-
1
-
-
0034723201
-
Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia
-
Faccio L, Fusco C, Chen A, Martinotti S, Bonventre JV, et al. (2000) Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia. J Biol Chem 275: 2581-2588.
-
(2000)
J Biol Chem
, vol.275
, pp. 2581-2588
-
-
Faccio, L.1
Fusco, C.2
Chen, A.3
Martinotti, S.4
Bonventre, J.V.5
-
2
-
-
34948867875
-
HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation
-
Huttunen HJ, Guenette SY, Peach C, Greco C, Xia W, et al. (2007) HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. J Biol Chem 282: 28285-28295.
-
(2007)
J Biol Chem
, vol.282
, pp. 28285-28295
-
-
Huttunen, H.J.1
Guenette, S.Y.2
Peach, C.3
Greco, C.4
Xia, W.5
-
3
-
-
4444260910
-
Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP
-
Seong YM, Choi JY, Park HJ, Kim KJ, Ahn SG, et al. (2004) Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP. J Biol Chem 279: 37588-37596.
-
(2004)
J Biol Chem
, vol.279
, pp. 37588-37596
-
-
Seong, Y.M.1
Choi, J.Y.2
Park, H.J.3
Kim, K.J.4
Ahn, S.G.5
-
4
-
-
0037016686
-
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
-
Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, et al. (2002) HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J Biol Chem 277: 445-454.
-
(2002)
J Biol Chem
, vol.277
, pp. 445-454
-
-
Verhagen, A.M.1
Silke, J.2
Ekert, P.G.3
Pakusch, M.4
Kaufmann, H.5
-
5
-
-
1542571796
-
Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi
-
Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, et al. (2003) Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi. J Biol Chem 278: 49417-49427.
-
(2003)
J Biol Chem
, vol.278
, pp. 49417-49427
-
-
Martins, L.M.1
Turk, B.E.2
Cowling, V.3
Borg, A.4
Jarrell, E.T.5
-
6
-
-
33947607164
-
Proteome-wide Identification of HtrA2/Omi Substrates
-
Vande Walle L, Van Damme P, Lamkanfi M, Saelens X, Vandekerckhove J, et al. (2007) Proteome-wide Identification of HtrA2/Omi Substrates. J Proteome Res 6: 1006-1015.
-
(2007)
J Proteome Res
, vol.6
, pp. 1006-1015
-
-
Vande Walle, L.1
Van Damme, P.2
Lamkanfi, M.3
Saelens, X.4
Vandekerckhove, J.5
-
7
-
-
0037016707
-
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
-
Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, et al. (2002) The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J Biol Chem 277: 439-444.
-
(2002)
J Biol Chem
, vol.277
, pp. 439-444
-
-
Martins, L.M.1
Iaccarino, I.2
Tenev, T.3
Gschmeissner, S.4
Totty, N.F.5
-
8
-
-
0036263973
-
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi
-
Li W, Srinivasula SM, Chai J, Li P, Wu JW, et al. (2002) Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi. Nat Struct Biol 9: 436-441.
-
(2002)
Nat Struct Biol
, vol.9
, pp. 436-441
-
-
Li, W.1
Srinivasula, S.M.2
Chai, J.3
Li, P.4
Wu, J.W.5
-
9
-
-
33644807298
-
The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity
-
Nam MK, Seong YM, Park HJ, Choi JY, Kang S, et al. (2006) The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity. Exp Mol Med 38: 36-43.
-
(2006)
Exp Mol Med
, vol.38
, pp. 36-43
-
-
Nam, M.K.1
Seong, Y.M.2
Park, H.J.3
Choi, J.Y.4
Kang, S.5
-
10
-
-
0033939134
-
Expression, purification, and functional analysis of the human serine protease HtrA2
-
Savopoulos JW, Carter PS, Turconi S, Pettman GR, Karran EH, et al. (2000) Expression, purification, and functional analysis of the human serine protease HtrA2. Protein Expr Purif 19: 227-234.
-
(2000)
Protein Expr Purif
, vol.19
, pp. 227-234
-
-
Savopoulos, J.W.1
Carter, P.S.2
Turconi, S.3
Pettman, G.R.4
Karran, E.H.5
-
11
-
-
0742324395
-
Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways
-
Suzuki Y, Takahashi-Niki K, Akagi T, Hashikawa T, Takahashi R (2004) Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways. Cell Death Differ 11: 208-216.
-
(2004)
Cell Death Differ
, vol.11
, pp. 208-216
-
-
Suzuki, Y.1
Takahashi-Niki, K.2
Akagi, T.3
Hashikawa, T.4
Takahashi, R.5
-
12
-
-
0034785591
-
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
-
Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, et al. (2001) A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 8: 613-621.
-
(2001)
Mol Cell
, vol.8
, pp. 613-621
-
-
Suzuki, Y.1
Imai, Y.2
Nakayama, H.3
Takahashi, K.4
Takio, K.5
-
13
-
-
18244386261
-
The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity
-
van Loo G, van Gurp M, Depuydt B, Srinivasula SM, Rodriguez I, et al. (2002) The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ 9: 20-26.
-
(2002)
Cell Death Differ
, vol.9
, pp. 20-26
-
-
van Loo, G.1
van Gurp, M.2
Depuydt, B.3
Srinivasula, S.M.4
Rodriguez, I.5
-
14
-
-
3142669325
-
Temperature dependent protease activity and structural properties of human HtrA2 protease
-
Zhang X, Chang Z (2004) Temperature dependent protease activity and structural properties of human HtrA2 protease. Biochemistry (Mosc) 69: 687-692.
-
(2004)
Biochemistry (Mosc)
, vol.69
, pp. 687-692
-
-
Zhang, X.1
Chang, Z.2
-
15
-
-
34547559252
-
Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain
-
Zhang Y, Appleton BA, Wu P, Wiesmann C, Sidhu SS (2007) Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain. Protein Sci 16: 1738-1750.
-
(2007)
Protein Sci
, vol.16
, pp. 1738-1750
-
-
Zhang, Y.1
Appleton, B.A.2
Wu, P.3
Wiesmann, C.4
Sidhu, S.S.5
-
16
-
-
37349004102
-
Parkinson's disease
-
Thomas B, Beal MF (2007) Parkinson's disease. Hum Mol Genet 16 Spec No. 2: R183-194.
-
(2007)
Hum Mol Genet
, vol.16
, Issue.SPEC 2
-
-
Thomas, B.1
Beal, M.F.2
-
17
-
-
25444498785
-
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
-
Strauss KM, Martins LM, Plun-Favreau H, Marx FP, Kautzmann S, et al. (2005) Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease. Hum Mol Genet 14: 2099-2111.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 2099-2111
-
-
Strauss, K.M.1
Martins, L.M.2
Plun-Favreau, H.3
Marx, F.P.4
Kautzmann, S.5
-
18
-
-
54449090491
-
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies
-
Kawamoto Y, Kobayashi Y, Suzuki Y, Inoue H, Tomimoto H, et al. (2008) Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies. J Neuropathol Exp Neurol 67: 984-993.
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, pp. 984-993
-
-
Kawamoto, Y.1
Kobayashi, Y.2
Suzuki, Y.3
Inoue, H.4
Tomimoto, H.5
-
20
-
-
53749093969
-
Genetic variation of Omi/HtrA2 and Parkinson's disease
-
Ross OA, Soto AI, Vilarino-Guell C, Heckman MG, Diehl NN, et al. (2008) Genetic variation of Omi/HtrA2 and Parkinson's disease. Parkinsonism Relat Disord 14: 539-543.
-
(2008)
Parkinsonism Relat Disord
, vol.14
, pp. 539-543
-
-
Ross, O.A.1
Soto, A.I.2
Vilarino-Guell, C.3
Heckman, M.G.4
Diehl, N.N.5
-
21
-
-
0027210409
-
mnd2: A new mouse model of inherited motor neuron disease
-
Jones JM, Albin RL, Feldman EL, Simin K, Schuster TG, et al. (1993) mnd2: a new mouse model of inherited motor neuron disease. Genomics 16: 669-677.
-
(1993)
Genomics
, vol.16
, pp. 669-677
-
-
Jones, J.M.1
Albin, R.L.2
Feldman, E.L.3
Simin, K.4
Schuster, T.G.5
-
22
-
-
0142246441
-
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice
-
Jones JM, Datta P, Srinivasula SM, Ji W, Gupta S, et al. (2003) Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature 425: 721-727.
-
(2003)
Nature
, vol.425
, pp. 721-727
-
-
Jones, J.M.1
Datta, P.2
Srinivasula, S.M.3
Ji, W.4
Gupta, S.5
-
23
-
-
7644230386
-
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice
-
Martins LM, Morrison A, Klupsch K, Fedele V, Moisoi N, et al. (2004) Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol Cell Biol 24: 9848-9862.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9848-9862
-
-
Martins, L.M.1
Morrison, A.2
Klupsch, K.3
Fedele, V.4
Moisoi, N.5
-
24
-
-
70349451286
-
-
Cell Death Differ
-
Moisoi N, Klupsch K, Fedele V, East P, Sharma S, et al. (2008) Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response. Cell Death Differ.
-
(2008)
Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response
-
-
Moisoi, N.1
Klupsch, K.2
Fedele, V.3
East, P.4
Sharma, S.5
-
25
-
-
9644259048
-
Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death
-
Cilenti L, Soundarapandian MM, Kyriazis GA, Stratico V, Singh S, et al. (2004) Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death. J Biol Chem 279: 50295-50301.
-
(2004)
J Biol Chem
, vol.279
, pp. 50295-50301
-
-
Cilenti, L.1
Soundarapandian, M.M.2
Kyriazis, G.A.3
Stratico, V.4
Singh, S.5
-
26
-
-
33845918450
-
Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria
-
Park HJ, Kim SS, Seong YM, Kim KH, Goo HG, et al. (2006) Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria. J Biol Chem 281: 34277-34287.
-
(2006)
J Biol Chem
, vol.281
, pp. 34277-34287
-
-
Park, H.J.1
Kim, S.S.2
Seong, Y.M.3
Kim, K.H.4
Goo, H.G.5
-
27
-
-
34249735817
-
Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212
-
Yang L, Sun M, Sun XM, Cheng GZ, Nicosia SV, et al. (2007) Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212. J Biol Chem 282: 10981-10987.
-
(2007)
J Biol Chem
, vol.282
, pp. 10981-10987
-
-
Yang, L.1
Sun, M.2
Sun, X.M.3
Cheng, G.Z.4
Nicosia, S.V.5
-
28
-
-
35748935851
-
-
Nat Cell Biol
-
Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, et al. (2007) The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol.
-
(2007)
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
-
-
Plun-Favreau, H.1
Klupsch, K.2
Moisoi, N.3
Gandhi, S.4
Kjaer, S.5
-
29
-
-
58149397651
-
Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin
-
Whitworth AJ, Lee JR, Ho VM, Flick R, Chowdhury R, et al. (2008) Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. Dis Model Mech 1: 168-174.
-
(2008)
Dis Model Mech
, vol.1
, pp. 168-174
-
-
Whitworth, A.J.1
Lee, J.R.2
Ho, V.M.3
Flick, R.4
Chowdhury, R.5
-
30
-
-
36049038504
-
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
-
Exner N, Treske B, Paquet D, Holmstrom K, Schiesling C, et al. (2007) Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci 27: 12413-12418.
-
(2007)
J Neurosci
, vol.27
, pp. 12413-12418
-
-
Exner, N.1
Treske, B.2
Paquet, D.3
Holmstrom, K.4
Schiesling, C.5
-
31
-
-
67650718212
-
-
Cell Death Differ
-
Tain LS, Chowdhury RB, Tao RN, Plun-Favreau H, Moisoi N, et al. (2009) Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin. Cell Death Differ.
-
(2009)
Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin
-
-
Tain, L.S.1
Chowdhury, R.B.2
Tao, R.N.3
Plun-Favreau, H.4
Moisoi, N.5
-
32
-
-
58149375389
-
Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo
-
Yun J, Cao JH, Dodson MW, Clark IE, Kapahi P, et al. (2008) Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo. J Neurosci 28: 14500-14510.
-
(2008)
J Neurosci
, vol.28
, pp. 14500-14510
-
-
Yun, J.1
Cao, J.H.2
Dodson, M.W.3
Clark, I.E.4
Kapahi, P.5
-
33
-
-
33750969672
-
The protease inhibitor Ucf-101 induces cellular responses independently of its known target, HtrA2/Omi
-
Klupsch K, Downward J (2006) The protease inhibitor Ucf-101 induces cellular responses independently of its known target, HtrA2/Omi. Cell Death Differ 13: 2157-2159.
-
(2006)
Cell Death Differ
, vol.13
, pp. 2157-2159
-
-
Klupsch, K.1
Downward, J.2
-
34
-
-
0037562009
-
Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2
-
Cilenti L, Lee Y, Hess S, Srinivasula S, Park KM, et al. (2003) Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2. J Biol Chem 278: 11489-11494.
-
(2003)
J Biol Chem
, vol.278
, pp. 11489-11494
-
-
Cilenti, L.1
Lee, Y.2
Hess, S.3
Srinivasula, S.4
Park, K.M.5
-
35
-
-
64549097439
-
Guidelines for the nomenclature of the human heat shock proteins
-
Kampinga HH, Hageman J, Vos MJ, Kubota H, Tanguay RM, et al. (2009) Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones 14: 105-111.
-
(2009)
Cell Stress Chaperones
, vol.14
, pp. 105-111
-
-
Kampinga, H.H.1
Hageman, J.2
Vos, M.J.3
Kubota, H.4
Tanguay, R.M.5
-
36
-
-
0037351068
-
Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals
-
Flynn JM, Neher SB, Kim YI, Sauer RT, Baker TA (2003) Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals. Mol Cell 11: 671-683.
-
(2003)
Mol Cell
, vol.11
, pp. 671-683
-
-
Flynn, J.M.1
Neher, S.B.2
Kim, Y.I.3
Sauer, R.T.4
Baker, T.A.5
-
37
-
-
33745776488
-
Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase
-
Kiang JG, Bowman PD, Lu X, Li Y, Ding XZ, et al. (2006) Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase. Am J Physiol Gastrointest Liver Physiol 291: G117-127.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.291
-
-
Kiang, J.G.1
Bowman, P.D.2
Lu, X.3
Li, Y.4
Ding, X.Z.5
-
38
-
-
33947537591
-
Proteomic identification of novel proteins in cortical lewy bodies
-
Leverenz JB, Umar I, Wang Q, Montine TJ, McMillan PJ, et al. (2007) Proteomic identification of novel proteins in cortical lewy bodies. Brain Pathol 17: 139-145.
-
(2007)
Brain Pathol
, vol.17
, pp. 139-145
-
-
Leverenz, J.B.1
Umar, I.2
Wang, Q.3
Montine, T.J.4
McMillan, P.J.5
-
39
-
-
0037314409
-
CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals
-
Jin S, Kalkum M, Overholtzer M, Stoffel A, Chait BT, et al. (2003) CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals. Genes Dev 17: 359-367.
-
(2003)
Genes Dev
, vol.17
, pp. 359-367
-
-
Jin, S.1
Kalkum, M.2
Overholtzer, M.3
Stoffel, A.4
Chait, B.T.5
-
40
-
-
57649194934
-
What have PINK1 and HtrA2 genes told us about the role of mitochondria in Parkinson's disease?
-
Plun-Favreau H, Gandhi S, Wood-Kaczmar A, Deas E, Yao Z, et al. (2008) What have PINK1 and HtrA2 genes told us about the role of mitochondria in Parkinson's disease? Ann N Y Acad Sci 1147: 30-36.
-
(2008)
Ann N Y Acad Sci
, vol.1147
, pp. 30-36
-
-
Plun-Favreau, H.1
Gandhi, S.2
Wood-Kaczmar, A.3
Deas, E.4
Yao, Z.5
-
41
-
-
0018247640
-
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor
-
Wigler M, Pellicer A, Silverstein S, Axel R (1978) Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell 14: 725-731.
-
(1978)
Cell
, vol.14
, pp. 725-731
-
-
Wigler, M.1
Pellicer, A.2
Silverstein, S.3
Axel, R.4
|