Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

Nature

Volumn 425, Issue 6959, 2003, Pages 721-727

  Jones, Julie M ^a   Datta, Pinaki ^c   Srinivasula, Srinivasa M ^c   Ji, Weizhen ^a   Gupta, Sanjeev ^c   Zhang, ZhiJia ^c   Davies, Erika ^d   Hajnóczky, György ^d   Saunders, Thomas L ^a   Van Keuren, Margaret L ^b   Fernandes Alnemri, Teresa ^c   Meisler, Miriam H ^a   Alnemri, Emad S ^c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; MUTAGENESIS; NEUROLOGY;

NEURODEGENERATION;

ENZYMES;

ANTIMYCIN A1; APOPTOSIS INDUCING FACTOR; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CALCIUM ION; CYSTEINE; CYTOCHROME C; ETOPOSIDE; MESSENGER RNA; MITOCHONDRIAL ENZYME; SERINE; SERINE PROTEINASE; SERINE PROTEINASE OMI; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CALCIUM CELL LEVEL; CELL DEATH; CONTROLLED STUDY; CORPUS STRIATUM; DNA SEQUENCE; ENZYME ACTIVITY; FEMALE; FIBROBLAST; GENE; HUMAN; HUMAN CELL; MALE; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MISSENSE MUTATION; MITOCHONDRIAL MEMBRANE; MND2 GENE; MOTOR NEURON DISEASE; MOUSE; NERVE DEGENERATION; NEUROMUSCULAR DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCIUM; CASEINS; CELL DEATH; CELLS, CULTURED; CHROMOSOME MAPPING; CROSSES, GENETIC; FEMALE; HOMOZYGOTE; HUMANS; MALE; MICE; MICE, NEUROLOGIC MUTANTS; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NEUROMUSCULAR DISEASES; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; BACTERIA (MICROORGANISMS); MUS MUSCULUS;

EID: 0142246441     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02052     Document Type: Article

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