Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in alzheimer's disease brain mitochondria

Journal of Alzheimer's Disease

Volumn 27, Issue 1, 2011, Pages 75-87

  Alikhani, Nyosha ^a,c   Guo, Lan ^a   Yan, Shiqiang ^a   Du, Heng ^a   Pinho, Catarina Moreira ^c   Chen, John Xi ^d   Glaser, Elzbieta ^c   Yan, Shirley Shidu ^a,b  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c STOCKHOLM UNIVERSITY   (Sweden)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Mitochondrial amyloid ; mitochondrial function; oxidative stress; presequence protease (PreP); proteolysis

Indexed keywords

4 HYDROXYNONENAL; AMYLOID BETA PROTEIN; CYTOCHROME C OXIDASE; ENZYME; PREP PEPTIDASOME; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN MITOCHONDRION; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUSE; NERVE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; TEMPORAL LOBE; TRANSGENIC MOUSE;

EID: 80155167229     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-101716     Document Type: Article

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