-
1
-
-
0036088493
-
Rhodopsin: insights from recent structural studies
-
Sakmar T.P., et al. Rhodopsin: insights from recent structural studies. Annu. Rev. Biophys. Biomol. Struct. 31 (2002) 443-484
-
(2002)
Annu. Rev. Biophys. Biomol. Struct.
, vol.31
, pp. 443-484
-
-
Sakmar, T.P.1
-
2
-
-
0037285444
-
Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking
-
Hubbell W.L., et al. Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking. Adv. Protein Chem. 63 (2003) 243-290
-
(2003)
Adv. Protein Chem.
, vol.63
, pp. 243-290
-
-
Hubbell, W.L.1
-
3
-
-
33645535034
-
G protein-coupled receptor rhodopsin
-
Palczewski K. G protein-coupled receptor rhodopsin. Annu. Rev. Biochem. 75 (2006) 743-767
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 743-767
-
-
Palczewski, K.1
-
4
-
-
0347379900
-
The three-dimensional structure of bovine rhodopsin determined by electron cryomicroscopy
-
Krebs A., et al. The three-dimensional structure of bovine rhodopsin determined by electron cryomicroscopy. J. Biol. Chem. 278 (2003) 50217-50225
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 50217-50225
-
-
Krebs, A.1
-
5
-
-
0032500697
-
Characterisation of an improved two-dimensional p22121 crystal from bovine rhodopsin
-
Krebs A., et al. Characterisation of an improved two-dimensional p22121 crystal from bovine rhodopsin. J. Mol. Biol. 282 (1998) 991-1003
-
(1998)
J. Mol. Biol.
, vol.282
, pp. 991-1003
-
-
Krebs, A.1
-
6
-
-
0031847518
-
Structure of rhodopsin
-
Schertler G.F. Structure of rhodopsin. Eye 12 (1998) 504-510
-
(1998)
Eye
, vol.12
, pp. 504-510
-
-
Schertler, G.F.1
-
7
-
-
0030775615
-
Arrangement of rhodopsin transmembrane alpha-helices
-
Unger V.M., et al. Arrangement of rhodopsin transmembrane alpha-helices. Nature 389 (1997) 203-206
-
(1997)
Nature
, vol.389
, pp. 203-206
-
-
Unger, V.M.1
-
8
-
-
0027190359
-
Projection structure of rhodopsin
-
Schertler G.F., et al. Projection structure of rhodopsin. Nature 362 (1993) 770-772
-
(1993)
Nature
, vol.362
, pp. 770-772
-
-
Schertler, G.F.1
-
9
-
-
0343081370
-
X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles
-
Okada T., et al. X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles. J. Struct. Biol. 130 (2000) 73-80
-
(2000)
J. Struct. Biol.
, vol.130
, pp. 73-80
-
-
Okada, T.1
-
10
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
Palczewski K., et al. Crystal structure of rhodopsin: A G protein-coupled receptor. Science 289 (2000) 739-745
-
(2000)
Science
, vol.289
, pp. 739-745
-
-
Palczewski, K.1
-
11
-
-
0037197848
-
Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography
-
Okada T., et al. Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 5982-5987
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 5982-5987
-
-
Okada, T.1
-
12
-
-
0035800032
-
Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs)
-
Teller D.C., et al. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry 40 (2001) 7761-7772
-
(2001)
Biochemistry
, vol.40
, pp. 7761-7772
-
-
Teller, D.C.1
-
13
-
-
4344581120
-
The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
-
Okada T., et al. The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J. Mol. Biol. 342 (2004) 571-583
-
(2004)
J. Mol. Biol.
, vol.342
, pp. 571-583
-
-
Okada, T.1
-
14
-
-
6344248639
-
Structure of bovine rhodopsin in a trigonal crystal form
-
Li J., et al. Structure of bovine rhodopsin in a trigonal crystal form. J. Mol. Biol. 343 (2004) 1409-1438
-
(2004)
J. Mol. Biol.
, vol.343
, pp. 1409-1438
-
-
Li, J.1
-
15
-
-
34548529916
-
Crystal structure of a thermally stable rhodopsin mutant
-
Standfuss J., et al. Crystal structure of a thermally stable rhodopsin mutant. J. Mol. Biol. 372 (2007) 1179-1188
-
(2007)
J. Mol. Biol.
, vol.372
, pp. 1179-1188
-
-
Standfuss, J.1
-
16
-
-
36248970132
-
Crystal structure of the human beta(2) adrenergic G-protein-coupled receptor
-
Rasmussen S.G., et al. Crystal structure of the human beta(2) adrenergic G-protein-coupled receptor. Nature 450 (2007) 383-387
-
(2007)
Nature
, vol.450
, pp. 383-387
-
-
Rasmussen, S.G.1
-
17
-
-
36448995359
-
High-resolution crystal structure of an engineered human {beta}2-Adrenergic G protein coupled receptor
-
Cherezov V., et al. High-resolution crystal structure of an engineered human {beta}2-Adrenergic G protein coupled receptor. Science 318 (2007) 1258-1265
-
(2007)
Science
, vol.318
, pp. 1258-1265
-
-
Cherezov, V.1
-
18
-
-
36448978229
-
GPCR Engineering yields high-resolution structural insights into {beta}2 adrenergic receptor function
-
Rosenbaum D.M., et al. GPCR Engineering yields high-resolution structural insights into {beta}2 adrenergic receptor function. Science 318 (2007) 1266-1273
-
(2007)
Science
, vol.318
, pp. 1266-1273
-
-
Rosenbaum, D.M.1
-
19
-
-
0033771402
-
The superfamily of heptahelical receptors
-
Lefkowitz R.J. The superfamily of heptahelical receptors. Nat. Cell Biol. 2 (2000) E133-E136
-
(2000)
Nat. Cell Biol.
, vol.2
-
-
Lefkowitz, R.J.1
-
20
-
-
0028809411
-
Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor
-
Kobilka B.K. Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor. Anal. Biochem. 231 (1995) 269-271
-
(1995)
Anal. Biochem.
, vol.231
, pp. 269-271
-
-
Kobilka, B.K.1
-
21
-
-
34447633368
-
Conformational complexity of G-protein-coupled receptors
-
Kobilka B.K., and Deupi X. Conformational complexity of G-protein-coupled receptors. Trends Pharmacol. Sci. 28 (2007) 397-406
-
(2007)
Trends Pharmacol. Sci.
, vol.28
, pp. 397-406
-
-
Kobilka, B.K.1
Deupi, X.2
-
22
-
-
35748947246
-
A monoclonal antibody for G protein-coupled receptor crystallography
-
Day P.W., et al. A monoclonal antibody for G protein-coupled receptor crystallography. Nat. Methods 4 (2007) 927-929
-
(2007)
Nat. Methods
, vol.4
, pp. 927-929
-
-
Day, P.W.1
-
23
-
-
0028890031
-
Structure at 2.8 A resolution of cytochrome c oxidase from Paracoccus denitrificans
-
Iwata S., et al. Structure at 2.8 A resolution of cytochrome c oxidase from Paracoccus denitrificans. Nature 376 (1995) 660-669
-
(1995)
Nature
, vol.376
, pp. 660-669
-
-
Iwata, S.1
-
24
-
-
0035499892
-
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution
-
Zhou Y., et al. Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution. Nature 414 (2001) 43-48
-
(2001)
Nature
, vol.414
, pp. 43-48
-
-
Zhou, Y.1
-
25
-
-
0029992660
-
Lipidic cubic phases: a novel concept for the crystallization of membrane proteins
-
Landau E.M., and Rosenbusch J.P. Lipidic cubic phases: a novel concept for the crystallization of membrane proteins. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 14532-14535
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 14532-14535
-
-
Landau, E.M.1
Rosenbusch, J.P.2
-
26
-
-
0037391107
-
Membrane protein crystallization
-
Caffrey M. Membrane protein crystallization. J. Struct. Biol. 142 (2003) 108-132
-
(2003)
J. Struct. Biol.
, vol.142
, pp. 108-132
-
-
Caffrey, M.1
-
27
-
-
0031879388
-
Small is beautiful: protein micro-crystallography
-
Cusack S., et al. Small is beautiful: protein micro-crystallography. Nat. Struct. Biol. 5 Suppl (1998) 634-637
-
(1998)
Nat. Struct. Biol.
, vol.5
, Issue.SUPPL
, pp. 634-637
-
-
Cusack, S.1
-
28
-
-
25844439404
-
Protein crystallography microdiffraction
-
Riekel C., et al. Protein crystallography microdiffraction. Curr. Opin. Struct. Biol. 15 (2005) 556-562
-
(2005)
Curr. Opin. Struct. Biol.
, vol.15
, pp. 556-562
-
-
Riekel, C.1
-
29
-
-
17644402459
-
Transduction of receptor signals by beta-arrestins
-
Lefkowitz R.J., and Shenoy S.K. Transduction of receptor signals by beta-arrestins. Science 308 (2005) 512-517
-
(2005)
Science
, vol.308
, pp. 512-517
-
-
Lefkowitz, R.J.1
Shenoy, S.K.2
-
30
-
-
0035800850
-
Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
-
Ballesteros J.A., et al. Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. J. Biol. Chem. 276 (2001) 29171-29177
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 29171-29177
-
-
Ballesteros, J.A.1
-
31
-
-
33746382921
-
Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor
-
Yao X., et al. Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor. Nat. Chem. Biol. 2 (2006) 417-422
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 417-422
-
-
Yao, X.1
-
32
-
-
0029907599
-
Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
-
Farrens D.L., et al. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science 274 (1996) 768-770
-
(1996)
Science
, vol.274
, pp. 768-770
-
-
Farrens, D.L.1
-
33
-
-
14044276985
-
Light-driven activation of beta 2-adrenergic receptor signaling by a chimeric rhodopsin containing the beta 2-adrenergic receptor cytoplasmic loops
-
Kim J.M., et al. Light-driven activation of beta 2-adrenergic receptor signaling by a chimeric rhodopsin containing the beta 2-adrenergic receptor cytoplasmic loops. Biochemistry 44 (2005) 2284-2292
-
(2005)
Biochemistry
, vol.44
, pp. 2284-2292
-
-
Kim, J.M.1
-
34
-
-
0021928722
-
Specificity of the functional interactions of the β-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles
-
Cerione R.A., et al. Specificity of the functional interactions of the β-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. J. Biol. Chem. 260 (1985) 1493-1500
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 1493-1500
-
-
Cerione, R.A.1
-
35
-
-
33846302070
-
The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors
-
Pardo L., et al. The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors. Chem BioChem 8 (2007) 19-24
-
(2007)
Chem BioChem
, vol.8
, pp. 19-24
-
-
Pardo, L.1
-
36
-
-
33646351764
-
Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery
-
Blundell T.L., et al. Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery. Philos. Trans. R. Soc. Lond. B Biol. Sci. 361 (2006) 413-423
-
(2006)
Philos. Trans. R. Soc. Lond. B Biol. Sci.
, vol.361
, pp. 413-423
-
-
Blundell, T.L.1
-
37
-
-
22044441118
-
Fragment-based lead discovery: leads by design
-
Carr R.A., et al. Fragment-based lead discovery: leads by design. Drug Discov. Today 10 (2005) 987-992
-
(2005)
Drug Discov. Today
, vol.10
, pp. 987-992
-
-
Carr, R.A.1
-
38
-
-
33847381100
-
A decade of fragment-based drug design: strategic advances and lessons learned
-
Hajduk P.J., and Greer J. A decade of fragment-based drug design: strategic advances and lessons learned. Nat. Rev. Drug Discov. 6 (2007) 211-219
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 211-219
-
-
Hajduk, P.J.1
Greer, J.2
-
39
-
-
0035816704
-
Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor
-
Ghanouni P., et al. Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor. J. Biol. Chem. 276 (2001) 24433-24436
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 24433-24436
-
-
Ghanouni, P.1
-
40
-
-
0036490372
-
NMR in drug discovery
-
Pellecchia M., et al. NMR in drug discovery. Nat. Rev. Drug Discov. 1 (2002) 211-219
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 211-219
-
-
Pellecchia, M.1
|