Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming

Genes and Development

Volumn 25, Issue 21, 2011, Pages 2291-2305

  Papizan, James B ^a   Singer, Ruth A ^a   Tschen, Shuen Ing ^b   Dhawan, Sangeeta ^b   Friel, Jessica M ^a   Hipkens, Susan B ^c   Magnuson, Mark A ^c   Bhushan, Anil ^b   Sussel, Lori ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cell reprogramming; DNA methylation; Dnmt3a; Islet development; Nkx2.2; Transcriptional repression

Indexed keywords

COMPLEMENTARY DNA; GHRELIN; GLUCAGON; GLUCOSE; INSULIN; MESSENGER RNA; TAMOXIFEN; TRANSCRIPTION FACTOR NKX2.2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL SPECIFICITY; CONTROLLED STUDY; DIABETES MELLITUS; DNA METHYLATION; EMBRYO; EMBRYO DEVELOPMENT; EPIGENETICS; GENE EXPRESSION; GENE MUTATION; GENE REPRESSION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; MOUSE; NEWBORN; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

ANIMALS; CELL DIFFERENTIATION; DIABETES MELLITUS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; GENE EXPRESSION REGULATION; GHRELIN; GLUCAGON; GLUCAGON-SECRETING CELLS; HOMEODOMAIN PROTEINS; INSULIN; INSULIN-SECRETING CELLS; MICE; MUTATION; ORGAN SPECIFICITY; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; TRANSCRIPTION FACTORS;

MUS;

EID: 80455173402     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.173039.111     Document Type: Article

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