ER stress, hypoxia tolerance and tumor progression

Current Molecular Medicine

Volumn 6, Issue 1, 2006, Pages 55-69

  Koumenis, Constantinos ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Hypoxia tolerance; Internal ribosome entry site (IRES); Radiotherapy; Ser51; Thapsigargin; UPR pathways

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; ANTINEOPLASTIC AGENT; BORTEZOMIB; CASPASE 12; ETOPOSIDE; GLUCOSE REGULATED PROTEIN 78; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 1; INITIATION FACTOR 2; INITIATION FACTOR 2ALPHA; INITIATION FACTOR 3; INITIATION FACTOR 4A; INITIATION FACTOR 4E; INITIATION FACTOR 4G; MESSENGER RNA; OXYGEN; PROTEASOME INHIBITOR; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN IRE1; REACTIVE OXYGEN METABOLITE; SERINE DERIVATIVE; THAPSIGARGIN; TIRAPAZAMINE; TUNICAMYCIN; UNINDEXED DRUG;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AUTOPHOSPHORYLATION; CANCER CELL; CANCER GROWTH; CANCER RESISTANCE; CELL ACTIVATION; CELL SURVIVAL; CLINICAL TRIAL; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME LOCALIZATION; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GENETIC CODE; HUMAN; HYPOXIA; IN VITRO STUDY; LUNG CANCER; MALIGNANT TRANSFORMATION; MULTIPLE MYELOMA; MUTATIONAL ANALYSIS; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROTEIN CONFORMATION; PROTEIN DEPHOSPHORYLATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS REGULATION; PROTEIN TARGETING; REVIEW; TRANSLATION INITIATION; UPREGULATION;

ANIMALS; CELL HYPOXIA; DISEASE PROGRESSION; EIF-2 KINASE; ENDOPLASMIC RETICULUM; HUMANS; NEOPLASMS; PROTEIN FOLDING;

MUS MUSCULUS;

EID: 33646167400     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652406775574604     Document Type: Review

References (128)

1. Sutherland, R.M., Ausserer, W.A., Murphy, B.J., and Laderoute, K.R. (1996) Semin. Radiat. Oncol., 6, 59-70.
2. Brown, J. M. and Giaccia, A.J. (1998) Cancer Res., 58, 1408-1416.
3. Chaplin, D.J. and Hill, S.A. (1995) Br. J. Cancer, 71, 1210-1213.
4. Sutherland, R.M., Eddy, H.A., Bareham, B., Reich, K., and Vanantwerp, D. (1979) Int. J. Radiat. Oncol. Biol. Phys., 5, 1225-1230.
5. Sutherland, R., Freyer, J., Mueller-Klieser, W., Wilson, R., Heacock, C., Sciandra, J., and Sordat, B. (1986) Int. J. Radiat. Oncol. Biol. Phys., 12, 611-615.
6. Luk, C.K. and Sutherland, R.M. (1986) Int. J. Cancer, 37, 883-890.
7. Teicher, B.A. (1994) Cancer Metastas. Rev., 13, 139-168.
8. Teicher, B.A. (1995) Hematol. Oncol. Clin. North Am., 9, 475-506.
9. Hill, R.P., De Jaeger, K., Jang, A., and Cairns, R. (2001) Novartis Found. Symp., 240, 154-165; discussion 165-158.
10. Cairns, R.A. and Hill, R.P. (2004) Cancer Res., 64, 2054-2061.
11. Evans, S.M., Judy, K.D., Dunphy, I., Jenkins, W.T., Hwang, W.T., Nelson, P.T., Lustig, R.A., Jenkins, K., Magarelli, D.P., Hahn, S.M., Collins, R.A., Grady, M.S., and Koch, C.J. (2004) Clin. Cancer Res., 10, 8177-8184.
12. Nordsmark, M., Bentzen, S.M., Rudat, V., Brizel, D., Lartigau, E., Stadler, P., Becker, A., Adam, M., Molls, M., Dunst, J., Terris, D.J., and Overgaard, J. (2005) Radiother. Oncol., 77, 18-24.
13. Hockel, M., Schlenger, K., Aral, B., Mitze, M., Schaffer, U., and Vaupel, P. (1996) Cancer Res., 56, 4509-4515.
14. Hockel, M. and Vaupel, P. (2001) Semin. Oncol., 28, 36-41.
15. Semenza, G.L. (2000) J. Clin. Invest., 106, 809-812.
16. Ratcliffe, P.J., O'Rourke, J.F., Maxwell, P.H., and Pugh, C.W. (1998) J. Exp. Biol., 201 (Pt 8), 1153-1162.
17. Maxwell, P.H., Dachs, G.U., Gleadle, J.M., Nicholls, L.G., Harris, A.L., Stratford, I.J., Hankinson, O., Pugh, C.W., and Ratcliffe, P.J. (1997) Proc. Natl. Acad. Sci. USA, 94, 8104-8109.
18. Ryan, H.E., Poloni, M., McNulty, W., Elson, D., Gassmann, M., Arbeit, J.M., and Johnson, R.S. (2000) Cancer Res., 60, 4010-4015.
19. Hochachka, P.W. (2000) Adv. Exp. Med. Biol, 475, 311-335.
20. Hochachka, P.W., Buck, L.T., Doll, C.J., and Land, S.C. (1996) Proc. Natl. Acad. Sci. USA, 93, 9493-9498.
21. Probst, H., Schiffer, H., Gekeler, V., Kienzle-Pfeilsticker, H., Stropp, U., Stotzer, K., and Frenzel-Stotzer, I. (1988) Cancer Res., 48, 2053-2060.
22. Probst, H., Hamprecht, K., and Gekeler, V. (1983) Biochem. Biophys. Res. Comm., 110, 688-693.
23. Probst, G., Riedinger, H.J., Martin, P., Engelcke, M., and Probst, H. (1999) Biol. Chem., 380, 1371-1382.
24. Green, S.L. and Giaccia, A.J. (1998) Cancer J. Sci. Am., 4, 218-223.
25. Giaccia, A.J. (1996) Semin. Radiat. Oncol., 6, 46-58.
26. Koch, C.J. (1982) Adv. Exp. Med. Biol., 157, 123-144.
27. Padilla, P.A., Nystul, T.G., Zager, R.A., Johnson, A.C., and Roth, M.B. (2002) Mol. Biol. Cell, 13, 1473-1483.
28. Padilla, P.A. and Roth, M.B. (2001) Proc. Natl. Acad. Sci. USA, 98, 7331-7335.
29. Frerichs, K.U., Smith, C.B., Brenner, M., DeGracia, D.J., Krause, G.S., Marrone, L., Dever, T.E., and Hallenbeck, J.M. (1998) Proc. Natl. Acad. Sci. USA, 95, 14511-14516.
30. Sciandra, J.J. and Subjeck, J. R. (1984) Cancer Res., 44, 5188-5194.
31. Pestova, T.V. and Hellen, C.U. (2005) Methods, 36, 261-269.
32. Johannes, G. and Sarnow, P. (1998) RNA, 4, 1500-1513.
33. Lang, K.J., Kappel, A., and Goodall, G.J. (2002) Mol. Biol. Cell, 13, 1792-1801.
34. Akiri, G., Nahari, D., Finkelstein, Y., Le, S.Y., Elroy-Stein, O., and Levi, B.Z. (1998) Oncogene, 17, 227-236.
35. Stein, I., Itin, A., Einat, P., Skaliter, R., Grossman, Z., and Keshet, E. (1998) Mol. Cell. Biol., 18, 3112-3119.
36. Vattem, K.M. and Wek, R.C. (2004) Proc. Natl. Acad. Sci. USA, 101, 11269-11274.
37. Luo, S., Baumeister, P., Yang, S., Abcouwer, S.F., and Lee, A.S. (2003) J. Biol. Chem., 278, 37375-37385.
38. Rutkowski, D.T. and Kaufman, R.J. (2003) Dev. Cell, 4, 442-444.
39. Pettersen, E.O., Juul, N.O., and Ronning, O.W. (1986) Cancer Res., 46, 4346-4351.
40. Kraggerud, S.M., Sandvik, J.A., and Pettersen, E.O. (1995) Anticancer Res., 15, 683-686.
41. Tinton, S., Tran-Nguyen, Q.N., and Buc-Calderon, P. (1997) Eur. J. Biochem., 249, 121-126.
42. Koumenis, C., Naczki, C., Koritzinsky, M., Rastani, S., Diehl, A., Sonenberg, N., Koromilas, A., and Wouters, B.G. (2002) Mol. Cell. Biol., 22, 7405-7416.
43. Dever, T.E. (1999) Trends Biochem. Sci., 24, 398-403.
44. Sheikh, M.S. and Fornace Jr, A.J. (1999) Oncogene, 18, 6121-6128.
45. Kozak, M. (1999) Gene, 234, 187-208.
46. Preiss, T. and Hentze, M.W. (1999) Curr. Opin. Genet. Dev., 9, 515-521.
47. Kimball, S.R. (1999) Int. J. Biochem. Cell. Biol., 31, 25-29.
48. Donze, O., Jagus, R., Koromilas, A.E., Hershey, J.W., and Sonenberg, N. (1995) EMBO J., 14, 3828-3834.
49. Scheuner, D., Song, B., McEwen, E., Liu, C., Laybutt, R., Gillespie, P., Saunders, T., Bonner-Weir, S., and Kaufman, R.J. (2001) Mol. Cell, 7, 1165-1176.
50. Gazit, G., Hung, G., Chen, X., Anderson, W.F., and Lee, A.S. (1999) Cancer Res., 59, 3100-3106.
51. Koong, A.C., Chen, E.Y., Lee, A.S., Brown, J.M., and Giaccia, A.J. (1994) Int. J. Radiat. Oncol. Biol. Phys., 28, 661-666.
52. Kuwabara, K., Matsumoto, M., Ikeda, J., Hori, O., Ogawa, S., Maeda, Y., Kitagawa, K., Imuta, N., Kinoshita, T., Stern, D.M., Yanagi, H., and Kamada, T. (1996) J. Biol. Chem., 271, 5025-5032.
53. Ozawa, K., Kuwabara, K., Tamatani, M., Takatsuji, K., Tsukamoto, Y., Kaneda, S., Yanagi, H., Stern, D.M., Eguchi, Y., Tsujimoto, Y., Ogawa, S., and Tohyama, M. (1999) J. Biol. Chem., 274, 6397-6404.
54. Brewer, J.W. and Diehl, J.A. (2000) Proc. Natl. Acad. Sci. USA, 97, 12625-12630.
55. Gingras, A.C., Raught, B., and Sonenberg, N. (2001) Genes Dev. 15, 807-826.
56. Martin, K.A. and Blenis, J. (2002) Adv. Cancer Res. 86, 1-39.
57. Arsham, A.M., Howell, J.J., and Simon, M.C. (2003) J.Biol.Chem. 278, 29655-29660.
58. Harding, H.P., Zhang, Y., Bertolotti, A., Zeng, H., and Ron, D. (2000) Mol. Cell, 5, 897-904.
59. Harding, H.P., Zhang, Y., and Ron, D. (1999) Nature, 397, 271-274.
60. Bertolotti, A., Zhang, Y., Hendershot, L.M., Harding, H.P., and Ron, D. (2000) Nat. Cell Biol. 2, 326-332.
61. Dorner, A.J., Wasley, L.C., and Kaufman, R.J. (1990) Proc. Natl. Acad. Sci. USA, 87, 7429-7432.
62. Shi, Y., Vattem, K.M., Sood, R., An, J., Liang, J., Stramm, L., and Wek, R.C. (1998) Mol. Cell. Biol., 18, 7499-7509.
63. Harding, H.P., Zhang, Y., Zeng, H., Novoa, I., Lu, P.D., Calfon, M., Sadri, N., Yun, C., Popko, B., Paules, R., Stojdl, D.F., Bell, J.C., Hettmann, T., Leiden, J.M., and Ron, D. (2003) Mol. Cell, 11, 619-633.
64. Harding, H.P., Novoa, I., Zhang, Y., Zeng, H., Wek, R., Schapira, M., and Ron, D. (2000) Mol. Cell, 6, 1099-1108.
65. Fawcett, T.W., Martindale, J.L., Guyton, K.Z., Hai, T., and Holbrook, N.J. (1999) Biochem. J., 339 (Pt 1), 135-141.
66. Lu, P.D., Jousse, C., Marciniak, S.J., Zhang, Y., Novoa, I., Scheuner, D., Kaufman, R.J., Ron, D., and Harding, H.P. (2004) EMBO J., 23, 169-179.
67. Ron, D. (2002) J. Clin. Invest., 110, 1383-1388.
68. Rutkowski, D.T. and Kaufman, R.J. (2004) Trends Cell. Biol., 14, 20-28.
69. Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., and Mori, K. (2001) Cell, 107, 881-891.
70. Calfon, M., Zeng, H., Urano, F., Till, J.H., Hubbard, S.R., Harding, H.P., Clark, S.G., and Ron, D. (2002) Nature, 415, 92-96.
71. Haze, K., Yoshida, H., Yanagi, H., Yura, T., and Mori, K. (1999) Mol. Biol. Cell, 10, 3787-3799.
72. Lee, A.H., Iwakoshi, N.N., and Glimcher, L.H. (2003) Mol. Cell. Biol., 23, 7448-7459.
73. Iwakoshi, N.N., Lee, A.H., and Glimcher, L.H. (2003) Immunol. Rev., 194, 29-38.
74. Shaffer, A.L., Shapiro-Shelef, M., Iwakoshi, N.N., Lee, A.H., Qian, S.B., Zhao, H., Yu, X., Yang, L., Tan, B.K., Rosenwald, A., Hurt, E.M., Petroulakis, E., Sonenberg, N., Yewdell, J.W., Calame, K., Glimcher, L.H., and Staudt, L.M. (2004) Immunity, 21, 81-93.
75. Reimold, A.M., Iwakoshi, N.N., Manis, J., Vallabhajosyula, P., Szomolanyi-Tsuda, E., Gravallese, E.M., Friend, D., Grusby, M.J., Alt, F., and Glimcher, L.H. (2001) Nature, 412, 300-307.
76. Sriburi, R., Jackowski, S., Mori, K., and Brewer, J.W. (2004) J. Cell. Biol., 167, 35-41.
77. Romero-Ramirez, L., Cao, H., Nelson, D., Hammond, E., Lee, A.H., Yoshida, H., Mori, K., Glimcher, L.H., Denko, N.C., Giaccia, A.J., Le, Q.T., and Koong, A.C. (2004) Cancer Res., 64, 5943-5947.
78. Wang, X.Z., Lawson, B., Brewer, J.W., Zinszner, H., Sanjay, A., Mi, L.J., Boorstein, R., Kreibich, G., Hendershot, L.M., and Ron, D. (1996) Mol. Cell. Biol., 16, 4273-4280.
79. Barone, M.V., Crozat, A., Tabaee, A., Philipson, L., and Ron, D. (1994) Genes Dev., 8, 453-464.
80. Oyadomari, S. and Mori, M. (2004) Cell Death Differ, 11, 381-389.
81. Ma, Y., Brewer, J.W., Diehl, J.A., and Hendershot, L.M. (2002) J. Mol. Biol., 318, 1351-1365.
82. Bruhat, A., Jousse, C., Carraro, V., Reimold, A.M., Ferrara, M., and Fafournoux, P. (2000) Mol. Cell. Biol., 20, 7192-7204.
83. Zinszner, H., Kuroda, M., Wang, X., Batchvarova, N., Lightfoot, R.T., Remotti, H., Stevens, J.L., and Ron, D. (1998) Genes Dev., 12, 982-995.
84. McCullough, K.D., Martindale, J.L., Klotz, L.O., Aw, T.Y., and Holbrook, N.J. (2001) Mol. Cell. Biol., 21, 1249-1259.
85. Marciniak, S.J., Yun, C.Y., Oyadomari, S., Novoa, I., Zhang, Y., Jungreis, R., Nagata, K., Harding, H.P., and Ron, D. (2004) Genes Dev., 18, 3066-3077.
86. Lam, M., Dubyak, G., Chen, L., Nunez, G., Miesfeld, R.L., and Distelhorst, C.W. (1994) Proc. Natl. Acad. Sci. USA, 91, 6569-6573.
87. Rao, R.V., Hermel, E., Castro-Obregon, S., del Rio, G., Ellerby, L.M., Ellerby, H.M., and Bredesen, D.E. (2001) J. Biol. Chem., 276, 33869-33874.
88. Denmeade, S.R., Jakobsen, C.M., Janssen, S., Khan, S.R., Garrett, E.S., Lilja, H., Christensen, S.B., and Isaacs, J.T. (2003) J. Natl. Cancer Inst., 95, 990-1000.
89. Paschen, W. (1996) Med. Hypotheses, 47, 283-288.
90. Ferrari, D., Pinton, P., Szabadkai, G., Chami, M., Campanella, M., Pozzan, T., and Rizzuto, R. (2002) Cell Calcium, 32, 413-420.
91. Kaufman, R.J. (2002) J. Clin. Invest., 110, 1389-1398.
92. Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B.A., and Yuan, J. (2000) Nature, 403, 98-103.
93. Fischer, H., Koenig, U., Eckhart, L., and Tschachler, E. (2002) Biochem. Biophys. Res. Commun., 293, 722-726.
94. Hacki, J., Egger, L., Monney, L., Conus, S., Rosse, T., Fellay, I., and Borner, C. (2000) Oncogene, 19, 2286-2295.
95. Boya, P., Cohen, I., Zamzami, N., Vieira, H.L., and Kroemer, G. (2002) Cell Death Differ., 9, 465-467.
96. Chae, H.J., Kim, H.R., Xu, C., Bailly-Maitre, B., Krajewska, M., Krajewski, S., Banares, S., Cui, J., Digicaylioglu, M., Ke, N., Kitada, S., Monosov, E., Thomas, M., Kress, C.L., Babendure, J.R., Tsien, R.Y., Lipton, S.A., and Reed, J.C. (2004) Mol. Cell, 15, 355-366.
97. Zong, W.X., Li, C., Hatzivassiliou, G., Lindsten, T., Yu, Q.C., Yuan, J., and Thompson, C.B. (2003) J. Cell. Biol., 162, 59-69.
98. Scorrano, L., Oakes, S.A., Opferman, J.T., Cheng, E.H., Sorcinelli, M.D., Pozzan, T., and Korsmeyer, S.J. (2003) Science, 300, 135-139.
99. Nutt, L.K., Pataer, A., Pahler, J., Fang, B., Roth, J., McConkey, D.J., and Swisher, S.G. (2002) J. Biol. Chem., 277, 9219-9225.
100. Breckenridge, D.G., Germain, M., Mathai, J.P., Nguyen, M., and Shore, G.C. (2003) Oncogene, 22, 8608-8618.
101. Mathai, J.P., Germain, M., and Shore, G.C. (2005) J. Biol. Chem., 280, 23829-23836.
102. Ma, Y. and Hendershot, L.M. (2004) Nat. Rev. Cancer, 4, 966-977.
103. Bi, M., Naczki, C., Koritzinsky, M., Fels, D., Blais, J., Hu, N., Harding, H., Novoa, I., Varia, M., Raleigh, J., Scheuner, D., Kaufman, R.J., Bell, J., Ron, D., Wouters, B.G., and Koumenis, C. (2005) EMBO J., 24, 3470-3481.
104. Koch, C.J. (2002) Methods Enzymol., 352, 3-31.
105. Laughlin, K.M., Evans, S.M., Jenkins, W.T., Tracy, M., Chan, C.Y., Lord, E.M., and Koch, C.J. (1996) J. Pharmacol. Exp. Ther., 277, 1049-1057.
106. Cullinan, S.B., Zhang, D., Hannink, M., Arvisais, E., Kaufman, R.J., and Diehl, J.A. (2003) Mol. Cell. Biol., 23, 7198-7209.
107. Harding, H.P., Zeng, H., Zhang, Y., Jungries, R., Chung, P., Plesken, H., Sabatini, D.D., and Ron, D. (2001) Mol. Cell, 7, 1153-1163.
108. Ameri, K., Lewis, C.E., Raida, M., Sowter, H., Hai, T., and Harris, A.L. (2004) Blood, 103, 1876-1882.
109. Blais, J.D., Filipenko, V., Bi, M., Ron, D., Koumenis, C., Wouters, B.G., and Bell, J.C. (2004) Mol. Cell. Biol., 24, 7469-7482.
110. Varia, M.A., Calkins-Adams, D.P., Rinker, L.H., Kennedy, A.S., Novotny, D.B., Fowler, W.C., Jr., and Raleigh, J.A. (1998) Gynecol. Oncol., 71, 270-277.
111. Liu, C.Y. and Kaufman, R.J. (2003) J. Cell Sci., 116, 1861-1862.
112. Mansfield, K.D., Guzy, R.D., Pan, Y., Young, R.M., Cash, T.P., Schumacker, P.T., and Simon, M.C. (2005) Cell Metab., 1, 393-399.
113. Guzy, R.D., Hoyos, B., Robin, E., Chen, H., Liu, L., Mansfield, K.D., Simon, M.C., Hammerling, U., and Schumacker, P.T. (2005) Cell Metab., 1, 401-408.
114. Hammond, E.M., Dorie, M.J., and Giaccia, A.J. (2003) J. Biol. Chem., 278, 12207-12213.
115. Tu, B.P. and Weissman, J.S. (2002) Mol. Cell, 10, 983-994.
116. Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J.M., Lane, W.S., and Kaelin, W.G., Jr. (2001) Science, 292, 464-468.
117. Epstein, A.C., Gleadle, J.M., McNeill, L.A., Hewitson, K.S., O'Rourke, J., Mole, D.R., Mukherji, M., Metzen, E., Wilson, M.I., Dhanda, A., Tian, Y.M., Masson, N., Hamilton, D.L., Jaakkola, P., Barstead, R., Hodgkin, J., Maxwell, P.H., Pugh, C.W., Schofield, C.J., and Ratcliffe, P.J. (2001) Cell, 107, 43-54.
118. Nelson, D.A., Tan, T.T., Rabson, A.B., Anderson, D., Degenhardt,K., and White, E. (2004) Genes Dev., 18, 2095-2107.
119. Wang, N.S., Unkila, M.T., Reineks, E.Z., and Distelhorst, C.W. (2001) J. Biol. Chem., 276, 44117-44128.
120. Brown, J.M. (2000) Mol. Med. Today, 6, 157-162.
121. Brown, J.M. (1999) Cancer Res., 59, 5863-5870.
122. von Pawel, J., von Roemeling, R., Gatzemeier, U., Boyer, M., Elisson, L.O., Clark, P., Talbot, D., Rey, A., Butler, T.W., Hirsh, V., Olver, I., Bergman, B., Ayoub, J., Richardson, G., Dunlop, D., Arcenas, A., Vescio, R., Viallet, J., and Treat, J. (2000) J. Clin. Oncol., 18, 1351-1359.
123. Gatzemeier, U., Rodriguez, G., Treat, J., Miller, V., von Roemeling, R., Viallet, J., and Rey, A. (1998) Br. J. Cancer, 77 Suppl 4, 15-17.
124. Koong, A.C., Chen, E.Y., Kim, C.Y., and Giaccia, A.J. (1994) Int. J. Radiat. Oncol. Biol. Phys., 29, 259-265.
125. Denmeade, S.R. and Isaacs, J.T. (2005) Cancer Biol. Ther 4, 14-22.
126. Fribley, A., Zeng, Q., and Wang, C.Y. (2004) Mol. Cell. Biol., 24, 9695-9704.
127. Lee, A.H., Iwakoshi, N.N., Anderson, K.C., and Glimcher, L.H. (2003) Proc. Natl. Acad. Sci. USA, 100, 9946-9951.
128. Folkman, J., Hahnfeldt, P. and Hlatky, L., (2000) Nature Rev. Mol. Cell. Biol, 1, 76-79.