-
5
-
-
0024293979
-
Single-chain antigen-binding proteins
-
(1988)
Science
, vol.242
, pp. 423-426
-
-
Bird, R.E.1
Hardmann, K.D.2
Jacobson, J.W.3
Johnson, S.4
Kaufman, B.M.5
Lee, S.6
Lee, T.7
Pope, S.H.8
Riordan, G.S.9
Whitlow, M.10
-
19
-
-
0032408704
-
Absolute conservation of residue 6 of immunoglobulin heavy chain variable regions of class IIA is required for correct folding
-
(1998)
Protein Eng.
, vol.11
, pp. 1267-1276
-
-
De Haard, H.J.W.1
Kazemier, B.2
Van der Bent, A.3
Oudshoorn, P.4
Boender, P.5
Van Gemen, B.6
Arends, J.-W.7
Hoogenboom, H.R.8
-
22
-
-
0027958069
-
The use of fluorescence methods to monitor unfolding transitions in proteins
-
(1994)
Biophys. J.
, vol.66
, pp. 482-501
-
-
Eftink, M.R.1
-
31
-
-
0030320813
-
Contribution of the intramolecular disulfide bridge to the folding stability of REI(v), the variable domain of a human immunoglobulin kappa light chain
-
(1996)
Folding Des.
, vol.1
, pp. 431-440
-
-
Frisch, C.1
Kolmar, H.2
Schmidt, A.3
Kleemann, G.4
Reinhardt, A.5
Pohl, E.6
Usón, I.7
Schneider, T.T.8
Fritz, H.J.9
-
34
-
-
0030814645
-
IMGT, the international ImMunoGeneTics database
-
(1997)
Nucl. Acids Res.
, vol.25
, pp. 206-211
-
-
Giudicelli, V.1
Chaume, D.2
Bodmer, J.3
Muller, W.4
Busin, C.5
Marsh, S.6
Bontrop, R.7
Marc, L.8
Malik, A.9
Lefranc, M.P.10
-
37
-
-
0018721964
-
The role of the intrachain disulfide bond in the conformation and stability of the constant fragment of the immunoglobulin light chain
-
(1979)
J. Biochem.
, vol.86
, pp. 1433-1441
-
-
Goto, Y.1
Hamaguchi, K.2
-
45
-
-
0031574037
-
Antibody-ribosome-mRNA (ARM), complexes as efficient selection particles for in vitro display and evolution of antibody combining sites
-
(1997)
Nucl. Acids Res.
, vol.25
, pp. 5132-5134
-
-
He, M.Y.1
Taussig, M.J.2
-
51
-
-
0004198722
-
Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digosin single-chain Fv analogue produced in Escherichia coli
-
(1988)
Proc. Natl Acad. Sci. USA
, vol.85
, pp. 5879-5883
-
-
Huston, J.S.1
Levinson, D.2
Mudgett-Hunter, M.3
Tai, M.4
Novotny, J.5
Margolies, M.N.6
Ridge, R.J.7
Bruccoleri, R.E.8
Haber, E.9
Crea, R.10
Oppermann, H.11
-
53
-
-
0027420237
-
Medical applications of single-chain antibodies
-
(1993)
Int. Rev. Immunol.
, vol.10
, pp. 195-217
-
-
Huston, J.S.1
McCartney, J.2
Tai, M.S.3
Mottola-Hartshorn, C.4
Jin, D.5
Warren, F.6
Keck, P.7
Oppermann, H.8
-
55
-
-
0345044918
-
Domain interactions in antibody Fv and scFv fragments: Effects on unfolding kinetics and equilibria
-
(1999)
FEBS Letters
, vol.462
, pp. 307-312
-
-
Jáger, M.1
Plückthun, A.2
-
64
-
-
0025993967
-
Chemical engineering of the monoclonal antibody A7 by polyethylene glycol for targeting cancer chemotherapy
-
(1991)
Cancer Res.
, vol.51
, pp. 4310-4315
-
-
Kitamura, K.1
Takahashi, T.2
Yamaguchi, T.3
Noguchi, A.4
Noguchi, A.5
Takashina, K.6
Tsurumi, H.7
Inagake, M.8
Toyokuni, T.9
Hakomori, S.10
-
66
-
-
0034635335
-
Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides
-
(2000)
J. Mol. Biol.
, vol.296
, pp. 57-86
-
-
Knappik, A.1
Ge, L.2
Honegger, A.3
Pack, P.4
Fischer, M.5
Wellnhofer, G.6
Hoess, A.7
Wölle, J.8
Plückthun, A.9
Virnekäs, B.10
-
71
-
-
0029294009
-
Intracellular antibodies (intrabodies) as research reagents and therapeutic molecules for gene therapy
-
(1995)
Immunotechnology
, vol.1
, pp. 1-19
-
-
Marasco, W.A.1
-
72
-
-
0033214755
-
In vitro folding and thermodynamic stability of an antibody fragment selected in vivo for high expression levels in Escherichia coli cytoplasm
-
(1999)
J. Mol. Biol.
, vol.292
, pp. 921-929
-
-
Martineau, P.1
Betton, J.-M.2
-
80
-
-
0022555885
-
Determination and analysis of urea and guanidine hydrochloride denaturation curves
-
(1986)
Methods Enzymol.
, vol.131
, pp. 266-290
-
-
Pace, C.N.1
-
84
-
-
0025788111
-
Conformational stability, folding, and ligand-binding affinity of single-chain Fv immunoglobulin fragments expressed in Escherichia coli
-
(1991)
Biochemistry
, vol.30
, pp. 10117-10125
-
-
Pantoliano, M.W.1
Bird, R.E.2
Johnson, S.3
Asel, E.D.4
Dodd, S.W.5
Wood, J.F.6
Hardman, K.D.7
-
87
-
-
0027008593
-
Monovalent and bivalent antibody fragments produced in Escherichia coli: Engineering, folding and antigen-binding
-
(1992)
Immunolog. Rev.
, vol.130
, pp. 151-188
-
-
Plückthun, A.1
-
89
-
-
0003046374
-
Producing antibodies in Escherichia coli: From PCR to fermentation
-
McCafferty, J., Hoogenboom, H. R. & Chiswell, D. J., eds, IRL Press, Oxford University Press, New York
-
(1996)
Antibody Engineering, A Practical Approach
, pp. 203-252
-
-
Plückthun, A.1
Krebber, A.2
Horn, U.3
Knüpfer, U.4
Wenderoth, R.5
Nieba, L.6
Proba, K.7
Riesenberg, D.8
-
92
-
-
0033020141
-
Physicochemical consequences of amino acid variations that contribute to fibril formation by immunoglobulin light chains
-
(1999)
Protein Sci.
, vol.8
, pp. 509-517
-
-
Raffen, R.1
Dieckman, L.J.2
Szpunar, M.3
Wunschl, C.4
Pokkuluri, P.R.5
Dave, P.6
Stevens, P.W.7
Cai, X.8
Schiffer, M.9
Stevens, F.J.10
-
99
-
-
0028959129
-
HER2 Fv-β-lactamase fusion protein for activation of a cephalosporin doxorubicin prodrug
-
(1995)
Cancer Res.
, vol.55
, pp. 63-70
-
-
Rodrigues, M.L.1
Presta, L.G.2
Kotts, C.E.3
Wirth, C.4
Mordenti, J.5
Osaka, G.6
Wong, W.L.T.7
Nuijens, A.8
Blackburn, B.9
Carter, P.10
-
103
-
-
0032516802
-
A reversibly unfolding fragment of P22 tailspike protein with native structure: The isolated beta-helix domain
-
(1998)
J. Mol. Biol.
, vol.281
, pp. 227-234
-
-
Schuler, B.1
Seckler, R.2
-
106
-
-
0028944024
-
Comparative thermodynamic analyses of the Fv, Fab* and Fab fragments of anti-dansyl mouse monoclonal antibody
-
(1995)
FEBS Letters
, vol.360
, pp. 247-250
-
-
Shimba, N.1
Torigoe, H.2
Takahashi, H.3
Masuda, K.4
Shimada, I.5
Arata, Y.6
Sarai, A.7
-
113
-
-
0028050350
-
Rapid evolution of a protein in vitro by DNA shuffling
-
(1994)
Nature
, vol.370
, pp. 389-391
-
-
Stemmer, W.P.C.1
-
116
-
-
0033152614
-
A single-chain antibody fragment is functionally expressed in the cytoplasm of both Escherichia coli and transgenic plants
-
(1999)
Eur. J. Biochem.
, vol.262
, pp. 617-624
-
-
Tavladoraki, P.1
Girotti, A.2
Donini, M.3
Arias, F.J.4
Mancini, C.5
Morea, V.6
Chiaraluce, R.7
Consalvi, V.8
Benvenuto, E.9
-
122
-
-
0002869401
-
Unfolding and inactivation: Genetic and chemical approaches to the stabilization of T4 lysozyme and interferon-gamma against irreversible thermal denaturation
-
Poste, G. & Hook, J. B., eds, Plenum, New York
-
(1990)
Protein Design and the Development of New Therapeutics and Vaccines; Proceedings of the Sixth Annual Smith, Kline and French Research Symposium
, pp. 79-115
-
-
Wetzel, R.1
Perry, L.J.2
Mulkerrin, M.G.3
Randall, M.4
-
123
-
-
0027332881
-
An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability
-
(1993)
Protein Eng.
, vol.6
, pp. 989-995
-
-
Whitlow, M.1
Bell, B.A.2
Feng, S.L.3
Filpula, D.4
Hardman, K.D.5
Hubert, S.L.6
Rollence, M.L.7
Wood, J.F.8
Schott, M.E.9
Milenic, D.E.10
Takashi, Y.11
Schlom, J.12
-
132
-
-
0032524034
-
An intrinsically stable antibody scFv fragment can tolerate the loss of both disulfide bonds and fold correctly
-
(1998)
FEBS Letters
, vol.237
, pp. 357-361
-
-
Wörn, A.1
Plückthun, A.2
-
133
-
-
0040964401
-
Different equilibrium stability behavior of scFv fragments: Identification, classification and improvement by protein engineering
-
(1999)
Biochemistry
, vol.38
, pp. 8739-8750
-
-
Wörn, A.1
Plückthun, A.2
|