Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease

Antioxidants and Redox Signaling

Volumn 9, Issue 5, 2007, Pages 553-561

  Wang, Hua Qin ^a   Takahashi, Ryosuke ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE;

CELL DEATH; CELL STRESS; ENDOPLASMIC RETICULUM; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN INDUCTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW;

ALPHA-SYNUCLEIN; ANIMALS; ENDOPLASMIC RETICULUM; HUMANS; MODELS, BIOLOGICAL; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; PARKINSON DISEASE; PARKINSONIAN DISORDERS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TOXINS, BIOLOGICAL; UBIQUITIN-PROTEIN LIGASES;

EID: 34247172998     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2006.1524     Document Type: Review

References (59)

1. Auluck PK, Chan HY, Trojanowski JQ, Lee VM, and Bonini NM. Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295: 865-868, 2002.
2. Back SH, Schroder M, Lee K, Zhang K, and Kaufman RJ. ER stress signaling by regulated splicing: IRE1/HAC1/XBP1. Methods 35: 395-416, 2005.
3. Beilina A, Van Der Brug M, Ahmad R, Kesavapany S, Miller DW, Petsko GA, and Cookson MR. Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. Proc Natl Acad Sci USA 102: 5703-5708, 2005.
4. Bence NF, Sampat RM, and Kopito RR. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292: 1552-1555, 2001.
5. Bertolotti A, Zhang Y, Hendershot LM, Harding HP, and Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2: 326-332, 2000.
6. Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, and Heutink P. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299: 256-259, 2003.
7. Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, and Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24: 197-211, 2003.
8. Canet-Aviles RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, and Cookson MR. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc Natl Acad Sci USA 101: 9103-9108, 2004.
9. Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, and Dawson TM. S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science 304: 1328-1331, 2004.
10. Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, and Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305: 1292-1295, 2004.
11. Deng H, Jankovic J, Guo Y, Xie W, and Le W. Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y. Biochem Biophys Res Commun 337: 1133-1138, 2005.
12. Fernagut PO and Chesselet ME Alpha-synuclein and transgenic mouse models. Neurobiol Dis 17: 123-130, 2004.
13. Friedlander R, Jarosch E, Urban J, Volkwein C, and Sommer T. A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2: 379-384, 2000.
14. Gee P and Davison AJ. Intermediates in the aerobic autoxidation of 6-hydroxydopamine: relative importance under different reaction conditions. Free Radic Biol Med 6: 271-284, 1989.
15. Ghee M, Fournier A, and Mallet J. Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex. J Neurochem 75: 2221-2224, 2000.
16. Holtz WA and O'Malley KL. Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons. J Biol Chem 278: 19367-19377, 2003.
17. Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, and Takahashi R. CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol Cell 10: 55-67, 2002.
18. Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, and Takahashi R. An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell 105: 891-902, 2001.
19. Imai Y, Soda M, and Takahashi R. Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J Biol Chem 275: 35661-35664, 2000.
20. Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, and Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392: 605-608, 1998.
21. Kitao Y, Imai Y, Ozawa K, Kataoka A, Ikeda T, Soda M, Namekawa K, Kiyama H, Stern DM, Hori O, Wakamatsu K, Ito S, Itohara S, Takahashi R, and Ogawa S. Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Hum Mol Genet 16: 50-60, 2007.
22. Kondo S, Murakami T, Tatsumi K, Ogata M, Kanemoto S, Otori K, Iseki K, Wanaka A, and Imaizumi K. OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes. Nat Cell Biol 7: 186-194, 2005.
23. Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S, Przuntek H, Epplen JT, Schols L, and Riess O. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 18: 106-108, 1998.
24. LaVoie MJ, Ostaszewski BL, Weihofen A, Schlossmacher MG, and Selkoe DJ. Dopamine covalently modifies and functionally inactivates parkin. Nat Med 11: 1214-1221, 2005.
25. Ledesma MD, Galvan C, Hellias B, Dotti C, and Jensen PH. Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress. J Neurochem 83: 1431-1440, 2002.
26. Lindholm D, Wootz H, and Korhonen L. ER stress and neurodegenerative diseases. Cell Death Differ 13: 385-392, 2006.
27. Lo Bianco C, Schneider BL, Bauer M, Sajadi A, Brice A, Iwatsubo T, and Aebischer P. Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proc Natl Acad Sci USA 101: 17510-17515, 2004.
28. Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, and Ron D. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 18: 3066-3077, 2004.
29. Mori K. Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell 101: 451-454, 2000.
30. Mouradian MM. Recent advances in the genetics and pathogenesis of Parkinson disease. Neurology 58: 179-185, 2002.
31. Murata S, Minami Y, Minami M, Chiba T, and Tanaka K. CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein. EMBO Rep 2: 1133-1138, 2001.
32. Nagamori I, Yabuta N, Fujii T, Tanaka H, Yomogida K, Nishimune Y, and Nojima H. Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway. Genes Cells 10: 575-594, 2005.
33. Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, and Ichijo H. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 16: 1345-1355, 2002.
34. Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, and Ron D. Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell 126: 727-739, 2006.
35. Paisan-Ruiz C, Jain S, Evans EW, Gilks WP, Simon J, van der Brug M, Lopez de Munain A, Aparicio S, Gil AM, Khan N, Johnson J, Martinez JR, Nicholl D, Carrera IM, Pena AS, de Silva R, Lees A, Marti-Masso JF, Perez-Tur J, Wood NW, and Singleton AB. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44: 595-600, 2004.
36. Plemper RK, Deak PM, Otto RT, and Wolf DH. Re-entering the translocon from the lumenal side of the endoplasmic reticulum. Studies on mutated carboxypeptidase yscY species. FEBS Lett 443: 241-245, 1999.
37. Plemper RK and Wolf DH. Endoplasmic reticulum degradation. Reverse protein transport and its end in the proteasome. Mol Biol Rep 26: 125-130, 1999.
38. Plemper RK and Wolf DH. Retrograde protein translocation: ERADication of secretory proteins in health and disease. Trends Biochem Sci 24: 266-270, 1999.
39. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, and Nussbaum RL. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047, 1997.
40. Rao RV and Bredesen DE. Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol 16: 653-662, 2004.
41. Reinheckel T, Ullrich O, Sitte N, and Grune T. Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress. Arch Biochem Biophys 377: 65-68, 2000.
42. Ryu EJ, Harding HP, Angelastro JM, Vitolo OV, Ron D, and Greene LA. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci 22: 10690-10698, 2002.
43. Schroder M and Kaufman RJ. ER stress and the unfolded protein response. Mutat Res 569: 29-63, 2005.
44. Schroder M and Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem 74: 739-789, 2005.
45. Selkoe DJ. Folding proteins in fatal ways. Nature 426: 900-904, 2003.
46. Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler C, Cookson MR, Muenter M, Baptista M, Miller D, Blancato J, Hardy J, and Gwinn-Hardy K. alpha-Synuclein locus triplication causes Parkinson's disease. Science 302: 841, 2003.
47. Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H, Sawa A, Dawson VL, Dawson TM, and Ross CA. Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Hum Mol Genet 14: 3801-3811, 2005.
48. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, and Goedert M. Alpha-synuclein in Lewy bodies. Nature 388: 839-840, 1997.
49. Springer W and Kahle PJ. Mechanisms and models of alpha-synuclein-related neurodegeneration. Curr Neurol Neurosci Rep 6: 432-436, 2006.
50. Stefanis L, Larsen KE, Rideout HJ, Sulzer D, and Greene LA. Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. J Neurosci 21: 9549-9560, 2001.
51. Tanaka Y, Engelender S, Igarashi S, Rao RK, Wanner T, Tanzi RE, Sawa A, V LD, Dawson TM, and Ross CA. Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria- dependent apoptosis. Hum Mol Genet 10: 919-926, 2001.
52. Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S, Ali Z, Del Turco D, Bentivoglio AR, Healy DG, Albanese A, Nussbaum R, Gonzalez-Maldonado R, Deller T, Salvi S, Cortelli P, Gilks WP, Latchman DS, Harvey RJ, Dallapiccola B, Auburger G, and Wood NW. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304: 1158-1160, 2004.
53. Webb JL, Ravikumar B, Atkins J, Skepper JN, and Rubinsztein DC. Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem 278: 25009-25013, 2003.
54. Yamamuro A, Yoshioka Y, Ogita K, and Maeda S. Involvement of endoplasmic reticulum stress on the cell death induced by 6-hydroxydopamine in human neuroblastoma SH-SY5Y cells. Neurochem Res 31: 657-664, 2006.
55. Yang Y, Nishimura I, Imai Y, Takahashi R, and Lu B. Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila. Neuron 37: 911-924, 2003.
56. Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, and Lipton SA. Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proc Natl Acad Sci USA 101: 10810-10814, 2004.
57. Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski DT, Back SH, and Kaufman RJ. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124: 587-599, 2006.
58. Zhao L and Ackerman SL. Endoplasmic reticulum stress in health and disease. Curr Opin Cell Biol 18: 444-452, 2006.
59. Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, Stoessl AJ, Pfeiffer RF, Patenge N, Carbajal IC, Vieregge P. Asmus F, Muller-Myhsok B, Dickson DW, Meitinger T, Strom TM, Wszolek ZK, and Gasser T. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44: 601-607, 2004.