Phosphorylation of Human TFAM in Mitochondria Impairs DNA Binding and Promotes Degradation by the AAA+ Lon Protease

Molecular Cell

Volumn 49, Issue 1, 2013, Pages 121-132

  Lu, Bin ^a   Lee, Jae ^a,d   Nie, Xiaobo ^a   Li, Min ^a   Morozov, Yaroslav I ^b   Venkatesh, Sundararajan ^a   Bogenhagen, Daniel F ^c   Temiakov, Dmitry ^b   Suzuki, Carolyn K ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c STONY BROOK UNIVERSITY   (United States)

^d WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; CYCLOHEXIMIDE; ENDOPEPTIDASE LA; HIGH MOBILITY GROUP B1 PROTEIN; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; SMALL INTERFERING RNA;

ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; GENE SILENCING; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRION; MUTATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; RNA INTERFERENCE; TRANSCRIPTION INITIATION;

AMINO ACID SUBSTITUTION; BASE SEQUENCE; BINDING SITES; BORONIC ACIDS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; GENE KNOCKDOWN TECHNIQUES; GENOME, MITOCHONDRIAL; HEK293 CELLS; HELA CELLS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEASE LA; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; PYRAZINES; RNA INTERFERENCE; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 84872271398     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.10.023     Document Type: Article

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