIN 7; SERINE PROTEINASE; SMALL INTERFERING RNA; ANTIMICROBIAL CATIONIC PEPTIDE; CAP18 LIPOPOLYSACCHARIDE BINDING PROTEIN; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE; KLK5 PROTEIN, HUMAN; KLK7 PROTEIN, HUMAN; SERINE PROTEINASE INHIBITOR; SPINK5 PROTEIN, MOUSE;

ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; IMMUNOADSORPTION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PROCESSING; REGULATORY MECHANISM; SKIN; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; WESTERN BLOTTING; ANIMAL; IMMUNOLOGY; INNATE IMMUNITY; ISOLATION AND PURIFICATION; METABOLISM; MOUSE MUTANT;

ANIMALIA;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; HUMANS; IMMUNITY, NATURAL; KALLIKREINS; MICE; MICE, KNOCKOUT; SERINE ENDOPEPTIDASES; SERPINS; SKIN;

EID: 33750139445     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-6075com     Document Type: Article

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