Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube

Cell

Volumn 104, Issue 6, 2001, Pages 861-873

  Muhr, Jonas ^a   Andersson, Elisabet ^a   Persson, Madelen ^a   Jessell, Thomas M ^b   Ericson, Johan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; HOMEODOMAIN PROTEIN; PROTEIN GRO; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FATE; CELL SPECIFICITY; GENE EXPRESSION; IN VIVO STUDY; NERVOUS SYSTEM DEVELOPMENT; NEURAL TUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; STEM CELL; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0035937415     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00283-5     Document Type: Article

References (46)

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4. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
5. The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription
6. The homeodomain transcription factor NK-4 acts as either a transcriptional activator or repressor and interacts with the p300 coactivator and the Groucho corepressor
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15. Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development
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27. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
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29. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
30. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and Nurr1
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39. LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons
40. A conserved region of engrailed, shared among all en-, gsc-, NK1, Nk2-, and msh-class homeoproteins, mediates active transcriptional repression in vivo
41. Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS
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