POU domain transcription factor brain 4 confers pancreatic α-cell- specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element

Molecular and Cellular Biology

Volumn 17, Issue 12, 1997, Pages 7186-7194

  Hussain, Mehboob A ^a   Lee, John ^a   Miller, Christopher P ^a,c   Habener, Joel F ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; HOMEODOMAIN PROTEIN; PROGLUCAGON; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRAIN 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN BHK; ELECTROPHORETIC MOBILITY; FEMALE; GENE EXPRESSION; MALE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PRIORITY JOURNAL; PROMOTER REGION; RAT; TRANSACTIVATION;

ANIMALIA;

EID: 0030712878     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.17.12.7186     Document Type: Article

References (52)

1. Alpert, S., D. Hanahan, and G. Teitelman. 1988. Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply relationship with neurons. Cell 53:295-308.
2. Bell, G. I., R. F. Santerre, and G. T. Mullenbach. 1983. Hamster proproglucagon contains the sequence of glucagon and two related peptides. Nature (London) 302:716-718.
3. de Kok, Y. J. M., S. M. van der Maarel, M. Bitner-Glindzicz, I. Huber, A. P. Monaco, S. Malcolm, M. E. Pembrey, H-H. Ropers, and F. P. M. Cremers. 1995. Association between X-linked mixed deafness and mutations in the POU domain gene POU3F4. Science 267:685-688.
4. DeWet, J. R., K. V. Wood, M. Delauca, D. R. Gelinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Genes Dev. 8:1-13.
5. Drucker, D. J., J. Philippe, L. Jepeal, and J. F. Habener. 1987. Glucagon 5′-flanking sequences promote islet cell-specific glucagon gene transcription. J. Biol. Chem. 262:15659-15665.
6. Drucker, D. J., and S. Asa. 1988. Glucagon gene expression in vertebrate brain. J. Biol. Chem. 263:13475-13478.
7. Drucker, D. J., P. Ehrlich, S. L. Asa, and P. Brubaker. 1996. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc. Natl. Acad. Sci. USA 93:7911-7916.
8. Drucker, D. J., J. Philipe, and S. Mojsov. 1988. Proglucagon gene expression and posttranslational processing in a hamster islet cell line. Endocrinology 123:1861-1867.
9. Fürstenau, U., M. Schwaninger, R. Blume, I. Kennerknecht, and W. Knepel. 1997. Characterization of a novel protein kinase C response element in the glucagon gene. Mol. Cell. Biol. 17:1805-1816.
10. German, M. S., J. Wang, R. B. Chadwick, and W. J. Rutter. 1992. Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. Genes Dev. 6:2165-2176.
11. Gstaiger, M., O. Georgiev, H. van Leeuwen, P. van der Vliet, and W. Schaffner. 1996. The B cell coactivator Bob1 shows DNA sequence dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation. EMBO J. 15:2781-2790.
12. Gstaiger, M., L. Knoepfel, O. Georgiev, W. Schaffner, and C. M. Hovens. 1995. A B-cell coactivator of octamer-binding transcription factors. Nature (London) 373:360-362.
13. Hara, Y., A. C. Rovescalli, Y. Kim, and M. Nirenberg. 1992. Structure and evolution of four POU domain genes expressed in mouse brain. Proc. Natl. Acad. Sci. USA 89:3280-3284.
14. Holz, G. G. I., W. M. Kühtreiber, and J. F. Habener. 1993. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7-37). Nature (London) 361:362-365.
15. 14a. Hussain, M. A., and J. F. Habener. Unpublished observations.
16. Jin, T., and D. J. Drucker. 1996. Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3. Mol. Cell. Biol. 16:19-28.
17. Knepel, W., L. Jepeal, and J. F. Habener. 1990. A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins. J. Biol. Chem. 265:8725-8735.
18. Knepel, W., M. Vallejo, J. A. Chafitz, and J. F. Habener. 1991. The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes. Mol. Endocrinol. 5:1457-1466.
19. Lacey, P. E., and M. Kosianovsky. 1967. Method for the isolation of intact pancreatic islets from the rat pancreas. Diabetes 16:35-39.
20. Laser, B., P. Meda, I. Constant, and J. Philippe. 1996. The caudal-related homeodomain protein cdx-2/3 regulates glucagon gene expression islet cells. J. Biol. Chem. 271:28964-28994.
21. Le Moine, C., and W. S. Young III. 1992. RHS2, a POU domain-containing gene, and its expression in developing and adult rat. Proc. Natl. Acad. Sci. USA 89:3285-3289.
22. Leonard, J., B. Peers, T. Johnson, K. Ferrei, S. Lee, and M. R. Montminy. 1993. Characterization of somatostatin transactivating factor-I, a novel homeobox factor that stimulates somatostatin gene expression in pancreatic islet cells. Mol. Endocrinol. 7:1275-1283.
23. Li, P., X. He, M. R. Gerreo, M. Mok, A. Aggarwal, and M. G. Rosenfeld. 1993. Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors. Genes Dev. 7:2483-2496.
24. Malik, K. F., J. Kim, A. L. Hartman, P. Kim, and W. S. Young III. 1996. Binding preferences of the POU domain protein brain-4: implications for autoregulation. Brain Res. 38:209-221.
25. Mathis, J. M., D. M. Simmons, X. He, L. W. Swanson, and M. G. Rosenfeld. 1992. Brain 4: a novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression. EMBO J. 11:2551-2561.
26. Miller, C. P., R. E. McGehee, and J. F. Habener. 1994. IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J. 4:2961-2969.
27. Mojsov, S., G. Heinrich, L. B. Wilson, M. Ravazzola, L. Orci, and J. F. Habener. 1986. Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J. Biol. Chem. 261: 11880-11889.
28. Morel, C., M. Cordier-Bussat, and J. Philippe. 1995. The upstream promoter element of the glucagon gene G1 confers pancreatic alpha cell-specific expression. J. Biol. Chem. 270:3046-3055.
29. Naya, F. J., C. M. M. Stellrecht, and M.-J. Tsai. 1995. Tissue-specific regulation of the insulin gene by a novel basic helix-loop helix transcription factor. Genes. Dev. 9:1009-1019.
30. Ohlsson, H., S. Thor, and T. Edlund. 1991. Novel insulin promoter-and enhancer-binding proteins that discriminate between pancreatic alpha-and beta-cells. Mol. Endocrinol. 5:897-904.
31. Okazawa, H., I. Imafuku, M. T. Minowa, I. Kanazawa, H. Hamada, and M. M. Mouradian. 1996. Regulation of striatal D1A Dopamine receptor gene transcription. Proc. Natl. Acad. Sci. USA 93:11933-11938.
32. Orskov, C., J. J. Holst, S. S. Poulsen, and P. Kirkegaard. 1987. Pancreatic and intestinal processing of proglucagon in man. Diabetelogia 30:874-881.
33. Peers, B., J. Leonard, S. Sharma, G. Teitelman, and M. R. Montminy. 1994. Insulin expression in pancreatic islet cells relies on cooperative interaction between helix-loop-helix factor E47 and the homeobox factor STF-1. Mol. Endocrinol. 8:1798-1806.
34. Philippe, J., D. J. Drucker, W. Knepel, L. Jepeal, Z. Misulovin, and J. F. Habener. 1988. Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by interactions of DNA-binding proteins. Mol. Cell. Biol. 8:4877-4888.
35. Philippe, J., C. Morel, and V. Prezioso. 1994. Glucagon gene expression is negatively regulated by hepatocyte nuclear factor 3β. Mol. Cell. Biol. 14: 3514-3523.
36. Philippe, J., C. Morel, and M. Cordier-Bussat. 1995. Islet-specific proteins interact with the insulin-response element of the glucagon gene. J. Biol. Chem. 270:3039-3045.
37. Philippe, J., W. C. Chick, and J. F. Habener. 1987. Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cells. J. Clin. Invest. 79:351-358.
38. Philippe, J., S. Mojsov, D. J. Drucker, and J. F. Habener. 1986. Proglucagon processing in rat islet cell line resembles phenotype of intestine rather than pancreas. Endocrinology 119:2833-2839.
39. Rudnick, A., T. Y. Ling, H. Odagiri, W. J. Rutter, and M. S. German. 1994. Pancreatic beta cells express a diverse set of homeobox genes. Proc. Natl. Acad. Sci. USA 91:12203-12207.
40. Schonemann, M. D., A. K. Ryan, R. J. Mcevilly, S. M. O'Conell, C. A. Arias, K. A. Kalla, P. Li, P. E. Sawchenko, and M. G. Rosenfeld. 1995. Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2. Genes Dev. 9:3122-3135.
41. Schreiber, E., P. Matthias, M. M. Müller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with 'mini-extracts' prepared from a small number of cells. Nucleic Acids Res. 17:6419.
42. Schubart, D. B., A. Rolink, M. H. Kosco-Vilois, F. Botteri, and P. Matthias. 1996. B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. Nature (London) 383:538-542.
43. Sosa-Pineda, B., K. Chowdhury, M. Torres, G. Oliver, and P. Gruss. 1997. The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas. Nature 386:399-402.
44. St.-Onge, L., B. Sosa-Pineda, K. Chowdhury, A. Mansouri, and P. Gruss. 1997. Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas. Nature (London) 387:406-409.
45. Strubin, M., J. W. Newell, and P. Matthias. 1995. OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell 80:497-506.
46. Suh, E., L. Chen, J. Taylor, and P. G. Traber. 1994. A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol. Cell. Biol. 14:7340-7351.
47. Turque, N., S. Plaza, F. Radvani, C. Carriere, and S. Saule. 1994. Pax-QNR/ Pax-6, a paired box-and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells. Mol. Endocrinol. 8:929-938.
48. Turton, D. D., D. O'Shea, J. Gunn, S. A. Beak, C. M. Edwards, K. Meeran, S. J. Choi, G. M. Taylor, M. M. Heath, P. D. Lambert, J. P. Wilding, D. M. Smith, M. A. Ghatei, J. Herbert, and S. R. Bloom. 1996. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature (London) 379:69-72.
49. Verrijier, C. P., M. J. Alkema, W. W. van Weperen, H. C. Van Leeuwen, M. J. J. Strating, and P. C. Van der Vliet. 1992. The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J. 11:4993-5003.
50. Wang, M., and D. J. Drucker. 1995. The LIM domain homeobox gene isl-1 a positive regulator of islet cell-specific proglucagon gene transcription. J. Biol. Chem. 270:12646-12652.
51. Wegner, M., D. W. Drolet, and M. G. Rosenfeld. 1993. POU-domain proteins: structure and function of developmental regulators. Curr. Opin. Cell. Biol. 5:488-498.
52. Wright, C. V., P. Schnegelsberg, and E. M. De Robertis. 1989. XIHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm. Development 105:787-794.