-
1
-
-
17644402459
-
Transduction of receptor signals by β-arrestins
-
Lefkowitz R.J., and Shenoy S.K. Transduction of receptor signals by β-arrestins. Science 308 (2005) 512-517
-
(2005)
Science
, vol.308
, pp. 512-517
-
-
Lefkowitz, R.J.1
Shenoy, S.K.2
-
2
-
-
0036473397
-
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
-
Luttrell L.M., and Lefkowitz R.J. The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals. J. Cell Sci. 115 (2002) 455-465
-
(2002)
J. Cell Sci.
, vol.115
, pp. 455-465
-
-
Luttrell, L.M.1
Lefkowitz, R.J.2
-
3
-
-
0141593597
-
β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
-
Azzi M., et al. β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 11406-11411
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 11406-11411
-
-
Azzi, M.1
-
4
-
-
0043235844
-
Ligand-selective receptor conformations revisited: the promise and the problem
-
Kenakin T. Ligand-selective receptor conformations revisited: the promise and the problem. Trends Pharmacol. Sci. 24 (2003) 346-354
-
(2003)
Trends Pharmacol. Sci.
, vol.24
, pp. 346-354
-
-
Kenakin, T.1
-
5
-
-
0036463901
-
Efficacy at G-protein-coupled receptors
-
Kenakin T. Efficacy at G-protein-coupled receptors. Nat. Rev. Drug Discov. 1 (2002) 103-110
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 103-110
-
-
Kenakin, T.1
-
6
-
-
0026320866
-
The energy landscapes and motions of proteins
-
Frauenfelder H., et al. The energy landscapes and motions of proteins. Science 254 (1991) 1598-1603
-
(1991)
Science
, vol.254
, pp. 1598-1603
-
-
Frauenfelder, H.1
-
7
-
-
0029832901
-
Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop
-
Kudo M., et al. Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop. J. Biol. Chem. 271 (1996) 22470-22478
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 22470-22478
-
-
Kudo, M.1
-
8
-
-
0031241723
-
An update on eicosanoids and inhibitors of cyclooxygenase enzyme systems
-
Sharma S., and Sharma S.C. An update on eicosanoids and inhibitors of cyclooxygenase enzyme systems. Indian J. Exp. Biol. 35 (1997) 1025-1031
-
(1997)
Indian J. Exp. Biol.
, vol.35
, pp. 1025-1031
-
-
Sharma, S.1
Sharma, S.C.2
-
9
-
-
0035890182
-
Structural domains of the CB1 cannabinoid receptor that contribute to constitutive activity and G-protein sequestration
-
Nie J., and Lewis D.L. Structural domains of the CB1 cannabinoid receptor that contribute to constitutive activity and G-protein sequestration. J. Neurosci. 21 (2001) 8758-8764
-
(2001)
J. Neurosci.
, vol.21
, pp. 8758-8764
-
-
Nie, J.1
Lewis, D.L.2
-
10
-
-
0036783213
-
Lessons from constitutively active mutants of G protein-coupled receptors
-
Parnot C., et al. Lessons from constitutively active mutants of G protein-coupled receptors. Trends Endocrinol. Metab. 13 (2002) 336-343
-
(2002)
Trends Endocrinol. Metab.
, vol.13
, pp. 336-343
-
-
Parnot, C.1
-
11
-
-
0031018485
-
Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility
-
Gether U., et al. Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility. J. Biol. Chem. 272 (1997) 2587-2590
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 2587-2590
-
-
Gether, U.1
-
12
-
-
0023889603
-
Chimeric α2,β2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity
-
Kobilka B.K., et al. Chimeric α2,β2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. Science 240 (1988) 1310-1316
-
(1988)
Science
, vol.240
, pp. 1310-1316
-
-
Kobilka, B.K.1
-
13
-
-
0029077235
-
Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor
-
Schoneberg T., et al. Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor. J. Biol. Chem. 270 (1995) 18000-18006
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 18000-18006
-
-
Schoneberg, T.1
-
14
-
-
0025007117
-
+, and 5-amino-substituted amiloride analogs
-
+, and 5-amino-substituted amiloride analogs. J. Biol. Chem. 265 (1990) 17318-17322
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 17318-17322
-
-
Wilson, A.L.1
-
15
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
Palczewski K., et al. Crystal structure of rhodopsin: A G protein-coupled receptor. Science 289 (2000) 739-745
-
(2000)
Science
, vol.289
, pp. 739-745
-
-
Palczewski, K.1
-
16
-
-
77957055780
-
Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein coupled receptors
-
Ballesteros J.A., and Weinstein H. Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein coupled receptors. Meth. Neurosci. 25 (1995) 366-428
-
(1995)
Meth. Neurosci.
, vol.25
, pp. 366-428
-
-
Ballesteros, J.A.1
Weinstein, H.2
-
17
-
-
0031446595
-
Structure and function in rhodopsin: rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state
-
Kim J.M., et al. Structure and function in rhodopsin: rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 14273-14278
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 14273-14278
-
-
Kim, J.M.1
-
18
-
-
0028061193
-
A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin
-
Arnis S., et al. A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin. J. Biol. Chem. 269 (1994) 23879-23881
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 23879-23881
-
-
Arnis, S.1
-
19
-
-
0033061256
-
2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6
-
2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6. Mol. Pharmacol. 56 (1999) 175-184
-
(1999)
Mol. Pharmacol.
, vol.56
, pp. 175-184
-
-
Rasmussen, S.G.1
-
21
-
-
0029897495
-
1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation
-
1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation. EMBO J. 15 (1996) 3566-3578
-
(1996)
EMBO J.
, vol.15
, pp. 3566-3578
-
-
Scheer, A.1
-
22
-
-
0030614337
-
1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate
-
1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 808-813
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 808-813
-
-
Scheer, A.1
-
23
-
-
0141811657
-
The role of a conserved region of the second intracellular loop in AT1 angiotensin receptor activation and signaling
-
Gaborik Z., et al. The role of a conserved region of the second intracellular loop in AT1 angiotensin receptor activation and signaling. Endocrinology 144 (2003) 2220-2228
-
(2003)
Endocrinology
, vol.144
, pp. 2220-2228
-
-
Gaborik, Z.1
-
24
-
-
33746382921
-
Coupling ligand structure to specific conformational switches in the β2-adrenoceptor
-
Yao X., et al. Coupling ligand structure to specific conformational switches in the β2-adrenoceptor. Nat. Chem. Biol. 2 (2006) 417-422
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 417-422
-
-
Yao, X.1
-
25
-
-
0029907599
-
Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
-
Farrens D.L., et al. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science 274 (1996) 768-770
-
(1996)
Science
, vol.274
, pp. 768-770
-
-
Farrens, D.L.1
-
26
-
-
0034603147
-
2 adrenoceptor function. Evidence for protonation-dependent activation
-
2 adrenoceptor function. Evidence for protonation-dependent activation. J. Biol. Chem. 275 (2000) 3121-3127
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3121-3127
-
-
Ghanouni, P.1
-
27
-
-
0027513982
-
A mutation-induced activated state of the β2-adrenergic receptor. Extending the ternary complex model
-
Samama P., et al. A mutation-induced activated state of the β2-adrenergic receptor. Extending the ternary complex model. J. Biol. Chem. 268 (1993) 4625-4636
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 4625-4636
-
-
Samama, P.1
-
29
-
-
0037007201
-
Ligands act as pharmacological chaperones and increase the efficiency of δ opioid receptor maturation
-
Petaja-Repo U.E., et al. Ligands act as pharmacological chaperones and increase the efficiency of δ opioid receptor maturation. EMBO J. 21 (2002) 1628-1637
-
(2002)
EMBO J.
, vol.21
, pp. 1628-1637
-
-
Petaja-Repo, U.E.1
-
30
-
-
0031041454
-
The conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII
-
Balmforth A.J., et al. The conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII. J. Biol. Chem. 272 (1997) 4245-4251
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4245-4251
-
-
Balmforth, A.J.1
-
31
-
-
0030614507
-
Mutation of Asn111 in the third transmembrane domain of the AT1A angiotensin II receptor induces its constitutive activation
-
Groblewski T., et al. Mutation of Asn111 in the third transmembrane domain of the AT1A angiotensin II receptor induces its constitutive activation. J. Biol. Chem. 272 (1997) 1822-1826
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 1822-1826
-
-
Groblewski, T.1
-
32
-
-
0030300155
-
The active state of the AT1 angiotensin receptor is generated by angiotensin II induction
-
Noda K., et al. The active state of the AT1 angiotensin receptor is generated by angiotensin II induction. Biochemistry 35 (1996) 16435-16442
-
(1996)
Biochemistry
, vol.35
, pp. 16435-16442
-
-
Noda, K.1
-
33
-
-
0037174606
-
2 Adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch
-
2 Adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch. J. Biol. Chem. 277 (2002) 40989-40996
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 40989-40996
-
-
Shi, L.1
-
34
-
-
0345791508
-
2 adrenoceptor: kinetic evidence for intermediate conformational states
-
2 adrenoceptor: kinetic evidence for intermediate conformational states. J. Biol. Chem. 279 (2004) 686-691
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 686-691
-
-
Swaminath, G.1
-
35
-
-
20444499405
-
Probing the β2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists
-
Swaminath G., et al. Probing the β2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists. J. Biol. Chem. 280 (2005) 22165-22171
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 22165-22171
-
-
Swaminath, G.1
-
36
-
-
2142703828
-
2 adrenergic receptor
-
2 adrenergic receptor. Mol. Pharmacol. 65 (2004) 1181-1190
-
(2004)
Mol. Pharmacol.
, vol.65
, pp. 1181-1190
-
-
Liapakis, G.1
-
38
-
-
0035816704
-
2 adrenergic receptor
-
2 adrenergic receptor. J. Biol. Chem. 276 (2001) 24433-24436
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 24433-24436
-
-
Ghanouni, P.1
-
39
-
-
0035860802
-
The neurokinin A receptor activates calcium and cAMP responses through distinct conformational states
-
Palanche T., et al. The neurokinin A receptor activates calcium and cAMP responses through distinct conformational states. J. Biol. Chem. 276 (2001) 34853-34861
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 34853-34861
-
-
Palanche, T.1
-
40
-
-
2142823785
-
Agonist binding: a multistep process
-
Kobilka B. Agonist binding: a multistep process. Mol. Pharmacol. 65 (2004) 1060-1062
-
(2004)
Mol. Pharmacol.
, vol.65
, pp. 1060-1062
-
-
Kobilka, B.1
|