Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

PLoS Genetics

Volumn 9, Issue 1, 2013, Pages

  Schaffer, Ashleigh E ^a   Taylor, Brandon L ^a   Benthuysen, Jacqueline R ^a   Liu, Jingxuan ^b   Thorel, Fabrizio ^c   Yuan, Weiping ^d   Jiao, Yang ^e   Kaestner, Klaus H ^e   Herrera, Pedro L ^c   Magnuson, Mark A ^d   May, Catherine Lee ^b   Sander, Maike ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^d VANDERBILT UNIVERSITY   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISL1 PROTEIN; PROTEIN; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARX GENE; CELL LINEAGE; CELL LOSS; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE FUNCTION; GENE INACTIVATION; GENE MUTATION; GENE REGULATORY NETWORK; GENE REPRESSION; GENE TARGETING; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRECURSOR; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; ENDOCRINE CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REGULATORY NETWORKS; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MAF TRANSCRIPTION FACTORS, LARGE; MICE; PANCREAS; STEM CELLS; TISSUE THERAPY; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 84873514082     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003274     Document Type: Article

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