Fragment screening of GPCRs using biophysical methods: Identification of ligands of the adenosine A2A receptor with novel biological activity

ACS Chemical Biology

Volumn 7, Issue 12, 2012, Pages 2064-2073

  Chen, Dan ^a   Errey, James C ^b   Heitman, Laura H ^c   Marshall, Fiona H ^b   Ijzerman, Adriaan P ^c   Siegal, Gregg ^a,d  

^a ZoBio BV   (Netherlands)

^b Heptares Therapeutics Ltd   (United Kingdom)

^c LEIDEN UNIVERSITY   (Netherlands)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2A RECEPTOR; G PROTEIN COUPLED RECEPTOR;

ALLOSTERISM; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; FEASIBILITY STUDY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROCEDURES; TARGET IMMOBILIZED NUCLEAR MAGNETIC RESONANCE SCREENING; WILD TYPE;

ALLOSTERIC SITE; ANIMALS; BIOPHYSICS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; LIGANDS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PURINERGIC P1;

EID: 84871572340     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb300436c     Document Type: Article

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