Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 1, 2012, Pages 119-124

  Deupi, Xavier ^a   Edwards, Patricia ^b   Singhal, Ankita ^a   Nickle, Benjamin ^c   Oprian, Daniel ^c   Schertler, Gebhard ^a   Standfuss, Jörg ^a  

^a PAUL SCHERRER INSTITUTE   (Switzerland)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c BRANDEIS UNIVERSITY   (United States)

Author keywords

Constitutive activity; GPCRs; Light activated; Rhodopsin

Indexed keywords

11 CIS RETINAL; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE PROTEIN; RHODOPSIN;

ARTICLE; BINDING SITE; CHROMATOPHORE; COMPLEX FORMATION; HUMAN; HUMAN CELL; ILLUMINATION; LIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE;

ANIMALS; BINDING SITES; CATTLE; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEINS; HEK293 CELLS; HUMANS; IONS; MODELS, MOLECULAR; MUTANT PROTEINS; MUTATION; PROTEIN STABILITY; RETINALDEHYDE; RHODOPSIN; SPECTRUM ANALYSIS;

EID: 84855990615     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114089108     Document Type: Article

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