Conversion of Mature Human β-Cells into Glucagon- Producing α-Cells

Diabetes

Volumn 62, Issue 7, 2013, Pages 2471-2480

  Spijker, H S ^a   Ravelli, Raimond B G ^a   Mommaas Kienhuis, A Mieke ^a   Van Apeldoorn, Aart A ^b   Engelse, Marten A ^a   Zaldumbide, Arnaud ^a   Bonner Weir, Susan ^c   Rabelink, Ton J ^a   Hoeben, Rob C ^a   Clevers, Hans ^d   Mummery, Christine L ^a   Carlotti, Françoise ^a   De Koning, Eelco J P ^a,d  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF TWENTE   (Netherlands)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HUBRECHT INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; LENTIVIRUS VECTOR; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PDX 1; GLUCOSE; HOMEODOMAIN PROTEIN; INSULIN; NKX6 1 PROTEIN, HUMAN; NKX6-1 PROTEIN, HUMAN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL AGGREGATION; CELL LINEAGE; CELL MATURATION; CELL STRUCTURE; DNA MODIFICATION; ENDOCRINE CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; LENTIVIRINAE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; ADULT; AGED; ANIMAL; CELL TRANSDIFFERENTIATION; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; MIDDLE AGED; PANCREAS ISLET; PHYSIOLOGY;

ADULT; AGED; ANIMALS; CELL LINEAGE; CELL TRANSDIFFERENTIATION; GLUCAGON-SECRETING CELLS; GLUCOSE; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MIDDLE AGED; TRANS-ACTIVATORS;

EID: 84883722508     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1001     Document Type: Article

References (31)

1. Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A. The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci USA 2006;103:2334-2339
2. Brissova M, Fowler MJ, Nicholson WE, et al. Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy. J Histochem Cytochem 2005;53:1087-1097
3. Bosco D, Armanet M, Morel P, et al. Unique arrangement of alpha- and beta-cells in human islets of Langerhans. Diabetes 2010;59:1202-1210
4. Seymour PA, Sander M. Historical perspective: beginnings of the betacell: current perspectives in beta-cell development. Diabetes 2011;60: 364-376
5. Courtney M, Pfeifer A, Al-Hasani K, et al. In vivo conversion of adult α-cells into β-like cells: a new research avenue in the context of type 1 diabetes. Diabetes Obes Metab 2011;13(Suppl. 1):47-52
6. Sander M, Sussel L, Conners J, et al. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development 2000;127:5533-5540
7. Szabat M, Lynn FC, Hoffman BG, Kieffer TJ, Allan DW, Johnson JD. Maintenance of b-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology. Diabetes 2012;61:1365- 1371
8. Ferber S, Halkin A, Cohen H, et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 2000;6:568-572
9. Kojima H, Fujimiya M, Matsumura K, et al. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 2003;9:596-603
10. Collombat P, Xu X, Ravassard P, et al. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 2009;138:449-462
11. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008; 455:627-632
12. Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV. Context-specific α to-β-cell reprogramming by forced Pdx1 expression. Genes Dev 2011;25: 1680-1685
13. Thorel F, Népote V, Avril I, et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 2010;464:1149-1154
14. Ricordi C, Lacy PE, Finke EH, Olack BJ, Scharp DW. Automated method for isolation of human pancreatic islets. Diabetes 1988;37:413-420
15. Rivron NC, Rouwkema J, Truckenmüller R, Karperien M, De Boer J, Van Blitterswijk CA. Tissue assembly and organization: developmental mechanisms in microfabricated tissues. Biomaterials 2009;30:4851-4858
16. Russ HA, Ravassard P, Kerr-Conte J, Pattou F, Efrat S. Epithelialmesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells. PLoS ONE 2009;4:e6417
17. Carlotti F, Bazuine M, Kekarainen T, et al. Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes. Mol Ther 2004;9:209- 217
18. Faas FG, Avramut MC, van den Berg BM, Mommaas AM, Koster AJ, Ravelli RB. Virtual nanoscopy: generation of ultra-large high resolution electron microscopy maps. J Cell Biol 2012;198:457-469
19. Bar-Nur O, Russ HA, Efrat S, Benvenisty N. Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell 2011; 9:17-23
20. Pisania A, Weir GC, O'Neil JJ, et al. Quantitative analysis of cell composition and purity of human pancreatic islet preparations. Lab Invest 2010; 90:1661-1675
21. Vierbuchen T, Wernig M. Direct lineage conversions: unnatural but useful? Nat Biotechnol 2011;29:892-907
22. Sapir T, Shternhall K, Meivar-Levy I, et al. Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells. Proc Natl Acad Sci USA 2005;102:7964-7969
23. Russ HA, Bar Y, Ravassard P, Efrat S. In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing. Diabetes 2008;57:1575-1583 H.S
24. Zhou Q, Melton DA. Extreme makeover: converting one cell into another. Cell Stem Cell 2008;3:382-388
25. Talchai C, Xuan S, Lin HV, Sussel L, Accili D. Pancreatic b cell dedifferentiation as a mechanism of diabetic b cell failure. Cell 2012;150:1223- 1234
26. Papizan JB, Singer RA, Tschen SI, et al. Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes Dev 2011;25:2291-2305
27. Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A. Pancreatic b cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell 2011;20:419-429
28. Deng S, Vatamaniuk M, Huang X, et al. Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects. Diabetes 2004; 53:624-632
29. Henquin JC, Rahier J. Pancreatic alpha cell mass in European subjects with type 2 diabetes. Diabetologia 2011;54:1720-1725
30. Jonas JC, Sharma A, Hasenkamp W, et al. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem 1999;274:14112-14121
31. Thorel F, Damond N, Chera S, et al. Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. Diabetes 2011;60: 2872-2882