메뉴 건너뛰기




Volumn 8, Issue 3, 2015, Pages 661-671

Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; ALPHA DEFENSIN 6; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG; ALPHA-DEFENSIN 6, HUMAN; ANTIINFECTIVE AGENT;

EID: 84928886700     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2014.100     Document Type: Article
Times cited : (86)

References (44)
  • 1
    • 32944466887 scopus 로고    scopus 로고
    • Ecological and evolutionary forces shaping microbial diversity in the human intestine
    • Ley, R. E., Peterson, D. A. & Gordon, J. I. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 124, 837-848 (2006).
    • (2006) Cell , vol.124 , pp. 837-848
    • Ley, R.E.1    Peterson, D.A.2    Gordon, J.I.3
  • 2
    • 20544444045 scopus 로고    scopus 로고
    • Diversity of the human intestinal microbial flora
    • Eckburg, P. B. et al. Diversity of the human intestinal microbial flora. Science 308, 1635-1638 (2005).
    • (2005) Science , vol.308 , pp. 1635-1638
    • Eckburg, P.B.1
  • 3
    • 84866146940 scopus 로고    scopus 로고
    • Diversity, stability and resilience of the human gut microbiota
    • Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K. & Knight, R. Diversity, stability and resilience of the human gut microbiota. Nature 489, 220-230 (2012).
    • (2012) Nature , vol.489 , pp. 220-230
    • Lozupone, C.A.1    Stombaugh, J.I.2    Gordon, J.I.3    Jansson, J.K.4    Knight, R.5
  • 4
    • 54449083567 scopus 로고    scopus 로고
    • The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
    • Johansson, M. E. V. et al. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc. Natl. Acad. Sci. USA 105, 15064-15069 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 15064-15069
    • Johansson, M.E.V.1
  • 5
    • 44149126798 scopus 로고    scopus 로고
    • Secreted enteric antimicrobial activity localises to the mucus surface layer
    • Meyer-Hoffert, U. et al. Secreted enteric antimicrobial activity localises to the mucus surface layer. Gut 57, 764-835 (2008).
    • (2008) Gut , vol.57 , pp. 764-835
    • Meyer-Hoffert, U.1
  • 6
    • 0025959114 scopus 로고
    • Defensins: Endogenous antibiotic peptides of animal cells
    • Lehrer, R. I., Ganz, T. & Selsted, M. E. Defensins: endogenous antibiotic peptides of animal cells. Cell 64, 229-230 (1991).
    • (1991) Cell , vol.64 , pp. 229-230
    • Lehrer, R.I.1    Ganz, T.2    Selsted, M.E.3
  • 7
    • 0029051685 scopus 로고
    • Defensins and other endogenous peptide antibiotics of vertebrates
    • Martin, E., Ganz, T. & Lehrer, R. I. Defensins and other endogenous peptide antibiotics of vertebrates. J. Leukoc. Biol. 58, 128-136 (1995).
    • (1995) J. Leukoc. Biol. , vol.58 , pp. 128-136
    • Martin, E.1    Ganz, T.2    Lehrer, R.I.3
  • 8
    • 0141799911 scopus 로고    scopus 로고
    • Defensins: Antimicrobial peptides of innate immunity
    • Ganz, T. Defensins: antimicrobial peptides of innate immunity. Nat. Rev. Immunol. 3, 710-720 (2003).
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 710-720
    • Ganz, T.1
  • 9
    • 29144483937 scopus 로고    scopus 로고
    • Reduced paneth cell alpha-defensins in ileal Crohn's disease
    • Wehkamp, J. et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc. Natl. Acad. Sci. USA 102, 18129-18134 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 18129-18134
    • Wehkamp, J.1
  • 10
    • 74049122536 scopus 로고    scopus 로고
    • Enteric defensins are essential regulators of intestinal microbial ecology
    • Salzman, N. H. et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat. Immunol. 11, 76-83 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 76-83
    • Salzman, N.H.1
  • 11
    • 82155195889 scopus 로고    scopus 로고
    • The potter's wheel: The host's role in sculpting its microbiota
    • Bevins, C. & Salzman, N. The potter's wheel: the host's role in sculpting its microbiota. Cell. Mol. Life Sci. 68, 3675-3760 (2011).
    • (2011) Cell. Mol. Life Sci. , vol.68 , pp. 3675-3760
    • Bevins, C.1    Salzman, N.2
  • 12
    • 84884928600 scopus 로고    scopus 로고
    • Antimicrobial peptides and gut microbiota in homeostasis and pathology
    • Ostaff, M. J., Stange, E. F. & Wehkamp, J. Antimicrobial peptides and gut microbiota in homeostasis and pathology. EMBO Mol. Med. 5, 1-19 (2013).
    • (2013) EMBO Mol. Med. , vol.5 , pp. 1-19
    • Ostaff, M.J.1    Stange, E.F.2    Wehkamp, J.3
  • 13
    • 79955555098 scopus 로고    scopus 로고
    • Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease
    • Kaser, A. & Blumberg, R. S. Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease. Gastroenterology 140, 1738-1747 (2011).
    • (2011) Gastroenterology , vol.140 , pp. 1738-1747
    • Kaser, A.1    Blumberg, R.S.2
  • 14
    • 84902134219 scopus 로고    scopus 로고
    • ATG16L1 Crohn's disease risk stresses the endoplasmic reticulum of Paneth cells
    • Kaser, A. & Blumberg, R. S. ATG16L1 Crohn's disease risk stresses the endoplasmic reticulum of Paneth cells. Gut 63, 1038-1039 (2013).
    • (2013) Gut , vol.63 , pp. 1038-1039
    • Kaser, A.1    Blumberg, R.S.2
  • 15
    • 84887621906 scopus 로고    scopus 로고
    • Paneth cells as a site of origin for intestinal inflammation
    • Adolph, T. E. et al. Paneth cells as a site of origin for intestinal inflammation. Nature 503, 272-276 (2013).
    • (2013) Nature , vol.503 , pp. 272-276
    • Adolph, T.E.1
  • 16
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell, K. et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456, 259-322 (2008).
    • (2008) Nature , vol.456 , pp. 259-322
    • Cadwell, K.1
  • 17
    • 84890735514 scopus 로고    scopus 로고
    • Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease
    • Van Dussen, K. L. et al. Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease. Gastroenterology 146, 200-209 (2014).
    • (2014) Gastroenterology , vol.146 , pp. 200-209
    • Van Dussen, K.L.1
  • 18
    • 84860136921 scopus 로고    scopus 로고
    • Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease
    • Thachil, E. et al. Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease. Gastroenterology 142, 1097-1099.e4 (2012).
    • (2012) Gastroenterology , vol.142 , pp. 1097-1099
    • Thachil, E.1
  • 19
    • 79954915318 scopus 로고    scopus 로고
    • Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
    • Bevins, C. L. & Salzman, N. H. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat. Rev. Microbiol. 9, 356-368 (2011).
    • (2011) Nat. Rev. Microbiol. , vol.9 , pp. 356-368
    • Bevins, C.L.1    Salzman, N.H.2
  • 20
    • 0027390031 scopus 로고
    • Defensin-6 mRNA in human Paneth cells: Implications for antimicrobial peptides in host defense of the human bowel
    • Jones, D. E. & Bevins, C. L. Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel. FEBS Lett. 315, 187-192 (1993).
    • (1993) FEBS Lett. , vol.315 , pp. 187-192
    • Jones, D.E.1    Bevins, C.L.2
  • 22
    • 84863582194 scopus 로고    scopus 로고
    • Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins
    • Eriguchi, Y. et al. Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins. Blood 120, 223-231 (2012).
    • (2012) Blood , vol.120 , pp. 223-231
    • Eriguchi, Y.1
  • 23
    • 0030913746 scopus 로고    scopus 로고
    • Broad-spectrum antimicrobial activity of human intestinal defensin 5
    • Porter, E. M., van, Dam, E., Valore, E. V. & Ganz, T. Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infect. Immun. 65, 2396-2401 (1997).
    • (1997) Infect. Immun. , vol.65 , pp. 2396-2401
    • Porter, E.M.1    Van-Dam, E.2    Valore, E.V.3    Ganz, T.4
  • 24
    • 84864335926 scopus 로고    scopus 로고
    • Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets
    • Chu, H. et al. Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science 337, 477-481 (2012).
    • (2012) Science , vol.337 , pp. 477-481
    • Chu, H.1
  • 25
    • 77951707995 scopus 로고    scopus 로고
    • Anaerobic infections: Update on treatment considerations
    • Nagy, E. Anaerobic infections: update on treatment considerations. Drugs 70, 841-858 (2010).
    • (2010) Drugs , vol.70 , pp. 841-858
    • Nagy, E.1
  • 26
    • 78751653584 scopus 로고    scopus 로고
    • Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1
    • Schroeder, B. O. et al. Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1. Nature 469, 419-423 (2011).
    • (2011) Nature , vol.469 , pp. 419-423
    • Schroeder, B.O.1
  • 27
    • 84884221399 scopus 로고    scopus 로고
    • Cell-mediated reduction of human β-defensin 1: A major role for mucosal thioredoxin
    • Jaeger, S.U. et al. Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin. Mucosal Immunol. 6, 1179-1190 (2013).
    • (2013) Mucosal Immunol. , vol.6 , pp. 1179-1190
    • Jaeger, S.U.1
  • 29
    • 0032436008 scopus 로고    scopus 로고
    • Isolation of human intestinal defensins from ileal neobladder urine
    • Porter, E.M. et al. Isolation of human intestinal defensins from ileal neobladder urine. FEBS Lett. 434, 272-276 (1998).
    • (1998) FEBS Lett. , vol.434 , pp. 272-276
    • Porter, E.M.1
  • 30
    • 84892373963 scopus 로고    scopus 로고
    • Antibacterial membrane attack by a pore-forming intestinal C-type lectin
    • Mukherjee, S. et al. Antibacterial membrane attack by a pore-forming intestinal C-type lectin. Nature 505, 103-107 (2014).
    • (2014) Nature , vol.505 , pp. 103-107
    • Mukherjee, S.1
  • 31
    • 77952693839 scopus 로고    scopus 로고
    • Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci
    • Sass, V. et al. Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci. Infect. Immun. 78, 2793-2800 (2010).
    • (2010) Infect. Immun. , vol.78 , pp. 2793-2800
    • Sass, V.1
  • 32
    • 0037329612 scopus 로고    scopus 로고
    • Growth promoting effect of thioredoxin on intestinal epithelial cells
    • Takaishi, S. et al. Growth promoting effect of thioredoxin on intestinal epithelial cells. Dig. Dis. Sci. 48, 379-464 (2003).
    • (2003) Dig. Dis. Sci. , vol.48 , pp. 379-464
    • Takaishi, S.1
  • 33
    • 0026443077 scopus 로고
    • Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway
    • Rubartelli, A., Bajetto, A., Allavena, G., Wollman, E. & Sitia, R. Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway. J. Biol. Chem. 267, 24161-24164 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 24161-24164
    • Rubartelli, A.1    Bajetto, A.2    Allavena, G.3    Wollman, E.4    Sitia, R.5
  • 34
    • 79954423210 scopus 로고    scopus 로고
    • Luminal sulfide and large intestine mucosa: Friend or foe?
    • Blachier, F. et al. Luminal sulfide and large intestine mucosa: friend or foe? Amino Acids 39, 335-347 (2010).
    • (2010) Amino Acids , vol.39 , pp. 335-347
    • Blachier, F.1
  • 35
    • 0034252293 scopus 로고    scopus 로고
    • Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria
    • Ayabe, T. et al. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat. Immunol. 1, 113-118 (2000).
    • (2000) Nat. Immunol. , vol.1 , pp. 113-118
    • Ayabe, T.1
  • 37
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 486, 207-214 (2012).
    • (2012) Nature , vol.486 , pp. 207-214
  • 38
    • 37349034233 scopus 로고    scopus 로고
    • Cell envelope stress response in Gram-positive bacteria
    • Jordan, S., Hutchings, M.I. & Mascher, T. Cell envelope stress response in Gram-positive bacteria. FEMS Microbiol. Rev. 32, 107-146 (2008).
    • (2008) FEMS Microbiol. Rev. , vol.32 , pp. 107-146
    • Jordan, S.1    Hutchings, M.I.2    Mascher, T.3
  • 39
    • 77952976637 scopus 로고    scopus 로고
    • Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II
    • (New York, NY)
    • Schneider, T. et al. Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II. Science (New York, NY) 328, 1168-1240 (2010).
    • (2010) Science , vol.328 , pp. 1168-1240
    • Schneider, T.1
  • 40
    • 33745217570 scopus 로고    scopus 로고
    • The co-evolution of host cationic antimicrobial peptides and microbial resistance
    • Peschel, A. & Sahl, H.-G. The co-evolution of host cationic antimicrobial peptides and microbial resistance. Nat. Rev. Microbiol. 4, 529-536 (2006).
    • (2006) Nat. Rev. Microbiol. , vol.4 , pp. 529-536
    • Peschel, A.1    Sahl, H.-G.2
  • 42
    • 84884236749 scopus 로고    scopus 로고
    • Fundamental role for HIF-1α in constitutive expression of human b defensin-1
    • Kelly, C.J. et al. Fundamental role for HIF-1α in constitutive expression of human b defensin-1. Mucosal Immunol. 6, 1110-1118 (2013).
    • (2013) Mucosal Immunol. , vol.6 , pp. 1110-1118
    • Kelly, C.J.1
  • 43
    • 84863472497 scopus 로고    scopus 로고
    • A crypt-specific core microbiota resides in the mouse colon
    • Pédron, T. et al. A crypt-specific core microbiota resides in the mouse colon. MBio 3, e00116-12 (2012).
    • (2012) MBio , vol.3 , pp. e00116-e00212
    • Pédron, T.1
  • 44
    • 0021143916 scopus 로고
    • Enzymatic reduction-oxidation of protein disulfides by thioredoxin
    • Holmgren, A. Enzymatic reduction-oxidation of protein disulfides by thioredoxin. Methods Enzymol. 107, 295-300 (1984).
    • (1984) Methods Enzymol. , vol.107 , pp. 295-300
    • Holmgren, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.