Regulation of the pancreatic pro-endocrine gene neurogenin3

Diabetes

Volumn 50, Issue 5, 2001, Pages 928-936

  Lee, Jane C ^a,b   Smith, Stewart B ^a   Watada, Hirotaka ^a   Lin, Joseph ^a   Scheel, David ^a   Wang, Juehu ^a   Mirmira, Raghavendra G ^a,c   German, Michael S ^a,b,d  

^a Hormone Research Institute   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; NEUROGENIN 3; NOTCH RECEPTOR; NUCLEAR FACTOR I; PROTEIN; PROTEIN NGN3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ENHANCER REGION; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE MAPPING; GENETIC TRANSCRIPTION; HUMAN; MOLECULAR CLONING; MOUSE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0035029838     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.5.928     Document Type: Article

References (47)

1. Transcribing pancreas
2. The β-cell transcription factors and development of the pancreas
3. Developmental biology of the pancreas
4. Notch signaling controls pancreatic cell differentiation
5. Independent development of pancreatic α- and β-cells from neurogenin3-expressing precursors: A role for the notch pathway in repression of premature differentiation
6. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
7. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
8. Control of endodermal endocrine development by Hes-1
9. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3
10. Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS
11. Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains
12. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split
13. Synergistic activation of the insulin gene by a LIM-homeodomain protein and a basic helix-loop-helix protein: Building a functional insulin minienhancer complex
14. Cell-free activation of a DNA-binding protein by epidermal growth factor
15. Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene
16. Long-term expression in sensory neurons in tissue culture from herpes simplex virus type 1 (HSV-1) promoters in an HSV-1-derived vector
17. Hepatocyte nuclear factor 3β is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene
18. Pancreatic beta cell-specific transcription of the pdx-1 gene: The role of conserved upstream control regions and their hepatic nuclear factor 3β sites
19. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1
20. Regulation of a transcription factor network required for differentiation and metabolism
21. Glucagon gene expression is negatively regulated by hepatocyte nuclear factor 3β
22. Inactivation of the winged helix transcription factor HNF3α affects glucose homeostasis and islet glucagon gene expression in vivo
23. Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes
24. Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters
25. Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES1: Negative autoregulation through the multiple N box elements
26. Negative regulation of proneural gene activity: Hairy is a direct transcriptional repressor of achaete
27. Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation
28. Chromatin remodeling and the control of gene expression
29. Eukaryotic transcription: An interlaced network of transcription factors and chromatin-modifying machines
30. Exploring the transcription-chromatin interface
31. An early developmental transcription factor complex that is more stable on nucleosome core particles than on free DNA
32. Hepatic specification of the gut endoderm in vitro: Cell signaling and transcriptional control
33. Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome
34. Developmental competence of the gut endoderm: Genetic potentiation by GATA and HNF3/fork head proteins
35. Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3α-deficient mice
36. Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3α, -3β, -3γ, -4γ and -6
37. The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3β in the developing murine liver and pancreas
38. The nuclear receptor fetoprotein transcription factor is coexpressed with its target gene HNF-3β in the developing murine liver, intestine and pancreas
39. Expression of liver type pyruvate kinase in insulinoma cells: Involvement of LF-B1 (HNF1)
40. Hepatocyte nuclear factor 1α is expressed in a hamster insulinoma line and transactivates the rat insulin I gene
41. Expression of the vHNF1/HNF1β homeoprotein gene during mouse organogenesis
42. Defective insulin secretion in hepatocyte nuclear factor 1α-deficient mice
43. Notch signaling and the control of cell fate choices in vertebrates
44. Notch signaling: Cell fate control and signal integration in development
45. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: A hairy-related protein (HES1) directly represses achaete-scute homolog-1 expression
46. The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-anuno-acid transcription repression and protein-protein interaction domain
47. Groucho/TLE family proteins and transcriptional repression