-
1
-
-
0026063384
-
Structure and pancreatic expression of the insulin and glucagon genes.
-
Philippe J. Structure and pancreatic expression of the insulin and glucagon genes. Endocr Rev 1991; 12: 252-271.
-
(1991)
Endocr Rev
, vol.12
, pp. 252-271
-
-
Philippe, J.1
-
2
-
-
47849093381
-
Mechanisms underlying proglucagon gene expression.
-
Jin T. Mechanisms underlying proglucagon gene expression. J Endocrinol 2008; 198: 17-28.
-
(2008)
J Endocrinol
, vol.198
, pp. 17-28
-
-
Jin, T.1
-
3
-
-
33846856711
-
Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains.
-
Gromada J, Franklin I, Wollheim CB. Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 2007; 28: 84-116.
-
(2007)
Endocr Rev
, vol.28
, pp. 84-116
-
-
Gromada, J.1
Franklin, I.2
Wollheim, C.B.3
-
4
-
-
0033955566
-
Transcription factors involved in pancreatic islet development.
-
Huang HP, Tsai MJ. Transcription factors involved in pancreatic islet development. J Biomed Sci 2000; 7: 27-34.
-
(2000)
J Biomed Sci
, vol.7
, pp. 27-34
-
-
Huang, H.P.1
Tsai, M.J.2
-
5
-
-
36849075622
-
Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression.
-
Gosmain Y, Avril I, Mamin A, Philippe J. Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression. J Biol Chem 2007; 282: 35024-35034.
-
(2007)
J Biol Chem
, vol.282
, pp. 35024-35034
-
-
Gosmain, Y.1
Avril, I.2
Mamin, A.3
Philippe, J.4
-
6
-
-
0036139165
-
Hepatic nuclear factor-3 (HNF-3 or Foxa2) regulates glucagon gene transcription by binding to the G1 and G2 promoter elements.
-
Gauthier BR, Schwitzgebel VM, Zaiko M, Mamin A, Ritz-Laser B, Philippe J. Hepatic nuclear factor-3 (HNF-3 or Foxa2) regulates glucagon gene transcription by binding to the G1 and G2 promoter elements. Mol Endocrinol 2002; 16: 170-183.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 170-183
-
-
Gauthier, B.R.1
Schwitzgebel, V.M.2
Zaiko, M.3
Mamin, A.4
Ritz-Laser, B.5
Philippe, J.6
-
7
-
-
0033548148
-
Pax-6 and Cdx-2/3 interact to activate glucagon gene expression on the G1 control element.
-
Ritz-Laser B, Estreicher A, Klages N, Saule S, Philippe J. Pax-6 and Cdx-2/3 interact to activate glucagon gene expression on the G1 control element. J Biol Chem 1999; 274: 4124-4132.
-
(1999)
J Biol Chem
, vol.274
, pp. 4124-4132
-
-
Ritz-Laser, B.1
Estreicher, A.2
Klages, N.3
Saule, S.4
Philippe, J.5
-
8
-
-
0030914931
-
Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas.
-
St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P. Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature 1997; 387: 406-409.
-
(1997)
Nature
, vol.387
, pp. 406-409
-
-
St-Onge, L.1
Sosa-Pineda, B.2
Chowdhury, K.3
Mansouri, A.4
Gruss, P.5
-
9
-
-
0033557490
-
Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo.
-
Kaestner KH, Katz J, Liu Y, Drucker DJ, Schutz G. Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo. Genes Dev 1999; 13: 495-504.
-
(1999)
Genes Dev
, vol.13
, pp. 495-504
-
-
Kaestner, K.H.1
Katz, J.2
Liu, Y.3
Drucker, D.J.4
Schutz, G.5
-
10
-
-
12944336527
-
Foxa2 is required for the differentiation of pancreatic alpha-cells.
-
Lee CS, Sund NJ, Behr R, Herrera PL, Kaestner KH. Foxa2 is required for the differentiation of pancreatic alpha-cells. Dev Biol 2005; 278: 484-495.
-
(2005)
Dev Biol
, vol.278
, pp. 484-495
-
-
Lee, C.S.1
Sund, N.J.2
Behr, R.3
Herrera, P.L.4
Kaestner, K.H.5
-
11
-
-
0032493623
-
Differential regulation of the glucagon and insulin I gene promoters by the basic helix-loop-helix transcription factors E47 and BETA2.
-
Dumonteil E, Laser B, Constant I, Philippe J. Differential regulation of the glucagon and insulin I gene promoters by the basic helix-loop-helix transcription factors E47 and BETA2. J Biol Chem 1998; 273: 19945-19954.
-
(1998)
J Biol Chem
, vol.273
, pp. 19945-19954
-
-
Dumonteil, E.1
Laser, B.2
Constant, I.3
Philippe, J.4
-
12
-
-
20044382778
-
Essential interaction of Egr-1 at an islet-specific response element for basal and gastrin-dependent glucagon gene transactivation in pancreatic alpha-cells.
-
Leung-Theung-Long S, Roulet E, Clerc P et al. Essential interaction of Egr-1 at an islet-specific response element for basal and gastrin-dependent glucagon gene transactivation in pancreatic alpha-cells. J Biol Chem 2005; 280: 7976-7984.
-
(2005)
J Biol Chem
, vol.280
, pp. 7976-7984
-
-
Leung-Theung-Long, S.1
Roulet, E.2
Clerc, P.3
-
13
-
-
14844312096
-
The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression.
-
Ritz-Laser B, Mamin A, Brun T, Avril I, Schwitzgebel VM, Philippe J. The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression. Mol Endocrinol 2005; 19: 759-770.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 759-770
-
-
Ritz-Laser, B.1
Mamin, A.2
Brun, T.3
Avril, I.4
Schwitzgebel, V.M.5
Philippe, J.6
-
14
-
-
0025221222
-
Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells.
-
Knepel W, Chafitz J, Habener JF. Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells. Mol Cell Biol 1990; 10: 6799-6804.
-
(1990)
Mol Cell Biol
, vol.10
, pp. 6799-6804
-
-
Knepel, W.1
Chafitz, J.2
Habener, J.F.3
-
15
-
-
0142091542
-
Opposing actions of Arx and Pax4 in endocrine pancreas development.
-
Collombat P, Mansouri A, Hecksher-Sorensen J et al. Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev 2003; 17: 2591-2603.
-
(2003)
Genes Dev
, vol.17
, pp. 2591-2603
-
-
Collombat, P.1
Mansouri, A.2
Hecksher-Sorensen, J.3
-
16
-
-
23144432613
-
The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas.
-
Collombat P, Hecksher-Sorensen J, Broccoli V et al. The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. Development 2005; 132: 2969-2980.
-
(2005)
Development
, vol.132
, pp. 2969-2980
-
-
Collombat, P.1
Hecksher-Sorensen, J.2
Broccoli, V.3
-
18
-
-
10744230721
-
Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription.
-
Ritz-Laser B, Gauthier BR, Estreicher A et al. Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription. Diabetologia 2003; 46: 810-821.
-
(2003)
Diabetologia
, vol.46
, pp. 810-821
-
-
Ritz-Laser, B.1
Gauthier, B.R.2
Estreicher, A.3
-
19
-
-
0036165598
-
The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6.
-
Ritz-Laser B, Estreicher A, Gauthier BR, Mamin A, Edlund H, Philippe J. The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6. Diabetologia 2002; 45: 97-107.
-
(2002)
Diabetologia
, vol.45
, pp. 97-107
-
-
Ritz-Laser, B.1
Estreicher, A.2
Gauthier, B.R.3
Mamin, A.4
Edlund, H.5
Philippe, J.6
-
20
-
-
34247853278
-
The beta-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6.
-
Gauthier BR, Gosmain Y, Mamin A, Philippe J. The beta-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6. Biochem J 2007; 403: 593-601.
-
(2007)
Biochem J
, vol.403
, pp. 593-601
-
-
Gauthier, B.R.1
Gosmain, Y.2
Mamin, A.3
Philippe, J.4
-
21
-
-
0030897629
-
The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas.
-
Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P. The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature 1997; 386: 399-402.
-
(1997)
Nature
, vol.386
, pp. 399-402
-
-
Sosa-Pineda, B.1
Chowdhury, K.2
Torres, M.3
Oliver, G.4
Gruss, P.5
-
22
-
-
0032525981
-
Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes.
-
Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H. Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 1998; 12: 1763-1768.
-
(1998)
Genes Dev
, vol.12
, pp. 1763-1768
-
-
Ahlgren, U.1
Jonsson, J.2
Jonsson, L.3
Simu, K.4
Edlund, H.5
-
23
-
-
0035816695
-
Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation.
-
Wang H, Maechler P, Ritz-Laser B et al. Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation. J Biol Chem 2001; 276: 25279-25286.
-
(2001)
J Biol Chem
, vol.276
, pp. 25279-25286
-
-
Wang, H.1
Maechler, P.2
Ritz-Laser, B.3
-
24
-
-
0036301577
-
Pancreatic organogenesis-developmental mechanisms and implications for therapy.
-
Edlund H. Pancreatic organogenesis-developmental mechanisms and implications for therapy. Nat Rev Genet 2002; 3: 524-532.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 524-532
-
-
Edlund, H.1
-
25
-
-
1842330860
-
Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.
-
Sander M, Neubuser A, Kalamaras J, Ee HC, Martin GR, German MS. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev 1997; 11: 1662-1673.
-
(1997)
Genes Dev
, vol.11
, pp. 1662-1673
-
-
Sander, M.1
Neubuser, A.2
Kalamaras, J.3
Ee, H.C.4
Martin, G.R.5
German, M.S.6
-
26
-
-
59449095319
-
Not for the eyes only: PAX6 and glucose metabolism.
-
Laakso M. Not for the eyes only: PAX6 and glucose metabolism. Diabetologia 2009; 52: 381-384.
-
(2009)
Diabetologia
, vol.52
, pp. 381-384
-
-
Laakso, M.1
-
27
-
-
20944441968
-
A case of novel de novo paired box gene 6 (PAX6) mutation with early-onset diabetes mellitus and aniridia.
-
Nishi M, Sasahara M, Shono T et al. A case of novel de novo paired box gene 6 (PAX6) mutation with early-onset diabetes mellitus and aniridia. Diabet Med 2005; 22: 641-644.
-
(2005)
Diabet Med
, vol.22
, pp. 641-644
-
-
Nishi, M.1
Sasahara, M.2
Shono, T.3
-
28
-
-
14544284571
-
Precocious retinal neurons. Pax6 controls timing of differentiation and determination of cell type.
-
Philips GT, Stair CN, Young Lee H et al. Precocious retinal neurons. Pax6 controls timing of differentiation and determination of cell type. Dev Biol 2005; 279: 308-321.
-
(2005)
Dev Biol
, vol.279
, pp. 308-321
-
-
Philips, G.T.1
Stair, C.N.2
Young Lee, H.3
-
29
-
-
1942489373
-
Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes.
-
Ashery-Padan R, Zhou X, Marquardt T et al. Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes. Dev Biol 2004; 269: 479-488.
-
(2004)
Dev Biol
, vol.269
, pp. 479-488
-
-
Ashery-Padan, R.1
Zhou, X.2
Marquardt, T.3
-
30
-
-
77950631621
-
Relative roles of the different Pax6 domains for pancreatic alpha cell development.
-
Dames P, Puff R, Weise M et al. Relative roles of the different Pax6 domains for pancreatic alpha cell development. BMC Dev Biol 2010; 10: 39.
-
(2010)
BMC Dev Biol
, vol.10
, pp. 39
-
-
Dames, P.1
Puff, R.2
Weise, M.3
-
31
-
-
55049119613
-
Concise review: Pax6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator.
-
Osumi N, Shinohara H, Numayama-Tsuruta K, Maekawa M. Concise review: Pax6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator. Stem Cells 2008; 26: 1663-1672.
-
(2008)
Stem Cells
, vol.26
, pp. 1663-1672
-
-
Osumi, N.1
Shinohara, H.2
Numayama-Tsuruta, K.3
Maekawa, M.4
-
32
-
-
77958512364
-
Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function.
-
Gosmain Y, Marthinet E, Cheyssac C et al. Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function. J Biol Chem 2010; 285: 33381-33393.
-
(2010)
J Biol Chem
, vol.285
, pp. 33381-33393
-
-
Gosmain, Y.1
Marthinet, E.2
Cheyssac, C.3
-
33
-
-
64649098184
-
Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2.
-
Katz LS, Gosmain Y, Marthinet E, Philippe J. Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2. Mol Cell Biol 2009; 29: 2322-2334.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2322-2334
-
-
Katz, L.S.1
Gosmain, Y.2
Marthinet, E.3
Philippe, J.4
-
34
-
-
0028898921
-
7B2 is a specific intracellular binding protein of the prohormone convertase PC2.
-
Benjannet S, Savaria D, Chretien M, Seidah NG. 7B2 is a specific intracellular binding protein of the prohormone convertase PC2. J Neurochem 1995; 64: 2303-2311.
-
(1995)
J Neurochem
, vol.64
, pp. 2303-2311
-
-
Benjannet, S.1
Savaria, D.2
Chretien, M.3
Seidah, N.G.4
-
35
-
-
0036091266
-
The lethal form of Cushing's in 7B2 null mice is caused by multiple metabolic and hormonal abnormalities.
-
Sarac MS, Zieske AW, Lindberg I. The lethal form of Cushing's in 7B2 null mice is caused by multiple metabolic and hormonal abnormalities. Endocrinology 2002; 143: 2324-2332.
-
(2002)
Endocrinology
, vol.143
, pp. 2324-2332
-
-
Sarac, M.S.1
Zieske, A.W.2
Lindberg, I.3
-
36
-
-
0033525771
-
The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease.
-
Westphal CH, Muller L, Zhou A et al. The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease. Cell 1999; 96: 689-700.
-
(1999)
Cell
, vol.96
, pp. 689-700
-
-
Westphal, C.H.1
Muller, L.2
Zhou, A.3
-
37
-
-
38949155905
-
Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.
-
Nishimura W, Rowan S, Salameh T et al. Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol 2008; 314: 443-456.
-
(2008)
Dev Biol
, vol.314
, pp. 443-456
-
-
Nishimura, W.1
Rowan, S.2
Salameh, T.3
-
38
-
-
0030886674
-
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice.
-
Naya FJ, Huang HP, Qiu Y et al. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 1997; 11: 2323-2334.
-
(1997)
Genes Dev
, vol.11
, pp. 2323-2334
-
-
Naya, F.J.1
Huang, H.P.2
Qiu, Y.3
-
39
-
-
43549108142
-
Glucolipotoxicity: fuel excess and beta-cell dysfunction.
-
Poitout V, Robertson RP. Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev 2008; 29: 351-366.
-
(2008)
Endocr Rev
, vol.29
, pp. 351-366
-
-
Poitout, V.1
Robertson, R.P.2
-
40
-
-
0016423677
-
The essential role of glucagon in the pathogenesis of diabetes mellitus.
-
Unger RH, Orci L. The essential role of glucagon in the pathogenesis of diabetes mellitus. Lancet 1975; 1: 14-16.
-
(1975)
Lancet
, vol.1
, pp. 14-16
-
-
Unger, R.H.1
Orci, L.2
-
41
-
-
24944577486
-
Alpha cell function in health and disease: influence of glucagon-like peptide-1.
-
Dunning BE, Foley JE, Ahren B. Alpha cell function in health and disease: influence of glucagon-like peptide-1. Diabetologia 2005; 48: 1700-1713.
-
(2005)
Diabetologia
, vol.48
, pp. 1700-1713
-
-
Dunning, B.E.1
Foley, J.E.2
Ahren, B.3
-
42
-
-
0037000489
-
Anx7 is required for nutritional control of gene expression in mouse pancreatic islets of Langerhans.
-
Srivastava M, Eidelman O, Leighton X, Glasman M, Goping G, Pollard HB. Anx7 is required for nutritional control of gene expression in mouse pancreatic islets of Langerhans. Mol Med 2002; 8: 781-797.
-
(2002)
Mol Med
, vol.8
, pp. 781-797
-
-
Srivastava, M.1
Eidelman, O.2
Leighton, X.3
Glasman, M.4
Goping, G.5
Pollard, H.B.6
-
43
-
-
0033553462
-
Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes.
-
Jonas JC, Sharma A, Hasenkamp W et al. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem 1999; 274: 14112-14121.
-
(1999)
J Biol Chem
, vol.274
, pp. 14112-14121
-
-
Jonas, J.C.1
Sharma, A.2
Hasenkamp, W.3
-
44
-
-
0037474332
-
Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes.
-
Laybutt DR, Glandt M, Xu G et al. Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes. J Biol Chem 2003; 278: 2997-3005.
-
(2003)
J Biol Chem
, vol.278
, pp. 2997-3005
-
-
Laybutt, D.R.1
Glandt, M.2
Xu, G.3
-
45
-
-
24144496798
-
Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.
-
Kjorholt C, Akerfeldt MC, Biden TJ, Laybutt DR. Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. Diabetes 2005; 54: 2755-2763.
-
(2005)
Diabetes
, vol.54
, pp. 2755-2763
-
-
Kjorholt, C.1
Akerfeldt, M.C.2
Biden, T.J.3
Laybutt, D.R.4
-
46
-
-
33747796601
-
Transcription factors of beta-cell differentiation and maturation in isolated human islets: effects of high glucose, high free fatty acids and type 2 diabetes.
-
Lupi R, Bugliani M, Del Guerra S et al. Transcription factors of beta-cell differentiation and maturation in isolated human islets: effects of high glucose, high free fatty acids and type 2 diabetes. Nutr Metab Cardiovasc Dis 2006; 16: e7-e8.
-
(2006)
Nutr Metab Cardiovasc Dis
, vol.16
-
-
Lupi, R.1
Bugliani, M.2
Del Guerra, S.3
-
47
-
-
0032415359
-
Pax 4 and 6 regulate gastrointestinal endocrine cell development.
-
Larsson LI, St-Onge L, Hougaard DM, Sosa-Pineda B, Gruss P. Pax 4 and 6 regulate gastrointestinal endocrine cell development. Mech Dev 1998; 79: 153-159.
-
(1998)
Mech Dev
, vol.79
, pp. 153-159
-
-
Larsson, L.I.1
St-Onge, L.2
Hougaard, D.M.3
Sosa-Pineda, B.4
Gruss, P.5
-
48
-
-
0033305721
-
Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription.
-
Hill ME, Asa SL, Drucker DJ. Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription. Mol Endocrinol 1999; 13: 1474-1486.
-
(1999)
Mol Endocrinol
, vol.13
, pp. 1474-1486
-
-
Hill, M.E.1
Asa, S.L.2
Drucker, D.J.3
|