-
1
-
-
0036286938
-
Novel vertebrate genes and putative regulatory elements identified at kidney disease and NR2E1/ fierce loci
-
Abrahams BS, Mak GM, Berry ML, Palmquist DL, Saionz JR, Tay A, Tan YH, Brenner S, Simpson EM, and Venkatesh B. Novel vertebrate genes and putative regulatory elements identified at kidney disease and NR2E1/ fierce loci. Genomics 80: 45-53, 2002.
-
(2002)
Genomics
, vol.80
, pp. 45-53
-
-
Abrahams, B.S.1
Mak, G.M.2
Berry, M.L.3
Palmquist, D.L.4
Saionz, J.R.5
Tay, A.6
Tan, Y.H.7
Brenner, S.8
Simpson, E.M.9
Venkatesh, B.10
-
2
-
-
33751072935
-
Bioenergetics and the formation of mitochondrial reactive oxygen species
-
Adam-Vizi V and Chinopoulos C. Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci 27: 639-645, 2006.
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 639-645
-
-
Adam-Vizi, V.1
Chinopoulos, C.2
-
3
-
-
79959493954
-
Targeting capacity and conservation of PreP homologues localization in mitochondria of different species
-
Alikhani N, Berglund AK, Engmann T, Spanning E, Vogtle FN, Pavlov P, Meisinger C, Langer T, and Glaser E. Targeting capacity and conservation of PreP homologues localization in mitochondria of different species. J Mol Biol 410: 400-410, 2011.
-
(2011)
J Mol Biol
, vol.410
, pp. 400-410
-
-
Alikhani, N.1
Berglund, A.K.2
Engmann, T.3
Spanning, E.4
Vogtle, F.N.5
Pavlov, P.6
Meisinger, C.7
Langer, T.8
Glaser, E.9
-
4
-
-
80155167229
-
Decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome in Alzheimer's disease brain mitochondria
-
Alikhani N, Guo L, Yan S, Du H, Pinho CM, Chen JX, Glaser E, and Yan SS. Decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome in Alzheimer's disease brain mitochondria. J Alzheimers Dis 27: 75-87, 2011.
-
(2011)
J Alzheimers Dis
, vol.27
, pp. 75-87
-
-
Alikhani, N.1
Guo, L.2
Yan, S.3
Du, H.4
Pinho, C.M.5
Chen, J.X.6
Glaser, E.7
Yan, S.S.8
-
5
-
-
84868628376
-
AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival
-
Almajan ER, Richter R, Paeger L, Martinelli P, Barth E, Decker T, Larsson NG, Kloppenburg P, Langer T, and Rugarli EI. AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival. J Clin Invest 122: 4048-4058, 2012.
-
(2012)
J Clin Invest
, vol.122
, pp. 4048-4058
-
-
Almajan, E.R.1
Richter, R.2
Paeger, L.3
Martinelli, P.4
Barth, E.5
Decker, T.6
Larsson, N.G.7
Kloppenburg, P.8
Langer, T.9
Rugarli, E.I.10
-
6
-
-
84899987055
-
SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS and is associated with multiple clinical phenotypes
-
Almontashiri NA, Chen HH, Mailloux RJ, Tatsuta T, Teng AC, Mahmoud AB, Ho T, Stewart NA, Rippstein P, Harper ME, Roberts R, Willenborg C, Erdmann J, CARDIoGRAM Consortium, Pastore A, McBride HM, Langer T, and Stewart AF. SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS and is associated with multiple clinical phenotypes. Cell Rep 7: 834-847, 2014.
-
(2014)
Cell Rep
, vol.7
, pp. 834-847
-
-
Almontashiri, N.A.1
Chen, H.H.2
Mailloux, R.J.3
Tatsuta, T.4
Teng, A.C.5
Mahmoud, A.B.6
Ho, T.7
Stewart, N.A.8
Rippstein, P.9
Harper, M.E.10
Roberts, R.11
Willenborg, C.12
Erdmann, J.13
Pastore, A.14
McBride, H.M.15
Langer, T.16
Stewart, A.F.17
-
7
-
-
84871821553
-
Proteolytic control of mitochondrial function and morphogenesis
-
Anand R, Langer T, and Baker MJ. Proteolytic control of mitochondrial function and morphogenesis. Biochim Biophys Acta 1833: 195-204, 2013.
-
(2013)
Biochim Biophys Acta
, vol.1833
, pp. 195-204
-
-
Anand, R.1
Langer, T.2
Baker, M.J.3
-
8
-
-
84926636909
-
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
-
Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli E, and Langer T. The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J Cell Biol 33: 578-593, 2014.
-
(2014)
J Cell Biol
, vol.33
, pp. 578-593
-
-
Anand, R.1
Wai, T.2
Baker, M.J.3
Kladt, N.4
Schauss, A.C.5
Rugarli, E.6
Langer, T.7
-
10
-
-
0032541406
-
The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m-AAA protease
-
Arlt H, Steglich G, Perryman R, Guiard B, Neupert W, and Langer T. The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m-AAA protease. EMBO J 17: 4837-4847, 1998.
-
(1998)
EMBO J
, vol.17
, pp. 4837-4847
-
-
Arlt, H.1
Steglich, G.2
Perryman, R.3
Guiard, B.4
Neupert, W.5
Langer, T.6
-
11
-
-
0030008581
-
The Yta10-12 complex, an AAA protease with chaperonelike activity in the inner membrane of mitochondria
-
Arlt H, Tauer R, Feldmann H, Neupert W, and Langer T. The Yta10-12 complex, an AAA protease with chaperonelike activity in the inner membrane of mitochondria. Cell 85: 875-885, 1996.
-
(1996)
Cell
, vol.85
, pp. 875-885
-
-
Arlt, H.1
Tauer, R.2
Feldmann, H.3
Neupert, W.4
Langer, T.5
-
12
-
-
79953888421
-
Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine
-
Aubin-Tam ME, Olivares AO, Sauer RT, Baker TA, and Lang MJ. Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine. Cell 145: 257-267, 2011.
-
(2011)
Cell
, vol.145
, pp. 257-267
-
-
Aubin-Tam, M.E.1
Olivares, A.O.2
Sauer, R.T.3
Baker, T.A.4
Lang, M.J.5
-
13
-
-
69749089007
-
An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases
-
Augustin S, Gerdes F, Lee S, Tsai FT, Langer T, and Tatsuta T. An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases. Mol Cell 35: 574-585, 2009.
-
(2009)
Mol Cell
, vol.35
, pp. 574-585
-
-
Augustin, S.1
Gerdes, F.2
Lee, S.3
Tsai, F.T.4
Langer, T.5
Tatsuta, T.6
-
14
-
-
76649093912
-
Degradation of an intramitochondrial protein by the cytosolic proteasome
-
Azzu V and Brand MD. Degradation of an intramitochondrial protein by the cytosolic proteasome. J Cell Sci 123: 578-585, 2010.
-
(2010)
J Cell Sci
, vol.123
, pp. 578-585
-
-
Azzu, V.1
Brand, M.D.2
-
15
-
-
76549091356
-
Rapid turnover of mitochondrial uncoupling protein 3
-
Azzu V, Mookerjee SA, and Brand MD. Rapid turnover of mitochondrial uncoupling protein 3. Biochem J 426: 13-17, 2010.
-
(2010)
Biochem J
, vol.426
, pp. 13-17
-
-
Azzu, V.1
Mookerjee, S.A.2
Brand, M.D.3
-
16
-
-
78049244477
-
VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease
-
Badadani M, Nalbandian A, Watts GD, Vesa J, Kitazawa M, Su H, Tanaja J, Dec E, Wallace DC, Mukherjee J, Caiozzo V, Warman M, and Kimonis VE. VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease. PLoS One 5: e13183, 2010.
-
(2010)
PLoS One
, vol.5
, pp. e13183
-
-
Badadani, M.1
Nalbandian, A.2
Watts, G.D.3
Vesa, J.4
Kitazawa, M.5
Su, H.6
Tanaja, J.7
Dec, E.8
Wallace, D.C.9
Mukherjee, J.10
Caiozzo, V.11
Warman, M.12
Kimonis, V.E.13
-
17
-
-
0037517056
-
Changes in rat liver mitochondria with aging: Ion protease-like activity and Necaboxymethyllysine accumulation in the matrix
-
Bakala H, Delaval E, Hamelin M, Bismuth J, Borot-Laloi C, Corman B, and Friguet B. Changes in rat liver mitochondria with aging: lon protease-like activity and Necaboxymethyllysine accumulation in the matrix. Eur J Biochem 270: 2295-2302, 2003.
-
(2003)
Eur J Biochem
, vol.270
, pp. 2295-2302
-
-
Bakala, H.1
Delaval, E.2
Hamelin, M.3
Bismuth, J.4
Borot-Laloi, C.5
Corman, B.6
Friguet, B.7
-
18
-
-
79955664111
-
Mitochondrial protein quality control during biogenesis and aging
-
Baker BM and Haynes CM. Mitochondrial protein quality control during biogenesis and aging. Trends Biol Sci 36: 254-261, 2011.
-
(2011)
Trends Biol Sci
, vol.36
, pp. 254-261
-
-
Baker, B.M.1
Haynes, C.M.2
-
19
-
-
84898603457
-
Stress-induced OMA1 activation and autocatalytic turnover regulates OPA1-dependent mitochondrial dynamics
-
Baker MJ, Lampe P, Stojanovski D, Korwitz A, Anand R, Tatsuta T, and Langer T. Stress-induced OMA1 activation and autocatalytic turnover regulates OPA1-dependent mitochondrial dynamics. EMBO J 33: 578-593, 2014.
-
(2014)
EMBO J
, vol.33
, pp. 578-593
-
-
Baker, M.J.1
Lampe, P.2
Stojanovski, D.3
Korwitz, A.4
Anand, R.5
Tatsuta, T.6
Langer, T.7
-
20
-
-
84869229480
-
Impaired folding of the mitochondrial small TIM chaperones induces clearance by the i-AAA protease
-
Baker MJ, Mooga VP, Guiard B, Langer T, Ryan MT, and Stojanovski D. Impaired folding of the mitochondrial small TIM chaperones induces clearance by the i-AAA protease. J Mol Biol Cell 424: 227-239, 2012.
-
(2012)
J Mol Biol Cell
, vol.424
, pp. 227-239
-
-
Baker, M.J.1
Mooga, V.P.2
Guiard, B.3
Langer, T.4
Ryan, M.T.5
Stojanovski, D.6
-
22
-
-
84855195754
-
ClpXP, an ATP-powered unfolding and protein degradation machine
-
Baker TA and Sauer RT. ClpXP, an ATP-powered unfolding and protein degradation machine. Biochim Biophys Acta 1823: 15-28, 2012.
-
(2012)
Biochim Biophys Acta
, vol.1823
, pp. 15-28
-
-
Baker, T.A.1
Sauer, R.T.2
-
23
-
-
18044383110
-
Mitochondrial dysfunction in cardiovascular disease
-
Ballinger SW. Mitochondrial dysfunction in cardiovascular disease. Free Radic Biol Med 38: 1278-1295, 2005.
-
(2005)
Free Radic Biol Med
, vol.38
, pp. 1278-1295
-
-
Ballinger, S.W.1
-
24
-
-
0037033115
-
Miochondrial DNA instability mutants of the bifunctional protein Ilv5p have altered organization in mitochondria and are targeted for degradation by Hsp78 and the Pim1p protease
-
Bateman JM, Iacovino M, Perlman PS, and Butow RA. Miochondrial DNA instability mutants of the bifunctional protein Ilv5p have altered organization in mitochondria and are targeted for degradation by Hsp78 and the Pim1p protease. J Biol Chem 277: 47946-47953, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 47946-47953
-
-
Bateman, J.M.1
Iacovino, M.2
Perlman, P.S.3
Butow, R.A.4
-
25
-
-
77951216461
-
Identification of novel oxidized protein substrates and physiological partners of the mitochondrial ATP-dependent Lon-like protease Pim1
-
Bayot A, Gareil M, Rogowska-Wrzesinska A, Roepstorff P, Friguet B, and Bulteau AL. Identification of novel oxidized protein substrates and physiological partners of the mitochondrial ATP-dependent Lon-like protease Pim1. J Biol Chem 285: 11445-11457, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 11445-11457
-
-
Bayot, A.1
Gareil, M.2
Rogowska-Wrzesinska, A.3
Roepstorff, P.4
Friguet, B.5
Bulteau, A.L.6
-
26
-
-
77950676470
-
The role of protein quality control in mitochondrial protein homeostasis under oxidative stress
-
Bender T, Leidhold C, Ruppert T, Franken S, and Voos W. The role of protein quality control in mitochondrial protein homeostasis under oxidative stress. Proteomics 10: 1426-1443, 2010.
-
(2010)
Proteomics
, vol.10
, pp. 1426-1443
-
-
Bender, T.1
Leidhold, C.2
Ruppert, T.3
Franken, S.4
Voos, W.5
-
27
-
-
70349266064
-
Collapse of protostasis represents an early molecular event in Caenorhabditis elegans aging
-
Ben-Zvi A, Miller EA, and Morimoto RI. Collapse of protostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci U S A 106: 14914-14919, 2009.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 14914-14919
-
-
Ben-Zvi, A.1
Miller, E.A.2
Morimoto, R.I.3
-
28
-
-
84859585597
-
The mitochondrial ATPdependent Lon protease: A novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives
-
Bernstein SH, Venkatesh S, Li M, Lee J, Lu B, Hilchey SP, Morse KM, Metcalfe HM, Skalska J, Andreeff M, Brookes PS, and Suzuki CK. The mitochondrial ATPdependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. Blood 119: 3321-3329, 2012.
-
(2012)
Blood
, vol.119
, pp. 3321-3329
-
-
Bernstein, S.H.1
Venkatesh, S.2
Li, M.3
Lee, J.4
Lu, B.5
Hilchey, S.P.6
Morse, K.M.7
Metcalfe, H.M.8
Skalska, J.9
Andreeff, M.10
Brookes, P.S.11
Suzuki, C.K.12
-
29
-
-
84861927005
-
Antioxidants supplements for prevention of mortality in healthy participants and patients with various diseases
-
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, and Gluud C. Antioxidants supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 3: CD007176, 2012.
-
(2012)
Cochrane Database Syst Rev
, vol.3
, pp. CD007176
-
-
Bjelakovic, G.1
Nikolova, D.2
Gluud, L.L.3
Simonetti, R.G.4
Gluud, C.5
-
30
-
-
33847378451
-
Mortality in randomized trials of antioxidants supplements for primary and secondary prevention: Systematic review and meta-analysis
-
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, and Gluud C. Mortality in randomized trials of antioxidants supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297: 842-857, 2007.
-
(2007)
JAMA
, vol.297
, pp. 842-857
-
-
Bjelakovic, G.1
Nikolova, D.2
Gluud, L.L.3
Simonetti, R.G.4
Gluud, C.5
-
31
-
-
84875754263
-
Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest
-
Bode M, Longen S, Morgan B, Peleh V, Dick TP, Bihlmaier K, and Herrmann JM. Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest. Antioxid Redox Signal 18: 1597-1612, 2013.
-
(2013)
Antioxid Redox Signal
, vol.18
, pp. 1597-1612
-
-
Bode, M.1
Longen, S.2
Morgan, B.3
Peleh, V.4
Dick, T.P.5
Bihlmaier, K.6
Herrmann, J.M.7
-
32
-
-
84900396722
-
Stress-triggered activation of the metalloprotease Oma1 involves its C-terminal region and is important for mitochondrial stress protection in yeast
-
Bohovych I, Donaldson G, Christianson S, Zahayko N, and Khalimonchuk O. Stress-triggered activation of the metalloprotease Oma1 involves its C-terminal region and is important for mitochondrial stress protection in yeast. J Biol Chem 289: 13259-13272, 2014.
-
(2014)
J Biol Chem
, vol.289
, pp. 13259-13272
-
-
Bohovych, I.1
Donaldson, G.2
Christianson, S.3
Zahayko, N.4
Khalimonchuk, O.5
-
33
-
-
79960047807
-
Presequence-dependent folding ensures MrpL32 processing by the m-AAA protease in mitochondria
-
Bonn F, Tatsuta T, Petrungaro C, Riemer J, and Langer T. Presequence-dependent folding ensures MrpL32 processing by the m-AAA protease in mitochondria. EMBO J 30: 2545-2556, 2011.
-
(2011)
EMBO J
, vol.30
, pp. 2545-2556
-
-
Bonn, F.1
Tatsuta, T.2
Petrungaro, C.3
Riemer, J.4
Langer, T.5
-
34
-
-
0036713692
-
Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism
-
Bota DA and Davies KJ. Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nat Cell Biol 4: 674-680, 2002.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 674-680
-
-
Bota, D.A.1
Davies, K.J.2
-
35
-
-
84879001260
-
The ubiquitin-proteasome system regulates mitochondrial intermembrane space proteins
-
Bragoszewski P, Gornicka A, Sztolsztener M, and Chacinska A. The ubiquitin-proteasome system regulates mitochondrial intermembrane space proteins. Mol Cell Biol 33: 2136-2148, 2013.
-
(2013)
Mol Cell Biol
, vol.33
, pp. 2136-2148
-
-
Bragoszewski, P.1
Gornicka, A.2
Sztolsztener, M.3
Chacinska, A.4
-
36
-
-
33746466098
-
Mitochondrial mutations in cancer
-
Brandon M, Baldi P, and Wallace DC. Mitochondrial mutations in cancer. Oncogene 25: 4647-4662, 2006.
-
(2006)
Oncogene
, vol.25
, pp. 4647-4662
-
-
Brandon, M.1
Baldi, P.2
Wallace, D.C.3
-
37
-
-
84870907436
-
Cleaning up: ER-associated degradation to the rescue
-
Brodsky JL. Cleaning up: ER-associated degradation to the rescue. Cell 151: 1163-1167, 2012.
-
(2012)
Cell
, vol.151
, pp. 1163-1167
-
-
Brodsky, J.L.1
-
38
-
-
0032511186
-
Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial protease
-
Casari G, De-Fusco M, Ciarmatori S, Zeviani M, Mora M, Fernandez P, DeMichele G, Filla A, Cocozza S, Marconi R, Durr A, Fontaine B, and Ballabio A. Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial protease. Cell 93: 973-983, 1998.
-
(1998)
Cell
, vol.93
, pp. 973-983
-
-
Casari, G.1
De-Fusco, M.2
Ciarmatori, S.3
Zeviani, M.4
Mora, M.5
Fernandez, P.6
DeMichele, G.7
Filla, A.8
Cocozza, S.9
Marconi, R.10
Durr, A.11
Fontaine, B.12
Ballabio, A.13
-
39
-
-
84869030015
-
Fusion and fission: Interlinked processes critical for mitochondrial health
-
Chan DC. Fusion and fission: interlinked processes critical for mitochondrial health. Annu Rev Genet 46: 265-287, 2013.
-
(2013)
Annu Rev Genet
, vol.46
, pp. 265-287
-
-
Chan, D.C.1
-
40
-
-
40449124712
-
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
-
Chao JR, Parganas E, Boyd K, Hong CY, Opferman JT, and Ihle JN. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nature 452: 98-102, 2008.
-
(2008)
Nature
, vol.452
, pp. 98-102
-
-
Chao, J.R.1
Parganas, E.2
Boyd, K.3
Hong, C.Y.4
Opferman, J.T.5
Ihle, J.N.6
-
41
-
-
77951737783
-
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations
-
Chen H, Vermlust M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, and Chan DC. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 141: 280-289, 2010.
-
(2010)
Cell
, vol.141
, pp. 280-289
-
-
Chen, H.1
Vermlust, M.2
Wang, Y.E.3
Chomyn, A.4
Prolla, T.A.5
McCaffery, J.M.6
Chan, D.C.7
-
42
-
-
34347394526
-
Collateral damage in cancer chemotherapy: Oxidative stress in nontargeted tissues
-
Chen Y, Jungsuwadee P, Vore M, Butterfield DA, and St. Clair DK. Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues. Mol Interv 7: 147-156, 2007.
-
(2007)
Mol Interv
, vol.7
, pp. 147-156
-
-
Chen, Y.1
Jungsuwadee, P.2
Vore, M.3
Butterfield, D.A.4
St Clair, D.K.5
-
43
-
-
84904540152
-
Msp1/ATAD maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins
-
Chen YC, Umanah GK, Dephoure N, Andrabi SA, Gygi SP, Dawson TM, Dawson VL, and Rutter J. Msp1/ATAD maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins. EMBO J 33: 758-767, 2014.
-
(2014)
EMBO J
, vol.33
, pp. 758-767
-
-
Chen, Y.C.1
Umanah, G.K.2
Dephoure, N.3
Andrabi, S.A.4
Gygi, S.P.5
Dawson, T.M.6
Dawson, V.L.7
Rutter, J.8
-
44
-
-
79951967246
-
HTRA proteases: Regulated proteolysis in protein quality control
-
Clausen T, Kaiser M, Huber R, and Ehrmann M. HTRA proteases: regulated proteolysis in protein quality control. Nat Rev Mol Cell Biol 12: 152-162, 2011.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 152-162
-
-
Clausen, T.1
Kaiser, M.2
Huber, R.3
Ehrmann, M.4
-
45
-
-
79551700415
-
Barth syndrome mutations that cause tafazzin complex lability
-
Claypool SM, Whited K, Srijumnong S, Han X, and Koehler CM. Barth syndrome mutations that cause tafazzin complex lability. J Cell Biol 192: 447-462, 2011.
-
(2011)
J Cell Biol
, vol.192
, pp. 447-462
-
-
Claypool, S.M.1
Whited, K.2
Srijumnong, S.3
Han, X.4
Koehler, C.M.5
-
46
-
-
84868596965
-
Intramitochondrial transport of phosphatidic acid in yeast by a lipid transfer protein
-
Connerth M, Tatsuta T, Haag M, Klecker T, Westermann B, and Langer T. Intramitochondrial transport of phosphatidic acid in yeast by a lipid transfer protein. Science 338: 815-818, 2012.
-
(2012)
Science
, vol.338
, pp. 815-818
-
-
Connerth, M.1
Tatsuta, T.2
Haag, M.3
Klecker, T.4
Westermann, B.5
Langer, T.6
-
47
-
-
79955787123
-
Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis
-
Daoud H, Valdmanis PN, Gros-Louis F, Belzil V, Spiegelman D, Henrion E, Diallo O, Desjarlais A, Gauthier J, Camu W, Dion PA, and Rouleau G. Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis. Arch Neurol 68: 587-593, 2011.
-
(2011)
Arch Neurol
, vol.68
, pp. 587-593
-
-
Daoud, H.1
Valdmanis, P.N.2
Gros-Louis, F.3
Belzil, V.4
Spiegelman, D.5
Henrion, E.6
Diallo, O.7
Desjarlais, A.8
Gauthier, J.9
Camu, W.10
Dion, P.A.11
Rouleau, G.12
-
48
-
-
79551574736
-
PINK1 cleavage at position A103 by the mitochondrial protease PARL
-
Deas E, Plun-Favreau H, Gandhi S, Desmond H, Kjaer S, Loh SH, Renton AE, Harvey RJ, Whitworth AJ, Martins LM, Abramov AY, and Wood NW. PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet 20: 867-879, 2011.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 867-879
-
-
Deas, E.1
Plun-Favreau, H.2
Gandhi, S.3
Desmond, H.4
Kjaer, S.5
Loh, S.H.6
Renton, A.E.7
Harvey, R.J.8
Whitworth, A.J.9
Martins, L.M.10
Abramov, A.Y.11
Wood, N.W.12
-
49
-
-
77950298030
-
Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28
-
Di Bella D, Lazzaro F, Brusco A, Plumari M, Battaglia G, Pastore A, Finardi A, Cagnoli C, Tempia F, Frontali M, Veneziano L, Sacco T, Boda E, Brussino A, Bonn F, Castellotti B, Baratta S, Mariotti C, Gellera C, Fracasso V, Magri S, Langer T, Plevani P, Di Donato S, Mauzi-Falconi M, and Taroni F. Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28. Nat Genet 42: 313-321, 2010.
-
(2010)
Nat Genet
, vol.42
, pp. 313-321
-
-
Di Bella, D.1
Lazzaro, F.2
Brusco, A.3
Plumari, M.4
Battaglia, G.5
Pastore, A.6
Finardi, A.7
Cagnoli, C.8
Tempia, F.9
Frontali, M.10
Veneziano, L.11
Sacco, T.12
Boda, E.13
Brussino, A.14
Bonn, F.15
Castellotti, B.16
Baratta, S.17
Mariotti, C.18
Gellera, C.19
Fracasso, V.20
Magri, S.21
Langer, T.22
Plevani, P.23
Di Donato, S.24
Mauzi-Falconi, M.25
Taroni, F.26
more..
-
51
-
-
30044444717
-
A ge-nome- wide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex
-
Dunn CD, Lee MS, Spencer FA, and Jensen RE. A ge-nome- wide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex. Mol Biol Cell 17: 213-226, 2006.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 213-226
-
-
Dunn, C.D.1
Lee, M.S.2
Spencer, F.A.3
Jensen, R.E.4
-
52
-
-
59449100177
-
Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex
-
Dunn CD, Tamura Y, Sesaki H, and Jensen RE. Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex. Mol Biol Cell 19: 5387-5397, 2008.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 5387-5397
-
-
Dunn, C.D.1
Tamura, Y.2
Sesaki, H.3
Jensen, R.E.4
-
53
-
-
34548349869
-
OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria
-
Duvezin-Caubet S, Koppen M, Wagener J, Zick M, Israel L, Bernacchia A, Jagasia R, Rugarli EI, Imhof A, Neupert W, Langer T, and Reichert AS. OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria. Mol Biol Cell 18: 3582-3590, 2007.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 3582-3590
-
-
Duvezin-Caubet, S.1
Koppen, M.2
Wagener, J.3
Zick, M.4
Israel, L.5
Bernacchia, A.6
Jagasia, R.7
Rugarli, E.I.8
Imhof, A.9
Neupert, W.10
Langer, T.11
Reichert, A.S.12
-
54
-
-
76149140917
-
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1
-
Ehses S, Raschke I, Mancuso G, Bernacchia A, Geimer S, Tondera D, Martinou JC, Westermann B, Rugarli EI, and Langer T. Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J Cell Biol 187: 1023-1036, 2009.
-
(2009)
J Cell Biol
, vol.187
, pp. 1023-1036
-
-
Ehses, S.1
Raschke, I.2
Mancuso, G.3
Bernacchia, A.4
Geimer, S.5
Tondera, D.6
Martinou, J.C.7
Westermann, B.8
Rugarli, E.I.9
Langer, T.10
-
55
-
-
84864382366
-
Cdc48p/p97-mediated regulation of mitochondrial morphology is Vms1p-independent
-
Esaki M and Ogura T. Cdc48p/p97-mediated regulation of mitochondrial morphology is Vms1p-independent. J Struct Biol 179: 112-120, 2012.
-
(2012)
J Struct Biol
, vol.179
, pp. 112-120
-
-
Esaki, M.1
Ogura, T.2
-
56
-
-
84898612040
-
Dynamic survey of mitochondria by ubiquitin
-
Escobar-Henriques M and Langer T. Dynamic survey of mitochondria by ubiquitin. EMBO Rep 15: 231-243, 2014.
-
(2014)
EMBO Rep
, vol.15
, pp. 231-243
-
-
Escobar-Henriques, M.1
Langer, T.2
-
57
-
-
0033609069
-
Mitochondrial disease in mouse results in increased oxidative stress
-
Esposito LA, Melov S, Panov A, Cottrell BA, and Wallace D. Mitochondrial disease in mouse results in increased oxidative stress. Proc Natl Acad Sci U S A 96: 4820-4825, 1999.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 4820-4825
-
-
Esposito, L.A.1
Melov, S.2
Panov, A.3
Cottrell, B.A.4
Wallace, D.5
-
58
-
-
0036424840
-
A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease Pcp1
-
Esser K, Tursun B, Ingenhoven M, Michaelis G, and Pratje E. A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease Pcp1. J Mol Biol 323: 835-843, 2002.
-
(2002)
J Mol Biol
, vol.323
, pp. 835-843
-
-
Esser, K.1
Tursun, B.2
Ingenhoven, M.3
Michaelis, G.4
Pratje, E.5
-
59
-
-
33749391917
-
Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome PreP
-
Falkevall A, Alikhani N, Bhushan S, Pavlov PF, Busch K, Johnson KA, Eneqvist T, Tjernberg L, Ankacrona M, and Glaser E. Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome PreP. J Biol Chem 281: 29096-29104, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 29096-29104
-
-
Falkevall, A.1
Alikhani, N.2
Bhushan, S.3
Pavlov, P.F.4
Busch, K.5
Johnson, K.A.6
Eneqvist, T.7
Tjernberg, L.8
Ankacrona, M.9
Glaser, E.10
-
60
-
-
33845964416
-
Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import
-
Fan AC, Bhangoo MK, and Young JC. Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import. J Biol Chem 281: 33313-33324, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 33313-33324
-
-
Fan, A.C.1
Bhangoo, M.K.2
Young, J.C.3
-
61
-
-
84878258476
-
Mitochondria as a source of reactive oxygen and nitrogen species: From molecular mechanisms to human health
-
Figueira TR, Barros MH, Camargo AA, Castilho RF, Ferreira JC, Kowaltowski AJ, Sluse FE, Souza-Pinto NC, and Vercesi AE. Mitochondria as a source of reactive oxygen and nitrogen species: from molecular mechanisms to human health. Antioxid Redox Signal 18: 2029-2074, 2013.
-
(2013)
Antioxid Redox Signal
, vol.18
, pp. 2029-2074
-
-
Figueira, T.R.1
Barros, M.H.2
Camargo, A.A.3
Castilho, R.F.4
Ferreira, J.C.5
Kowaltowski, A.J.6
Sluse, F.E.7
Souza-Pinto, N.C.8
Vercesi, A.E.9
-
62
-
-
84879151902
-
Human CLPP reverts the longevity of a fungal ClpP deletion strain
-
Fischer F, Weil A, Hamann A, and Osiewacz HD. Human CLPP reverts the longevity of a fungal ClpP deletion strain. Nat Commun 4: 1397, 2013.
-
(2013)
Nat Commun
, vol.4
, pp. 1397
-
-
Fischer, F.1
Weil, A.2
Hamann, A.3
Osiewacz, H.D.4
-
63
-
-
84870669523
-
Mitochondrial protein synthesis, import and assembly
-
Fox TD. Mitochondrial protein synthesis, import and assembly. Genetics 192: 1203-1234, 2012.
-
(2012)
Genetics
, vol.192
, pp. 1203-1234
-
-
Fox, T.D.1
-
64
-
-
84892600839
-
Mitochondrial form and function
-
Friedman JR and Nunnari J. Mitochondrial form and function. Nature 505: 335-343, 2014.
-
(2014)
Nature
, vol.505
, pp. 335-343
-
-
Friedman, J.R.1
Nunnari, J.2
-
65
-
-
33947724515
-
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
-
Fukuda R, Zhang H, Kim J, Shimoda L, Dang CV, and Semenza GL. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 129: 111-122, 2007.
-
(2007)
Cell
, vol.129
, pp. 111-122
-
-
Fukuda, R.1
Zhang, H.2
Kim, J.3
Shimoda, L.4
Dang, C.V.5
Semenza, G.L.6
-
66
-
-
78649463381
-
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/Parkin-dependent manner upon induction of mitophagy
-
Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, and Taanman JW. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/Parkin-dependent manner upon induction of mitophagy. Hum Mol Genet 19: 4861-4870, 2010.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 4861-4870
-
-
Gegg, M.E.1
Cooper, J.M.2
Chau, K.Y.3
Rojo, M.4
Schapira, A.H.5
Taanman, J.W.6
-
67
-
-
84901494659
-
Mitochondrial matrix proteases as novel therapeutic targets in malignancy
-
Goard CA and Schimmer AD. Mitochondrial matrix proteases as novel therapeutic targets in malignancy. Oncogene 33: 2690-2699, 2014.
-
(2014)
Oncogene
, vol.33
, pp. 2690-2699
-
-
Goard, C.A.1
Schimmer, A.D.2
-
68
-
-
79955623510
-
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
-
Gomes LC, Di Benedetto G, and Scorrano L. During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol 13: 589-598, 2011.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 589-598
-
-
Gomes, L.C.1
Di Benedetto, G.2
Scorrano, L.3
-
69
-
-
33749257835
-
Substrate specific consequences of central pore mutations in the i-AAA protease Yme1 on substrate engagement
-
Graef M and Langer T. Substrate specific consequences of central pore mutations in the i-AAA protease Yme1 on substrate engagement. J Mol Biol 156: 101-108, 2006.
-
(2006)
J Mol Biol
, vol.156
, pp. 101-108
-
-
Graef, M.1
Langer, T.2
-
70
-
-
34147215426
-
Substrate recognition by AAA + ATPases: Distinct substrate binding modes in ATP-dependent protease Yme1 of the mitochondrial intermembrane space
-
Graef M, Seewald G, and Langer T. Substrate recognition by AAA + ATPases: distinct substrate binding modes in ATP-dependent protease Yme1 of the mitochondrial intermembrane space. Mol Cell Biol 27: 2476-2485, 2007.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 2476-2485
-
-
Graef, M.1
Seewald, G.2
Langer, T.3
-
71
-
-
34548313686
-
Regulation of the dynamin-like mitochondrila protein Opa1 by proteolytic cleavage
-
Griparic L, Kanazawa T, and van der Bliek A. Regulation of the dynamin-like mitochondrila protein Opa1 by proteolytic cleavage. J Cell Biol 178: 757-764, 2007.
-
(2007)
J Cell Biol
, vol.178
, pp. 757-764
-
-
Griparic, L.1
Kanazawa, T.2
Van Der Bliek, A.3
-
72
-
-
50049083221
-
Recognition of misfolded proteins by Lon, a AAA (+) protease
-
Gur E and Sauer RT. Recognition of misfolded proteins by Lon, a AAA (+) protease. Genes Dev 22: 2267-2277, 2008.
-
(2008)
Genes Dev
, vol.22
, pp. 2267-2277
-
-
Gur, E.1
Sauer, R.T.2
-
73
-
-
0024276898
-
Mitochondrial protein import: Identification of processing peptidase and of PEP, a processing enhancing protein
-
Halwitschek G, Schneider H, Schmidt B, Tropschug M, Hartl FU, and Neupert W. Mitochondrial protein import: identification of processing peptidase and of PEP, a processing enhancing protein. Cell 53: 795-806, 1988.
-
(1988)
Cell
, vol.53
, pp. 795-806
-
-
Halwitschek, G.1
Schneider, H.2
Schmidt, B.3
Tropschug, M.4
Hartl, F.U.5
Neupert, W.6
-
74
-
-
43049159563
-
Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13)
-
Hansen J, Corydon TJ, Palmfeldt J, Durr A, Fontaine B, Nielsen MN, Christensen JH, Gregersen N, and Bross P. Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13). Neuroscience 153: 474-482, 2008.
-
(2008)
Neuroscience
, vol.153
, pp. 474-482
-
-
Hansen, J.1
Corydon, T.J.2
Palmfeldt, J.3
Durr, A.4
Fontaine, B.5
Nielsen, M.N.6
Christensen, J.H.7
Gregersen, N.8
Bross, P.9
-
75
-
-
79960652801
-
Chaperoneprotease networks in protein folding and homeostasis
-
Hartl FU, Bracher A, and Hayer-Hartl M. Chaperoneprotease networks in protein folding and homeostasis. Nature 475: 324-332, 2011.
-
(2011)
Nature
, vol.475
, pp. 324-332
-
-
Hartl, F.U.1
Bracher, A.2
Hayer-Hartl, M.3
-
76
-
-
84879602902
-
Evaluating and responding to mitochondrial dysfunction: The mitochondrial unfolded protein response and beyond
-
Haynes CM, Fiorese CJ, and Lin YF. Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded protein response and beyond. Trends Cell Biol 23: 311-318, 2013.
-
(2013)
Trends Cell Biol
, vol.23
, pp. 311-318
-
-
Haynes, C.M.1
Fiorese, C.J.2
Lin, Y.F.3
-
77
-
-
76849100919
-
The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans
-
Haynes CM, Yang Y, Blais SP, Neubert TA, and Ron D. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell 37: 529-540, 2010.
-
(2010)
Mol Cell
, vol.37
, pp. 529-540
-
-
Haynes, C.M.1
Yang, Y.2
Blais, S.P.3
Neubert, T.A.4
Ron, D.5
-
78
-
-
76149093590
-
Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells
-
Head B, Griparic L, Gandre-Babbe S, and van der Bliek AM. Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells. J Cell Biol 187: 959-966, 2009.
-
(2009)
J Cell Biol
, vol.187
, pp. 959-966
-
-
Head, B.1
Griparic, L.2
Gandre-Babbe, S.3
Van Der Bliek, A.M.4
-
79
-
-
78149429951
-
A stress-responsive system for mitochondria protein degradation
-
Heo JM, Livnat-Levanon N, Taylor EB, Jones KT, Dephoure N, Ring J, Xie J, Brodsky JL, Madeo F, Gygi SP, Ashrafi K, Glickman MH, and Rutter J. A stress-responsive system for mitochondria protein degradation. Mol Cell 40: 465-480, 2010.
-
(2010)
Mol Cell
, vol.40
, pp. 465-480
-
-
Heo, J.M.1
Livnat-Levanon, N.2
Taylor, E.B.3
Jones, K.T.4
Dephoure, N.5
Ring, J.6
Xie, J.7
Brodsky, J.L.8
Madeo, F.9
Gygi, S.P.10
Ashrafi, K.11
Glickman, M.H.12
Rutter, J.13
-
80
-
-
84877132944
-
Intramolecular interactions control Vms1 translocation to damaged mitochondria
-
Heo JM, Nielson JR, Dephoure N, Gygi SP, and Rutter J. Intramolecular interactions control Vms1 translocation to damaged mitochondria. Mol Biol Cell 24: 1263-1273, 2013.
-
(2013)
Mol Biol Cell
, vol.24
, pp. 1263-1273
-
-
Heo, J.M.1
Nielson, J.R.2
Dephoure, N.3
Gygi, S.P.4
Rutter, J.5
-
81
-
-
0042526632
-
Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA
-
Herlan M, Vogel F, Bornhovd C, Neupert W, and Reichert A. Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem 278: 27781-27788, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 27781-27788
-
-
Herlan, M.1
Vogel, F.2
Bornhovd, C.3
Neupert, W.4
Reichert, A.5
-
82
-
-
77957060561
-
The intermembrane space of mitochondria
-
Herrmann JM and Riemer J. The intermembrane space of mitochondria. Antioxid Redox Signal 13: 1341-1358, 2010.
-
(2010)
Antioxid Redox Signal
, vol.13
, pp. 1341-1358
-
-
Herrmann, J.M.1
Riemer, J.2
-
83
-
-
77955280924
-
The PARL family of mitochondrial rhomboid proteases
-
Hill RB and Pellegrini L. The PARL family of mitochondrial rhomboid proteases. Semin Cell Dev Biol 21: 582-592, 2010.
-
(2010)
Semin Cell Dev Biol
, vol.21
, pp. 582-592
-
-
Hill, R.B.1
Pellegrini, L.2
-
84
-
-
84858001999
-
Nonsense mutations in COX1 subunit impair the stability of respiratory chain complexes rather then their assembly
-
Horing-Do HT, Tatsuta T, Buckermann A, Bust M, Kollberg G, Rotig A, Hellmich M, Nijtmans L, and Wiesner RJ. Nonsense mutations in COX1 subunit impair the stability of respiratory chain complexes rather then their assembly. EMBO J 31: 1293-1307, 2012.
-
(2012)
EMBO J
, vol.31
, pp. 1293-1307
-
-
Horing-Do, H.T.1
Tatsuta, T.2
Buckermann, A.3
Bust, M.4
Kollberg, G.5
Rotig, A.6
Hellmich, M.7
Nijtmans, L.8
Wiesner, R.J.9
-
85
-
-
0027978980
-
Antibacterial peptides and mitochondrial presequences affect mitochondrial coupling, respiration and protein import
-
Hugosson M, Andreu D, Boman HG, and Glaser E. Antibacterial peptides and mitochondrial presequences affect mitochondrial coupling, respiration and protein import. Eur J Biochem 223: 1027-1033, 1994.
-
(1994)
Eur J Biochem
, vol.223
, pp. 1027-1033
-
-
Hugosson, M.1
Andreu, D.2
Boman, H.G.3
Glaser, E.4
-
86
-
-
84889592795
-
Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a car-boxy- terminal targeting sequence
-
Ieva R, Heisswolf AK, Gebert M, Vogtle FN, Wollweber F, Mehnert CS, Oeljeklaus S, Warscheid B, Meisinger C, van der Laan M, and Pfanner N. Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a car-boxy- terminal targeting sequence. Nat Commun 4: 2853-2864, 2013.
-
(2013)
Nat Commun
, vol.4
, pp. 2853-2864
-
-
Ieva, R.1
Heisswolf, A.K.2
Gebert, M.3
Vogtle, F.N.4
Wollweber, F.5
Mehnert, C.S.6
Oeljeklaus, S.7
Warscheid, B.8
Meisinger, C.9
Van Der Laan, M.10
Pfanner, N.11
-
87
-
-
84881260124
-
Parkin-catalyzed ubiquitin esther transfer is triggered by PINK1-dependent phosphorylation
-
Iguchi M, Kujiro Y, Okatsu K, Koyano F, Kosako S, Kimura M, Suzuki N, Uchiyama S, Tanaka K, and Matsuda N. Parkin-catalyzed ubiquitin esther transfer is triggered by PINK1-dependent phosphorylation. J Biol Chem 288: 22019-22032, 2013.
-
(2013)
J Biol Chem
, vol.288
, pp. 22019-22032
-
-
Iguchi, M.1
Kujiro, Y.2
Okatsu, K.3
Koyano, F.4
Kosako, S.5
Kimura, M.6
Suzuki, N.7
Uchiyama, S.8
Tanaka, K.9
Matsuda, N.10
-
88
-
-
0036173013
-
Protein dislocation from the ER requires polyubiqitination and the AAA-ATPase Cdc48
-
Jarosch E, Taxis C, Volkwein C, Bordallo J, Finley D, Wolf DH, and Sommer T. Protein dislocation from the ER requires polyubiqitination and the AAA-ATPase Cdc48. Nat Cell Biol 4: 134-139, 2002.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 134-139
-
-
Jarosch, E.1
Taxis, C.2
Volkwein, C.3
Bordallo, J.4
Finley, D.5
Wolf, D.H.6
Sommer, T.7
-
89
-
-
78649685455
-
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
-
Jin SM, Lazarou M, Wang C, Kane LA, Narendra DP, and Youle RJ. Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol 191: 933-942, 2010.
-
(2010)
J Cell Biol
, vol.191
, pp. 933-942
-
-
Jin, S.M.1
Lazarou, M.2
Wang, C.3
Kane, L.A.4
Narendra, D.P.5
Youle, R.J.6
-
90
-
-
0142246441
-
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice
-
Johnes JM, Datta P, Sirinivasula SM, Ji W, Gupta S, Zhang Z, Davies E, Hajnoczky G, Saunders TL, Van Keuren ML, Fernandes-Alnemri T, Meisler MH, and Alnemri ES. Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature 425: 721-727, 2003.
-
(2003)
Nature
, vol.425
, pp. 721-727
-
-
Johnes, J.M.1
Datta, P.2
Sirinivasula, S.M.3
Ji, W.4
Gupta, S.5
Zhang, Z.6
Davies, E.7
Hajnoczky, G.8
Saunders, T.L.9
Van Keuren, M.L.10
Fernandes-Alnemri, T.11
Meisler, M.H.12
Alnemri, E.S.13
-
91
-
-
70349459398
-
Novel mitochondrial substrates of omi indicate a new regulatory role in neurode-generative disorders
-
Johnson F and Kaplitt MG. Novel mitochondrial substrates of omi indicate a new regulatory role in neurode-generative disorders. PLoS One 4: e7100, 2009.
-
(2009)
PLoS One
, vol.4
, pp. e7100
-
-
Johnson, F.1
Kaplitt, M.G.2
-
92
-
-
21244505013
-
Role of the novel metallopeptidase Mop112 and saccharolysin for the complete degradation of proteins residing in different subcompartments of mitochondria
-
Kambacheld M, Augustin S, Tatsuta T, Muller S, and Langer T. Role of the novel metallopeptidase Mop112 and saccharolysin for the complete degradation of proteins residing in different subcompartments of mitochondria. J Biol Chem 280: 20132-20139, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 20132-20139
-
-
Kambacheld, M.1
Augustin, S.2
Tatsuta, T.3
Muller, S.4
Langer, T.5
-
93
-
-
84899539731
-
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
-
Kane LA, Lazarou M, Fogel AI, Li Y, Yamano K, Sarraf SA, Banerjee S, and Youle RJ. PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol 205: 143-153, 2014.
-
(2014)
J Cell Biol
, vol.205
, pp. 143-153
-
-
Kane, L.A.1
Lazarou, M.2
Fogel, A.I.3
Li, Y.4
Yamano, K.5
Sarraf, S.A.6
Banerjee, S.7
Youle, R.J.8
-
94
-
-
27444440627
-
Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX
-
Kang SG, Dimitrova MN, Ortega J, Ginsburg A, and Maurizi MR. Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX. J Biol Chem 280: 35424-35432, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 35424-35432
-
-
Kang, S.G.1
Dimitrova, M.N.2
Ortega, J.3
Ginsburg, A.4
Maurizi, M.R.5
-
95
-
-
84857030799
-
Neurodegeneration as a consequence of failed mitochondrial maintenance
-
Karbowski M and Neutzner A. Neurodegeneration as a consequence of failed mitochondrial maintenance. Acta Neuropathol 123: 157-171, 2011.
-
(2011)
Acta Neuropathol
, vol.123
, pp. 157-171
-
-
Karbowski, M.1
Neutzner, A.2
-
96
-
-
79960716413
-
Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation
-
Karbowski M and Youle RJ. Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation. Curr Opin Cell Biol 23: 476-482, 2011.
-
(2011)
Curr Opin Cell Biol
, vol.23
, pp. 476-482
-
-
Karbowski, M.1
Youle, R.J.2
-
97
-
-
0344012569
-
Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease
-
Kaser M, Kambacheld M, Kisters-Woike B, and Langer T. Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease. J Biol Chem 278: 46414-46423, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 46414-46423
-
-
Kaser, M.1
Kambacheld, M.2
Kisters-Woike, B.3
Langer, T.4
-
98
-
-
54449090491
-
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies
-
Kawamoto Y, Kobayashi Y, Suzuki Y, Inoue H, Tomimoto H, Akiguchi I, Budka H, Martins LM, Downward J, and Takahashi R. Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies. J Neuropathol Exp Neurol 67: 984-993, 2008.
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, pp. 984-993
-
-
Kawamoto, Y.1
Kobayashi, Y.2
Suzuki, Y.3
Inoue, H.4
Tomimoto, H.5
Akiguchi, I.6
Budka, H.7
Martins, L.M.8
Downward, J.9
Takahashi, R.10
-
99
-
-
34547113093
-
Evidence for a pro-oxidant intermediate in the assembly of cytochrome oxidase
-
Khalimonchuk O, Bird A, and Winge DR. Evidence for a pro-oxidant intermediate in the assembly of cytochrome oxidase. J Biol Chem 282: 17442-17449, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 17442-17449
-
-
Khalimonchuk, O.1
Bird, A.2
Winge, D.R.3
-
100
-
-
84857692699
-
Selective Oma1-mediated proteolysis of the Cox1 subunit of cytochrome oxidase in assembly mutants
-
Khalimonchuk O, Jeong MY, Watts T, Ferris E, and Winge DR. Selective Oma1-mediated proteolysis of the Cox1 subunit of cytochrome oxidase in assembly mutants. J Biol Chem 287: 7289-7300, 2012.
-
(2012)
J Biol Chem
, vol.287
, pp. 7289-7300
-
-
Khalimonchuk, O.1
Jeong, M.Y.2
Watts, T.3
Ferris, E.4
Winge, D.R.5
-
101
-
-
0032499264
-
Mutations in parkin gene cause recessive juvenile parkinsonism
-
Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, and Shimizu N. Mutations in parkin gene cause recessive juvenile parkinsonism. Nature 392: 605-608, 1998.
-
(1998)
Nature
, vol.392
, pp. 605-608
-
-
Kitada, T.1
Asakawa, S.2
Hattori, N.3
Matsumine, H.4
Yamamura, Y.5
Minoshima, S.6
Yokochi, M.7
Mizuno, Y.8
Shimizu, N.9
-
102
-
-
84899885579
-
Loss of the m-AAA protease subunit AFG3L2 causes mitochondrial transport defects and tau hyperphosphorylation
-
Konradi AK, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, Herholz D, Baker MJ, Schauss AC, Langer T, and Rugarli EI. Loss of the m-AAA protease subunit AFG3L2 causes mitochondrial transport defects and tau hyperphosphorylation. EMBO J 33: 1011-1026, 2014.
-
(2014)
EMBO J
, vol.33
, pp. 1011-1026
-
-
Konradi, A.K.1
Wang, S.2
Montagner, S.3
Kladt, N.4
Korwitz, A.5
Martinelli, P.6
Herholz, D.7
Baker, M.J.8
Schauss, A.C.9
Langer, T.10
Rugarli, E.I.11
-
103
-
-
33846127778
-
Variable and tissue-specific subunit composition of mitochondrial m-AAA protease complexes linked to hereditary spastic paraplegia
-
Koppen M, Metodiev MD, Casari G, Rugarli EI, and Langer T. Variable and tissue-specific subunit composition of mitochondrial m-AAA protease complexes linked to hereditary spastic paraplegia. Mol Cell Biol 27: 758-767, 2007.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 758-767
-
-
Koppen, M.1
Metodiev, M.D.2
Casari, G.3
Rugarli, E.I.4
Langer, T.5
-
104
-
-
79955398591
-
Otto Warburg's contributions to current concepts of cancer metabolism
-
Koppenol WH, Bounds PL, and Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 11: 325-337, 2011.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
105
-
-
4444332721
-
Membrane protein turnover by the m-AAA protease in mitochondria depends on the transmembrane domains of its subunits
-
Korbel D, Wurth S, Kaser M, and Langer T. Membrane protein turnover by the m-AAA protease in mitochondria depends on the transmembrane domains of its subunits. EMBO Rep 5: 698-703, 2004.
-
(2004)
EMBO Rep
, vol.5
, pp. 698-703
-
-
Korbel, D.1
Wurth, S.2
Kaser, M.3
Langer, T.4
-
106
-
-
84901751574
-
Ubiquitin is phosphorylated by PINK1 to activate Parkin
-
Koyano F, Okatsu K, Kosako S, Tamura Y, Go E, Kimura M, Kimura Y, Tsuchiya H, Yoshihara H, Hirokawa T, Endo T, Fon EA, Trempe JF, Saeki Y, Tanaka K, and Matsuda N. Ubiquitin is phosphorylated by PINK1 to activate Parkin. Nature 510: 162-166, 2014.
-
(2014)
Nature
, vol.510
, pp. 162-166
-
-
Koyano, F.1
Okatsu, K.2
Kosako, S.3
Tamura, Y.4
Go, E.5
Kimura, M.6
Kimura, Y.7
Tsuchiya, H.8
Yoshihara, H.9
Hirokawa, T.10
Endo, T.11
Fon, E.A.12
Trempe, J.F.13
Saeki, Y.14
Tanaka, K.15
Matsuda, N.16
-
107
-
-
0035878402
-
Molecular and functional analyses of the human and mouse genes encoding AFG3L1, a mitochondrial metalloprotease homologous to the human spastic paraplegia protein
-
Kremmiotidis G, Gardner AE, Settasatian C, Savoia A, Sutherland GR, and Callen DF. Molecular and functional analyses of the human and mouse genes encoding AFG3L1, a mitochondrial metalloprotease homologous to the human spastic paraplegia protein. Genomics 76: 58-65, 2001.
-
(2001)
Genomics
, vol.76
, pp. 58-65
-
-
Kremmiotidis, G.1
Gardner, A.E.2
Settasatian, C.3
Savoia, A.4
Sutherland, G.R.5
Callen, D.F.6
-
108
-
-
79953010046
-
Electron cryomicroscopy structure of a mem-brane- anchored mitochondrial AAA protease
-
Lee S, Augustin S, Tatsuta T, Gerdes F, Langer T, and Tsai FT. Electron cryomicroscopy structure of a mem-brane- anchored mitochondrial AAA protease. J Biol Chem 286: 4404-4411, 2011.
-
(2011)
J Biol Chem
, vol.286
, pp. 4404-4411
-
-
Lee, S.1
Augustin, S.2
Tatsuta, T.3
Gerdes, F.4
Langer, T.5
Tsai, F.T.6
-
109
-
-
6344274848
-
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1 and Opa1 in apoptosis
-
Lee YJ, Jeong SY, Karbowski M, Smith CL, and Youle RJ. Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1 and Opa1 in apoptosis. Mol Biol Cell 15: 5001-5011, 2004.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 5001-5011
-
-
Lee, Y.J.1
Jeong, S.Y.2
Karbowski, M.3
Smith, C.L.4
Youle, R.J.5
-
110
-
-
0026686760
-
AFG1, a new member of the SEC18-NSF, PAS1, CDC48-VCP, TBP family of ATPases
-
Lee YJ and Wickner RB. AFG1, a new member of the SEC18-NSF, PAS1, CDC48-VCP, TBP family of ATPases. Yeast 8: 787-790, 1992.
-
(1992)
Yeast
, vol.8
, pp. 787-790
-
-
Lee, Y.J.1
Wickner, R.B.2
-
111
-
-
0034604519
-
Absence of mitochondrial AAA protease Yme1p restores Fo-ATPase subunit accumulation in an oxa1 deletion mutant of Saccheromyces cerevisiae
-
Lemaire C, Hamel P, Velours J, and Dujardin G. Absence of mitochondrial AAA protease Yme1p restores Fo-ATPase subunit accumulation in an oxa1 deletion mutant of Saccheromyces cerevisiae . J Biol Chem 275: 23471-23475, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 23471-23475
-
-
Lemaire, C.1
Hamel, P.2
Velours, J.3
Dujardin, G.4
-
112
-
-
0033639076
-
Membrane protein degradation by AAA proteases in mitochondria: Extraction of substrates from either membrane surface
-
Leonhard K, Guiard B, Pellecchia G, Tzagoloff A, Neupert W, and Langer T. Membrane protein degradation by AAA proteases in mitochondria: extraction of substrates from either membrane surface. Mol Cell 5: 629-638, 2000.
-
(2000)
Mol Cell
, vol.5
, pp. 629-638
-
-
Leonhard, K.1
Guiard, B.2
Pellecchia, G.3
Tzagoloff, A.4
Neupert, W.5
Langer, T.6
-
113
-
-
0029775087
-
AAA proteases with catalytic sites on opposite membrane surfaces comprise a proteolytic system for the ATP-dependent degradation of inner membrane proteins in mitochondria
-
Leonhard K, Herrmann JM, Stuart RA, Mannhaupt G, Neupert W, and Langer T. AAA proteases with catalytic sites on opposite membrane surfaces comprise a proteolytic system for the ATP-dependent degradation of inner membrane proteins in mitochondria. EMBO J 15: 4218-4229, 1996.
-
(1996)
EMBO J
, vol.15
, pp. 4218-4229
-
-
Leonhard, K.1
Herrmann, J.M.2
Stuart, R.A.3
Mannhaupt, G.4
Neupert, W.5
Langer, T.6
-
114
-
-
77954174214
-
Processing of the dynamin Msp1p in S. pombe reveals an evolutionary switch between its orthologs Mgm1 in S. cerevisiae and OPA1 in mammals
-
Leroy I, Khosrobakhsh F, Diot A, Daloyau M, Arnaune- Pelloquin L, Cavelier C, Emorine EJ, and Belenguer P. Processing of the dynamin Msp1p in S. pombe reveals an evolutionary switch between its orthologs Mgm1 in S. cerevisiae and OPA1 in mammals. FEBS Lett 584: 3153-3157, 2010.
-
(2010)
FEBS Lett
, vol.584
, pp. 3153-3157
-
-
Leroy, I.1
Khosrobakhsh, F.2
Diot, A.3
Daloyau, M.4
Arnaune- Pelloquin, L.5
Cavelier, C.6
Emorine, E.J.7
Belenguer, P.8
-
115
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
Lin MT and Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443: 787-795, 2006.
-
(2006)
Nature
, vol.443
, pp. 787-795
-
-
Lin, M.T.1
Beal, M.F.2
-
116
-
-
79151480727
-
Ubiquitin-proteasome system and mitochondria-reciprocity
-
Livnat-Levanon N and Glickman MH. Ubiquitin-proteasome system and mitochondria-reciprocity. Biochim Biophys Acta 1809: 480-487, 2011.
-
(2011)
Biochim Biophys Acta
, vol.1809
, pp. 480-487
-
-
Livnat-Levanon, N.1
Glickman, M.H.2
-
117
-
-
84872271398
-
Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease
-
Lu B, Lee J, Nie X, Li M, Morozov YI, Venkatesh S, Bogenhagen DF, Temiakov D, and Suzuki CK. Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease. Mol Cell 49: 18410-18415, 2013.
-
(2013)
Mol Cell
, vol.49
, pp. 18410-18415
-
-
Lu, B.1
Lee, J.2
Nie, X.3
Li, M.4
Morozov, Y.I.5
Venkatesh, S.6
Bogenhagen, D.F.7
Temiakov, D.8
Suzuki, C.K.9
-
118
-
-
67650091290
-
Increasing organismal healthspan by enhancing mitochondrial protein quality control
-
Luce K and Osiewacz HD. Increasing organismal healthspan by enhancing mitochondrial protein quality control. Nat Cell Biol 11: 852-858, 2009.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 852-858
-
-
Luce, K.1
Osiewacz, H.D.2
-
119
-
-
84892140580
-
Mitophagy
-
MacVicar T. Mitophagy. Essays Biochem 55: 93-104, 2013.
-
(2013)
Essays Biochem
, vol.55
, pp. 93-104
-
-
MacVicar, T.1
-
120
-
-
84926609133
-
Impaired OMA1-dependent cleavage of OPA1and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation
-
MacVicar TD and Lane JD. Impaired OMA1-dependent cleavage of OPA1and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation. J Cell Sci 204: 919-929, 2014.
-
(2014)
J Cell Sci
, vol.204
, pp. 919-929
-
-
MacVicar, T.D.1
Lane, J.D.2
-
121
-
-
31344455097
-
Proteomic analysis of mitochondrial protein turnover: Identification of novel substrate proteins of the matrix protease Pim1
-
Major T, von Janowsky B, Ruppert T, Mogk A, and Voos W. Proteomic analysis of mitochondrial protein turnover: identification of novel substrate proteins of the matrix protease Pim1. Mol Cell Biol 26: 762-776, 2006.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 762-776
-
-
Major, T.1
Von Janowsky, B.2
Ruppert, T.3
Mogk, A.4
Voos, W.5
-
122
-
-
42449147510
-
Hsp90 inhibition decreases mitochondrial protein turnover
-
Margineantu DH, Emerson CB, Diaz D, and Hockenberry DM. Hsp90 inhibition decreases mitochondrial protein turnover. PLoS One 10: e1066, 2007.
-
(2007)
PLoS One
, vol.10
, pp. e1066
-
-
Margineantu, D.H.1
Emerson, C.B.2
Diaz, D.3
Hockenberry, D.M.4
-
123
-
-
7644230386
-
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice
-
Martins LM, Morrison A, Klupsch K, Fedele V, Moisoi N, Teismann P, Abuin A, Grau E, Geppert M, Livi GP, Creasy CL, Martin A, Hargreaves I, Heales SJ, Okada H, Brander S, Schultz JB, Mak T, and Downward J. Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol Cell Biol 24: 9848-9862, 2004.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9848-9862
-
-
Martins, L.M.1
Morrison, A.2
Klupsch, K.3
Fedele, V.4
Moisoi, N.5
Teismann, P.6
Abuin, A.7
Grau, E.8
Geppert, M.9
Livi, G.P.10
Creasy, C.L.11
Martin, A.12
Hargreaves, I.13
Heales, S.J.14
Okada, H.15
Brander, S.16
Schultz, J.B.17
Mak, T.18
Downward, J.19
-
124
-
-
78649842154
-
Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)
-
Matsushima Y, Goto Y, and Kaguni LS. Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM). Proc Natl Acad Sci U S A 107: 18410-18415, 2010.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 18410-18415
-
-
Matsushima, Y.1
Goto, Y.2
Kaguni, L.S.3
-
125
-
-
77955872123
-
Assembly factors of human mitochondrial complex I and their defects in disease
-
McKenzie M and Ryan MT. Assembly factors of human mitochondrial complex I and their defects in disease. IUBMB Life 62: 497-502, 2010.
-
(2010)
IUBMB Life
, vol.62
, pp. 497-502
-
-
McKenzie, M.1
Ryan, M.T.2
-
126
-
-
84897863239
-
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
-
McLelland GL, Soubannier V, Chen CX, McBride HM, and Fon EA. Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J 33: 282-295, 2014.
-
(2014)
EMBO J
, vol.33
, pp. 282-295
-
-
McLelland, G.L.1
Soubannier, V.2
Chen, C.X.3
McBride, H.M.4
Fon, E.A.5
-
127
-
-
0038700756
-
Mitochondrial membrane remodeling regulated by a conserved rhomboid protease
-
McQuibban GA, Saurya S, and Freeman M. Mitochondrial membrane remodeling regulated by a conserved rhomboid protease. Nature 423: 537-541, 2003.
-
(2003)
Nature
, vol.423
, pp. 537-541
-
-
McQuibban, G.A.1
Saurya, S.2
Freeman, M.3
-
128
-
-
78650483039
-
Inventory control: Cytochrome c oxidase assembly regulates mitochondrial translation
-
Mick DU, Fox TD, and Rehling P. Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation. Nat Rev Mol Cell Biol 12: 14-20, 2011.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 14-20
-
-
Mick, D.U.1
Fox, T.D.2
Rehling, P.3
-
129
-
-
60849097548
-
Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptionsl stress response
-
Moisoi N, Klupsch K, Fedele V, East P, Sharma S, Renton A, Plun-Favreau H, Edwaqrds RE, Teismann P, Eposti MD, Morrison AD, Wood NW, Downward J, and Martins LM. Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptionsl stress response. Cell Death Differ 16: 449-464, 2009.
-
(2009)
Cell Death Differ
, vol.16
, pp. 449-464
-
-
Moisoi, N.1
Klupsch, K.2
Fedele, V.3
East, P.4
Sharma, S.5
Renton, A.6
Plun-Favreau, H.7
Edwaqrds, R.E.8
Teismann, P.9
Eposti, M.D.10
Morrison, A.D.11
Wood, N.W.12
Downward, J.13
Martins, L.M.14
-
130
-
-
0038054341
-
PGC-1alpharesponsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, and Groop LC. PGC-1alpharesponsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34: 267-273, 2003.
-
(2003)
Nat Genet
, vol.34
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
Eriksson, K.F.3
Subramanian, A.4
Sihag, S.5
Lehar, J.6
Puigserver, P.7
Carlsson, E.8
Ridderstrale, M.9
Laurila, E.10
Houstis, N.11
Daly, M.J.12
Patterson, N.13
Mesirov, J.P.14
Golub, T.R.15
Tamayo, P.16
Spiegelman, B.17
Lander, E.S.18
Hirschhorn, J.N.19
Altshuler, D.20
Groop, L.C.21
more..
-
132
-
-
84905860097
-
The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase
-
Na U, Yu W, Cox J, Bricker DK, Brockmann K, Rutter J, Thummel CS, and Winge DR. The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase. Cell Metab 20: 253-266, 2014.
-
(2014)
Cell Metab
, vol.20
, pp. 253-266
-
-
Na, U.1
Yu, W.2
Cox, J.3
Bricker, D.K.4
Brockmann, K.5
Rutter, J.6
Thummel, C.S.7
Winge, D.R.8
-
133
-
-
71049136017
-
Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55
-
Naamati A, Regev-Rudzki N, Galperin S, Lill R, and Pines O. Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55. J Biol Chem 284: 30200-302028, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 30200-302028
-
-
Naamati, A.1
Regev-Rudzki, N.2
Galperin, S.3
Lill, R.4
Pines, O.5
-
134
-
-
0029042705
-
Multiple genes, including a member of the AAA family, are essential for degradation of unassembled subunit 2 of cytochrome c oxidase in yeast mitochondria
-
Nakai T, Yasuhara T, Fujiki Y, and Ohashi A. Multiple genes, including a member of the AAA family, are essential for degradation of unassembled subunit 2 of cytochrome c oxidase in yeast mitochondria. Mol Cell Biol 15: 4441-4452, 1995.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 4441-4452
-
-
Nakai, T.1
Yasuhara, T.2
Fujiki, Y.3
Ohashi, A.4
-
135
-
-
84864744900
-
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation
-
Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM, and Haynes CM. Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science 337: 587-590, 2012.
-
(2012)
Science
, vol.337
, pp. 587-590
-
-
Nargund, A.M.1
Pellegrino, M.W.2
Fiorese, C.J.3
Baker, B.M.4
Haynes, C.M.5
-
136
-
-
34249873947
-
Translocation of proteins into mitochondria
-
Neupert W and Herrmann JM. Translocation of proteins into mitochondria. Annu Rev Biochem 76: 723-749, 2007.
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 723-749
-
-
Neupert, W.1
Herrmann, J.M.2
-
137
-
-
38349023008
-
Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers
-
Neuspiel M, Schauss AC, Braschi E, Zunino R, Rippstein P, Rachubinski RA, Andrade-Navarro MA, and McBride HM. Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers. Curr Biol 18: 102-108, 2008.
-
(2008)
Curr Biol
, vol.18
, pp. 102-108
-
-
Neuspiel, M.1
Schauss, A.C.2
Braschi, E.3
Zunino, R.4
Rippstein, P.5
Rachubinski, R.A.6
Andrade-Navarro, M.A.7
McBride, H.M.8
-
138
-
-
84926651265
-
Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization
-
Neuspiel M, Zunino R, Gangaraju S, Rippstein P, and McBride HM. Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization. EMBO Rep 13: 909-915, 2012.
-
(2012)
EMBO Rep
, vol.13
, pp. 909-915
-
-
Neuspiel, M.1
Zunino, R.2
Gangaraju, S.3
Rippstein, P.4
McBride, H.M.5
-
139
-
-
0028238446
-
Effects of amphipathic peptides, including presequences, on the functional integrity of rat liver mitochondrial membranes
-
Nikolay K, Laterveer FD, and van Heerde WL. Effects of amphipathic peptides, including presequences, on the functional integrity of rat liver mitochondrial membranes. J Bioenerg Biomembr 26: 327-334, 1994.
-
(1994)
J Bioenerg Biomembr
, vol.26
, pp. 327-334
-
-
Nikolay, K.1
Laterveer, F.D.2
Van Heerde, W.L.3
-
140
-
-
26844484821
-
The m-AAA protease defective in hereditary spastic paraplegia controls ribosome assembly in mitochondria
-
Nolden M, Ehses S, Koppen M, Bernacchia A, Rugarli EI, and Langer T. The m-AAA protease defective in hereditary spastic paraplegia controls ribosome assembly in mitochondria. Cell 123: 277-289, 2005.
-
(2005)
Cell
, vol.123
, pp. 277-289
-
-
Nolden, M.1
Ehses, S.2
Koppen, M.3
Bernacchia, A.4
Rugarli, E.I.5
Langer, T.6
-
141
-
-
84858376953
-
Mitochondria: In sickness and in health
-
Nunnari J and Suomalainen A. Mitochondria: in sickness and in health. Cell 148: 1145-1159, 2012.
-
(2012)
Cell
, vol.148
, pp. 1145-1159
-
-
Nunnari, J.1
Suomalainen, A.2
-
142
-
-
84901837721
-
The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins
-
Okreglak V and Walter P. The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins. Proc Natl Acad Sci U S A 111: 8019-8024, 2014.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 8019-8024
-
-
Okreglak, V.1
Walter, P.2
-
143
-
-
33846826875
-
The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase
-
Osman C, Wilmes C, Tatsuta T, and Langer T. The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase. Mol Biol Cell 18: 627-635, 2007.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 627-635
-
-
Osman, C.1
Wilmes, C.2
Tatsuta, T.3
Langer, T.4
-
144
-
-
84875273810
-
New insights into the function and regulation of mitochondrial fission
-
Otera H, Ishihara N, and Mihara K. New insights into the function and regulation of mitochondrial fission. Biochim Biophys Acta 1833: 1256-1268, 2013.
-
(2013)
Biochim Biophys Acta
, vol.1833
, pp. 1256-1268
-
-
Otera, H.1
Ishihara, N.2
Mihara, K.3
-
145
-
-
63049132799
-
The yeast HtrA orthologue Ynm3 is a protease with chaprone activity that aids survival under heat stress
-
Padmanabhan N, Fichtner L, Dickmans A, Ficner R, Schulz JB, and Braus BH. The yeast HtrA orthologue Ynm3 is a protease with chaprone activity that aids survival under heat stress. Mol Biol Cell 20: 68-77, 2009.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 68-77
-
-
Padmanabhan, N.1
Fichtner, L.2
Dickmans, A.3
Ficner, R.4
Schulz, J.B.5
Braus, B.H.6
-
146
-
-
46349103594
-
A mitochondrial protein compendium elucidates complex I disease biology
-
Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, and Mootha VK. A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-123, 2008.
-
(2008)
Cell
, vol.134
, pp. 112-123
-
-
Pagliarini, D.J.1
Calvo, S.E.2
Chang, B.3
Sheth, S.A.4
Vafai, S.B.5
Ong, S.E.6
Walford, G.A.7
Sugiana, C.8
Boneh, A.9
Chen, W.K.10
Hill, D.E.11
Vidal, M.12
Evans, J.G.13
Thorburn, D.R.14
Carr, S.A.15
Mootha, V.K.16
-
147
-
-
79959450877
-
Mitochondrial DNA mutations in disease and aging
-
Park CB and Larsson NG. Mitochondrial DNA mutations in disease and aging. J Cell Biol 193: 809-818, 2011.
-
(2011)
J Cell Biol
, vol.193
, pp. 809-818
-
-
Park, C.B.1
Larsson, N.G.2
-
148
-
-
0029163565
-
Degradation of cytochrome oxidase subunits in mutants of yeast lacking cytochrome c and suppression of the degradation by mutation of yme1
-
Pearce DA and Sherman F. Degradation of cytochrome oxidase subunits in mutants of yeast lacking cytochrome c and suppression of the degradation by mutation of yme1. J Biol Chem 270: 20879-20882, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 20879-20882
-
-
Pearce, D.A.1
Sherman, F.2
-
149
-
-
68249121088
-
Muscle mitochondrial function in patients with Type 2 diabetes and peripheral arterial disease: Implications in vascular surgery
-
Pedersen BL, Baekgaard N, and Quistorff B. Muscle mitochondrial function in patients with Type 2 diabetes and peripheral arterial disease: implications in vascular surgery. Eur J Vasc Endovasc Surg 38: 356-364, 2009.
-
(2009)
Eur J Vasc Endovasc Surg
, vol.38
, pp. 356-364
-
-
Pedersen, B.L.1
Baekgaard, N.2
Quistorff, B.3
-
150
-
-
80055087830
-
Whole-exome sequencing identifies homozygous AFG3L2 mutations in a spastic ataxia-neuropathy syndrome linked to mitochondrial m-AAA proteases
-
Pierson TM, Adams D, Bonn F, Martinelli P, Cherukuri PF, Teer JK, Hansen NF, Cruz P, Mullicin JC (for the NISC Comparative Sequencing Program), Blakesley RW, Golas G, Kwan J, Sandler A, Fuentes Fajardo K, Markello T, Tifft C, Blackstone C, Rugarli EI, Langer T, Gahl WA, and Toro C. Whole-exome sequencing identifies homozygous AFG3L2 mutations in a spastic ataxia-neuropathy syndrome linked to mitochondrial m-AAA proteases. PLoS Genet 7: e1002325, 2012.
-
(2012)
PLoS Genet
, vol.7
, pp. e1002325
-
-
Pierson, T.M.1
Adams, D.2
Bonn, F.3
Martinelli, P.4
Cherukuri, P.F.5
Teer, J.K.6
Hansen, N.F.7
Cruz, P.8
Mullicin, J.C.9
Blakesley, R.W.10
Golas, G.11
Kwan, J.12
Sandler, A.13
Fuentes Fajardo, K.14
Markello, T.15
Tifft, C.16
Blackstone, C.17
Rugarli, E.I.18
Langer, T.19
Gahl, W.A.20
Toro, C.21
NISC Comparative Sequencing Program22
more..
-
151
-
-
35748935851
-
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
-
Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D, Harvey K, Deas E, Harvey RJ, McDonald N, Wood NW, Martins LM, and Downward J. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol 9: 1243-1252, 2007.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1243-1252
-
-
Plun-Favreau, H.1
Klupsch, K.2
Moisoi, N.3
Gandhi, S.4
Kjaer, S.5
Frith, D.6
Harvey, K.7
Deas, E.8
Harvey, R.J.9
McDonald, N.10
Wood, N.W.11
Martins, L.M.12
Downward, J.13
-
152
-
-
77956391459
-
Regulation of mitochondrial phospholipids by Ups1/ PRELI-like proteins depends on proteolysis and Mdm35
-
Potting C, Wilmes C, Engmann T, Osman C, and Langer T. Regulation of mitochondrial phospholipids by Ups1/ PRELI-like proteins depends on proteolysis and Mdm35. EMBO J 29: 2888-2898, 2010.
-
(2010)
EMBO J
, vol.29
, pp. 2888-2898
-
-
Potting, C.1
Wilmes, C.2
Engmann, T.3
Osman, C.4
Langer, T.5
-
153
-
-
84904795370
-
ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity
-
Quiros PM, Espanol Y, Acin-Perez R, Rodriguez F, Barcena C, Watanabe K, Calvo E, Loureiro M, Fernandez-Garcia MS, Fueyo A, Vazquez J, Enriquez JA, and Lopez-Otin C. ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity. Cell Rep 8: 542-556, 2014.
-
(2014)
Cell Rep
, vol.8
, pp. 542-556
-
-
Quiros, P.M.1
Espanol, Y.2
Acin-Perez, R.3
Rodriguez, F.4
Barcena, C.5
Watanabe, K.6
Calvo, E.7
Loureiro, M.8
Fernandez-Garcia, M.S.9
Fueyo, A.10
Vazquez, J.11
Enriquez, J.A.12
Lopez-Otin, C.13
-
154
-
-
84860505850
-
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice
-
Quiros PM, Ramsay AJ, Sala D, Fernandez-Vizarra E, Rodrigues F, Peinado JR, Fernandez-Garcia MS, Vega JA, Enriques JA, Zorzano A, and Lopez-Otin C. Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice. EMBO J 31: 2117-2133, 2012.
-
(2012)
EMBO J
, vol.31
, pp. 2117-2133
-
-
Quiros, P.M.1
Ramsay, A.J.2
Sala, D.3
Fernandez-Vizarra, E.4
Rodrigues, F.5
Peinado, J.R.6
Fernandez-Garcia, M.S.7
Vega, J.A.8
Enriques, J.A.9
Zorzano, A.10
Lopez-Otin, C.11
-
155
-
-
79959987510
-
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation
-
Rambold AS, Kostelecky B, Elia N, and Lippincott- Schwartz J. Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci U S A 108: 10190-10195, 2011.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 10190-10195
-
-
Rambold, A.S.1
Kostelecky, B.2
Elia, N.3
Lippincott- Schwartz, J.4
-
156
-
-
84874956967
-
Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging
-
Rhee HW, Zou P, Udeshi ND, Martell JD, Mootha VK, Carr SA, and Ting AY. Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging. Science 339: 1328-1331, 2013.
-
(2013)
Science
, vol.339
, pp. 1328-1331
-
-
Rhee, H.W.1
Zou, P.2
Udeshi, N.D.3
Martell, J.D.4
Mootha, V.K.5
Carr, S.A.6
Ting, A.Y.7
-
157
-
-
84858791998
-
Mitochondrial quality control: A matter of life and death for neurons
-
Rugarli EI and Langer T. Mitochondrial quality control: a matter of life and death for neurons. EMBO J 31: 1336-1349, 2012.
-
(2012)
EMBO J
, vol.31
, pp. 1336-1349
-
-
Rugarli, E.I.1
Langer, T.2
-
158
-
-
84876296881
-
Landscape of the PARKIN-dependent ubiquitilome in response to mitochondrial depolarization
-
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, and Harper JW. Landscape of the PARKIN-dependent ubiquitilome in response to mitochondrial depolarization. Nature 496: 372-376, 2013.
-
(2013)
Nature
, vol.496
, pp. 372-376
-
-
Sarraf, S.A.1
Raman, M.2
Guarani-Pereira, V.3
Sowa, M.E.4
Huttlin, E.L.5
Gygi, S.P.6
Harper, J.W.7
-
159
-
-
79959389010
-
AAA + proteases: ATP-fueled machines of protein destruction
-
Sauer RT and Baker TA. AAA + proteases: ATP-fueled machines of protein destruction. Annu Rev Biochem 80: 587-612, 2011.
-
(2011)
Annu Rev Biochem
, vol.80
, pp. 587-612
-
-
Sauer, R.T.1
Baker, T.A.2
-
160
-
-
0032493810
-
ATP-dependent proteolysis in mitochondria. m-AAA protease and Pim1 protease exert overlapping substrate specificities and cooperate with mtHsp70 system
-
Savelev AS, Novikova LA, Kovaleva IE, Luzikov VN, Neupert W, and Langer T. ATP-dependent proteolysis in mitochondria. m-AAA protease and Pim1 protease exert overlapping substrate specificities and cooperate with mtHsp70 system. J Biol Chem 273: 20596-20602, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 20596-20602
-
-
Savelev, A.S.1
Novikova, L.A.2
Kovaleva, I.E.3
Luzikov, V.N.4
Neupert, W.5
Langer, T.6
-
161
-
-
84901052694
-
ROS function in redox signaling and oxidative stress
-
Schieber M and Chandel NS. ROS function in redox signaling and oxidative stress. Curr Biol 24: R453-R462, 2014.
-
(2014)
Curr Biol
, vol.24
, pp. R453-R462
-
-
Schieber, M.1
Chandel, N.S.2
-
162
-
-
84869221103
-
Role of the AAA protease Yme1 in folding of protein in the intermembrane space of mitochondria
-
Schreinr B, Westerburg H, Forne I, Imhof A, Neupert W, and Mokranjac D. Role of the AAA protease Yme1 in folding of protein in the intermembrane space of mitochondria. Mol Biol Cell 23: 143-153, 2012.
-
(2012)
Mol Biol Cell
, vol.23
, pp. 143-153
-
-
Schreinr, B.1
Westerburg, H.2
Forne, I.3
Imhof, A.4
Neupert, W.5
Mokranjac, D.6
-
163
-
-
79955410000
-
Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease
-
Shi G, Lee JR, Grimes DA, Racacho L, Ye D, Yang H, Ross OA, Farrer M, McQuibban GA, and Bulman DE. Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease. Hum Mol Genet 20: 1966-1974, 2011.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 1966-1974
-
-
Shi, G.1
Lee, J.R.2
Grimes, D.A.3
Racacho, L.4
Ye, D.5
Yang, H.6
Ross, O.A.7
Farrer, M.8
McQuibban, G.A.9
Bulman, D.E.10
-
164
-
-
84926633494
-
The intracellular redox state is a core determinant of mitochondrial fusion
-
Shutt T, Geoffrion M, Milne R, and McBride HM. The intracellular redox state is a core determinant of mitochondrial fusion. J Biol Chem 280: 25060-25070, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 25060-25070
-
-
Shutt, T.1
Geoffrion, M.2
Milne, R.3
McBride, H.M.4
-
165
-
-
0345687191
-
The proteome of Saccharomyces cerevisiae
-
Sickmann A, Reinders J, Wagner Y, Joppich C, Zahedi R, Meyer HE, Schonfisch B, Perschil I, Chacinska A, Guiard B, Rehling P, Pfanner N and Meisinger C. The proteome of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 100: 13207-13212, 2003.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 13207-13212
-
-
Sickmann, A.1
Reinders, J.2
Wagner, Y.3
Joppich, C.4
Zahedi, R.5
Meyer, H.E.6
Schonfisch, B.7
Perschil, I.8
Chacinska, A.9
Guiard, B.10
Rehling, P.11
Pfanner, N.12
Meisinger, C.13
-
166
-
-
84856221632
-
A vesicular transport pathway shuttles cargo from mitochondria to lysosomes
-
Soubannier V, McLelland GL, Zunino R, Braschi E, Rippstein P, Fon EA, and McBride HM. A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr Biol 24: 135-141, 2012.
-
(2012)
Curr Biol
, vol.24
, pp. 135-141
-
-
Soubannier, V.1
McLelland, G.L.2
Zunino, R.3
Braschi, E.4
Rippstein, P.5
Fon, E.A.6
McBride, H.M.7
-
167
-
-
0033536010
-
Mitochondrial Lon of Saccharomyces cerevisiae is a ring-shaped protease with seven flexible subunits
-
Stahlberg H, Kutejova E, Suda K, Wolpensinger B, Lustig A, Schatz G, Engel A, and Suzuki CK. Mitochondrial Lon of Saccharomyces cerevisiae is a ring-shaped protease with seven flexible subunits. Proc Natl Acad Sci U S A 96: 6787-6790, 1999.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 6787-6790
-
-
Stahlberg, H.1
Kutejova, E.2
Suda, K.3
Wolpensinger, B.4
Lustig, A.5
Schatz, G.6
Engel, A.7
Suzuki, C.K.8
-
168
-
-
84858411560
-
YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis and cell proliferation
-
Stiburek L, Cesnekova J, Kostkova O, Fornuskova D, Vinsova K, Wenchich L, Houstek J, and Zeman J. YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis and cell proliferation. Mol Biol Cell 23: 1010-1023, 2012.
-
(2012)
Mol Biol Cell
, vol.23
, pp. 1010-1023
-
-
Stiburek, L.1
Cesnekova, J.2
Kostkova, O.3
Fornuskova, D.4
Vinsova, K.5
Wenchich, L.6
Houstek, J.7
Zeman, J.8
-
169
-
-
25444498785
-
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
-
Strauss KM, Martins LM, Plun-Favreau H, Marx FP, Kautzmann S, Berg D, Gasser T, Wszolek Z, Muller T, Bornemann A, Wolburg H, Downward J, Riess O, Schulz JB, and Kruger R. Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease. Hum Mol Genet 14: 2099-2111, 2005.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 2099-2111
-
-
Strauss, K.M.1
Martins, L.M.2
Plun-Favreau, H.3
Marx, F.P.4
Kautzmann, S.5
Berg, D.6
Gasser, T.7
Wszolek, Z.8
Muller, T.9
Bornemann, A.10
Wolburg, H.11
Downward, J.12
Riess, O.13
Schulz, J.B.14
Kruger, R.15
-
170
-
-
84908085343
-
A new pathway for mitochondrial quality control: Mito-chondrial- derived vesicles
-
Sugiura A, McLelland GL, Fon EA, and McBride HM. A new pathway for mitochondrial quality control: mito-chondrial- derived vesicles. EMBO J 33: 2142-2156, 2014.
-
(2014)
EMBO J
, vol.33
, pp. 2142-2156
-
-
Sugiura, A.1
McLelland, G.L.2
Fon, E.A.3
McBride, H.M.4
-
171
-
-
0028362456
-
Requirement for the yeast gene LON in intramitochodnrial proteolysis and maintenance of respiration
-
Suzuki CK, Suda K, Wang N, and Schatz G. Requirement for the yeast gene LON in intramitochodnrial proteolysis and maintenance of respiration. Science 264: 273-276, 1994.
-
(1994)
Science
, vol.264
, pp. 273-276
-
-
Suzuki, C.K.1
Suda, K.2
Wang, N.3
Schatz, G.4
-
172
-
-
78650729600
-
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
-
Tanaka A, Cleland MM, Xu S, Narendra DP, Suen DF, Karbowski M, and Youle RJ. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol 191: 1367-1380, 2010.
-
(2010)
J Cell Biol
, vol.191
, pp. 1367-1380
-
-
Tanaka, A.1
Cleland, M.M.2
Xu, S.3
Narendra, D.P.4
Suen, D.F.5
Karbowski, M.6
Youle, R.J.7
-
173
-
-
84861210856
-
The N-end rule pathway
-
Tasaki T, Sriram SM, Park SO, and Kwon YT. The N-end rule pathway. Annu Rev Biochem 81: 261-289, 2012.
-
(2012)
Annu Rev Biochem
, vol.81
, pp. 261-289
-
-
Tasaki, T.1
Sriram, S.M.2
Park, S.O.3
Kwon, Y.T.4
-
174
-
-
33846490396
-
m-AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondria
-
Tatsuta T, Augustin S, Nolden M, Friedrichs B, and Langer T. m-AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondria. EMBO J 26: 325-335, 2007.
-
(2007)
EMBO J
, vol.26
, pp. 325-335
-
-
Tatsuta, T.1
Augustin, S.2
Nolden, M.3
Friedrichs, B.4
Langer, T.5
-
175
-
-
80053352130
-
Mitochondrial quality control by the ubiquitin-proteasome system
-
Taylor EB and Rutter J. Mitochondrial quality control by the ubiquitin-proteasome system. Biochem Soc Trans 39: 1509-1513, 2011.
-
(2011)
Biochem Soc Trans
, vol.39
, pp. 1509-1513
-
-
Taylor, E.B.1
Rutter, J.2
-
176
-
-
84871796609
-
Processing peptidases in mitochondria and chloroplasts
-
Teixeira PF and Glaser E. Processing peptidases in mitochondria and chloroplasts. Biochim Biophys Acta 1833: 360-370, 2013.
-
(2013)
Biochim Biophys Acta
, vol.1833
, pp. 360-370
-
-
Teixeira, P.F.1
Glaser, E.2
-
177
-
-
68949089051
-
SLP-2 is required for stress-induced mitochondrial hyperfusion
-
Tondera D, Grandemange S, Jourdain A, Karbowski M, Mattenberger Y, Herzig S, Da Cruz S, Clerc P, Raschke I, Merkwirth C, Ehses S, Krause F, Chan DC, Alexander C, Bauer C, Youle R, Langer T, and Martinou JC. SLP-2 is required for stress-induced mitochondrial hyperfusion. EMBO J 33: 578-593, 2009.
-
(2009)
EMBO J
, vol.33
, pp. 578-593
-
-
Tondera, D.1
Grandemange, S.2
Jourdain, A.3
Karbowski, M.4
Mattenberger, Y.5
Herzig, S.6
Da Cruz, S.7
Clerc, P.8
Raschke, I.9
Merkwirth, C.10
Ehses, S.11
Krause, F.12
Chan, D.C.13
Alexander, C.14
Bauer, C.15
Youle, R.16
Langer, T.17
Martinou, J.C.18
-
178
-
-
38549110110
-
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
-
Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BC, and Shirihai OS. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 27: 433-446, 2008.
-
(2008)
EMBO J
, vol.27
, pp. 433-446
-
-
Twig, G.1
Elorza, A.2
Molina, A.J.3
Mohamed, H.4
Wikstrom, J.D.5
Walzer, G.6
Stiles, L.7
Haigh, S.E.8
Katz, S.9
Las, G.10
Alroy, J.11
Wu, M.12
Py, B.F.13
Yuan, J.14
Deeney, J.T.15
Corkey, B.C.16
Shirihai, O.S.17
-
179
-
-
84869051280
-
Mitochondrial disorders as windows into an ancient organelle
-
Vafai SB and Mootha VK. Mitochondrial disorders as windows into an ancient organelle. Nature 491: 374-383, 2012.
-
(2012)
Nature
, vol.491
, pp. 374-383
-
-
Vafai, S.B.1
Mootha, V.K.2
-
181
-
-
84855225838
-
Multitasking in the mitochondrion by the ATP-dependent Lon protease
-
Venkatesh S, Lee J, Singh K, Lee I, and Suzuki CK. Multitasking in the mitochondrion by the ATP-dependent Lon protease. Biochim Biophys Acta 1823: 56-66, 2012.
-
(2012)
Biochim Biophys Acta
, vol.1823
, pp. 56-66
-
-
Venkatesh, S.1
Lee, J.2
Singh, K.3
Lee, I.4
Suzuki, C.K.5
-
182
-
-
84876213313
-
The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo
-
Vincow ES, Merrihew G, Thomas RE, Shulman NJ, Beyer RP, MacCoss MJ, and Pallanck LJ. The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo. Proc Natl Acad Sci U S A 110: 5603-6405, 2013.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 5603-6405
-
-
Vincow, E.S.1
Merrihew, G.2
Thomas, R.E.3
Shulman, N.J.4
Beyer, R.P.5
MacCoss, M.J.6
Pallanck, L.J.7
-
183
-
-
84870683876
-
Intermembrane space proteome of yeast mitochondria
-
Vogtle FN, Burkhart JM, Rao S, Gerbeth C, Hinrichs J, Martinou JC, Chacinska A, Sickmann A, Zahedi R, and Meisinger C. Intermembrane space proteome of yeast mitochondria. Mol Cell Proteomics 11: 1840-1852, 2012.
-
(2012)
Mol Cell Proteomics
, vol.11
, pp. 1840-1852
-
-
Vogtle, F.N.1
Burkhart, J.M.2
Rao, S.3
Gerbeth, C.4
Hinrichs, J.5
Martinou, J.C.6
Chacinska, A.7
Sickmann, A.8
Zahedi, R.9
Meisinger, C.10
-
184
-
-
79959871792
-
Mitochondrial protein turnover: Role of the precursor intermediate peptidase Oct1 in protein stabilization
-
Vogtle FN, Prinz C, Kellermann J, Lottspeich F, Pfanner N, and Meisinger C. Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization. Mol Biol Cell 22: 2135-2143, 2011.
-
(2011)
Mol Biol Cell
, vol.22
, pp. 2135-2143
-
-
Vogtle, F.N.1
Prinz, C.2
Kellermann, J.3
Lottspeich, F.4
Pfanner, N.5
Meisinger, C.6
-
185
-
-
70349840621
-
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability
-
Vogtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A, Pfanner N, and Meisinger C. Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell 139: 428-439, 2009.
-
(2009)
Cell
, vol.139
, pp. 428-439
-
-
Vogtle, F.N.1
Wortelkamp, S.2
Zahedi, R.P.3
Becker, D.4
Leidhold, C.5
Gevaert, K.6
Kellermann, J.7
Voos, W.8
Sickmann, A.9
Pfanner, N.10
Meisinger, C.11
-
186
-
-
29044432842
-
Structural properties of substrate proteins determine their proteolysis by the mitochondrial AAA+ protease Pim1
-
von Janowsky B, Knapp K, Major T, Krayl M, Guiard B, and Voos W. Structural properties of substrate proteins determine their proteolysis by the mitochondrial AAA+ protease Pim1. Biol Chem 386: 1307-1317, 2005.
-
(2005)
Biol Chem
, vol.386
, pp. 1307-1317
-
-
Von Janowsky, B.1
Knapp, K.2
Major, T.3
Krayl, M.4
Guiard, B.5
Voos, W.6
-
187
-
-
84871793725
-
Chaperone-protease networks in mitochondrial protein homeostasis
-
Voos W. Chaperone-protease networks in mitochondrial protein homeostasis. Biochim Biophys Acta 1833: 388-399, 2013.
-
(2013)
Biochim Biophys Acta
, vol.1833
, pp. 388-399
-
-
Voos, W.1
-
188
-
-
23844558266
-
A mitochondrial paradigm of metabolic and degenerative diseases, aging and cancer: A dawn for evolutionary medicine
-
Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging and cancer: a dawn for evolutionary medicine. Annu Rev Genet 39: 359-407, 2005.
-
(2005)
Annu Rev Genet
, vol.39
, pp. 359-407
-
-
Wallace, D.C.1
-
189
-
-
81055140895
-
PINK1 and Parkin target Miro for phosphorylationand degradation to arrest mitochondrial motility
-
Wang X, Winter D, Ashrafi G, Schlehe J, Wong YL, Selkoe D, Rice S, Steen J, LaVoie MJ, and Schwartz TL. PINK1 and Parkin target Miro for phosphorylationand degradation to arrest mitochondrial motility. Cell 147: 893-906, 2011.
-
(2011)
Cell
, vol.147
, pp. 893-906
-
-
Wang, X.1
Winter, D.2
Ashrafi, G.3
Schlehe, J.4
Wong, Y.L.5
Selkoe, D.6
Rice, S.7
Steen, J.8
LaVoie, M.J.9
Schwartz, T.L.10
-
190
-
-
0030020360
-
Biochemical and functional analysis of the YME1 gene product, an ATP and zinc-dependent mitochondrial protease from S. cerevisiae
-
Weber ER, Hanekamp T, and Thorsness P. Biochemical and functional analysis of the YME1 gene product, an ATP and zinc-dependent mitochondrial protease from S. cerevisiae. Mol Biol Cell 7: 307-317, 1996.
-
(1996)
Mol Biol Cell
, vol.7
, pp. 307-317
-
-
Weber, E.R.1
Hanekamp, T.2
Thorsness, P.3
-
191
-
-
84908077262
-
Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population
-
Wu Y, Williams EG, Dubuis S, Mottis A, Jovaisaite V, Houten SM, Argmann CA, Faridi P, Wolski W, Kutalik Z, Zamboni N, Auwerx J, and Aebersold R. Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population. Cell 158: 1415-1430, 2014.
-
(2014)
Cell
, vol.158
, pp. 1415-1430
-
-
Wu, Y.1
Williams, E.G.2
Dubuis, S.3
Mottis, A.4
Jovaisaite, V.5
Houten, S.M.6
Argmann, C.A.7
Faridi, P.8
Wolski, W.9
Kutalik, Z.10
Zamboni, N.11
Auwerx, J.12
Aebersold, R.13
-
192
-
-
84901712100
-
OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury
-
Xiao X, Hu Y, Quiros PM, Wei Q, Lopez-Otin C, and Dong Z. OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury. Am J Physiol Renal Physiol 306: F1318-F1326, 2014.
-
(2014)
Am J Physiol Renal Physiol
, vol.306
, pp. F1318-F1326
-
-
Xiao, X.1
Hu, Y.2
Quiros, P.M.3
Wei, Q.4
Lopez-Otin, C.5
Dong, Z.6
-
193
-
-
79551663809
-
The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover
-
Xu S, Peng G, Wang Y, Fang S, and Karbowski M. The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover. Mol Biol Cell 22: 291-300, 2010.
-
(2010)
Mol Biol Cell
, vol.22
, pp. 291-300
-
-
Xu, S.1
Peng, G.2
Wang, Y.3
Fang, S.4
Karbowski, M.5
-
196
-
-
84865544952
-
Mitochondrial fission, fusion and stress
-
Youle RJ and van der Bliek A. Mitochondrial fission, fusion and stress. Science 337: 1062-1065, 2012.
-
(2012)
Science
, vol.337
, pp. 1062-1065
-
-
Youle, R.J.1
Van Der Bliek, A.2
-
197
-
-
0037428164
-
Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the import receptor Tom70
-
Young JC, Hoogenraad NJ, and Hartl FU. Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the import receptor Tom70. Cell 112: 41-50, 2003.
-
(2003)
Cell
, vol.112
, pp. 41-50
-
-
Young, J.C.1
Hoogenraad, N.J.2
Hartl, F.U.3
-
198
-
-
33644912080
-
Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins
-
Zahedi RP, Sickmann A, Boehm AM, Winkler C, Zufall N, Schonfisch B, Guiard B, Pfanner N, and Meisinger C. Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol Biol Cell 17: 1436-14501, 2006.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 1436-14501
-
-
Zahedi, R.P.1
Sickmann, A.2
Boehm, A.M.3
Winkler, C.4
Zufall, N.5
Schonfisch, B.6
Guiard, B.7
Pfanner, N.8
Meisinger, C.9
-
199
-
-
33846813499
-
The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase
-
Zeng X, Neupert W, and Tzagoloff A. The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase. Mol Biol Cell 18: 617-626, 2007.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 617-626
-
-
Zeng, X.1
Neupert, W.2
Tzagoloff, A.3
-
200
-
-
84899844027
-
Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage
-
Zhang K, Li H, and Song Z. Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage. EMBO Rep 15: 576-585, 2014.
-
(2014)
EMBO Rep
, vol.15
, pp. 576-585
-
-
Zhang, K.1
Li, H.2
Song, Z.3
|