-
1
-
-
32944466887
-
Ecological and evolutionary forces shaping microbial diversity in the human intestine
-
Ley, R. E., Peterson, D. A. & Gordon, J. I. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 124, 837-848 (2006).
-
(2006)
Cell
, vol.124
, pp. 837-848
-
-
Ley, R.E.1
Peterson, D.A.2
Gordon, J.I.3
-
2
-
-
20544444045
-
Diversity of the human intestinal microbial flora
-
Eckburg, P. B. et al. Diversity of the human intestinal microbial flora. Science 308, 1635-1638 (2005).
-
(2005)
Science
, vol.308
, pp. 1635-1638
-
-
Eckburg, P.B.1
-
3
-
-
84866146940
-
Diversity, stability and resilience of the human gut microbiota
-
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K. & Knight, R. Diversity, stability and resilience of the human gut microbiota. Nature 489, 220-230 (2012).
-
(2012)
Nature
, vol.489
, pp. 220-230
-
-
Lozupone, C.A.1
Stombaugh, J.I.2
Gordon, J.I.3
Jansson, J.K.4
Knight, R.5
-
4
-
-
54449083567
-
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
-
Johansson, M. E. V. et al. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc. Natl. Acad. Sci. USA 105, 15064-15069 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 15064-15069
-
-
Johansson, M.E.V.1
-
5
-
-
44149126798
-
Secreted enteric antimicrobial activity localises to the mucus surface layer
-
Meyer-Hoffert, U. et al. Secreted enteric antimicrobial activity localises to the mucus surface layer. Gut 57, 764-835 (2008).
-
(2008)
Gut
, vol.57
, pp. 764-835
-
-
Meyer-Hoffert, U.1
-
6
-
-
0025959114
-
Defensins: Endogenous antibiotic peptides of animal cells
-
Lehrer, R. I., Ganz, T. & Selsted, M. E. Defensins: endogenous antibiotic peptides of animal cells. Cell 64, 229-230 (1991).
-
(1991)
Cell
, vol.64
, pp. 229-230
-
-
Lehrer, R.I.1
Ganz, T.2
Selsted, M.E.3
-
7
-
-
0029051685
-
Defensins and other endogenous peptide antibiotics of vertebrates
-
Martin, E., Ganz, T. & Lehrer, R. I. Defensins and other endogenous peptide antibiotics of vertebrates. J. Leukoc. Biol. 58, 128-136 (1995).
-
(1995)
J. Leukoc. Biol.
, vol.58
, pp. 128-136
-
-
Martin, E.1
Ganz, T.2
Lehrer, R.I.3
-
8
-
-
0141799911
-
Defensins: Antimicrobial peptides of innate immunity
-
Ganz, T. Defensins: antimicrobial peptides of innate immunity. Nat. Rev. Immunol. 3, 710-720 (2003).
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 710-720
-
-
Ganz, T.1
-
9
-
-
29144483937
-
Reduced paneth cell alpha-defensins in ileal Crohn's disease
-
Wehkamp, J. et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc. Natl. Acad. Sci. USA 102, 18129-18134 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 18129-18134
-
-
Wehkamp, J.1
-
10
-
-
74049122536
-
Enteric defensins are essential regulators of intestinal microbial ecology
-
Salzman, N. H. et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat. Immunol. 11, 76-83 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 76-83
-
-
Salzman, N.H.1
-
11
-
-
82155195889
-
The potter's wheel: The host's role in sculpting its microbiota
-
Bevins, C. & Salzman, N. The potter's wheel: the host's role in sculpting its microbiota. Cell. Mol. Life Sci. 68, 3675-3760 (2011).
-
(2011)
Cell. Mol. Life Sci.
, vol.68
, pp. 3675-3760
-
-
Bevins, C.1
Salzman, N.2
-
12
-
-
84884928600
-
Antimicrobial peptides and gut microbiota in homeostasis and pathology
-
Ostaff, M. J., Stange, E. F. & Wehkamp, J. Antimicrobial peptides and gut microbiota in homeostasis and pathology. EMBO Mol. Med. 5, 1-19 (2013).
-
(2013)
EMBO Mol. Med.
, vol.5
, pp. 1-19
-
-
Ostaff, M.J.1
Stange, E.F.2
Wehkamp, J.3
-
13
-
-
79955555098
-
Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease
-
Kaser, A. & Blumberg, R. S. Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease. Gastroenterology 140, 1738-1747 (2011).
-
(2011)
Gastroenterology
, vol.140
, pp. 1738-1747
-
-
Kaser, A.1
Blumberg, R.S.2
-
14
-
-
84902134219
-
ATG16L1 Crohn's disease risk stresses the endoplasmic reticulum of Paneth cells
-
Kaser, A. & Blumberg, R. S. ATG16L1 Crohn's disease risk stresses the endoplasmic reticulum of Paneth cells. Gut 63, 1038-1039 (2013).
-
(2013)
Gut
, vol.63
, pp. 1038-1039
-
-
Kaser, A.1
Blumberg, R.S.2
-
15
-
-
84887621906
-
Paneth cells as a site of origin for intestinal inflammation
-
Adolph, T. E. et al. Paneth cells as a site of origin for intestinal inflammation. Nature 503, 272-276 (2013).
-
(2013)
Nature
, vol.503
, pp. 272-276
-
-
Adolph, T.E.1
-
16
-
-
56249135538
-
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
-
Cadwell, K. et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456, 259-322 (2008).
-
(2008)
Nature
, vol.456
, pp. 259-322
-
-
Cadwell, K.1
-
17
-
-
84890735514
-
Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease
-
Van Dussen, K. L. et al. Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease. Gastroenterology 146, 200-209 (2014).
-
(2014)
Gastroenterology
, vol.146
, pp. 200-209
-
-
Van Dussen, K.L.1
-
18
-
-
84860136921
-
Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease
-
Thachil, E. et al. Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease. Gastroenterology 142, 1097-1099.e4 (2012).
-
(2012)
Gastroenterology
, vol.142
, pp. 1097-1099
-
-
Thachil, E.1
-
19
-
-
79954915318
-
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
-
Bevins, C. L. & Salzman, N. H. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat. Rev. Microbiol. 9, 356-368 (2011).
-
(2011)
Nat. Rev. Microbiol.
, vol.9
, pp. 356-368
-
-
Bevins, C.L.1
Salzman, N.H.2
-
20
-
-
0027390031
-
Defensin-6 mRNA in human Paneth cells: Implications for antimicrobial peptides in host defense of the human bowel
-
Jones, D. E. & Bevins, C. L. Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel. FEBS Lett. 315, 187-192 (1993).
-
(1993)
FEBS Lett.
, vol.315
, pp. 187-192
-
-
Jones, D.E.1
Bevins, C.L.2
-
22
-
-
84863582194
-
Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins
-
Eriguchi, Y. et al. Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins. Blood 120, 223-231 (2012).
-
(2012)
Blood
, vol.120
, pp. 223-231
-
-
Eriguchi, Y.1
-
23
-
-
0030913746
-
Broad-spectrum antimicrobial activity of human intestinal defensin 5
-
Porter, E. M., van, Dam, E., Valore, E. V. & Ganz, T. Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infect. Immun. 65, 2396-2401 (1997).
-
(1997)
Infect. Immun.
, vol.65
, pp. 2396-2401
-
-
Porter, E.M.1
Van-Dam, E.2
Valore, E.V.3
Ganz, T.4
-
24
-
-
84864335926
-
Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets
-
Chu, H. et al. Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science 337, 477-481 (2012).
-
(2012)
Science
, vol.337
, pp. 477-481
-
-
Chu, H.1
-
25
-
-
77951707995
-
Anaerobic infections: Update on treatment considerations
-
Nagy, E. Anaerobic infections: update on treatment considerations. Drugs 70, 841-858 (2010).
-
(2010)
Drugs
, vol.70
, pp. 841-858
-
-
Nagy, E.1
-
26
-
-
78751653584
-
Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1
-
Schroeder, B. O. et al. Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1. Nature 469, 419-423 (2011).
-
(2011)
Nature
, vol.469
, pp. 419-423
-
-
Schroeder, B.O.1
-
27
-
-
84884221399
-
Cell-mediated reduction of human β-defensin 1: A major role for mucosal thioredoxin
-
Jaeger, S.U. et al. Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin. Mucosal Immunol. 6, 1179-1190 (2013).
-
(2013)
Mucosal Immunol.
, vol.6
, pp. 1179-1190
-
-
Jaeger, S.U.1
-
28
-
-
0025774414
-
Ultrasensitive assays for endogenous antimicrobial polypeptides
-
Lehrer, R.I., Rosenman, M., Harwig, S.S., Jackson, R. & Eisenhauer, P. Ultrasensitive assays for endogenous antimicrobial polypeptides. J. Immunol. Methods 137, 167-173 (1991).
-
(1991)
J. Immunol. Methods
, vol.137
, pp. 167-173
-
-
Lehrer, R.I.1
Rosenman, M.2
Harwig, S.S.3
Jackson, R.4
Eisenhauer, P.5
-
29
-
-
0032436008
-
Isolation of human intestinal defensins from ileal neobladder urine
-
Porter, E.M. et al. Isolation of human intestinal defensins from ileal neobladder urine. FEBS Lett. 434, 272-276 (1998).
-
(1998)
FEBS Lett.
, vol.434
, pp. 272-276
-
-
Porter, E.M.1
-
30
-
-
84892373963
-
Antibacterial membrane attack by a pore-forming intestinal C-type lectin
-
Mukherjee, S. et al. Antibacterial membrane attack by a pore-forming intestinal C-type lectin. Nature 505, 103-107 (2014).
-
(2014)
Nature
, vol.505
, pp. 103-107
-
-
Mukherjee, S.1
-
31
-
-
77952693839
-
Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci
-
Sass, V. et al. Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci. Infect. Immun. 78, 2793-2800 (2010).
-
(2010)
Infect. Immun.
, vol.78
, pp. 2793-2800
-
-
Sass, V.1
-
32
-
-
0037329612
-
Growth promoting effect of thioredoxin on intestinal epithelial cells
-
Takaishi, S. et al. Growth promoting effect of thioredoxin on intestinal epithelial cells. Dig. Dis. Sci. 48, 379-464 (2003).
-
(2003)
Dig. Dis. Sci.
, vol.48
, pp. 379-464
-
-
Takaishi, S.1
-
33
-
-
0026443077
-
Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway
-
Rubartelli, A., Bajetto, A., Allavena, G., Wollman, E. & Sitia, R. Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway. J. Biol. Chem. 267, 24161-24164 (1992).
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 24161-24164
-
-
Rubartelli, A.1
Bajetto, A.2
Allavena, G.3
Wollman, E.4
Sitia, R.5
-
34
-
-
79954423210
-
Luminal sulfide and large intestine mucosa: Friend or foe?
-
Blachier, F. et al. Luminal sulfide and large intestine mucosa: friend or foe? Amino Acids 39, 335-347 (2010).
-
(2010)
Amino Acids
, vol.39
, pp. 335-347
-
-
Blachier, F.1
-
35
-
-
0034252293
-
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria
-
Ayabe, T. et al. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat. Immunol. 1, 113-118 (2000).
-
(2000)
Nat. Immunol.
, vol.1
, pp. 113-118
-
-
Ayabe, T.1
-
37
-
-
84862276328
-
Structure, function and diversity of the healthy human microbiome
-
Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 486, 207-214 (2012).
-
(2012)
Nature
, vol.486
, pp. 207-214
-
-
-
38
-
-
37349034233
-
Cell envelope stress response in Gram-positive bacteria
-
Jordan, S., Hutchings, M.I. & Mascher, T. Cell envelope stress response in Gram-positive bacteria. FEMS Microbiol. Rev. 32, 107-146 (2008).
-
(2008)
FEMS Microbiol. Rev.
, vol.32
, pp. 107-146
-
-
Jordan, S.1
Hutchings, M.I.2
Mascher, T.3
-
39
-
-
77952976637
-
Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II
-
(New York, NY)
-
Schneider, T. et al. Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II. Science (New York, NY) 328, 1168-1240 (2010).
-
(2010)
Science
, vol.328
, pp. 1168-1240
-
-
Schneider, T.1
-
40
-
-
33745217570
-
The co-evolution of host cationic antimicrobial peptides and microbial resistance
-
Peschel, A. & Sahl, H.-G. The co-evolution of host cationic antimicrobial peptides and microbial resistance. Nat. Rev. Microbiol. 4, 529-536 (2006).
-
(2006)
Nat. Rev. Microbiol.
, vol.4
, pp. 529-536
-
-
Peschel, A.1
Sahl, H.-G.2
-
41
-
-
84884615559
-
Reduction of human defensin 5 affords a high-affinity zinc-chelating peptide
-
Zhang, Y., Cougnon, F.B.L., Wanniarachchi, Y.A., Hayden, J.A. & Nolan, E.M. Reduction of human defensin 5 affords a high-affinity zinc-chelating peptide. ACS Chem. Biol. 8, 1907-1911 (2013).
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 1907-1911
-
-
Zhang, Y.1
Cougnon, F.B.L.2
Wanniarachchi, Y.A.3
Hayden, J.A.4
Nolan, E.M.5
-
42
-
-
84884236749
-
Fundamental role for HIF-1α in constitutive expression of human b defensin-1
-
Kelly, C.J. et al. Fundamental role for HIF-1α in constitutive expression of human b defensin-1. Mucosal Immunol. 6, 1110-1118 (2013).
-
(2013)
Mucosal Immunol.
, vol.6
, pp. 1110-1118
-
-
Kelly, C.J.1
-
43
-
-
84863472497
-
A crypt-specific core microbiota resides in the mouse colon
-
Pédron, T. et al. A crypt-specific core microbiota resides in the mouse colon. MBio 3, e00116-12 (2012).
-
(2012)
MBio
, vol.3
, pp. e00116-e00212
-
-
Pédron, T.1
-
44
-
-
0021143916
-
Enzymatic reduction-oxidation of protein disulfides by thioredoxin
-
Holmgren, A. Enzymatic reduction-oxidation of protein disulfides by thioredoxin. Methods Enzymol. 107, 295-300 (1984).
-
(1984)
Methods Enzymol.
, vol.107
, pp. 295-300
-
-
Holmgren, A.1
|