Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics

EMBO Journal

Volumn 33, Issue 6, 2014, Pages 578-593

  Baker, Michael J ^a   Lampe, Philipp A ^a   Stojanovski, Diana ^b   Korwitz, Anne ^a   Anand, Ruchika ^a   Tatsuta, Takashi ^a   Langer, Thomas ^a,c  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING   (Germany)

Author keywords

mitochondria; mitochondrial fusion; OMA1; OPA1; stress

Indexed keywords

METALLOPROTEINASE; MITOCHONDRIAL PROTEIN; PROTEIN OMA1; PROTEIN OPA1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENZYME DEGRADATION; ENZYME REGULATION; ENZYME STABILITY; EUKARYOTE; HEAT STRESS; HUMAN; HUMAN CELL; MAMMAL CELL; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OLIGOMERIZATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; REGULATORY MECHANISM; TURNOVER TIME; YEAST CELL;

ANIMALS; CENTRIFUGATION, DENSITY GRADIENT; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; FIBROBLASTS; GTP PHOSPHOHYDROLASES; IMMUNOBLOTTING; METALLOPROTEASES; MICE; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL PROTEINS; MODELS, BIOLOGICAL; STRESS, PHYSIOLOGICAL;

EID: 84898603457     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1002/embj.201386474     Document Type: Article

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