Thermostabilisation of an agonist-bound conformation of the human adenosine A2A receptor

Journal of Molecular Biology

Volumn 409, Issue 3, 2011, Pages 298-310

  Lebon, Guillaume ^a   Bennett, Kirstie ^b   Jazayeri, Ali ^b   Tate, Christopher G ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b Heptares Therapeutics Ltd   (United Kingdom)

Author keywords

5' N ethylcarboxamidoadenosine; Chinese hamster ovary; CHO; DDM; DM; EDTA; ethylenediaminetetraacetic acid; FBS; fetal bovine serum; G protein coupled receptor; GPCR; n decyl d maltopyranoside; n dodecyl d maltopyranoside; NECA; NG; nonylglucoside; T4 lysozyme; T4L; TM; transmembrane region; wild type; WT

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR ANTAGONIST; MUTANT PROTEIN; SCH 58621; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL INTERACTION; CHO CELL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG RECEPTOR BINDING; HUMAN; LIGAND BINDING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PURIFICATION; PROTEIN STABILITY; THERMOSTABILITY; UNFOLDED PROTEIN RESPONSE; WILD TYPE;

BOVINAE; CRICETULUS GRISEUS;

EID: 79956124396     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.03.075     Document Type: Article

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