Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 25, 1998, Pages 14675-14680

  Nikolova, Penka V ^a   Henckel, Julia ^a   Lane, David P ^b   Fersht, Alan R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Protein design; Thermodynamic stability

Indexed keywords

MUTANT PROTEIN; PROTEIN P53;

ARTICLE; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN STABILITY; THERMODYNAMICS; TUMOR SUPPRESSOR GENE;

BINDING SITES; DNA-BINDING PROTEINS; DRUG DESIGN; ESCHERICHIA COLI; GENES, TUMOR SUPPRESSOR; HUMANS; MUTAGENESIS, SITE-DIRECTED; PROTEIN ENGINEERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032437592     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.25.14675     Document Type: Article

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