Solution structures of human ll-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region

Journal of the American Chemical Society

Volumn 128, Issue 17, 2006, Pages 5776-5785

  Li, Xia ^a   Li, Yifeng ^a,b   Han, Huiyun ^c   Miller, Donald W ^c   Wang, Guangshun ^a,b,c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; ESCHERICHIA COLI; MICELLES; NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPIC ANALYSIS; TOXICITY;

ANTIBACTERIAL ACTIVITY; BACTERIAL MEMBRANES; DIOCTANOYL PHOSPHATIDYLGLYCEROL; DRUG-RESISTANT CANCER CELLS; HUMAN LL-37; HYDROPHOBIC DEFECTS;

POLYPEPTIDES;

ANTINEOPLASTIC AGENT; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; DODECYL SULFATE SODIUM; PHOSPHATIDYLGLYCEROL; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG CYTOTOXICITY; DRUG STRUCTURE; ESCHERICHIA COLI; HUMAN; HUMAN CELL; HYDROPHOBICITY; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION;

EID: 33646597266     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0584875     Document Type: Article

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