Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: Relevance to the molecular basis for its non-cell-selective activity

Biochemical Journal

Volumn 341, Issue 3, 1999, Pages 501-513

  Oren, Ziv ^a   Lerman, Jeffrey C ^a   Gudmundsson, Gudmundur H ^b   Agerberth, Birgitta ^c   Shai, Yechiel ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Amphipathic helix; Antimicrobial peptide; Cathelicidin; Innate immunity; LL 37

Indexed keywords

ANTIINFECTIVE AGENT; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; MEMBRANE PHOSPHOLIPID; MEMBRANE PROTEIN; MONOMER; MUTANT PROTEIN; OLIGOMER; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; HEMOLYSIS; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BIOPOLYMERS; CARRIER PROTEINS; ESCHERICHIA COLI; HEMOLYSIS; HUMANS; HYDROLYSIS; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; SOLUTIONS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); EUKARYOTA; MAMMALIA;

EID: 0033178532     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3410501     Document Type: Article

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