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Volumn 54, Issue 2, 2015, Pages R103-R117

Role of transcription factors in the transdifferentiation of pancreatic islet cells

Author keywords

ARX; Dedifferentiation; Diabetes; FOXO1; NKX2 2; PAX4; PDX1; Transdifferentiation; cell; cell

Indexed keywords

MEN1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR MAFB; TRANSCRIPTION FACTOR NKX2.2; TRANSCRIPTION FACTOR NKX6 1; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR PTF1A; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84929068995     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-14-0290     Document Type: Review
Times cited : (102)

References (125)
  • 1
    • 0032525981 scopus 로고    scopus 로고
    • β-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes
    • Ahlgren U, Jonsson J, Jonsson L, Simu K & Edlund H 1998 β-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes and Development 12 1763–1768. (doi:10.1101/gad.12.12.1763)
    • (1998) Genes and Development , vol.12 , pp. 1763-1768
    • Ahlgren, U.1    Jonsson, J.2    Jonsson, L.3    Simu, K.4    Edlund, H.5
  • 7
    • 0034312313 scopus 로고    scopus 로고
    • Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    • Ashery-Padan R, Marquardt T, Zhou X & Gruss P 2000 Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes and Development 14 2701–2711. (doi:10.1101/gad.184000)
    • (2000) Genes and Development , vol.14 , pp. 2701-2711
    • Ashery-Padan, R.1    Marquardt, T.2    Zhou, X.3    Gruss, P.4
  • 9
    • 84904517798 scopus 로고    scopus 로고
    • The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long noncoding RNA and protein-coding gene expression
    • Benner C, van der Meulen T, Caceres E, Tigyi K, Donaldson CJ & Huising MO 2014 The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long noncoding RNA and protein-coding gene expression. BMC Genomics 15 620. (doi:10.1186/1471-2164-15-620)
    • (2014) BMC Genomics , vol.15
    • Benner, C.1    Van Der Meulen, T.2    Caceres, E.3    Tigyi, K.4    Donaldson, C.J.5    Huising, M.O.6
  • 11
    • 84894454462 scopus 로고    scopus 로고
    • Human b-cell proliferation and intracellular signaling part 2: Still driving in the dark without a road map
    • Bernal-Mizrachi E, Kulkarni RN, Scott DK, Mauvais-Jarvis F, Stewart AF & Garcia-Ocana A 2014 Human b-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map. Diabetes 63 819–831. (doi:10.2337/db13-1146)
    • (2014) Diabetes , vol.63 , pp. 819-831
    • Bernal-Mizrachi, E.1    Kulkarni, R.N.2    Scott, D.K.3    Mauvais-Jarvis, F.4    Stewart, A.F.5    Garcia-Ocana, A.6
  • 12
    • 79961187994 scopus 로고    scopus 로고
    • Transcriptional regulation of a-cell differentiation. Diabetes
    • Bramswig NC & Kaestner KH 2011 Transcriptional regulation of a-cell differentiation. Diabetes, Obesity & Metabolism 13 (Suppl 1) 13–20. (doi:10.1111/j.1463-1326.2011.01440.x)
    • (2011) Obesity & Metabolism , vol.13 , pp. 13-20
    • Bramswig, N.C.1    Kaestner, K.H.2
  • 17
    • 77953434957 scopus 로고    scopus 로고
    • C-Myc directly induces both impaired insulin secretion and loss of b-cell mass, independently of hyperglycemia in vivo
    • Cheung L, Zervou S, Mattsson G, Abouna S, Zhou L, Ifandi V, Pelengaris S & Khan M 2010 c-Myc directly induces both impaired insulin secretion and loss of b-cell mass, independently of hyperglycemia in vivo. Islets 2 37–45. (doi:10.4161/isl.2.1.10196)
    • (2010) Islets , vol.2 , pp. 37-45
    • Cheung, L.1    Zervou, S.2    Mattsson, G.3    Abouna, S.4    Zhou, L.5    Ifandi, V.6    Pelengaris, S.7    Khan, M.8
  • 19
    • 23144432613 scopus 로고    scopus 로고
    • The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the a-and b-cell lineages in the mouse endocrine pancreas
    • Collombat P, Hecksher-Sorensen J, Broccoli V, Krull J, Ponte I, Mundiger T, Smith J, Gruss P, Serup P & Mansouri A 2005 The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the a-and b-cell lineages in the mouse endocrine pancreas. Development 132 2969–2980. (doi:10.1242/dev.01870)
    • (2005) Development , vol.132 , pp. 2969-2980
    • Collombat, P.1    Hecksher-Sorensen, J.2    Broccoli, V.3    Krull, J.4    Ponte, I.5    Mundiger, T.6    Smith, J.7    Gruss, P.8    Serup, P.9    Mansouri, A.10
  • 25
    • 79954563768 scopus 로고    scopus 로고
    • Pancreatic b cell identity is maintained by DNA methylation-mediated repression of Arx
    • Dhawan S, Georgia S, Tschen SI, Fan G & Bhushan A 2011 Pancreatic b cell identity is maintained by DNA methylation-mediated repression of Arx. Developmental Cell 20 419–429. (doi:10.1016/j.devcel.2011.03.012)
    • (2011) Developmental Cell , vol.20 , pp. 419-429
    • Dhawan, S.1    Georgia, S.2    Tschen, S.I.3    Fan, G.4    Bhushan, A.5
  • 26
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic b-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI & Melton DA 2004 Adult pancreatic b-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429 41–46. (doi:10.1038/nature02520)
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 27
    • 70349145464 scopus 로고    scopus 로고
    • Islet-1 is required for thematuration, proliferation, and survival of the endocrine pancreas
    • Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R & May CL 2009 Islet-1 is required for thematuration, proliferation, and survival of the endocrine pancreas. Diabetes 58 2059–2069. (doi:10.2337/db08-0987)
    • (2009) Diabetes , vol.58 , pp. 2059-2069
    • Du, A.1    Hunter, C.S.2    Murray, J.3    Noble, D.4    Cai, C.L.5    Evans, S.M.6    Stein, R.7    May, C.L.8
  • 28
    • 0032493623 scopus 로고    scopus 로고
    • Differential regulation of the glucagon and insulin I gene promoters by the basic helix–loop– helix transcription factors E47 and BETA2
    • Dumonteil E, Laser B, Constant I & Philippe J 1998 Differential regulation of the glucagon and insulin I gene promoters by the basic helix–loop– helix transcription factors E47 and BETA2. Journal of Biological Chemistry 273 19945–19954. (doi:10.1074/jbc.273.32.19945)
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 19945-19954
    • Dumonteil, E.1    Laser, B.2    Constant, I.3    Philippe, J.4
  • 30
    • 20044374696 scopus 로고    scopus 로고
    • B-cell secretory products activate a-cell ATP-dependent potassium channels to inhibit glucagon release
    • Franklin I, Gromada J, Gjinovci A, Theander S & Wollheim CB 2005 b-cell secretory products activate a-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes 54 1808–1815. (doi:10.2337/diabetes.54.6.1808)
    • (2005) Diabetes , vol.54 , pp. 1808-1815
    • Franklin, I.1    Gromada, J.2    Gjinovci, A.3    Theander, S.4    Wollheim, C.B.5
  • 31
    • 30944438716 scopus 로고    scopus 로고
    • Targeted deletion of a cisregulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation
    • Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA & Wright CV 2006 Targeted deletion of a cisregulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes and Development 20 253–266. (doi:10.1101/gad.1360106)
    • (2006) Genes and Development , vol.20 , pp. 253-266
    • Fujitani, Y.1    Fujitani, S.2    Boyer, D.F.3    Gannon, M.4    Kawaguchi, Y.5    Ray, M.6    Shiota, M.7    Stein, R.W.8    Magnuson, M.A.9    Wright, C.V.10
  • 33
    • 0034101423 scopus 로고    scopus 로고
    • Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas
    • Gannon M, Shiota C, Postic C, Wright CV & Magnuson M 2000 Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis 26 139–142. (doi:10.1002/(SICI)1526-968X(200002)26:2!139::AID-GENE12O3.0.CO;2-7)
    • (2000) Genesis , vol.26 , pp. 139-142
    • Gannon, M.1    Shiota, C.2    Postic, C.3    Wright, C.V.4    Magnuson, M.5
  • 34
    • 38949149704 scopus 로고    scopus 로고
    • Pdx-1 function is specifically required in embryonic b cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis
    • Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA & Wright CV 2008 pdx-1 function is specifically required in embryonic b cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Developmental Biology 314 406–417. (doi:10.1016/j.ydbio.2007.10.038)
    • (2008) Developmental Biology , vol.314 , pp. 406-417
    • Gannon, M.1    Ables, E.T.2    Crawford, L.3    Lowe, D.4    Offield, M.F.5    Magnuson, M.A.6    Wright, C.V.7
  • 36
    • 36849075622 scopus 로고    scopus 로고
    • Pax-6 and c-Maf functionally interact with the a-cell-specific DNA element G1 in vivo to promote glucagon gene expression
    • Gosmain Y, Avril I, Mamin A & Philippe J 2007 Pax-6 and c-Maf functionally interact with the a-cell-specific DNA element G1 in vivo to promote glucagon gene expression. Journal of Biological Chemistry 282 35024–35034. (doi:10.1074/jbc.M702795200)
    • (2007) Journal of Biological Chemistry , vol.282 , pp. 35024-35034
    • Gosmain, Y.1    Avril, I.2    Mamin, A.3    Philippe, J.4
  • 37
    • 79961198913 scopus 로고    scopus 로고
    • Glucagon gene expression in the endocrine pancreas: The role of the transcription factor Pax6 in a-cell differentiation, glucagon biosynthesis and secretion. Diabetes
    • Gosmain Y, Cheyssac C, Heddad Masson M, Dibner C & Philippe J 2011 Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in a-cell differentiation, glucagon biosynthesis and secretion. Diabetes, Obesity & Metabolism 13 (Suppl 1) 31–38. (doi:10.1111/j.1463-1326.2011.01445.x)
    • (2011) Obesity & Metabolism , vol.13 , pp. 31-38
    • Gosmain, Y.1    Cheyssac, C.2    Heddad Masson, M.3    Dibner, C.4    Philippe, J.5
  • 38
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl G, Dierich A, LeMeur M & Guillemot F 2000 Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. PNAS 97 1607–1611. (doi:10.1073/pnas.97.4.1607)
    • (2000) PNAS , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    Lemeur, M.3    Guillemot, F.4
  • 39
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3C cells are islet progenitors and are distinct from duct progenitors
    • Gu G, Dubauskaite J & Melton DA 2002 Direct evidence for the pancreatic lineage: NGN3C cells are islet progenitors and are distinct from duct progenitors. Development 129 2447–2457.
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 40
    • 0028869514 scopus 로고
    • Expression of murine STF-1, a putative insulin gene transcription factor, in b cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
    • Guz Y, Montminy MR, Stein R, Leonard J, Gamer LW, Wright CV & Teitelman G 1995 Expression of murine STF-1, a putative insulin gene transcription factor, in b cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121 11–18.
    • (1995) Development , vol.121 , pp. 11-18
    • Guz, Y.1    Montminy, M.R.2    Stein, R.3    Leonard, J.4    Gamer, L.W.5    Wright, C.V.6    Teitelman, G.7
  • 41
    • 14244266611 scopus 로고    scopus 로고
    • Minireview: Transcriptional regulation in pancreatic development
    • Habener JF, Kemp DM & Thomas MK 2005 Minireview: Transcriptional regulation in pancreatic development. Endocrinology 146 1025–1034. (doi:10.1210/en.2004-1576)
    • (2005) Endocrinology , vol.146 , pp. 1025-1034
    • Habener, J.F.1    Kemp, D.M.2    Thomas, M.K.3
  • 42
    • 43949111010 scopus 로고    scopus 로고
    • Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development
    • Hald J, Sprinkel AE, Ray M, Serup P, Wright C & Madsen OD 2008 Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development. Journal of Histochemistry and Cytochemistry 56 587–595. (doi:10.1369/jhc.2008.950675)
    • (2008) Journal of Histochemistry and Cytochemistry , vol.56 , pp. 587-595
    • Hald, J.1    Sprinkel, A.E.2    Ray, M.3    Serup, P.4    Wright, C.5    Madsen, O.D.6
  • 45
    • 23144437373 scopus 로고    scopus 로고
    • NKX6 transcription factor activity is required for a-and b-cell development in the pancreas
    • Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J & Sander M 2005 NKX6 transcription factor activity is required for a-and b-cell development in the pancreas. Development 132 3139–3149. (doi:10.1242/dev.01875)
    • (2005) Development , vol.132 , pp. 3139-3149
    • Henseleit, K.D.1    Nelson, S.B.2    Kuhlbrodt, K.3    Hennings, J.C.4    Ericson, J.5    Sander, M.6
  • 46
    • 0034121735 scopus 로고    scopus 로고
    • Adult insulin-and glucagon-producing cells differentiate from two independent cell lineages
    • Herrera PL 2000 Adult insulin-and glucagon-producing cells differentiate from two independent cell lineages. Development 127 2317–2322.
    • (2000) Development , vol.127 , pp. 2317-2322
    • Herrera, P.L.1
  • 47
    • 0030712878 scopus 로고    scopus 로고
    • POU domain transcription factor brain 4 confers pancreatic a-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element
    • Hussain MA, Lee J, Miller CP & Habener JF 1997 POU domain transcription factor brain 4 confers pancreatic a-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element. Molecular and Cellular Biology 17 7186–7194.
    • (1997) Molecular and Cellular Biology , vol.17 , pp. 7186-7194
    • Hussain, M.A.1    Lee, J.2    Miller, C.P.3    Habener, J.F.4
  • 48
    • 33847217554 scopus 로고    scopus 로고
    • Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types
    • Johansson KA, Dursun U, Jordan N, Gu G, Beermann F, Gradwohl G & Grapin-Botton A 2007 Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Developmental Cell 12 457–465. (doi:10.1016/j.devcel.2007.02.010)
    • (2007) Developmental Cell , vol.12 , pp. 457-465
    • Johansson, K.A.1    Dursun, U.2    Jordan, N.3    Gu, G.4    Beermann, F.5    Gradwohl, G.6    Grapin-Botton, A.7
  • 50
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson J, Carlsson L, Edlund T & Edlund H 1994 Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371 606–609. (doi:10.1038/371606a0)
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 51
    • 0032716367 scopus 로고    scopus 로고
    • Cloning and DNA-binding properties of the rat pancreatic b-cellspecific factor Nkx6.1
    • Jorgensen MC, Vestergard Petersen H, Ericson J, Madsen OD & Serup P 1999 Cloning and DNA-binding properties of the rat pancreatic b-cellspecific factor Nkx6.1. FEBS Letters 461 287–294. (doi:10.1016/S0014-5793(99)01436-2)
    • (1999) FEBS Letters , vol.461 , pp. 287-294
    • Jorgensen, M.C.1    Vestergard Petersen, H.2    Ericson, J.3    Madsen, O.D.4    Serup, P.5
  • 52
    • 0033557490 scopus 로고    scopus 로고
    • Inactivation of the winged helix transcription factor HNF3a affects glucose homeostasis and islet glucagon gene expression in vivo
    • Kaestner KH, Katz J, Liu Y, Drucker DJ & Schutz G 1999 Inactivation of the winged helix transcription factor HNF3a affects glucose homeostasis and islet glucagon gene expression in vivo. Genes and Development 13 495–504. (doi:10.1101/gad.13.4.495)
    • (1999) Genes and Development , vol.13 , pp. 495-504
    • Kaestner, K.H.1    Katz, J.2    Liu, Y.3    Drucker, D.J.4    Schutz, G.5
  • 53
    • 0037147306 scopus 로고    scopus 로고
    • MafA is a glucose-regulated and pancreatic b-cell-specific transcriptional activator for the insulin gene
    • Kataoka K, Han SI, Shioda S, Hirai M, Nishizawa M & Handa H 2002 MafA is a glucose-regulated and pancreatic b-cell-specific transcriptional activator for the insulin gene. Journal of Biological Chemistry 277 49903–49910. (doi:10.1074/jbc.M206796200)
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 49903-49910
    • Kataoka, K.1    Han, S.I.2    Shioda, S.3    Hirai, M.4    Nishizawa, M.5    Handa, H.6
  • 54
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    • Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ & Wright CV 2002 The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nature Genetics 32 128–134. (doi:10.1038/ng959)
    • (2002) Nature Genetics , vol.32 , pp. 128-134
    • Kawaguchi, Y.1    Cooper, B.2    Gannon, M.3    Ray, M.4    Macdonald, R.J.5    Wright, C.V.6
  • 55
    • 0028893424 scopus 로고
    • Evidence that glucagon stimulates insulin secretion through its own receptor in rats
    • Kawai K, Yokota C, Ohashi S, Watanabe Y & Yamashita K 1995 Evidence that glucagon stimulates insulin secretion through its own receptor in rats. Diabetologia 38 274–276. (doi:10.1007/BF00400630)
    • (1995) Diabetologia , vol.38 , pp. 274-276
    • Kawai, K.1    Yokota, C.2    Ohashi, S.3    Watanabe, Y.4    Yamashita, K.5
  • 59
    • 27744518040 scopus 로고    scopus 로고
    • FoxO1 protects against pancreatic b cell failure through NeuroD and MafA induction
    • Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, Gu W& Accili D 2005 FoxO1 protects against pancreatic b cell failure through NeuroD and MafA induction. Cell Metabolism 2 153–163. (doi:10.1016/j.cmet.2005.08.004)
    • (2005) Cell Metabolism , vol.2 , pp. 153-163
    • Kitamura, Y.I.1    Kitamura, T.2    Kruse, J.P.3    Raum, J.C.4    Stein, R.5    W&, G.6    Accili, D.7
  • 63
    • 79951539242 scopus 로고    scopus 로고
    • Sox9C ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
    • Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J & Sander M 2011 Sox9C ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 138 653–665. (doi:10.1242/dev.056499)
    • (2011) Development , vol.138 , pp. 653-665
    • Kopp, J.L.1    Dubois, C.L.2    Schaffer, A.E.3    Hao, E.4    Shih, H.P.5    Seymour, P.A.6    Ma, J.7    Sander, M.8
  • 64
    • 80052177191 scopus 로고    scopus 로고
    • Arx and Nkx2.2 compound deficiency redirects pancreatic alpha-and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage
    • Kordowich S, Collombat P, Mansouri A & Serup P 2011 Arx and Nkx2.2 compound deficiency redirects pancreatic alpha-and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage. BMC Developmental Biology 11 52. (doi:10.1186/1471-213X-11-52)
    • (2011) BMC Developmental Biology , vol.11
    • Kordowich, S.1    Collombat, P.2    Mansouri, A.3    Serup, P.4
  • 65
    • 0029737816 scopus 로고    scopus 로고
    • The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix–loop–helix protein
    • Krapp A, Knofler M, Frutiger S, Hughes GJ, Hagenbuchle O & Wellauer PK 1996 The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix–loop–helix protein. EMBO Journal 15 4317–4329.
    • (1996) EMBO Journal , vol.15 , pp. 4317-4329
    • Krapp, A.1    Knofler, M.2    Frutiger, S.3    Hughes, G.J.4    Hagenbuchle, O.5    Wellauer, P.K.6
  • 66
    • 84865520395 scopus 로고    scopus 로고
    • Human b-cell proliferation and intracellular signaling: Driving in the dark without a road map
    • Kulkarni RN, Mizrachi EB, Ocana AG & Stewart AF 2012 Human b-cell proliferation and intracellular signaling: driving in the dark without a road map. Diabetes 61 2205–2213. (doi:10.2337/db12-0018)
    • (2012) Diabetes , vol.61 , pp. 2205-2213
    • Kulkarni, R.N.1    Mizrachi, E.B.2    Ocana, A.G.3    Stewart, A.F.4
  • 68
    • 12944336527 scopus 로고    scopus 로고
    • Foxa2 is required for the differentiation of pancreatic a-cells
    • Lee CS, Sund NJ, Behr R, Herrera PL & Kaestner KH 2005 Foxa2 is required for the differentiation of pancreatic a-cells. Developmental Biology 278 484–495. (doi:10.1016/j.ydbio.2004.10.012)
    • (2005) Developmental Biology , vol.278 , pp. 484-495
    • Lee, C.S.1    Sund, N.J.2    Behr, R.3    Herrera, P.L.4    Kaestner, K.H.5
  • 69
    • 38149112594 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia type 1 (MEN1): Analysis of 1336 mutations reported in the first decade following identification of the gene
    • Lemos MC & Thakker RV 2008 Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene. Human Mutation 29 22–32. (doi:10.1002/humu.20605)
    • (2008) Human Mutation , vol.29 , pp. 22-32
    • Lemos, M.C.1    Thakker, R.V.2
  • 70
    • 84861444859 scopus 로고    scopus 로고
    • Regulation of glucose transport by insulin: Traffic control of GLUT4. Nature Reviews
    • Leto D & Saltiel AR 2012 Regulation of glucose transport by insulin: traffic control of GLUT4. Nature Reviews. Molecular Cell Biology 13 383–396. (doi:10.1038/nrm3351)
    • (2012) Molecular Cell Biology , vol.13 , pp. 383-396
    • Leto, D.1    Saltiel, A.R.2
  • 71
    • 1242331851 scopus 로고    scopus 로고
    • Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1
    • Liberzon A, Ridner G & Walker MD 2004 Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1. Nucleic Acids Research 32 54–64. (doi:10.1093/nar/gkh156)
    • (2004) Nucleic Acids Research , vol.32 , pp. 54-64
    • Liberzon, A.1    Ridner, G.2    Walker, M.D.3
  • 72
    • 79959962745 scopus 로고    scopus 로고
    • Hormonal regulation of hepatic glucose production in health and disease
    • Lin HV & Accili D 2011 Hormonal regulation of hepatic glucose production in health and disease. Cell Metabolism 14 9–19. (doi:10.1016/j.cmet.2011.06.003)
    • (2011) Cell Metabolism , vol.14 , pp. 9-19
    • Lin, H.V.1    Accili, D.2
  • 73
    • 79952428530 scopus 로고    scopus 로고
    • Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues
    • Lin HV, Ren H, Samuel VT, Lee HY, Lu TY, Shulman GI & Accili D 2011 Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues. Diabetes 60 700–709. (doi:10.2337/db10-1056)
    • (2011) Diabetes , vol.60 , pp. 700-709
    • Lin, H.V.1    Ren, H.2    Samuel, V.T.3    Lee, H.Y.4    Lu, T.Y.5    Shulman, G.I.6    Accili, D.7
  • 74
    • 77951840060 scopus 로고    scopus 로고
    • A-Cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development
    • Lu J, Herrera PL, Carreira C, Bonnavion R, Seigne C, Calender A, Bertolino P & Zhang CX 2010 a-Cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development. Gastroenterology 138 1954–1965. (doi:10.1053/j.gastro.2010.01.046)
    • (2010) Gastroenterology , vol.138 , pp. 1954-1965
    • Lu, J.1    Herrera, P.L.2    Carreira, C.3    Bonnavion, R.4    Seigne, C.5    Calender, A.6    Bertolino, P.7    Zhang, C.X.8
  • 75
    • 84884590283 scopus 로고    scopus 로고
    • Making b cells from adult cells within the pancreas
    • Lysy PA, Weir GC & Bonner-Weir S 2013 Making b cells from adult cells within the pancreas. Current Diabetes Reports 13 695–703. (doi:10.1007/s11892-013-0400-1)
    • (2013) Current Diabetes Reports , vol.13 , pp. 695-703
    • Lysy, P.A.1    Weir, G.C.2    Bonner-Weir, S.3
  • 76
    • 80053580232 scopus 로고    scopus 로고
    • Nkx2-2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression
    • Mastracci TL, Wilcox CL, Arnes L, Panea C, Golden JA, May CL & Sussel L 2011 Nkx2-2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Developmental Biology 359 1–11. (doi:10.1016/j.ydbio.2011.08.001)
    • (2011) Developmental Biology , vol.359 , pp. 1-11
    • Mastracci, T.L.1    Wilcox, C.L.2    Arnes, L.3    Panea, C.4    Golden, J.A.5    May, C.L.6    Sussel, L.7
  • 78
    • 84871276716 scopus 로고    scopus 로고
    • Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells
    • van der Meulen T, Xie R, Kelly OG, Vale WW, Sander M & Huising MO 2012 Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells. PLoS ONE 7 e52181. (doi:10.1371/journal.pone.0052181)
    • (2012) Plos ONE , vol.7
    • Van Der Meulen, T.1    Xie, R.2    Kelly, O.G.3    Vale, W.W.4    Sander, M.5    Huising, M.O.6
  • 80
    • 0035937415 scopus 로고    scopus 로고
    • Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
    • Muhr J, Andersson E, Persson M, Jessell TM & Ericson J 2001 Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube. Cell 104 861–873. (doi:10.1016/S0092-8674(01)00283-5)
    • (2001) Cell , vol.104 , pp. 861-873
    • Muhr, J.1    Ersson, E.2    Persson, M.3    Jessell, T.M.4    Ericson, J.5
  • 81
    • 0344736673 scopus 로고    scopus 로고
    • Notch signaling controls multiple steps of pancreatic differentiation
    • Murtaugh LC, Stanger BZ, Kwan KM & Melton DA 2003 Notch signaling controls multiple steps of pancreatic differentiation. PNAS 100 14920–14925. (doi:10.1073/pnas.2436557100)
    • (2003) PNAS , vol.100 , pp. 14920-14925
    • Murtaugh, L.C.1    Stanger, B.Z.2    Kwan, K.M.3    Melton, D.A.4
  • 82
    • 0028941181 scopus 로고
    • Tissue-specific regulation of the insulin gene by a novel basic helix–loop–helix transcription factor
    • Naya FJ, Stellrecht CM & Tsai MJ 1995 Tissue-specific regulation of the insulin gene by a novel basic helix–loop–helix transcription factor. Genes and Development 9 1009–1019. (doi:10.1101/gad.9.8.1009)
    • (1995) Genes and Development , vol.9 , pp. 1009-1019
    • Naya, F.J.1    Stellrecht, C.M.2    Tsai, M.J.3
  • 85
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson H, Karlsson K & Edlund T 1993 IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO Journal 12 4251–4259.
    • (1993) EMBO Journal , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 86
    • 0037076351 scopus 로고    scopus 로고
    • Identification of b-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA
    • Olbrot M, Rud J, Moss LG & Sharma A 2002 Identification of b-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. PNAS 99 6737–6742. (doi:10.1073/pnas.102168499)
    • (2002) PNAS , vol.99 , pp. 6737-6742
    • Olbrot, M.1    Rud, J.2    Moss, L.G.3    Sharma, A.4
  • 88
    • 84873111871 scopus 로고    scopus 로고
    • Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration
    • Pan FC, Bankaitis ED, Boyer D, Xu X, Van de Casteele M, Magnuson MA, Heimberg H & Wright CV 2013 Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development 140 751–764. (doi:10.1242/dev.090159)
    • (2013) Development , vol.140 , pp. 751-764
    • Pan, F.C.1    Bankaitis, E.D.2    Boyer, D.3    Xu, X.4    Van De Casteele, M.5    Magnuson, M.A.6    Heimberg, H.7    Wright, C.V.8
  • 92
    • 0028206319 scopus 로고
    • XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor
    • Peshavaria M, Gamer L, Henderson E, Teitelman G, Wright CV & Stein R 1994 XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Molecular Endocrinology 8 806–816. (doi:10.1210/mend.8.6.7935494)
    • (1994) Molecular Endocrinology , vol.8 , pp. 806-816
    • Peshavaria, M.1    Gamer, L.2    Henderson, E.3    Teitelman, G.4    Wright, C.V.5    Stein, R.6
  • 94
    • 1542267814 scopus 로고    scopus 로고
    • Ghrelin cells replace insulin-producing b cells in two mouse models of pancreas development
    • Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B & Sussel L 2004 Ghrelin cells replace insulin-producing b cells in two mouse models of pancreas development. PNAS 101 2924–2929. (doi:10.1073/pnas.0308604100)
    • (2004) PNAS , vol.101 , pp. 2924-2929
    • Prado, C.L.1    Pugh-Bernard, A.E.2    Elghazi, L.3    Sosa-Pineda, B.4    Sussel, L.5
  • 95
    • 79961187989 scopus 로고    scopus 로고
    • Physiologic action of glucagon on liver glucosemetabolism. Diabetes
    • Ramnanan CJ, Edgerton DS, Kraft G & Cherrington AD 2011 Physiologic action of glucagon on liver glucosemetabolism. Diabetes, Obesity & Metabolism 13 (Suppl 1) 118–125. (doi:10.1111/j.1463-1326.2011.01454.x)
    • (2011) Obesity & Metabolism , vol.13 , pp. 118-125
    • Ramnanan, C.J.1    Edgerton, D.S.2    Kraft, G.3    Cherrington, A.D.4
  • 97
    • 84856715292 scopus 로고    scopus 로고
    • Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas
    • Riedel MJ, Asadi A, Wang R, Ao Z, Warnock GL & Kieffer TJ 2012 Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas. Diabetologia 55 372–381. (doi:10.1007/s00125-011-2344-9)
    • (2012) Diabetologia , vol.55 , pp. 372-381
    • Riedel, M.J.1    Asadi, A.2    Wang, R.3    Ao, Z.4    Warnock, G.L.5    Kieffer, T.J.6
  • 98
    • 0036165598 scopus 로고    scopus 로고
    • The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6
    • Ritz-Laser B, Estreicher A, Gauthier BR, Mamin A, Edlund H & Philippe J 2002 The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6. Diabetologia 45 97–107. (doi:10.1007/s125-002-8249-9)
    • (2002) Diabetologia , vol.45 , pp. 97-107
    • Ritz-Laser, B.1    Estreicher, A.2    Gauthier, B.R.3    Mamin, A.4    Edlund, H.5    Philippe, J.6
  • 99
    • 68149156892 scopus 로고    scopus 로고
    • Epithelial– mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells
    • Russ HA, Ravassard P, Kerr-Conte J, Pattou F & Efrat S 2009 Epithelial– mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells. PLoS ONE 4 e6417. (doi:10.1371/journal.pone.0006417)
    • (2009) Plos ONE , vol.4
    • Russ, H.A.1    Ravassard, P.2    Kerr-Conte, J.3    Pattou, F.4    Efrat, S.5
  • 100
    • 0001293564 scopus 로고
    • Promotion of Insulin Secretion by Glucagon
    • Samols E, Marri G & Marks V 1965 Promotion of Insulin Secretion by Glucagon. Lancet 2 415–416. (doi:10.1016/S0140-6736(65)90761-0)
    • (1965) Lancet , vol.2 , pp. 415-416
    • Samols, E.1    Marri, G.2    Marks, V.3
  • 101
    • 1842330860 scopus 로고    scopus 로고
    • Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development
    • Sander M, Neubuser A, Kalamaras J, Ee HC, Martin GR & German MS 1997 Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes and Development 11 1662–1673. (doi:10.1101/gad.11.13.1662)
    • (1997) Genes and Development , vol.11 , pp. 1662-1673
    • Sander, M.1    Neubuser, A.2    Kalamaras, J.3    Ee, H.C.4    Martin, G.R.5    German, M.S.6
  • 103
    • 77955978501 scopus 로고    scopus 로고
    • Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    • Schaffer AE, Freude KK, Nelson SB & Sander M 2010 Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. Developmental Cell 18 1022–1029. (doi:10.1016/j.devcel.2010.05.015)
    • (2010) Developmental Cell , vol.18 , pp. 1022-1029
    • Schaffer, A.E.1    Freude, K.K.2    Nelson, S.B.3    Sander, M.4
  • 105
    • 21044433282 scopus 로고    scopus 로고
    • The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells
    • Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG et al. 2005 The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. PNAS 102 7297–7302. (doi:10.1073/pnas.0502168102)
    • (2005) PNAS , vol.102 , pp. 7297-7302
    • Schisler, J.C.1    Jensen, P.B.2    Taylor, D.G.3    Becker, T.C.4    Knop, F.K.5    Takekawa, S.6    German, M.7    Weir, G.C.8    Lu, D.9    Mirmira, R.G.10
  • 106
    • 37149010976 scopus 로고    scopus 로고
    • Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers
    • Seo S, Lim JW, Yellajoshyula D, Chang LW& Kroll KL 2007 Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers. EMBO Journal 26 5093–5108. (doi:10.1038/sj.emboj.7601923)
    • (2007) EMBO Journal , vol.26 , pp. 5093-5108
    • Seo, S.1    Lim, J.W.2    Yellajoshyula, D.3    Lw&, C.4    Kroll, K.L.5
  • 107
    • 84888155347 scopus 로고    scopus 로고
    • Islet transplantation in type 1 diabetes: Ongoing challenges, refined procedures, and long-term outcome
    • Shapiro AM 2012 Islet transplantation in type 1 diabetes: ongoing challenges, refined procedures, and long-term outcome. Review of Diabetic Studies 9 385–406. (doi:10.1900/RDS.2012.9.385)
    • (2012) Review of Diabetic Studies , vol.9 , pp. 385-406
    • Shapiro, A.M.1
  • 108
    • 0033499662 scopus 로고    scopus 로고
    • Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development
    • Smith SB, Ee HC, Conners JR & German MS 1999 Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development. Molecular and Cellular Biology 19 8272–8280.
    • (1999) Molecular and Cellular Biology , vol.19 , pp. 8272-8280
    • Smith, S.B.1    Ee, H.C.2    Conners, J.R.3    German, M.S.4
  • 109
    • 0030897629 scopus 로고    scopus 로고
    • The Pax4 gene is essential for differentiation of insulin-producing b cells in the mammalian pancreas
    • Sosa-Pineda B, Chowdhury K, Torres M, Oliver G & Gruss P 1997 The Pax4 gene is essential for differentiation of insulin-producing b cells in the mammalian pancreas. Nature 386 399–402. (doi:10.1038/386399a0)
    • (1997) Nature , vol.386 , pp. 399-402
    • Sosa-Pineda, B.1    Chowdhury, K.2    Torres, M.3    Oliver, G.4    Gruss, P.5
  • 111
    • 0030914931 scopus 로고    scopus 로고
    • Pax6 is required for differentiation of glucagon-producing a-cells in mouse pancreas
    • St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A & Gruss P 1997 Pax6 is required for differentiation of glucagon-producing a-cells in mouse pancreas. Nature 387 406–409. (doi:10.1038/387406a0)
    • (1997) Nature , vol.387 , pp. 406-409
    • St-Onge, L.1    Sosa-Pineda, B.2    Chowdhury, K.3    Mansouri, A.4    Gruss, P.5
  • 112
    • 0034465470 scopus 로고    scopus 로고
    • Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: An in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice
    • Strowski MZ, Parmar RM, Blake AD & Schaeffer JM 2000 Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice. Endocrinology 141 111–117. (doi:10.1210/endo.141.1.7263)
    • (2000) Endocrinology , vol.141 , pp. 111-117
    • Strowski, M.Z.1    Parmar, R.M.2    Blake, A.D.3    Schaeffer, J.M.4
  • 114
    • 84866389264 scopus 로고    scopus 로고
    • Pancreatic b cell dedifferentiation as a mechanism of diabetic b cell failure
    • Talchai C, Xuan S, Lin HV, Sussel L & Accili D 2012 Pancreatic b cell dedifferentiation as a mechanism of diabetic b cell failure. Cell 150 1223–1234. (doi:10.1016/j.cell.2012.07.029)
    • (2012) Cell , vol.150 , pp. 1223-1234
    • Talchai, C.1    Xuan, S.2    Lin, H.V.3    Sussel, L.4    Accili, D.5
  • 115
    • 84884590826 scopus 로고    scopus 로고
    • Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells
    • Taylor BL, Liu FF & Sander M 2013 Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. Cell Reports 4 1262–1275. (doi:10.1016/j.celrep.2013.08.010)
    • (2013) Cell Reports , vol.4 , pp. 1262-1275
    • Taylor, B.L.1    Liu, F.F.2    Sander, M.3
  • 117
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic a-cells to b-cells after extreme b-cell loss
    • Thorel F, Nepote V, Avril I, Kohno K, Desgraz R, Chera S & Herrera PL 2010 Conversion of adult pancreatic a-cells to b-cells after extreme b-cell loss. Nature 464 1149–1154. (doi:10.1038/nature08894)
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1    Nepote, V.2    Avril, I.3    Kohno, K.4    Desgraz, R.5    Chera, S.6    Herrera, P.L.7
  • 118
    • 84855459920 scopus 로고    scopus 로고
    • Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover
    • Unger RH & Cherrington AD 2012 Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. Journal of Clinical Investigation 122 4–12. (doi:10.1172/JCI60016)
    • (2012) Journal of Clinical Investigation , vol.122 , pp. 4-12
    • Unger, R.H.1    Cherrington, A.D.2
  • 119
    • 77958014883 scopus 로고    scopus 로고
    • Paracrinology of islets and the paracrinopathy of diabetes
    • Unger RH & Orci L 2010 Paracrinology of islets and the paracrinopathy of diabetes. PNAS 107 16009–16012. (doi:10.1073/pnas.1006639107)
    • (2010) PNAS , vol.107 , pp. 16009-16012
    • Unger, R.H.1    Orci, L.2
  • 120
    • 0029047865 scopus 로고
    • The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription
    • Wang M & Drucker DJ 1995 The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription. Journal of Biological Chemistry 270 12646–12652. (doi:10.1074/jbc.270.21.12646)
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 12646-12652
    • Wang, M.1    Drucker, D.J.2
  • 121
    • 84900330718 scopus 로고    scopus 로고
    • Pancreatic b cell dedifferentiation in diabetes and redifferentiation following insulin therapy
    • Wang Z, York NW, Nichols CG & Remedi MS 2014 Pancreatic b cell dedifferentiation in diabetes and redifferentiation following insulin therapy. Cell Metabolism 19 872–882. (doi:10.1016/j.cmet.2014.03.010)
    • (2014) Cell Metabolism , vol.19 , pp. 872-882
    • Wang, Z.1    York, N.W.2    Nichols, C.G.3    Remedi, M.S.4
  • 122
    • 84878983251 scopus 로고    scopus 로고
    • Pancreatic a-cell specific deletion of mouse Arx leads to a-cell identity loss
    • Wilcox CL, Terry NA, Walp ER, Lee RA & May CL 2013 Pancreatic a-cell specific deletion of mouse Arx leads to a-cell identity loss. PLoS ONE 8 e66214. (doi:10.1371/journal.pone.0066214)
    • (2013) Plos ONE , vol.8
    • Wilcox, C.L.1    Terry, N.A.2    Walp, E.R.3    Lee, R.A.4    May, C.L.5
  • 123
    • 84860410786 scopus 로고    scopus 로고
    • Context-specific a-to-b-cell reprogramming by forced Pdx1 expression
    • Yang YP, Thorel F, Boyer DF, Herrera PL & Wright CV 2011 Context-specific a-to-b-cell reprogramming by forced Pdx1 expression. Genes and Development 25 1680–1685. (doi:10.1101/gad.16875711)
    • (2011) Genes and Development , vol.25 , pp. 1680-1685
    • Yang, Y.P.1    Thorel, F.2    Boyer, D.F.3    Herrera, P.L.4    Wright, C.V.5
  • 125
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to b-cells
    • Zhou Q, Brown J, Kanarek A, Rajagopal J & Melton DA 2008 In vivo reprogramming of adult pancreatic exocrine cells to b-cells. Nature 455 627–632. (doi:10.1038/nature07314)
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5


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