Research resource: The Pdx1 cistrome of pancreatic islets

Molecular Endocrinology

Volumn 26, Issue 3, 2012, Pages 521-533

  Khoo, Cynthia ^a   Yang, Juxiang ^a   Weinrott, Samuel A ^a   Kaestner, Klaus H ^a   Naji, Ali ^a   Schug, Jonathan ^a   Stoffers, Doris A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR PDX 1;

ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; ENDOCRINE SYSTEM; GENE TARGETING; HUMAN; HUMAN TISSUE; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MOTIF; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; BINDING SITES; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CONSENSUS SEQUENCE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME, HUMAN; HOMEODOMAIN PROTEINS; HUMANS; ISLETS OF LANGERHANS; MICE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SEQUENCE ANALYSIS, DNA; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION;

MUS;

EID: 84863181834     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2011-1231     Document Type: Article

References (68)

1. Seshasai SR, Kaptoge S, Thompson A, Di Angelantonio E, Gao P, Sarwar N, Whincup PH, Mukamal KJ, Gillum RF, Holme I, Njølstad I, Fletcher A, Nilsson P, Lewington S, Collins R, Gudnason V, Thompson SG, Sattar N, Selvin E, Hu FB, Danesh J 2011 Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 364:829-841
2. Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF 1997 Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 15:106-110
3. Jonsson J, Carlsson L, Edlund T, EdlundH1994 Insulin-promoterfactor 1 is required for pancreas development in mice. Nature 371: 606-609
4. Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H 1998 β-Cellspecific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev 12: 1763-1768
5. Stoffers DA, Ferrer J, Clarke WL, Habener JF 1997 Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet 17: 138-139
6. Hani EH, Stoffers DA, Chèvre JC, Durand E, Stanojevic V, Dina C, Habener JF, Froguel P 1999 Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest 104:R41-R48
7. Macfarlane WM, Frayling TM, Ellard S, Evans JC, Allen LI, Bulman MP, Ayres S, Shepherd M, Clark P, Millward A, Demaine A, Wilkin T, Docherty K, Hattersley AT 1999 Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes. J Clin Invest 104:R33-R39
8. Nicolino M, Claiborn KC, Senèe V, Boland A, Stoffers DA, Julier C 2010 A novel hypomorphic PDX1 mutation responsible for permanent neonatal diabetes with subclinical exocrine deficiency. Diabetes 59:733-740
9. Ohlsson H, Karlsson K, Edlund T 1993 IPF1, a homeodomaincontaining transactivator of the insulin gene. EMBO J 12:4251-4259
10. Mosley AL, Corbett JA, Ozcan S 2004 Glucose regulation of insulin gene expression requires the recruitment of p300 by the β-cellspecific transcription factor Pdx-1. Mol Endocrinol 18:2279-2290
11. Francis J, Chakrabarti SK, Garmey JC, Mirmira RG 2005 Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription. J Biol Chem 280: 36244-36253
12. McGinnis W, Krumlauf R 1992 Homeobox genes and axial patterning. Cell 68:283-302
13. Chang CP, Brocchieri L, Shen WF, Largman C, Cleary ML 1996 Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus. Mol Cell Biol 16:1734-1745
14. Dutta S, Gannon M, Peers B, Wright C, Bonner-Weir S, Montminy M 2001 PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. Proc Natl Acad Sci USA 98:1065-1070
15. Goudet G, Delhalle S, Biemar F, Martial JA, Peers B 1999 Functional and cooperative interactions between the homeodomain PDX1, Pbx, and Prep1 factors on the somatostatin promoter. J Biol Chem 274:4067-4073
16. Andersen FG, Jensen J, Heller RS, Petersen HV, Larsson LI, Madsen OD, Serup P 1999 Pax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancer. FEBS Lett 445:315-320
17. Swift GH, Liu Y, Rose SD, Bischof LJ, Steelman S, Buchberg AM, Wright CV, MacDonald RJ 1998 An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2). Mol Cell Biol 18:5109-5120
18. Deramaudt TB, Sachdeva MM, Wescott MP, Chen Y, Stoffers DA, Rustgi AK 2006 The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter. J Biol Chem 281:38385-38395
19. Babu DA, Chakrabarti SK, Garmey JC, Mirmira RG 2008 Pdx1 and β2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene. J Biol Chem 283:8164-8172
20. Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA 2009 The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest 119:1888-1898
21. Brissova M, Shiota M, Nicholson WE, Gannon M, Knobel SM, Piston DW, Wright CV, Powers AC 2002 Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem 277:11225-11232
22. Johnson JD, Ahmed NT, Luciani DS, Han Z, Tran H, Fujita J, Misler S, Edlund H, Polonsky KS 2003 Increased islet apoptosis in Pdx1+/- mice. J Clin Invest 111:1147-1160
23. Petersen HV, Serup P, Leonard J, Michelsen BK, Madsen OD 1994 Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. Proc Natl Acad Sci USA 91:10465-10469
24. Waeber G, Thompson N, Nicod P, Bonny C 1996 Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol 10:1327-1334
25. Raum JC, Gerrish K, Artner I, Henderson E, Guo M, Sussel L, Schisler JC, Newgard CB, Stein R 2006 FoxA2, Nkx2.2, and PDX-1 regulate islet β-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol 26:5735-5743
26. Svensson P, Williams C, Lundeberg J, Rydèn P, Bergqvist I, Edlund H 2007 Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells. BMC Dev Biol 7:129
27. Gauthier BR, Brun T, Sarret EJ, Ishihara H, Schaad O, Descombes P, Wollheim CB 2004 Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets. J Biol Chem 279:31121-31130
28. Gauthier BR, Wiederkehr A, Baquié M, Dai C, Powers AC, Kerr- Conte J, Pattou F, MacDonald RJ, Ferrer J, Wollheim CB 2009 PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression. Cell Metab 10:110-118
29. Silva JP, Köhler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG 2000 Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes. Nat Genet 26:336-340
30. Fujimoto K, Ford EL, Tran H, Wice BM, Crosby SD, Dorn 2nd GW, Polonsky KS 2010 Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes. J Clin Invest 120: 4031-4039
31. Sachdeva MM, Claiborn KC, Khoo C, Yang J, Groff DN, Mirmira RG, Stoffers DA 2009 Pdx1 (MODY4) regulates pancreatic β cell susceptibility to ER stress. Proc Natl Acad Sci USA 106:19090-19095
32. Keller DM, McWeeney S, Arsenlis A, Drouin J, Wright CV, Wang H, Wollheim CB, White P, Kaestner KH, Goodman RH 2007 Char- acterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J Biol Chem 282:32084-32092
33. Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M 2004 A pancreatic islet-specific microRNA regulates insulin secretion. Nature 432:226-230
34. Tuteja G, White P, Schug J, Kaestner KH 2009 Extracting transcription factor targets from ChIP-Seq data. Nucleic Acids Res 37: e113
35. Soccio RE, Tuteja G, Everett LJ, Li Z, Lazar MA, Kaestner KH 2011 Species-specific strategies underlying conserved functions of metabolic transcription factors. Mol Endocrinol 25:694-706
36. Kim SK, Selleri L, Lee JS, Zhang AY, Gu X, Jacobs Y, Cleary ML 2002 Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Nat Genet 30: 430-435
37. Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P 1997 The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas. Nature 386:399-402
38. Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M 2005 NKX6 transcription factor activity is required for α-and β-cell development in the pancreas. Development 132: 3139-3149
39. Decker K, Goldman DC, Grasch CL, Sussel L 2006 Gata6 is an important regulator of mouse pancreas development. Dev Biol 298: 415-429
40. Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F, Schwitzgebel V, Hayes-Jordan A, German M 2000 Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas. Development 127:5533-5540
41. St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P 1997 Pax6 is required for differentiation of glucagon-producing α -cells in mouse pancreas. Nature 387:406-409
42. Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M, Montminy M 2003 cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2. Genes Dev 17:1575-1580
43. Hussain MA, Porras DL, Rowe MH, West JR, Song WJ, Schreiber WE, Wondisford FE 2006 Increased pancreatic β-cell proliferation mediated by CREB binding protein gene activation. Mol Cell Biol 26:7747-7759
44. Haumaitre C, Barbacci E, Jenny M, Ott MO, Gradwohl G, Cereghini S 2005 Lack of TCF2/vHNF1 in mice leads to pancreas agenesis. Proc Natl Acad Sci USA 102:1490-1495
45. Pontoglio M, Sreenan S, Roe M, Pugh W, Ostrega D, Doyen A, Pick AJ, Baldwin A, Velho G, Froguel P, Levisetti M, Bonner-Weir S, Bell GI, Yaniv M, Polonsky KS 1998 Defective insulin secretion in hepatocyte nuclear factor 1α-deficient mice. J Clin Invest 101: 2215-2222
46. Artner I, Blanchi B, Raum JC, Guo M, Kaneko T, Cordes S, Sieweke M, Stein R 2007 MafB is required for islet β cell maturation. Proc Natl Acad Sci USA 104:3853-3858
47. Ritz-Laser B, Estreicher A, Gauthier B, Philippe J 2000 The paired homeodomain transcription factor Pax-2 is expressed in the endocrine pancreas and transactivates the glucagon gene promoter. J Biol Chem 275:32708-32715
48. Zaiko M, Estreicher A, Ritz-Laser B, Herrera P, Favor J, Meda P, Philippe J 2004 Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin and glucagon content. Eur J Endocrinol 150:389-395
49. Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, et al. 2006 Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320-323
50. Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjögren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L 2007 Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117:2155-2163
51. Khoo C, Yang J, Rajpal G, Wang Y, Liu J, Arvan P, Stoffers DA 2011 Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells. Endocrinology 152:2599-2608
52. Li C, Chen P, Vaughan J, Blount A, Chen A, Jamieson PM, Rivier J, Smith MS, Vale W 2003 Urocortin III is expressed in pancreatic β-cells and stimulates insulin and glucagon secretion. Endocrinology 144:3216-3224
53. Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Boström KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, et al. 2008 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638-645
54. Gurzov EN, Germano CM, Cunha DA, Ortis F, Vanderwinden JM, Marchetti P, Zhang L, Eizirik DL 2010 p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic β-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress. J Biol Chem 285:19910-19920
55. Nakano K, Vousden KH 2001 PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7:683-694
56. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N 2000 Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288:1053-1058
57. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA 2008 In vivo reprogramming of adult pancreatic exocrine cells to β-cells. Nature 455:627-632
58. Hoffman BG, Robertson G, Zavaglia B, Beach M, Cullum R, Lee S, Soukhatcheva G, Li L, Wederell ED, Thiessen N, Bilenky M, Cezard T, Tam A, Kamoh B, Birol I, Dai D, Zhao Y, Hirst M, Verchere CB, Helgason CD, Marra MA, Jones SJ, Hoodless PA 2010 Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver. Genome Res 20:1037-1051
59. Li C, Chen P, Vaughan J, Lee KF, Vale W 2007 Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis. Proc Natl Acad Sci USA 104:4206-4211
60. Marselli L, Thorne J, Dahiya S, Sgroi DC, Sharma A, Bonner-Weir S, Marchetti P, Weir GC 2010 Gene expression profiles of β-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One 5:e11499
61. Claas C, Seiter S, Claas A, Savelyeva L, Schwab M, Zöller M 1998 Association between the rat homologue of CO-029, a metastasisassociated tetraspanin molecule and consumption coagulopathy. J Cell Biol 141:267-280
62. Gesierich S, Paret C, Hildebrand D, Weitz J, Zgraggen K, Schmitz- Winnenthal FH, Horejsi V, Yoshie O, Herlyn D, Ashman LK, Zöller M 2005 Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility. Clin Cancer Res 11:2840-2852
63. Gesierich S, Berezovskiy I, Ryschich E, Zöller M 2006 Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029. Cancer Res 66:7083-7094
64. Champy MF, Le Voci L, Selloum M, Peterson LB, Cumiskey AM, Blom D 2011 Reduced body weight in male Tspan8-deficient mice. Int J Obes 35:605-617
65. Holland AM, Góñez LJ, Naselli G, Macdonald RJ, Harrison LC 2005 Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of β-cells in the adult pancreas. Diabetes 54:2586-2595
66. Deng S, Vatamaniuk M, Huang X, Doliba N, Lian MM, Frank A, Velidedeoglu E, Desai NM, Koeberlein B, Wolf B, Barker CF, Naji A, Matschinsky FM, Markmann JF 2004 Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects. Diabetes 53:624-632
67. Scharp DW, Kemp CB, Knight MJ, Ballinger WF, Lacy PE 1973 The use of ficoll in the preparation of viable islets of langerhans from the rat pancreas. Transplantation 16:686-689
68. Gao N, LeLay J, Vatamaniuk MZ, Rieck S, Friedman JR, Kaestner KH 2008 Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev 22:3435-3448