-
1
-
-
66349117317
-
Membrane phospholipid synthesis and endoplasmic reticulum function
-
Suppl.
-
Fagone P, Jackowski S. 2009. Membrane phospholipid synthesis and endoplasmic reticulum function. J. Lipid Res. 50(Suppl.):S311-16
-
(2009)
J. Lipid Res.
, vol.50
, pp. S311-S316
-
-
Fagone, P.1
Jackowski, S.2
-
2
-
-
38549103628
-
Protein quality control in the early secretory pathway
-
Anelli T, Sitia R. 2008. Protein quality control in the early secretory pathway. EMBO J. 27:315-27
-
(2008)
EMBO J.
, vol.27
, pp. 315-327
-
-
Anelli, T.1
Sitia, R.2
-
3
-
-
0842266604
-
Oxidative protein folding in eukaryotes: Mechanisms and consequences
-
Tu BP, Weissman JS. 2004. Oxidative protein folding in eukaryotes: mechanisms and consequences. J. Cell Biol. 164:341-46
-
(2004)
J. Cell Biol.
, vol.164
, pp. 341-346
-
-
Tu, B.P.1
Weissman, J.S.2
-
4
-
-
0036842559
-
Formation and transfer of disulphide bonds in living cells
-
Sevier CS, Kaiser CA. 2002. Formation and transfer of disulphide bonds in living cells. Nat. Rev. Mol. Cell Biol. 3:836-47
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 836-847
-
-
Sevier, C.S.1
Kaiser, C.A.2
-
5
-
-
23744457478
-
Versatility of the endoplasmic reticulum protein folding factory
-
van Anken E, Braakman I. 2005. Versatility of the endoplasmic reticulum protein folding factory. Crit. Rev. Biochem. Mol. Biol. 40:191-228
-
(2005)
Crit. Rev. Biochem. Mol. Biol.
, vol.40
, pp. 191-228
-
-
Van Anken, E.1
Braakman, I.2
-
6
-
-
56349087407
-
Real-Time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions
-
Merksamer PI, Trusina A, Papa FR. 2008. Real-Time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell 135:933-47
-
(2008)
Cell
, vol.135
, pp. 933-947
-
-
Merksamer, P.I.1
Trusina, A.2
Papa, F.R.3
-
7
-
-
4444318357
-
ER chaperone functions during normal and stress conditions
-
Ma Y, Hendershot LM. 2004. ER chaperone functions during normal and stress conditions. J. Chem. Neuroanat. 28:51-65
-
(2004)
J. Chem. Neuroanat.
, vol.28
, pp. 51-65
-
-
Ma, Y.1
Hendershot, L.M.2
-
8
-
-
0042318739
-
Evolving questions and paradigm shifts in endoplasmic-reticulumassociated degradation (ERAD)
-
McCracken AA, Brodsky JL. 2003. Evolving questions and paradigm shifts in endoplasmic-reticulumassociated degradation (ERAD). Bioessays 25:868-77
-
(2003)
Bioessays
, vol.25
, pp. 868-877
-
-
McCracken, A.A.1
Brodsky, J.L.2
-
9
-
-
82255161944
-
Road to ruin: Targeting proteins for degradation in the endoplasmic reticulum
-
Smith MH, Ploegh HL, Weissman JS. 2011. Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science 334:1086-90
-
(2011)
Science
, vol.334
, pp. 1086-1090
-
-
Smith, M.H.1
Ploegh, H.L.2
Weissman, J.S.3
-
12
-
-
79957900616
-
Dynamics of insulin secretion and the clinical implications for obesity and diabetes
-
Seino S, Shibasaki T, Minami K. 2011. Dynamics of insulin secretion and the clinical implications for obesity and diabetes. J. Clin. Investig. 121:2118-25
-
(2011)
J. Clin. Investig.
, vol.121
, pp. 2118-2125
-
-
Seino, S.1
Shibasaki, T.2
Minami, K.3
-
13
-
-
70350130802
-
Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1
-
van Anken E, Pena F, Hafkemeijer N, Christis C, Romijn EP, et al. 2009. Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1. PNAS 106:17019-24
-
(2009)
PNAS
, vol.106
, pp. 17019-17024
-
-
Van Anken, E.1
Pena, F.2
Hafkemeijer, N.3
Christis, C.4
Romijn, E.P.5
-
14
-
-
79952264011
-
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
-
Tabas I, Ron D. 2011. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat. Cell Biol. 13:184-90
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 184-190
-
-
Tabas, I.1
Ron, D.2
-
15
-
-
0036175128
-
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
-
Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, et al. 2002. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J. Clin. Investig. 109:525-32
-
(2002)
J. Clin. Investig.
, vol.109
, pp. 525-532
-
-
Oyadomari, S.1
Koizumi, A.2
Takeda, K.3
Gotoh, T.4
Akira, S.5
-
16
-
-
77956642651
-
Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1
-
Zhang HM, Ye X, Su Y, Yuan J, Liu Z, et al. 2010. Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1. J. Virol. 84:8446-59
-
(2010)
J. Virol.
, vol.84
, pp. 8446-8459
-
-
Zhang, H.M.1
Ye, X.2
Su, Y.3
Yuan, J.4
Liu, Z.5
-
18
-
-
84859612545
-
Protein quality control in neurodegenerative disease
-
Gestwicki JE, Garza D. 2012. Protein quality control in neurodegenerative disease. Prog. Mol. Biol. Transl. Sci. 107:327-53
-
(2012)
Prog. Mol. Biol. Transl. Sci.
, vol.107
, pp. 327-353
-
-
Gestwicki, J.E.1
Garza, D.2
-
19
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D, Walter P. 2007. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8:519-29
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
20
-
-
84863740827
-
The impact of the unfolded protein response on human disease
-
Wang S, Kaufman RJ. 2012. The impact of the unfolded protein response on human disease. J. Cell Biol. 197:857-67
-
(2012)
J. Cell Biol.
, vol.197
, pp. 857-867
-
-
Wang, S.1
Kaufman, R.J.2
-
21
-
-
77955023666
-
BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response
-
Pincus D, Chevalier MW, Aragon T, van Anken E, Vidal SE, et al. 2010. BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response. PLOS Biol. 8:e1000415
-
(2010)
PLOS Biol.
, vol.8
, pp. e1000415
-
-
Pincus, D.1
Chevalier, M.W.2
Aragon, T.3
Van Anken, E.4
Vidal, S.E.5
-
22
-
-
80053369081
-
Unfolded proteins are Ire1-Activating ligands that directly induce the unfolded protein response
-
Gardner BM, Walter P. 2011. Unfolded proteins are Ire1-Activating ligands that directly induce the unfolded protein response. Science 333:1891-94
-
(2011)
Science 333
, pp. 1891-1894
-
-
Gardner, B.M.1
Walter, P.2
-
23
-
-
30044432596
-
On themechanism of sensing unfolded protein in the endoplasmic reticulum
-
Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. 2005. On themechanism of sensing unfolded protein in the endoplasmic reticulum. PNAS 102:18773-84
-
(2005)
PNAS
, vol.102
, pp. 18773-18784
-
-
Credle, J.J.1
Finer-Moore, J.S.2
Papa, F.R.3
Stroud, R.M.4
Walter, P.5
-
24
-
-
82255173966
-
The unfolded protein response: From stress pathway to homeostatic regulation
-
Walter P, Ron D. 2011. The unfolded protein response: from stress pathway to homeostatic regulation. Science 334:1081-86
-
(2011)
Science
, vol.334
, pp. 1081-1086
-
-
Walter, P.1
Ron, D.2
-
25
-
-
0032525990
-
Astress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
-
Tirasophon W, Welihinda AA, Kaufman RJ. 1998.Astress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 12:1812-24
-
(1998)
Genes Dev.
, vol.12
, pp. 1812-1824
-
-
Tirasophon, W.1
Welihinda, A.A.2
Kaufman, R.J.3
-
26
-
-
0032190546
-
Cloning of mammalian Ire1 reveals diversity in the ER stress responses
-
Wang XZ, Harding HP, Zhang Y, Jolicoeur EM, Kuroda M, Ron D. 1998. Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 17:5708-17
-
(1998)
EMBO J.
, vol.17
, pp. 5708-5717
-
-
Wang, X.Z.1
Harding, H.P.2
Zhang, Y.3
Jolicoeur, E.M.4
Kuroda, M.5
Ron, D.6
-
27
-
-
84870159094
-
Structural basis of the unfolded protein response
-
Korennykh A, Walter P. 2012. Structural basis of the unfolded protein response. Annu. Rev. Cell Dev. Biol. 28:251-77
-
(2012)
Annu. Rev. Cell Dev. Biol.
, vol.28
, pp. 251-277
-
-
Korennykh, A.1
Walter, P.2
-
28
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, et al. 2002. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415:92-96
-
(2002)
Nature
, vol.415
, pp. 92-96
-
-
Calfon, M.1
Zeng, H.2
Urano, F.3
Till, J.H.4
Hubbard, S.R.5
-
29
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
-
Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. 2001. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107:881-91
-
(2001)
Cell
, vol.107
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
-
30
-
-
34548172495
-
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6α and XBP1
-
Yamamoto K, Sato T, Matsui T, Sato M, Okada T, et al. 2007. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6α and XBP1. Dev. Cell 13:365-76
-
(2007)
Dev. Cell
, vol.13
, pp. 365-376
-
-
Yamamoto, K.1
Sato, T.2
Matsui, T.3
Sato, M.4
Okada, T.5
-
31
-
-
0034637605
-
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum
-
Liu CY, Schroder M, Kaufman RJ. 2000. Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum. J. Biol. Chem. 275:24881-85
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 24881-24885
-
-
Liu, C.Y.1
Schroder, M.2
Kaufman, R.J.3
-
32
-
-
0033782015
-
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
-
Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. 2000. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2:326-32
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
33
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmicreticulum-resident kinase
-
Harding HP, Zhang Y, Ron D. 1999. Protein translation and folding are coupled by an endoplasmicreticulum-resident kinase. Nature 397:271-74
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
34
-
-
0034515724
-
ER stress induces cleavage of membranebound ATF6 by the same proteases that process SREBPs
-
Ye J, Rawson RB, Komuro R, Chen X, Dave UP, et al. 2000. ER stress induces cleavage of membranebound ATF6 by the same proteases that process SREBPs. Mol. Cell 6:1355-64
-
(2000)
Mol. Cell
, vol.6
, pp. 1355-1364
-
-
Ye, J.1
Rawson, R.B.2
Komuro, R.3
Chen, X.4
Dave, U.P.5
-
35
-
-
79954426157
-
Signaling cell death from the endoplasmic reticulum stress response
-
Shore GC, Papa FR, Oakes SA. 2011. Signaling cell death from the endoplasmic reticulum stress response. Curr. Opin. Cell Biol. 23:143-49
-
(2011)
Curr. Opin. Cell Biol.
, vol.23
, pp. 143-149
-
-
Shore, G.C.1
Papa, F.R.2
Oakes, S.A.3
-
36
-
-
0035144493
-
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
-
McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ. 2001. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell. Biol. 21:1249-59
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1249-1259
-
-
McCullough, K.D.1
Martindale, J.L.2
Klotz, L.O.3
Aw, T.Y.4
Holbrook, N.J.5
-
37
-
-
10644233167
-
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
-
Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, et al. 2004. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 18:3066-77
-
(2004)
Genes Dev.
, vol.18
, pp. 3066-3077
-
-
Marciniak, S.J.1
Yun, C.Y.2
Oyadomari, S.3
Novoa, I.4
Zhang, Y.5
-
38
-
-
68049110633
-
IRE1α kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates
-
Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, et al. 2009. IRE1α kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 138:562-75
-
(2009)
Cell
, vol.138
, pp. 562-575
-
-
Han, D.1
Lerner, A.G.2
Vande Walle, L.3
Upton, J.P.4
Xu, W.5
-
39
-
-
33745893809
-
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response
-
Hollien J, Weissman JS. 2006. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science 313:104-7
-
(2006)
Science
, vol.313
, pp. 104-107
-
-
Hollien, J.1
Weissman, J.S.2
-
40
-
-
84868525253
-
IRE1αcleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2
-
Upton JP, Wang L, HanD, Wang ES, Huskey NE, et al. 2012. IRE1αcleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science 338:818-22
-
(2012)
Science
, vol.338
, pp. 818-822
-
-
Upton, J.P.1
Wang, L.2
Hand Wang, E.S.3
Huskey, N.E.4
-
41
-
-
84864682160
-
IRE1α induces thioredoxininteracting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress
-
Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, et al. 2012. IRE1α induces thioredoxininteracting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 16:250-64
-
(2012)
Cell Metab.
, vol.16
, pp. 250-264
-
-
Lerner, A.G.1
Upton, J.P.2
Praveen, P.V.3
Ghosh, R.4
Nakagawa, Y.5
-
42
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, et al. 2000. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287:664-66
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
Bertolotti, A.3
Zhang, Y.4
Chung, P.5
-
43
-
-
0036606540
-
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
-
Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, et al. 2002. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 16:1345-55
-
(2002)
Genes Dev.
, vol.16
, pp. 1345-1355
-
-
Nishitoh, H.1
Matsuzawa, A.2
Tobiume, K.3
Saegusa, K.4
Takeda, K.5
-
44
-
-
73349091842
-
The role of mitochondria in apoptosis
-
Wang C, Youle RJ. 2009. The role of mitochondria in apoptosis. Annu. Rev. Genet. 43:95-118
-
(2009)
Annu. Rev. Genet.
, vol.43
, pp. 95-118
-
-
Wang, C.1
Youle, R.J.2
-
45
-
-
75949105922
-
The BCL-2 family reunion
-
Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR. The BCL-2 family reunion. Mol. Cell 37:299-310
-
Mol. Cell
, vol.37
, pp. 299-310
-
-
Chipuk, J.E.1
Moldoveanu, T.2
Llambi, F.3
Parsons, M.J.4
Green, D.R.5
-
46
-
-
68149154728
-
BH3-only proteins and their roles in programmed cell death
-
Giam M, Huang DC, Bouillet P. 2008. BH3-only proteins and their roles in programmed cell death. Oncogene 27(Suppl. 1):S128-36
-
(2008)
Oncogene
, vol.27
, pp. S128-S136
-
-
Giam, M.1
Huang, D.C.2
Bouillet, P.3
-
47
-
-
44949233264
-
Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress
-
Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, et al. 2008. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol. Cell. Biol. 28:3943-51
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 3943-3951
-
-
Upton, J.P.1
Austgen, K.2
Nishino, M.3
Coakley, K.M.4
Hagen, A.5
-
48
-
-
34250758642
-
ER stress triggers apoptosis by activating BH3-only protein Bim
-
Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, et al. 2007. ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 129:1337-49
-
(2007)
Cell
, vol.129
, pp. 1337-1349
-
-
Puthalakath, H.1
O'reilly, L.A.2
Gunn, P.3
Lee, L.4
Kelly, P.N.5
-
49
-
-
33646373219
-
Endoplasmic reticulum stress-induced apoptosis: Multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53
-
Li J, Lee B, Lee AS. 2006. Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J. Biol. Chem. 281:7260-70
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 7260-7270
-
-
Li, J.1
Lee, B.2
Lee, A.S.3
-
50
-
-
57049117856
-
Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities
-
Kim I, XuW, Reed JC. 2008. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat. Rev. Drug Discov. 7:1013-30
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 1013-1030
-
-
Kim, I.1
Xuw Reed, J.C.2
-
51
-
-
43549105167
-
The unfolded protein response: A pathway that links insulin demand with β-cell failure and diabetes
-
Scheuner D, Kaufman RJ. 2008. The unfolded protein response: a pathway that links insulin demand with β-cell failure and diabetes. Endocr. Rev. 29:317-33
-
(2008)
Endocr. Rev.
, vol.29
, pp. 317-333
-
-
Scheuner, D.1
Kaufman, R.J.2
-
52
-
-
0034070828
-
New aspects of proinsulin physiology and pathophysiology
-
Steiner DF. 2000. New aspects of proinsulin physiology and pathophysiology. J. Pediatr. Endocrinol. Metab. 13:229-39
-
(2000)
J. Pediatr. Endocrinol. Metab.
, vol.13
, pp. 229-239
-
-
Steiner, D.F.1
-
53
-
-
0036175125
-
Proteotoxicity in the endoplasmic reticulum: Lessons from the Akita diabetic mouse
-
Ron D. 2002. Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse. J. Clin. Investig. 109:443-45
-
(2002)
J. Clin. Investig.
, vol.109
, pp. 443-445
-
-
Ron, D.1
-
54
-
-
0037312881
-
Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse
-
Izumi T, Yokota-Hashimoto H, Zhao S, Wang J, Halban PA, Takeuchi T. 2003. Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse. Diabetes 52:409-16
-
(2003)
Diabetes
, vol.52
, pp. 409-416
-
-
Izumi, T.1
Yokota-Hashimoto, H.2
Zhao, S.3
Wang, J.4
Halban, P.A.5
Takeuchi, T.6
-
55
-
-
0032918044
-
A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse
-
Wang J, Takeuchi T, Tanaka S, Kubo SK, Kayo T, et al. 1999. A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse. J. Clin. Investig. 103:27-37
-
(1999)
J. Clin. Investig.
, vol.103
, pp. 27-37
-
-
Wang, J.1
Takeuchi, T.2
Tanaka, S.3
Kubo, S.K.4
Kayo, T.5
-
56
-
-
17144365015
-
Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum
-
Liu M, Li Y, Cavener D, Arvan P. 2005. Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum. J. Biol. Chem. 280:13209-12
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 13209-13212
-
-
Liu, M.1
Li, Y.2
Cavener, D.3
Arvan, P.4
-
57
-
-
35448994352
-
Insulin gene mutations as a cause of permanent neonatal diabetes
-
Stoy J, Edghill EL, Flanagan SE, Ye H, Paz VP, et al. 2007. Insulin gene mutations as a cause of permanent neonatal diabetes. PNAS 104:15040-44
-
(2007)
PNAS
, vol.104
, pp. 15040-15044
-
-
Stoy, J.1
Edghill, E.L.2
Flanagan, S.E.3
Ye, H.4
Paz, V.P.5
-
58
-
-
0033634641
-
Perk is essential for translational regulation and cell survival during the unfolded protein response
-
Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D. 2000. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol. Cell 5:897-904
-
(2000)
Mol. Cell
, vol.5
, pp. 897-904
-
-
Harding, H.P.1
Zhang, Y.2
Bertolotti, A.3
Zeng, H.4
Ron, D.5
-
59
-
-
0034425698
-
EIF2AK3, encoding translation initiation factor 2-αkinase 3, is mutated in patients with Wolcott-Rallison syndrome
-
Delepine M, Nicolino M, Barrett T, Golamaully M, Lathrop GM, Julier C. 2000. EIF2AK3, encoding translation initiation factor 2-αkinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat. Genet. 25:406-9
-
(2000)
Nat. Genet.
, vol.25
, pp. 406-409
-
-
Delepine, M.1
Nicolino, M.2
Barrett, T.3
Golamaully, M.4
Lathrop, G.M.5
Julier, C.6
-
60
-
-
71049135314
-
PERK regulates the proliferation and development of insulinsecreting beta-cell tumors in the endocrine pancreas of mice
-
Gupta S, McGrath B, Cavener DR. 2009. PERK regulates the proliferation and development of insulinsecreting beta-cell tumors in the endocrine pancreas of mice. PLOS ONE 4:e8008
-
(2009)
PLOS ONE
, vol.4
, pp. e8008
-
-
Gupta, S.1
McGrath, B.2
Cavener, D.R.3
-
61
-
-
79957773163
-
Dual and opposing roles of the unfolded protein response regulated by IRE1α and XBP1 in proinsulin processing and insulin secretion
-
Lee AH, Heidtman K, Hotamisligil GS, Glimcher LH. 2011. Dual and opposing roles of the unfolded protein response regulated by IRE1α and XBP1 in proinsulin processing and insulin secretion. PNAS 108:8885-90
-
(2011)
PNAS
, vol.108
, pp. 8885-8890
-
-
Lee, A.H.1
Heidtman, K.2
Hotamisligil, G.S.3
Glimcher, L.H.4
-
62
-
-
84864278763
-
Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance
-
Usui M, Yamaguchi S, Tanji Y, Tominaga R, Ishigaki Y, et al. 2012. Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance. Metabolism 61:1118-28
-
(2012)
Metabolism
, vol.61
, pp. 1118-1128
-
-
Usui, M.1
Yamaguchi, S.2
Tanji, Y.3
Tominaga, R.4
Ishigaki, Y.5
-
63
-
-
58149488703
-
Rationalizing translation attenuation in the network architecture of the unfolded protein response
-
Trusina A, Papa FR, Tang C. 2008. Rationalizing translation attenuation in the network architecture of the unfolded protein response. PNAS 105:20280-85
-
(2008)
PNAS
, vol.105
, pp. 20280-20285
-
-
Trusina, A.1
Papa, F.R.2
Tang, C.3
-
64
-
-
0034973982
-
Translational control is required for the unfolded protein response and in vivo glucose homeostasis
-
Scheuner D, Song B, McEwen E, Liu C, Laybutt R, et al. 2001. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol. Cell 7:1165-76
-
(2001)
Mol. Cell
, vol.7
, pp. 1165-1176
-
-
Scheuner, D.1
Song, B.2
McEwen, E.3
Liu, C.4
Laybutt, R.5
-
65
-
-
22544444513
-
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis
-
Scheuner D, Vander Mierde D, Song B, Flamez D, Creemers JW, et al. 2005. Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat. Med. 11:757-64
-
(2005)
Nat. Med.
, vol.11
, pp. 757-764
-
-
Scheuner, D.1
Vander Mierde, D.2
Song, B.3
Flamez, D.4
Creemers, J.W.5
-
66
-
-
33847677975
-
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
-
Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, et al. 2007. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 50:752-63
-
(2007)
Diabetologia
, vol.50
, pp. 752-763
-
-
Laybutt, D.R.1
Preston, A.M.2
Akerfeldt, M.C.3
Kench, J.G.4
Busch, A.K.5
-
67
-
-
33747175431
-
Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload
-
Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, et al. 2006. Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell 126:727-39
-
(2006)
Cell
, vol.126
, pp. 727-739
-
-
Oyadomari, S.1
Yun, C.2
Fisher, E.A.3
Kreglinger, N.4
Kreibich, G.5
-
68
-
-
20144386666
-
Pancreatic β-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK
-
Ladiges WC, Knoblaugh SE, Morton JF, Korth MJ, Sopher BL, et al. 2005. Pancreatic β-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK. Diabetes 54:1074-81
-
(2005)
Diabetes
, vol.54
, pp. 1074-1081
-
-
Ladiges, W.C.1
Knoblaugh, S.E.2
Morton, J.F.3
Korth, M.J.4
Sopher, B.L.5
-
69
-
-
27744523525
-
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis
-
Riggs AC, Bernal-Mizrachi E, Ohsugi M, Wasson J, Fatrai S, et al. 2005. Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis. Diabetologia 48:2313-21
-
(2005)
Diabetologia
, vol.48
, pp. 2313-2321
-
-
Riggs, A.C.1
Bernal-Mizrachi, E.2
Ohsugi, M.3
Wasson, J.4
Fatrai, S.5
-
70
-
-
28244435870
-
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic β-cells
-
Fonseca SG, Fukuma M, Lipson KL, Nguyen LX, Allen JR, et al. 2005. WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic β-cells. J. Biol. Chem. 280:39609-15
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 39609-39615
-
-
Fonseca, S.G.1
Fukuma, M.2
Lipson, K.L.3
Nguyen, L.X.4
Allen, J.R.5
-
71
-
-
77949751415
-
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells
-
Fonseca SG, Ishigaki S, Oslowski CM, Lu S, Lipson KL, et al. 2010. Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J. Clin. Investig. 120:744-55
-
(2010)
J. Clin. Investig.
, vol.120
, pp. 744-755
-
-
Fonseca, S.G.1
Ishigaki, S.2
Oslowski, C.M.3
Lu, S.4
Lipson, K.L.5
-
72
-
-
1842612402
-
A transgenic mouse model for monitoring endoplasmic reticulum stress
-
Iwawaki T, Akai R, Kohno K, Miura M. 2004. A transgenic mouse model for monitoring endoplasmic reticulum stress. Nat. Med. 10:98-102
-
(2004)
Nat. Med.
, vol.10
, pp. 98-102
-
-
Iwawaki, T.1
Akai, R.2
Kohno, K.3
Miura, M.4
-
73
-
-
84859553400
-
Isletβ-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model
-
Tersey SA, Nishiki Y, Templin AT, Cabrera SM, Stull ND, et al. 2012. Isletβ-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes 61:818-27
-
(2012)
Diabetes
, vol.61
, pp. 818-827
-
-
Tersey, S.A.1
Nishiki, Y.2
Templin, A.T.3
Cabrera, S.M.4
Stull, N.D.5
-
74
-
-
78651132915
-
Excessive insulin response to glucose in obese subjects as measured by immunochemical assay
-
Karam JH, Grodsky GM, Forsham PH. 1963. Excessive insulin response to glucose in obese subjects as measured by immunochemical assay. Diabetes 12:197-204
-
(1963)
Diabetes
, vol.12
, pp. 197-204
-
-
Karam, J.H.1
Grodsky, G.M.2
Forsham, P.H.3
-
75
-
-
9444242665
-
Five stages of evolving β-cell dysfunction during progression to diabetes
-
Weir GC, Bonner-Weir S. 2004. Five stages of evolving β-cell dysfunction during progression to diabetes. Diabetes 53(Suppl. 3):S16-21
-
(2004)
Diabetes 53(Suppl. 3):S16-21
-
-
Weir, G.C.1
Bonner-Weir, S.2
-
76
-
-
0019996086
-
Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans
-
Stefan Y, Orci L, Malaisse-Lagae F, Perrelet A, Patel Y, Unger RH. 1982. Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans. Diabetes 31:694-700
-
(1982)
Diabetes
, vol.31
, pp. 694-700
-
-
Stefan, Y.1
Orci, L.2
Malaisse-Lagae, F.3
Perrelet, A.4
Patel, Y.5
Unger, R.H.6
-
77
-
-
0037034257
-
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
-
Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, et al. 2002. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346:393-403
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 393-403
-
-
Knowler, W.C.1
Barrett-Connor, E.2
Fowler, S.E.3
Hamman, R.F.4
Lachin, J.M.5
-
78
-
-
84859059508
-
Persistence of prolonged C-peptide production in type 1 diabetes as measured with an ultrasensitive C-peptide assay
-
Wang L, Lovejoy NF, Faustman DL. 2012. Persistence of prolonged C-peptide production in type 1 diabetes as measured with an ultrasensitive C-peptide assay. Diabetes Care 35:465-70
-
(2012)
Diabetes Care
, vol.35
, pp. 465-470
-
-
Wang, L.1
Lovejoy, N.F.2
Faustman, D.L.3
-
79
-
-
3142514201
-
Protein aggregation and neurodegenerative disease
-
Suppl.
-
Ross CA, Poirier MA. 2004. Protein aggregation and neurodegenerative disease. Nat. Med. 10(Suppl.):S10-17
-
(2004)
Nat. Med.
, vol.10
, pp. S10-17
-
-
Ross, C.A.1
Poirier, M.A.2
-
80
-
-
79551584057
-
The unfolded protein response in familial amyotrophic lateral sclerosis
-
Wang L, Popko B, Roos RP. 2011. The unfolded protein response in familial amyotrophic lateral sclerosis. Hum. Mol. Genet. 20:1008-15
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 1008-1015
-
-
Wang, L.1
Popko, B.2
Roos, R.P.3
-
81
-
-
78650827764
-
Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease
-
Vidal R, Caballero B, Couve A, Hetz C. 2011. Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease. Curr. Mol. Med. 11:1-12
-
(2011)
Curr. Mol. Med.
, vol.11
, pp. 1-12
-
-
Vidal, R.1
Caballero, B.2
Couve, A.3
Hetz, C.4
-
82
-
-
84860513477
-
Endoplasmic reticulum stress and prion diseases
-
Xu K, Zhu XP. 2012. Endoplasmic reticulum stress and prion diseases. Rev. Neurosci. 23:79-84
-
(2012)
Rev. Neurosci.
, vol.23
, pp. 79-84
-
-
Xu, K.1
Zhu, X.P.2
-
83
-
-
7244236320
-
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
-
Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. 2004. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431:805-10
-
(2004)
Nature
, vol.431
, pp. 805-810
-
-
Arrasate, M.1
Mitra, S.2
Schweitzer, E.S.3
Segal, M.R.4
Finkbeiner, S.5
-
84
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins
-
Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, et al. 1998. Diffusible, nonfibrillar ligands derived from Aâ1-42 are potent central nervous system neurotoxins. PNAS 95:6448-53
-
(1998)
PNAS
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
-
85
-
-
0037077040
-
Toxic proteins in neurodegenerative disease
-
Taylor JP, Hardy J, Fischbeck KH. 2002. Toxic proteins in neurodegenerative disease. Science 296:1991-95
-
(2002)
Science
, vol.296
, pp. 1991-1995
-
-
Taylor, J.P.1
Hardy, J.2
Fischbeck, K.H.3
-
87
-
-
63149175877
-
Endoplasmic reticulum protein quality control in neurodegenerative disease: The good, the bad and the therapy
-
Scheper W, Hoozemans JJ. 2009. Endoplasmic reticulum protein quality control in neurodegenerative disease: the good, the bad and the therapy. Curr. Med. Chem. 16:615-26
-
(2009)
Curr. Med. Chem.
, vol.16
, pp. 615-626
-
-
Scheper, W.1
Hoozemans, J.J.2
-
88
-
-
84870838478
-
Endoplasmic reticulum dysfunction in neurological disease
-
Roussel BD, Kruppa AJ, Miranda E, Crowther DC, Lomas DA, Marciniak SJ. 2013. Endoplasmic reticulum dysfunction in neurological disease. Lancet Neurol. 12:105-18
-
(2013)
Lancet Neurol.
, vol.12
, pp. 105-118
-
-
Roussel, B.D.1
Kruppa, A.J.2
Miranda, E.3
Crowther, D.C.4
Lomas, D.A.5
Marciniak, S.J.6
-
89
-
-
0025736490
-
Expression of heat shock proteins in Alzheimer's disease
-
Hamos JE, Oblas B, Pulaski-Salo D, Welch WJ, Bole DG, Drachman DA. 1991. Expression of heat shock proteins in Alzheimer's disease. Neurology 41:345-50
-
(1991)
Neurology
, vol.41
, pp. 345-350
-
-
Hamos, J.E.1
Oblas, B.2
Pulaski-Salo, D.3
Welch, W.J.4
Bole, D.G.5
Drachman, D.A.6
-
90
-
-
24344489466
-
The unfolded protein response is activated in Alzheimer's disease
-
Hoozemans JJ, Veerhuis R, Van Haastert ES, Rozemuller JM, Baas F, et al. 2005. The unfolded protein response is activated in Alzheimer's disease. Acta Neuropathol. 110:165-72
-
(2005)
Acta Neuropathol.
, vol.110
, pp. 165-172
-
-
Hoozemans, J.J.1
Veerhuis, R.2
Van Haastert, E.S.3
Rozemuller, J.M.4
Baas, F.5
-
91
-
-
65349093893
-
The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus
-
Hoozemans JJ, van Haastert ES, Nijholt DA, Rozemuller AJ, Eikelenboom P, Scheper W. 2009. The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus. Am. J. Pathol. 174:1241-51
-
(2009)
Am. J. Pathol.
, vol.174
, pp. 1241-1251
-
-
Hoozemans, J.J.1
Van Haastert, E.S.2
Nijholt, D.A.3
Rozemuller, A.J.4
Eikelenboom, P.5
Scheper, W.6
-
92
-
-
33744985455
-
Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo
-
Unterberger U, Hoftberger R, Gelpi E, Flicker H, Budka H, Voigtlander T. 2006. Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo. J. Neuropathol. Exp. Neurol. 65:348-57
-
(2006)
J. Neuropathol. Exp. Neurol.
, vol.65
, pp. 348-357
-
-
Unterberger, U.1
Hoftberger, R.2
Gelpi, E.3
Flicker, H.4
Budka, H.5
Voigtlander, T.6
-
93
-
-
33846605587
-
Activation of the unfolded protein response in Parkinson's disease
-
Hoozemans JJ, van Haastert ES, Eikelenboom P, de Vos RA, Rozemuller JM, ScheperW. 2007. Activation of the unfolded protein response in Parkinson's disease. Biochem. Biophys. Res. Commun. 354:707-11
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.354
, pp. 707-711
-
-
Hoozemans, J.J.1
Van Haastert, E.S.2
Eikelenboom, P.3
De Vos, R.A.4
Rozemuller, J.M.5
Scheper, W.6
-
94
-
-
34247172998
-
Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease
-
Wang HQ, Takahashi R. 2007. Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease. Antioxid. Redox Signal. 9:553-61
-
(2007)
Antioxid. Redox Signal.
, vol.9
, pp. 553-561
-
-
Wang, H.Q.1
Takahashi, R.2
-
95
-
-
43649100018
-
Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis
-
Atkin JD, Farg MA, Walker AK, McLean C, Tomas D, Horne MK. 2008. Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis. Neurobiol. Dis. 30:400-7
-
(2008)
Neurobiol. Dis.
, vol.30
, pp. 400-407
-
-
Atkin, J.D.1
Farg, M.A.2
Walker, A.K.3
McLean, C.4
Tomas, D.5
Horne, M.K.6
-
96
-
-
0038143287
-
Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons
-
HoltzWA, O'Malley KL. 2003. Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons. J. Biol. Chem. 278:19367-77
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19367-19377
-
-
Holtz, W.A.1
O'malley, K.L.2
-
97
-
-
33749563294
-
Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1
-
Atkin JD, Farg MA, Turner BJ, Tomas D, Lysaght JA, et al. 2006. Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1. J. Biol. Chem. 281:30152-65
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 30152-30165
-
-
Atkin, J.D.1
Farg, M.A.2
Turner, B.J.3
Tomas, D.4
Lysaght, J.A.5
-
98
-
-
33645798615
-
Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model
-
Kikuchi H, Almer G, Yamashita S, Guegan C, Nagai M, et al. 2006. Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. PNAS 103:6025-30
-
(2006)
PNAS
, vol.103
, pp. 6025-6030
-
-
Kikuchi, H.1
Almer, G.2
Yamashita, S.3
Guegan, C.4
Nagai, M.5
-
99
-
-
44849124411
-
ALS-linked mutant SOD1 induces ER stress-And ASK1-dependentmotor neuron death by targeting Derlin-1
-
Nishitoh H, Kadowaki H, Nagai A, Maruyama T, Yokota T, et al. 2008. ALS-linked mutant SOD1 induces ER stress-And ASK1-dependentmotor neuron death by targeting Derlin-1. GenesDev. 22:1451-64
-
(2008)
Genes Dev.
, vol.22
, pp. 1451-1464
-
-
Nishitoh, H.1
Kadowaki, H.2
Nagai, A.3
Maruyama, T.4
Yokota, T.5
-
100
-
-
79959689333
-
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy
-
Hoglinger GU, Melhem NM, Dickson DW, Sleiman PM, Wang LS, et al. 2011. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nat. Genet. 43:699-705
-
(2011)
Nat. Genet.
, vol.43
, pp. 699-705
-
-
Hoglinger, G.U.1
Melhem, N.M.2
Dickson, D.W.3
Sleiman, P.M.4
Wang, L.S.5
-
101
-
-
85048240730
-
The unfolded protein response is activated in disease-Affected brain regions in progressive supranuclear palsy and Alzheimer's disease
-
Stutzbach LD, Xie SX, Naj AC, Albin R, Gilman S, et al. 2013. The unfolded protein response is activated in disease-Affected brain regions in progressive supranuclear palsy and Alzheimer's disease. Acta Neuropathol. Commun. 1:31
-
(2013)
Acta Neuropathol. Commun.
, vol.1
, pp. 31
-
-
Stutzbach, L.D.1
Xie, S.X.2
Naj, A.C.3
Albin, R.4
Gilman, S.5
-
102
-
-
36749067790
-
Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis
-
Ilieva EV, Ayala V, Jove M, Dalfo E, Cacabelos D, et al. 2007. Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis. Brain 130:3111-23
-
(2007)
Brain
, vol.130
, pp. 3111-3123
-
-
Ilieva, E.V.1
Ayala, V.2
Jove, M.3
Dalfo, E.4
Cacabelos, D.5
-
103
-
-
67349164383
-
A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice
-
Saxena S, Cabuy E, Caroni P. 2009. A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice. Nat. Neurosci. 12:627-36
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 627-636
-
-
Saxena, S.1
Cabuy, E.2
Caroni, P.3
-
104
-
-
84883453343
-
Suppression of eIF2αkinases alleviates Alzheimer's disease-related plasticity and memory deficits
-
Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, et al. 2013. Suppression of eIF2αkinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat. Neurosci. 16:1299-305
-
(2013)
Nat. Neurosci.
, vol.16
, pp. 1299-1305
-
-
Ma, T.1
Trinh, M.A.2
Wexler, A.J.3
Bourbon, C.4
Gatti, E.5
-
105
-
-
84885463900
-
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice
-
Moreno JA, Halliday M, Molloy C, Radford H, Verity N, et al. 2013. Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. Sci. Transl. Med. 5:206ra138
-
(2013)
Sci. Transl. Med.
, pp. 5206ra138
-
-
Moreno, J.A.1
Halliday, M.2
Molloy, C.3
Radford, H.4
Verity, N.5
-
106
-
-
78349265743
-
Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease
-
Minamino T, Komuro I, Kitakaze M. 2010. Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease. Circ. Res. 107:1071-82
-
(2010)
Circ. Res.
, vol.107
, pp. 1071-1082
-
-
Minamino, T.1
Komuro, I.2
Kitakaze, M.3
-
107
-
-
34948866189
-
Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome
-
Myoishi M, Hao H, Minamino T, Watanabe K, Nishihira K, et al. 2007. Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome. Circulation 116:1226-33
-
(2007)
Circulation
, vol.116
, pp. 1226-1233
-
-
Myoishi, M.1
Hao, H.2
Minamino, T.3
Watanabe, K.4
Nishihira, K.5
-
108
-
-
17144419252
-
Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice
-
Zhou J, Lhotak S, Hilditch BA, Austin RC. 2005. Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation 111:1814-21
-
(2005)
Circulation
, vol.111
, pp. 1814-1821
-
-
Zhou, J.1
Lhotak, S.2
Hilditch, B.A.3
Austin, R.C.4
-
109
-
-
77958532945
-
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress
-
Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, et al. 2010. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab. 12:467-82
-
(2010)
Cell Metab.
, vol.12
, pp. 467-482
-
-
Seimon, T.A.1
Nadolski, M.J.2
Liao, X.3
Magallon, J.4
Nguyen, M.5
-
110
-
-
9144231898
-
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling
-
Yamaguchi O, Higuchi Y, Hirotani S, Kashiwase K, Nakayama H, et al. 2003. Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling. PNAS 100:15883-88
-
(2003)
PNAS
, vol.100
, pp. 15883-15888
-
-
Yamaguchi, O.1
Higuchi, Y.2
Hirotani, S.3
Kashiwase, K.4
Nakayama, H.5
-
111
-
-
1842854719
-
Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP
-
Tajiri S, Oyadomari S, Yano S, Morioka M, Gotoh T, et al. 2004. Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP. Cell Death Differ. 11:403-15
-
(2004)
Cell Death Differ.
, vol.11
, pp. 403-415
-
-
Tajiri, S.1
Oyadomari, S.2
Yano, S.3
Morioka, M.4
Gotoh, T.5
-
112
-
-
10344222124
-
The role of the unfolded protein response in tumour development: Friend or foe?. Nat
-
Ma Y, Hendershot LM. 2004. The role of the unfolded protein response in tumour development: friend or foe?. Nat. Rev. Cancer 4:966-77
-
(2004)
Rev. Cancer
, vol.4
, pp. 966-977
-
-
Ma, Y.1
Hendershot, L.M.2
-
114
-
-
33646167400
-
ER stress, hypoxia tolerance and tumor progression
-
Koumenis C. 2006. ER stress, hypoxia tolerance and tumor progression. Curr. Mol. Med. 6:55-69
-
(2006)
Curr. Mol. Med.
, vol.6
, pp. 55-69
-
-
Koumenis, C.1
-
116
-
-
34047136169
-
The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis
-
Carrasco DR, Sukhdeo K, Protopopova M, Sinha R, Enos M, et al. 2007. The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell 11:349-60
-
(2007)
Cancer Cell
, vol.11
, pp. 349-360
-
-
Carrasco, D.R.1
Sukhdeo, K.2
Protopopova, M.3
Sinha, R.4
Enos, M.5
-
117
-
-
0034021399
-
Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions
-
Fernandez PM, Tabbara SO, Jacobs LK, Manning FC, Tsangaris TN, et al. 2000. Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions. Breast Cancer Res. Treat. 59:15-26
-
(2000)
Breast Cancer Res. Treat.
, vol.59
, pp. 15-26
-
-
Fernandez, P.M.1
Tabbara, S.O.2
Jacobs, L.K.3
Manning, F.C.4
Tsangaris, T.N.5
-
118
-
-
0038216621
-
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis
-
Shuda M, Kondoh N, Imazeki N, Tanaka K, Okada T, et al. 2003. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. J. Hepatol. 38:605-14
-
(2003)
J. Hepatol.
, vol.38
, pp. 605-614
-
-
Shuda, M.1
Kondoh, N.2
Imazeki, N.3
Tanaka, K.4
Okada, T.5
-
119
-
-
0035890417
-
Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-e/ERK/AP-1 signaling cascade
-
Song MS, Park YK, Lee JH, Park K. 2001. Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-e/ERK/AP-1 signaling cascade. Cancer Res. 61:8322-30
-
(2001)
Cancer Res.
, vol.61
, pp. 8322-8330
-
-
Song, M.S.1
Park, Y.K.2
Lee, J.H.3
Park, K.4
-
120
-
-
0036193187
-
Overexpression of glucose-regulated protein 94 (Grp94) in esophageal adenocarcinomas of a rat surgical model and humans
-
Chen X, Ding Y, Liu CG, Mikhail S, Yang CS. 2002. Overexpression of glucose-regulated protein 94 (Grp94) in esophageal adenocarcinomas of a rat surgical model and humans. Carcinogenesis 23:123-30
-
(2002)
Carcinogenesis
, vol.23
, pp. 123-130
-
-
Chen, X.1
Ding, Y.2
Liu, C.G.3
Mikhail, S.4
Yang, C.S.5
-
121
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, et al. 2007. Patterns of somatic mutation in human cancer genomes. Nature 446:153-58
-
(2007)
Nature
, vol.446
, pp. 153-158
-
-
Greenman, C.1
Stephens, P.2
Smith, R.3
Dalgliesh, G.L.4
Hunter, C.5
-
122
-
-
35448967382
-
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas
-
Pyrko P, Schonthal AH, Hofman FM, Chen TC, Lee AS. 2007. The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res. 67:9809-16
-
(2007)
Cancer Res.
, vol.67
, pp. 9809-9816
-
-
Pyrko, P.1
Schonthal, A.H.2
Hofman, F.M.3
Chen, T.C.4
Lee, A.S.5
-
123
-
-
84874112079
-
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies
-
Luo B, Lee AS. 2013. The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene 32:805-18
-
(2013)
Oncogene
, vol.32
, pp. 805-818
-
-
Luo, B.1
Lee, A.S.2
-
124
-
-
0029817451
-
Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME
-
Jamora C, Dennert G, Lee AS. 1996. Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME. PNAS 93:7690-94
-
(1996)
PNAS
, vol.93
, pp. 7690-7694
-
-
Jamora, C.1
Dennert, G.2
Lee, A.S.3
-
125
-
-
4444302042
-
Effect on tumor cells of blocking survival response to glucose deprivation
-
Park HR, Tomida A, Sato S, Tsukumo Y, Yun J, et al. 2004. Effect on tumor cells of blocking survival response to glucose deprivation. J. Natl. Cancer Inst. 96:1300-10
-
(2004)
J. Natl. Cancer Inst.
, vol.96
, pp. 1300-1310
-
-
Park, H.R.1
Tomida, A.2
Sato, S.3
Tsukumo, Y.4
Yun, J.5
-
126
-
-
4344660747
-
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth
-
Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, et al. 2004. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res. 64:5943-47
-
(2004)
Cancer Res.
, vol.64
, pp. 5943-5947
-
-
Romero-Ramirez, L.1
Cao, H.2
Nelson, D.3
Hammond, E.4
Lee, A.H.5
-
127
-
-
84857099440
-
Multiple defects, including premature apoptosis, preventKaposi's sarcoma-Associated herpesvirus replication in murine cells
-
Austgen K, Oakes SA, Ganem D. 2012. Multiple defects, including premature apoptosis, preventKaposi's sarcoma-Associated herpesvirus replication in murine cells. J. Virol. 86:1877-82
-
(2012)
J. Virol.
, vol.86
, pp. 1877-1882
-
-
Austgen, K.1
Oakes, S.A.2
Ganem, D.3
-
128
-
-
77957288028
-
Inositol-requiring enzyme 1αis a key regulator of angiogenesis and invasion in malignant glioma
-
Auf G, Jabouille A, Guerit S, Pineau R, Delugin M, et al. 2010. Inositol-requiring enzyme 1αis a key regulator of angiogenesis and invasion in malignant glioma. PNAS 107:15553-58
-
(2010)
PNAS
, vol.107
, pp. 15553-15558
-
-
Auf, G.1
Jabouille, A.2
Guerit, S.3
Pineau, R.4
Delugin, M.5
-
129
-
-
77949699965
-
Transcriptional regulation of VEGF-A by the unfolded protein response pathway
-
Ghosh R, Lipson KL, Sargent KE, Mercurio AM, Hunt JS, et al. 2010. Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLOS ONE 5:e9575
-
(2010)
PLOS ONE
, vol.5
, pp. e9575
-
-
Ghosh, R.1
Lipson, K.L.2
Sargent, K.E.3
Mercurio, A.M.4
Hunt, J.S.5
-
130
-
-
0035913294
-
Plasma cell differentiation requires the transcription factor XBP-1
-
Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, et al. 2001. Plasma cell differentiation requires the transcription factor XBP-1. Nature 412:300-7
-
(2001)
Nature
, vol.412
, pp. 300-307
-
-
Reimold, A.M.1
Iwakoshi, N.N.2
Manis, J.3
Vallabhajosyula, P.4
Szomolanyi-Tsuda, E.5
-
131
-
-
14944371187
-
Theunfolded protein response sensor IRE1αis required at 2 distinct steps in B cell lymphopoiesis
-
Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ. 2005.Theunfolded protein response sensor IRE1αis required at 2 distinct steps in B cell lymphopoiesis. J. Clin. Investig. 115:268-81
-
(2005)
J. Clin. Investig.
, vol.115
, pp. 268-281
-
-
Zhang, K.1
Wong, H.N.2
Song, B.3
Miller, C.N.4
Scheuner, D.5
Kaufman, R.J.6
-
134
-
-
79251589342
-
Identification of an Ire1α endonuclease specific inhibitor with cytotoxic activity against humanmultiplemyeloma
-
Papandreou I, Denko NC, Olson M, Van Melckebeke H, Lust S, et al. 2011. Identification of an Ire1α endonuclease specific inhibitor with cytotoxic activity against humanmultiplemyeloma. Blood 117:1311-14
-
(2011)
Blood
, vol.117
, pp. 1311-1314
-
-
Papandreou, I.1
Denko, N.C.2
Olson, M.3
Van Melckebeke, H.4
Lust, S.5
-
135
-
-
84862501186
-
Blockade of XBP1 splicing by inhibition of IRE1αis a promising therapeutic option in multiple myeloma
-
Mimura N, Fulciniti M, Gorgun G, Tai YT, Cirstea D, et al. 2012. Blockade of XBP1 splicing by inhibition of IRE1αis a promising therapeutic option in multiple myeloma. Blood 119:5772-81
-
(2012)
Blood
, vol.119
, pp. 5772-5781
-
-
Mimura, N.1
Fulciniti, M.2
Gorgun, G.3
Tai, Y.T.4
Cirstea, D.5
-
136
-
-
84859625301
-
Differentiation induction enhances bortezomib efficacy and overcomes drug resistance in multiple myeloma
-
Gu JL, Li J, Zhou ZH, Liu JR, Huang BH, et al. 2012. Differentiation induction enhances bortezomib efficacy and overcomes drug resistance in multiple myeloma. Biochem. Biophys. Res. Commun. 420:644-50
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.420
, pp. 644-650
-
-
Gu, J.L.1
Li, J.2
Zhou, Z.H.3
Liu, J.R.4
Huang, B.H.5
-
137
-
-
84855224484
-
Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1
-
Ling SC, Lau EK, Al-Shabeeb A, Nikolic A, Catalano A, et al. 2012. Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1. Haematologica 97:64-72
-
(2012)
Haematologica
, vol.97
, pp. 64-72
-
-
Ling, S.C.1
Lau, E.K.2
Al-Shabeeb, A.3
Nikolic, A.4
Catalano, A.5
-
138
-
-
79951494668
-
Initial genome sequencing and analysis of multiple myeloma
-
Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, et al. 2011. Initial genome sequencing and analysis of multiple myeloma. Nature 471:467-72
-
(2011)
Nature
, vol.471
, pp. 467-472
-
-
Chapman, M.A.1
Lawrence, M.S.2
Keats, J.J.3
Cibulskis, K.4
Sougnez, C.5
-
139
-
-
84883625365
-
Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma
-
Leung-Hagesteijn C, Erdmann N, Cheung G, Keats JJ, Stewart AK, et al. 2013. Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma. Cancer Cell 24:289-304
-
(2013)
Cancer Cell
, vol.24
, pp. 289-304
-
-
Leung-Hagesteijn, C.1
Erdmann, N.2
Cheung, G.3
Keats, J.J.4
Stewart, A.K.5
-
140
-
-
13644256191
-
A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress
-
Boyce M, Bryant KF, Jousse C, Long K, Harding HP, et al. 2005. A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 307:935-39
-
(2005)
Science
, vol.307
, pp. 935-939
-
-
Boyce, M.1
Bryant, K.F.2
Jousse, C.3
Long, K.4
Harding, H.P.5
-
141
-
-
0842285401
-
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2
-
Lu PD, Jousse C, Marciniak SJ, Zhang Y, Novoa I, et al. 2004. Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J. 23:169-79
-
(2004)
EMBO J.
, vol.23
, pp. 169-179
-
-
Lu, P.D.1
Jousse, C.2
Marciniak, S.J.3
Zhang, Y.4
Novoa, I.5
-
142
-
-
36849026845
-
A kinase inhibitor activates the IRE1αRNase to confer cytoprotection against ER stress
-
Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR. 2008. A kinase inhibitor activates the IRE1αRNase to confer cytoprotection against ER stress. Biochem. Biophys. Res. Commun. 365:777-83
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.365
, pp. 777-783
-
-
Han, D.1
Upton, J.P.2
Hagen, A.3
Callahan, J.4
Oakes, S.A.5
Papa, F.R.6
-
143
-
-
36049049392
-
IRE1 signaling affects cell fate during the unfolded protein response
-
Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, et al. 2007. IRE1 signaling affects cell fate during the unfolded protein response. Science 318:944-49
-
(2007)
Science
, vol.318
, pp. 944-949
-
-
Lin, J.H.1
Li, H.2
Yasumura, D.3
Cohen, H.R.4
Zhang, C.5
-
144
-
-
0344395603
-
Bypassing a kinase activity with an ATP-competitive drug
-
Papa FR, Zhang C, Shokat K, Walter P. 2003. Bypassing a kinase activity with an ATP-competitive drug. Science 302:1533-37
-
(2003)
Science
, vol.302
, pp. 1533-1537
-
-
Papa, F.R.1
Zhang, C.2
Shokat, K.3
Walter, P.4
-
145
-
-
84870357261
-
Divergent allosteric control of the IRE1αendoribonuclease using kinase inhibitors
-
Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, et al. 2012. Divergent allosteric control of the IRE1αendoribonuclease using kinase inhibitors. Nat. Chem. Biol. 8:982-89
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 982-989
-
-
Wang, L.1
Perera, B.G.2
Hari, S.B.3
Bhhatarai, B.4
Backes, B.J.5
-
146
-
-
84875235453
-
Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity
-
Atkins C, Liu Q, Minthorn E, Zhang SY, Figueroa DJ, et al. 2013. Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 73:1993-2002
-
(2013)
Cancer Res.
, vol.73
, pp. 1993-2002
-
-
Atkins, C.1
Liu, Q.2
Minthorn, E.3
Zhang, S.Y.4
Figueroa, D.J.5
-
147
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, et al. 2006. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313:1137-40
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
-
148
-
-
84890076252
-
Restoration of the unfolded protein response in pancreatic βcells protects mice against type 1 diabetes
-
211ra156
-
Engin F, Yermalovich A, Nguyen T, Hummasti S, FuW, et al. 2013. Restoration of the unfolded protein response in pancreatic βcells protects mice against type 1 diabetes. Sci. Transl. Med. 5:211ra156
-
(2013)
Sci. Transl. Med.
, vol.5
-
-
Engin, F.1
Yermalovich, A.2
Nguyen, T.3
Hummasti, S.4
Fu, W.5
-
149
-
-
84921912315
-
2014. Endoplasmic reticulum: ER stress
-
ed. LM McManus, RN Mitchell, San Diego: Elsevier.
-
Oakes SA. 2014. Endoplasmic reticulum: ER stress. In Pathobiology of Human Disease, ed. LM McManus, RN Mitchell, pp. 114-123. San Diego: Elsevier.
-
Pathobiology of Human Disease
, pp. 114-123
-
-
Oakes, S.A.1
|