Membrane protein degradation by AAA proteases in mitochondria: Extraction of substrates from either membrane surface

Molecular Cell

Volumn 5, Issue 4, 2000, Pages 629-638

  Leonhard, Klaus ^a   Guiard, Bernard ^b   Pellecchia, Giovanna ^a   Tzagoloff, Alexander ^c   Neupert, Walter ^a   Langer, Thomas ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b CENTRE DE GÉNÉTIQUE MOLÉCULAIRE   (France)

^c Howard Hughes Medical Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; PROTEINASE;

ARTICLE; BACTERIAL MEMBRANE; ENZYME ACTIVITY; EXTRACTION; MEMBRANE STRUCTURE; MEMBRANE TRANSPORT; MITOCHONDRION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FOLDING; YEAST;

EID: 0033639076     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80242-7     Document Type: Article

References (41)

1. FtsH
2. FtsH, a membrane-bound ATPase, forms a complex in the cytoplasmic membrane of Escherichia coli
3. The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria
4. The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m-AAA protease
5. The base of the proteasome regulatory particle exhibits chaperone-like activity
6. Mitochondrial morphological and functional defects in yeast caused by yme1 are suppressed by mutation of a 26S protease subunit homologue
7. Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease
8. Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex
9. Sequence of the AFG3 gene encoding a new member of the FtsH/Yme1/Tma subfamily of the AAA-protein family
10. Afg3p, a mitochondrial ATP-dependent metalloprotease, is involved in the degradation of mitochondrially-encoded Cox1, Cox3, Cob, Su6, Su8 and Su9 subunits of the inner membrane complexes III, IV and V
11. Carboxymethylation
12. Inactivation of YME2/RNA12, which encodes an integral inner mitochondrial membrane protein, causes increased escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae
13. Isolation of yeast mitochondria and study of mitochondrial protein translation
14. Gettin' down with ubiquitin: Turning off cell-surface receptors, transporter and channels
15. Yeast/E. coli shuttle vectors with multiple unique restriction sites
16. Dislocation of membrane proteins in FtsH-mediated proteolysis
17. AAA-proteases-cellular machines for the degradation of membrane proteins
18. AAA proteases with catalytic sites on opposite membrane surfaces comprise a proteolytic system for the ATP-dependent degradation of inner membrane proteins in mitochondria
19. Chaperone-like activity of the AAA domain of the yeast Yme1 AAA protease
20. Role for the ubiquitin-proteasome system in the vacuolar degradation of Ste6p, the a-factor transporter in Saccharomyces cerevisiae
21. Self-compartmentalizing proteases
22. Prevention of protein denaturation under heat stress by the chaperonin Hsp60
23. Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein
24. Multiple genes, including a member of the AAA family, are essential for the degradation of unassembled subunit 2 of cytochrome c oxidase in yeast mitochondria
25. Protein import into mitochondria
26. The AAA team: Related ATPases with diverse functions
27. 1-ATPase assembly in Saccharomyces cerevisiae
28. Degradation of cytochrome oxidase subunits in mutants of yeast lacking cytochrome c and suppression of the degradation by mutation of yme1
29. Retrograde protein translocation:ERADication of secretory proteins in health and disease
30. Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation
31. Substitution of PIM1 protease in mitochondria by Escherichia coli Lon protease
32. Inactivation of YME1, a member of the ftsH-SEC18-PAS1-CDC48 family of putative ATPase-encoding genes, causes increased escape of DNA from mitochondria in Saccharomyces cerevisiae
33. The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression
34. A new member of a family of ATPases is essential for assembly of mitochondrial respiratory chain and ATP synthetase complexes in Saccharomyces cerevisiae
35. Point mutations destabilizing a precursor protein enhance its post-translational import into mitochondria
36. Molecular chaperones cooperate with PIM1 protease in the degradation of misfolded proteins in mitochondria
37. Biochemical and functional analysis of the YME1 gene product, an ATP and zinc-dependent mitochondrial protease from S. cerevisiae
38. Global unfolding of a substrate protein by the Hsp100 chaperone ClpA
39. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
40. Two nuclear mutations that block mitochondrial protein import in yeast
41. The engagement of Sec61p in the ER dislocation process