A kinase inhibitor activates the IRE1α RNase to confer cytoprotection against ER stress

Biochemical and Biophysical Research Communications

Volumn 365, Issue 4, 2008, Pages 777-783

  Han, Dan ^a   Upton, John Paul ^a   Hagen, Andrew ^a   Callahan, Joseph ^a   Oakes, Scott A ^a   Papa, Feroz R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endoplasmic reticulum; Endoribonuclease; Inhibitor; Kinase; Protein folding disease

Indexed keywords

ADENOSINE TRIPHOSPHATE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN IRE1; RIBONUCLEASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; MISSENSE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

ANIMALS; CELLS, CULTURED; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; ENZYME ACTIVATION; FIBROBLASTS; MICE; OXIDATIVE STRESS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES;

MURINAE;

EID: 36849026845     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.11.040     Document Type: Article

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