Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

Nature

Volumn 514, Issue 7253, 2014, Pages 503-507

  Chera, Simona ^a   Baronnier, Delphine ^a   Ghila, Luiza ^a   Cigliola, Valentina ^a   Jensen, Jan N ^b   Gu, Guoqiang ^c   Furuyama, Kenichiro ^a   Thorel, Fabrizio ^a   Gribble, Fiona M ^d   Reimann, Frank ^d   Herrera, Pedro L ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b NOVO NORDISK A S   (Denmark)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; INSULIN; SOMATOSTATIN; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE;

AGE; ANATOMY; CELLS AND CELL COMPONENTS; DIABETES; DIFFERENTIATION; HORMONE; IMMUNITY;

ADULT; AGED; AGING; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL LOSS; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET DELTA CELL; PRIORITY JOURNAL; SENESCENCE; ANIMAL; BIOSYNTHESIS; CELL DEDIFFERENTIATION; CELL TRANSDIFFERENTIATION; CYTOLOGY; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; REGENERATION; SECRETION (PROCESS); SEXUAL MATURATION; SOMATOSTATIN CELL;

MUS;

AGING; ANIMALS; CELL DEDIFFERENTIATION; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FORKHEAD TRANSCRIPTION FACTORS; GLUCAGON-SECRETING CELLS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; REGENERATION; SEXUAL MATURATION; SOMATOSTATIN; SOMATOSTATIN-SECRETING CELLS;

EID: 84920744392     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13633     Document Type: Article

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