Stabilization of G protein-coupled receptors by point mutations

Frontiers in Pharmacology

Volumn 6, Issue MAR, 2015, Pages

  Heydenreich, Franziska M ^a,b   Vuckovic, Ziva ^a,b   Matkovic, Milos ^a,b   Veprintsev, Dmitry B ^a,b  

^a PAUL SCHERRER INSTITUTE   (Switzerland)

^b ETH ZURICH   (Switzerland)

Author keywords

Alanine scanning; Conformational thermostabilization; G protein coupled receptors; GPCRs; Pharmacology; Protein engineering; Stabilizing mutations

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR;

ARTICLE; DENATURATION; DIRECTED MOLECULAR EVOLUTION; FLUORESCENCE; FLUOROMETRY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; LIGAND BINDING; MUTAGENESIS; NONHUMAN; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; THERMOSTABILITY;

EID: 84926677065     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2015.00082     Document Type: Article

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