C-Myc directly induces both impaired insulin secretion and loss of β-cell mass, independently of hyperglycaemia in vivo

Islets

Volumn 2, Issue 1, 2010, Pages

  Cheung, Linda ^a   Zervou, Sevasti ^b,c   Mattsson, Göran ^b   Abouna, Sylvie ^b   Zhou, Luxian ^b   Ifandi, Vasiliki ^b   Pelengaris, Stella ^a   Khan, Michael ^b  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Beta cell differentiation; c Myc; Hyperglycaemia; Islet transplantation; cell mass

Indexed keywords

GLUCOSE; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL LOSS; CONTROLLED STUDY; GENE ACTIVATION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; INSULIN RELEASE; MOUSE; NONHUMAN; ONCOGENE C MYC; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; ANIMAL; C57BL MOUSE; CBA MOUSE; CELL COUNT; CELL CYCLE; CYTOLOGY; FEMALE; GENETICS; MALE; METABOLISM; ONCOGENE MYC; ORGAN SIZE; PANCREAS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION; TRANSGENE; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; CELL COUNT; CELL CYCLE; CELL DIFFERENTIATION; FEMALE; GENES, MYC; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; ORGAN SIZE; PANCREAS; TRANSGENES; UP-REGULATION;

EID: 77953434957     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: None     Document Type: Article

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