Paracrinology of islets and the paracrinopathy of diabetes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 37, 2010, Pages 16009-16012

  Unger, Roger H ^a,b   Orci, Lelio ^c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Glucagon; Glycemic control; Insulin; Leptin; Type 1 diabetes

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN; INSULIN ANTIBODY; LEPTIN; RECOMBINANT LEPTIN; GLUCOSE BLOOD LEVEL;

BIOMEDICINE; COMPETITIVE INHIBITION; DIABETES MELLITUS; DIABETIC PATIENT; ENDOCRINE DISEASE; GLUCAGON RELEASE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLYCOGENOLYSIS; HUMAN; HYPERGLUCAGONEMIA; HYPERGLYCEMIA; INSULIN DEFICIENCY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN TREATMENT; KETOGENESIS; LIVER; LOW DRUG DOSE; MONOTHERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PARACRINE SIGNALING; PARACRINOLOGY; PARACRINOPATHY; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; ANIMAL; METABOLISM;

MUS;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; GLUCAGON; GLUCAGON-SECRETING CELLS; HUMANS; INSULIN-SECRETING CELLS; PARACRINE COMMUNICATION;

EID: 77958014883     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1006639107     Document Type: Review

References (33)

1. Müller WA, Faloona GR, Unger RH (1971) The effect of experimental insulin deficiency on glucagon secretion. J Clin Invest 50:1992-1999.
2. Samols E, Bonner-Weir S, Weir GC (1986) Intra-islet insulin-glucagon- somatostatin relationships. Clin Endocrinol Metab 15:33-58.
3. Unger RH, Aguilar-Parada E, Müller WA, Eisentraut AM (1970) Studies of pancreatic alpha cell function in normal and diabetic subjects. J Clin Invest 49:837-848.
4. Unger RH, Orci L (1981) Glucagon and the A cell: Physiology and pathophysiology (first two parts). N Engl J Med 304:1518-1524.
5. Exton JH, et al. (1970) The hormonal control of hepatic gluconeogenesis. Recent Prog Horm Res 26:411-461.
6. Cherrington AD, Chiasson JL, Liljenquist JE, Lacy WW, Park CR (1978) Control of hepatic glucose output by glucagon and insulin in the intact dog. Biochem Soc Symp 43):31-45.
7. Keller U, et al. (1977) The roles of insulin, glucagon, and free fatty acids in the regulation of ketogenesis in dogs. Diabetes 26:1040-1051. (Pubitemid 8229936)
8. Baetens D, Malaisse-Lagae F, Perrelet A, Orci L (1979) Endocrine pancreas: three-dimensional reconstruction shows two types of islets of langerhans. Science 206:1323-1325. (Pubitemid 10170025)
9. Bonner-Weir S, Orci L (1982) New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes 31:883-889.
10. Maruyama H, Hisatomi A, Orci L, Grodsky GM, Unger RH (1984) Insulin within islets is a physiologic glucagon release inhibitor. J Clin Invest 74:2296-2299.
11. Bosco D, et al. (2010) Unique arrangement of alpha- and beta-cells in human islets of Langerhans. Diabetes 59:1202-1210.
12. Orci L (1982) Macro- and micro-domains in the endocrine pancreas. Diabetes 31:538-565.
13. Cabrera O, et al. (2006) The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci USA 103:2334-2339. (Pubitemid 43271670)
14. Gerich JE (2002) Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes? Diabetes 51 (suppl 1):S117-S121.
15. Dobbs R, et al. (1975) Glucagon: Role in the hyperglycemia of diabetes mellitus. Science 187:544-547.
16. Gerich JE, et al. (1975) Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon. N Engl J Med 292:985-989.
17. Raskin P, Unger RH (1978) Hyperglucagonemia and its suppression. Importance in the metabolic control of diabetes. N Engl J Med 299:433-436.
18. Wang MY, et al. (2010) Leptin therapy in insulin-deficient type I diabetes. Proc Natl Acad Sci USA 107:4813-4819.
19. Yu X, Park BH, Wang MY, Wang ZV, Unger RH (2008) Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci USA 105:14070-14075.
20. Rivera N, et al. (2007) A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog. J Pharmacol Exp Ther 321:743-752.
21. Braaten JT, Faloona GR, Unger RH (1974) The effect of insulin on the alpha-cell response to hyperglycemia in long-standing alloxan diabetes. J Clin Invest 53:1017-1021.
22. Le Marchand SJ, Piston DW (2010) Glucose suppression of glucagon secretion: metabolic and calcium responses from alpha-cells in intact mouse pancreatic islets. J Biol Chem 285:14389-14398.
23. Hovorka R, et al. (2010) Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial. Lancet 375:743-751.
24. Wilinska ME, et al. (2009) Overnight closed-loop insulin delivery with model predictive control: Assessment of hypoglycemia and hyperglycemia risk using simulation studies. J Diabetes Sci Tech 3:1109-1120.
25. Tominaga M, et al. (1987) Morphologic and functional changes in sympathetic nerve relationships with pancreatic alpha-cells after destruction of beta-cells in rats. Diabetes 36:365-373. (Pubitemid 18028430)
26. Hedbacker K, et al. (2010) Antidiabetic effects of IGFBP2, a leptin-regulated gene. Cell Metab 11:11-22.
27. Shulman GI (2004) Unraveling the cellular mechanism of insulin resistance in humans: new insights from magnetic resonance spectroscopy. Physiology (Bethesda) 19:183-190.
28. Larsen J, et al. (2002) Silent coronary atheromatosis in type 1 diabetic patients and its relation to long-term glycemic control. Diabetes 51:2637-2641.
29. Orchard TJ, Costacou T, Kretowski A, Nesto RW (2006) Type 1 diabetes and coronary artery disease. Diabetes Care 29:2528-2538. (Pubitemid 44912266)
30. Bonner-Weir S, O'Brien TD (2008) Islets in type 2 diabetes: In honor of Dr. Robert C. Turner. Diabetes 57:2899-2904.
31. Derr R, Garrett E, Stacy GA, Saudek CD (2003) Is HbA (1c) affected by glycemic instability? Diabetes Care 26:2728-2733.
32. Ward WK, Beard JC, Halter JB, Porte D Jr (1985) Pathophysiology of insulin secretion in diabetes mellitus. Adv Exp Med Biol 189:137-158.
33. Müller WA, Faloona GR, Aguilar-Parada E, Unger RH (1970) Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion. N Engl J Med 283:109-115.