Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse

Diabetes

Volumn 52, Issue 2, 2003, Pages 409-416

  Izumi, Tetsuro ^a   Yokota Hashimoto, Hiromi ^a   Zhao, Shengli ^a   Wang, Jie ^a,c   Halban, Philippe A ^b   Takeuchi, Toshiyuki ^a  

^a GUNMA UNIVERSITY   (Japan)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; HORMONE PRECURSOR; PROINSULIN; PROINSULIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL ORGANELLE; CELL STRUCTURE; CONTROLLED STUDY; DIABETES MELLITUS; DISULFIDE BOND; ENDOPLASMIC RETICULUM; GENE; GENE MUTATION; GOLGI COMPLEX; HETEROZYGOSITY; INSULIN 2 GENE; INSULIN DEFICIENCY; MOUSE; MOUSE STRAIN; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN SYNTHESIS; PROTEIN TRANSPORT;

AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; CHO CELLS; CRICETINAE; CYSTEINE; CYSTEINE ENDOPEPTIDASES; DIABETES MELLITUS, TYPE 1; DNA PRIMERS; ENDOPLASMIC RETICULUM; GENES, DOMINANT; GOLGI APPARATUS; HETEROZYGOTE; ISLETS OF LANGERHANS; MICE; MICE, MUTANT STRAINS; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PROINSULIN; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0037312881     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.2.409     Document Type: Article

References (29)

1. Aridor M, Balch WE: Integration of endoplasmic reticulum signaling in health and disease. Nat Med 5:745-751, 1999
2. Yoshioka M, Kayo T, Ikeda T, Koizumi A: A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46:887-894, 1997
3. Wang J, Takeuchi T, Tanaka S, Kubo S-K, Kayo T, Lu D, Takata K, Koizumi A, Izumi T: A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse. J Clin Invest 103:27-37, 1999
4. Kaufman RJ: Stress signaling from the luman of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Der 13:1211-1233, 1999
5. Mori K: Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell 101:451-454, 2000
6. Ellgaard L, Molinari M, Helenius A: Setting the standards: quality control in the secretory pathway. Science 286:1882-1888, 1999
7. Guo Z-Y, Feng Y-M: Effects of cysteine to serine substitutions in the two inter-chain disulfide bonds of insulin. Biol Chem 382:443-448, 2001
8. Hua Q-X, Nakagawa SH, Jia W, Hu S-Q, Chu YC, Katsoyannis PG, Weiss MA: Hierarchical protein folding: asymmetric unfolding of an insulin analogue lacking the A7-B7 interchain disulfide bridge. Biochemistry 40:12299-12311, 2001
9. Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E, Mori M: Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 109:525-532, 2002
10. Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, Stevens JL, Ron D: CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 12:982-995, 1998
11. McCullough KD, Martindale JL, Klotz L-O, Aw T-Y, Holbrook NJ: Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21:1249-1259, 2001
12. Leroux L, Desbois P, Lamotte L, Duvillié B, Cordonnier N, Jackerott M, Jami J, Bucchini D, Joshi RL: Compensatory responses in mice carrying a null mutation for Ins1 or Ins2. Diabetes 50:S150-S153, 2001
13. Yi Z, Yokota H, Torii S, Aoki T, Hosaka M, Zhao S, Takata K, Takeuchi T, Izumi T: The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol Cell Biol 22:1858-1867, 2002
14. Chen W, Helenius J, Braakman I, Helenius A: Cotranslational folding and calnexin binding during glycoprotein synthesis. Proc Natl Acad Sci U S A 92:6229-6233, 1995
15. Molinete M, Lilla V, Jain R, Joyce PBM, Gorr S-U, Ravazzola M, Halban PA: Trafficking of non-regulated secretory proteins in insulin secreting (INS-1) cells. Diabetologia 43:1157-1164, 2000
16. Cullen BR, Malim MH: Secreted placental alkaline phosphatases as a eukaryotic reporter gene. Methods Enzymol 216:362-368, 1992
17. Plemper RK, Wolf DH: Retrograde protein translocation: ERADication of secretory proteins in health and disease. Trends Biochem Sci 24:266-270, 1999
18. Lee DH, Goldberg AL: Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol 8:397-403, 1998
19. Shi Y, Vattem KM, Sood R, An J, Liang J, Stramm L, Wek RC: Identification and characterization of pancreatic eukaryotic initiation factor 2α-subunit kinase, PEK, involved in translational control. Mol Cell Biol 18:7499-7509, 1998
20. Harding HP, Zhang Y, Ron D: Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397:271-274, 1999
21. Jackson CL, Casanova JE: Turning on ARF: the Sec7 family of guaninenucleotide-exchange factors. Trends Cell Biol 10:60-67, 2000
22. Ferri KF, Kroemer G: Organelle-specific initiation of cell death pathways. Nat Cell Biol 3:E255-E263, 2001
23. Steiner DF, Tager HS, Chan SJ, Nanjo K, Sanke T, Rubenstein AH: Lessons learned from molecular biology of insulin-gene mutations. Diabetes Care 13:600-609, 1990
24. Molinari M, Helenius A: Glycoproteins from mixed disulphides with oxidoreductases during folding in living cells. Nature 402:90-93, 1999
25. Clarke PG: Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol 181:195-213, 1990
26. O'Brien BA, Huang Y, Geng X, Dutz JP, Finegood DT: Phagocytosis of apoptotic cells by macrophages from NOD mice is reduced. Diabetes 51:2481-2488, 2002
27. Vashist S, Kim W, Belden WJ, Spear ED, Barlowe C, Ng DTW: Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding. J Cell Biol 155:355-367, 2001
28. Caldwell SR, Hill KJ, Cooper AA: Degradation of endoplasmic reticulum (ER) quality control substrates requires transport between the ER and Golgi. J Biol Chem 276:23296-23303, 2001
29. Aridor M, Bannykh SI, Rowe T, Balch WE: Cargo can modulate COPII vesicle formation from the endoplasmic reticulum. J Biol Chem 274:4389-4399, 1999