Molecular biology of KSHV lytic reactivation

Viruses

Volumn 7, Issue 1, 2015, Pages 116-153

  Purushothaman, Pravinkumar ^a   Uppal, Timsy ^a   Verma, Subhash C ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Hypoxia; KSHV; LANA; Lytic DNA replication; Reactivation; RTA

Indexed keywords

ORF59 PROTEIN; ORF6 PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

CHEMICAL MODIFICATION; DNA REPLICATION; DOWN REGULATION; GENE EXPRESSION; GENE SEQUENCE; HUMAN HERPESVIRUS 8; HYPOXIA; IMMUNE RESPONSE; IMMUNOREGULATION; MIXED INFECTION; MOLECULAR BIOLOGY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; VIRUS CARCINOGENESIS; VIRUS INFECTION; VIRUS REACTIVATION; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; PHYSIOLOGY; VIRUS ACTIVATION; VIRUS LATENCY;

HERPESVIRIDAE; HUMAN HERPESVIRUS 8;

EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 8, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; VIRUS ACTIVATION; VIRUS LATENCY;

EID: 84921486405     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v7010116     Document Type: Review

References (260)

1. Sturzl, M.; Zietz, C.; Monini, P.; Ensoli, B. Human herpesvirus-8 and Kaposi's sarcoma: Relationship with the multistep concept of tumorigenesis. Adv. Cancer Res. 2001, 81, 125-159.
2. Cesarman, E.; Chang, Y.; Moore, P.S.; Said, J.W.; Knowles, D.M. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 1995, 332, 1186-1191.
3. Soulier, J.; Grollet, L.; Oksenhendler, E.; Cacoub, P.; Cazals-Hatem, D.; Babinet, P.; d'Agay, M.F.; Clauvel, J.P.; Raphael, M.; Degos, L.; et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 1995, 86, 1276-1280.
4. Uldrick, T.S.; Wang, V.; O'Mahony, D.; Aleman, K.; Wyvill, K.M.; Marshall, V.; Steinberg, S.M.; Pittaluga, S.; Maric, I.; Whitby, D.; et al. An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without Multicentric Castleman disease. Clin. Infect. Dis. 2010, 51, 350-358.
5. Dittmer, D.; Stoddart, C.; Renne, R.; Linquist-Stepps, V.; Moreno, M.E.; Bare, C.; McCune, J.M.; Ganem, D. Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice. J. Exp. Med. 1999, 190, 1857-1868.
6. Chang, Y.; Cesarman, E.; Pessin, M.S.; Lee, F.; Culpepper, J.; Knowles, D.M.; Moore, P.S. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994, 266, 1865-1869.
7. Verma, S.C.; Robertson, E.S. Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus. FEMS Microbiol. Lett. 2003, 222, 155-163.
8. Veettil, M.V.; Bandyopadhyay, C.; Dutta, D.; Chandran, B. Interaction of KSHV with host cell surface receptors and cell entry. Viruses 2014, 6, 4024-4046.
9. Knipe, D.M.; Lieberman, P.M.; Jung, J.U.; McBride, A.A.; Morris, K.V.; Ott, M.; Margolis, D.; Nieto, A.; Nevels, M.; Parks, R.J.; et al. Snapshots: Chromatin control of viral infection. Virology 2013, 435, 141-156.
10. Dourmishev, L.A.; Dourmishev, A.L.; Palmeri, D.; Schwartz, R.A.; Lukac, D.M. Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis. Microbiol. Mol. Biol. Rev. 2003, 67, 175-212.
11. Mesri, E.A.; Cesarman, E.; Boshoff, C. Kaposi's sarcoma and its associated herpesvirus. Nat. Rev. Cancer 2010, 10, 707-719.
12. Ballestas, M.E.; Kaye, K.M. The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency. Future Microbiol. 2011, 6, 1399-1413.
13. Chen, L.; Lagunoff, M. Establishment and maintenance of Kaposi's sarcoma-associated herpesvirus latency in B cells. J. Virol. 2005, 79, 14383-14391.
14. Renne, R.; Zhong, W.; Herndier, B.; McGrath, M.; Abbey, N.; Kedes, D.; Ganem, D. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat. Med. 1996, 2, 342-346.
15. Sun, R.; Lin, S.F.; Staskus, K.; Gradoville, L.; Grogan, E.; Haase, A.; Miller, G. Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression. J. Virol. 1999, 73, 2232-2242.
16. Jenner, R.G.; Alba, M.M.; Boshoff, C.; Kellam, P. Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays. J. Virol. 2001, 75, 891-902.
17. Cai, Q.; Verma, S.C.; Lu, J.; Robertson, E.S. Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis. Adv. Virus Res. 2010, 78, 87-142.
18. Wang, S.E.; Wu, F.Y.; Yu, Y.; Hayward, G.S. CCAAT/enhancer-binding protein-α is induced during the early stages of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic cycle reactivation and together with the KSHV replication and transcription activator (RTA) cooperatively stimulates the viral RTA, MTA, and PAN promoters. J. Virol. 2003, 77, 9590-9612.
19. Deng, H.; Young, A.; Sun, R. Auto-activation of the rta gene of human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus. J. Gen. Virol. 2000, 81, 3043-3048.
20. Song, M.J.; Deng, H.; Sun, R. Comparative study of regulation of RTA-responsive genes in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. J. Virol. 2003, 77, 9451-9462.
21. Wang, Y.; Tang, Q.; Maul, G.G.; Yuan, Y. Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: Dual role of replication and transcription activator. J. Virol. 2006, 80, 12171-12186.
22. Lin, C.L.; Li, H.; Wang, Y.; Zhu, F.X.; Kudchodkar, S.; Yuan, Y. Kaposi's sarcoma-associated herpesvirus lytic origin (ori-Lyt)-dependent DNA replication: Identification of the ori-Lyt and association of K8 bZip protein with the origin. J. Virol. 2003, 77, 5578-5588.
23. AuCoin, D.P.; Colletti, K.S.; Xu, Y.; Cei, S.A.; Pari, G.S. Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) contains two functional lytic origins of DNA replication. J. Virol. 2002, 76, 7890-7896.
24. Krishnan, H.H.; Naranatt, P.P.; Smith, M.S.; Zeng, L.; Bloomer, C.; Chandran, B. Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. J. Virol. 2004, 78, 3601-3620.
25. Toth, Z.; Brulois, K.; Lee, H.R.; Izumiya, Y.; Tepper, C.; Kung, H.J.; Jung, J.U. Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. PLoS Pathog. 2013, 9, e1003813.
26. Lan, K.; Kuppers, D.A.; Verma, S.C.; Sharma, N.; Murakami, M.; Robertson, E.S. Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: A novel mechanism for establishment of latency. J. Virol. 2005, 79, 7453-7465.
27. Li, Q.; Zhou, F.; Ye, F.; Gao, S.J. Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional program. Virology 2008, 379, 234-244.
28. Lu, F.; Day, L.; Gao, S.J.; Lieberman, P.M. Acetylation of the latency-associated nuclear antigen regulates repression of Kaposi's sarcoma-associated herpesvirus lytic transcription. J. Virol. 2006, 80, 5273-5282.
29. Lan, K.; Kuppers, D.A.; Robertson, E.S. Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jκ, the major downstream effector of the Notch signaling pathway. J. Virol. 2005, 79, 3468-3478.
30. Chen, J.; Ueda, K.; Sakakibara, S.; Okuno, T.; Parravicini, C.; Corbellino, M.; Yamanishi, K. Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator. Proc. Natl. Acad. Sci. USA 2001, 98, 4119-4124.
31. Shamay, M.; Krithivas, A.; Zhang, J.; Hayward, S.D. Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA. Proc. Natl. Acad. Sci. USA 2006, 103, 14554-14559.
32. Gunther, T.; Grundhoff, A. The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes. PLoS Pathog. 2010, 6, e1000935.
33. Woodard, C.; Shamay, M.; Liao, G.; Zhu, J.; Ng, A.N.; Li, R.; Newman, R.; Rho, H.S.; Hu, J.; Wan, J.; et al. Phosphorylation of the chromatin binding domain of KSHV LANA. PLoS Pathog. 2012, 8, e1002972.
34. Chang, P.C.; Cheng, C.Y.; Campbell, M.; Yang, Y.C.; Hsu, H.W.; Chang, T.Y.; Chu, C.H.; Lee, Y.W.; Hung, C.L.; Lai, S.M.; et al. The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi's sarcoma associated herpesvirus reactivation. BMC Genomics 2013, 14, 824.
35. Chang, P.C.; Izumiya, Y.; Wu, C.Y.; Fitzgerald, L.D.; Campbell, M.; Ellison, T.J.; Lam, K.S.; Luciw, P.A.; Kung, H.J. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a SUMO E3 ligase that is SIM-dependent and SUMO-2/3-specific. J. Biol. Chem. 2010, 285, 5266-5273.
36. Bajaj, B.G.; Verma, S.C.; Lan, K.; Cotter, M.A.; Woodman, Z.L.; Robertson, E.S. KSHV encoded LANA upregulates Pim-1 and is a substrate for its kinase activity. Virology 2006, 351, 18-28.
37. Cha, S.; Lim, C.; Lee, J.Y.; Song, Y.J.; Park, J.; Choe, J.; Seo, T. DNA-PK/Ku complex binds to latency-associated nuclear antigen and negatively regulates Kaposi's sarcoma-associated herpesvirus latent replication. Biochem. Biophys. Res. Commun. 2010, 394, 934-939.
38. Liu, J.; Martin, H.; Shamay, M.; Woodard, C.; Tang, Q.Q.; Hayward, S.D. Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation. J. Virol. 2007, 81, 4722-4731.
39. Campbell, M.; Chang, P.C.; Huerta, S.; Izumiya, C.; Davis, R.; Tepper, C.G.; Kim, K.Y.; Shevchenko, B.; Wang, D.H.; Jung, J.U.; et al. Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen. J. Biol. Chem. 2012, 287, 5806-5818.
40. Campbell, M.; Izumiya, Y. Post-Translational Modifications of Kaposi's Sarcoma-Associated Herpesvirus Regulatory Proteins-SUMO and KSHV. Front. Microbiol. 2012, 3, 31.
41. Toth, Z.; Maglinte, D.T.; Lee, S.H.; Lee, H.R.; Wong, L.Y.; Brulois, K.F.; Lee, S.; Buckley, J.D.; Laird, P.W.; Marquez, V.E.; et al. Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog. 2010, 6, e1001013.
42. Lim, C.; Lee, D.; Seo, T.; Choi, C.; Choe, J. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus functionally interacts with heterochromatin protein 1. J. Biol. Chem. 2003, 278, 7397-7405.
43. Matsumura, S.; Persson, L.M.; Wong, L.; Wilson, A.C. The latency-associated nuclear antigen interacts with MeCP2 and nucleosomes through separate domains. J. Virol. 2010, 84, 2318-2330.
44. Krithivas, A.; Young, D.B.; Liao, G.; Greene, D.; Hayward, S.D. Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. J. Virol. 2000, 74, 9637-9645.
45. Stuber, G.; Mattsson, K.; Flaberg, E.; Kati, E.; Markasz, L.; Sheldon, J.A.; Klein, G.; Schulz, T.F.; Szekely, L. HHV-8 encoded LANA-1 alters the higher organization of the cell nucleus. Mol. Cancer 2007, 6, 28.
46. Kim, K.Y.; Huerta, S.B.; Izumiya, C.; Wang, D.H.; Martinez, A.; Shevchenko, B.; Kung, H.J.; Campbell, M.; Izumiya, Y. Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen regulates the KSHV epigenome by association with the histone demethylase KDM3A. J. Virol. 2013, 87, 6782-6793.
47. Hu, J.; Yang, Y.; Turner, P.C.; Jain, V.; McIntyre, L.M.; Renne, R. LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complex. PLoS Pathog. 2014, 10, e1004240.
48. Guito, J.; Lukac, D.M. KSHV Rta Promoter Specification and Viral Reactivation. Front. Microbiol. 2012, 3, 30.
49. Jones, T.; Ye, F.; Bedolla, R.; Huang, Y.; Meng, J.; Qian, L.; Pan, H.; Zhou, F.; Moody, R.; Wagner, B.; et al. Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV. J. Clin. Investig. 2012, 122, 1076-1081.
50. Vieira, J.; O'Hearn, P.; Kimball, L.; Chandran, B.; Corey, L. Activation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) lytic replication by human cytomegalovirus. J. Virol. 2001, 75, 1378-1386.
51. Zhou, F.; Xue, M.; Qin, D.; Zhu, X.; Wang, C.; Zhu, J.; Hao, T.; Cheng, L.; Chen, X.; Bai, Z.; et al. HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3beta signaling pathway. PLoS One 2013, 8, e53145.
52. Zhu, X.; Guo, Y.; Yao, S.; Yan, Q.; Xue, M.; Hao, T.; Zhou, F.; Zhu, J.; Qin, D.; Lu, C. Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: Role of the AKT signaling pathway. Oncogene 2014, 33, 1986-1996.
53. Roupelieva, M.; Griffiths, S.J.; Kremmer, E.; Meisterernst, M.; Viejo-Borbolla, A.; Schulz, T.; Haas, J. Kaposi's sarcoma-associated herpesvirus Lana-1 is a major activator of the serum response element and mitogen-activated protein kinase pathways via interactions with the Mediator complex. J. Gen. Virol. 2010, 91, 1138-1149.
54. Tang, Q.; Qin, D.; Lv, Z.; Zhu, X.; Ma, X.; Yan, Q.; Zeng, Y.; Guo, Y.; Feng, N.; Lu, C. Herpes simplex virus type 2 triggers reactivation of Kaposi's sarcoma-associated herpesvirus from latency and collaborates with HIV-1 Tat. PLoS One 2012, 7, e31652.
55. Lu, C.; Zeng, Y.; Huang, Z.; Huang, L.; Qian, C.; Tang, G.; Qin, D. Human herpesvirus 6 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus. Am. J. Pathol. 2005, 166, 173-183.
56. Blauvelt, A. Skin diseases associated with human herpesvirus 6, 7, and 8 infection. J. Investig. Dermatol. Symp. Proc. 2001, 6, 197-202.
57. Rady, P.L.; Yen, A.; Rollefson, J.L.; Orengo, I.; Bruce, S.; Hughes, T.K.; Tyring, S.K. Herpesvirus-like DNA sequences in non-Kaposi's sarcoma skin lesions of transplant patients. Lancet 1995, 345, 1339-1340.
58. Mercader, M.; Taddeo, B.; Panella, J.R.; Chandran, B.; Nickoloff, B.J.; Foreman, K.E. Induction of HHV-8 lytic cycle replication by inflammatory cytokines produced by HIV-1-infected T cells. Am. J. Pathol. 2000, 156, 1961-1971.
59. Ye, F.; Lei, X.; Gao, S.J. Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and Reactivation. Adv. Virol. 2011, 2011, doi:10.1155/2011/193860.
60. Romero-Ramirez, L.; Cao, H.; Nelson, D.; Hammond, E.; Lee, A.H.; Yoshida, H.; Mori, K.; Glimcher, L.H.; Denko, N.C.; Giaccia, A.J.; et al. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res. 2004, 64, 5943-5947.
61. Cai, Q.; Lan, K.; Verma, S.C.; Si, H.; Lin, D.; Robertson, E.S. Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1α to upregulate RTA expression during hypoxia: Latency control under low oxygen conditions. J. Virol. 2006, 80, 7965-7975.
62. Cai, Q.; Cai, S.; Zhu, C.; Verma, S.C.; Choi, J.Y.; Robertson, E.S. A unique SUMO-2-interacting motif within LANA is essential for KSHV latency. PLoS Pathog. 2013, 9, e1003750.
63. Zhang, L.; Zhu, C.; Guo, Y.; Wei, F.; Lu, J.; Qin, J.; Banerjee, S.; Wang, J.; Shang, H.; Verma, S.C.; et al. Inhibition of KAP1 enhances hypoxia-induced Kaposi's sarcoma-associated herpesvirus reactivation through RBP-Jκ. J. Virol. 2014, 88, 6873-6884.
64. Ye, F.; Zhou, F.; Bedolla, R.G.; Jones, T.; Lei, X.; Kang, T.; Guadalupe, M.; Gao, S.J. Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS Pathog. 2011, 7, e1002054.
65. 2-induced cell death. Eur. J. Pharmacol. 2004, 483, 163-173.
66. Li, X.; Feng, J.; Sun, R. Oxidative stress induces reactivation of Kaposi's sarcoma-associated herpesvirus and death of primary effusion lymphoma cells. J. Virol. 2011, 85, 715-724.
67. Shin, H.J.; DeCotiis, J.; Giron, M.; Palmeri, D.; Lukac, D.M. Histone deacetylase classes I and II regulate Kaposi's sarcoma-associated herpesvirus reactivation. J. Virol. 2014, 88, 1281-1292.
68. Li, Q.; He, M.; Zhou, F.; Ye, F.; Gao, S.J. Activation of Kaposi's sarcoma-associated herpesvirus (KSHV) by inhibitors of class III histone deacetylases: Identification of sirtuin 1 as a regulator of the KSHV life cycle. J. Virol. 2014, 88, 6355-6367.
69. Dyson, O.F.; Walker, L.R.; Whitehouse, A.; Cook, P.P.; Akula, S.M. Resveratrol inhibits KSHV reactivation by lowering the levels of cellular EGR-1. PLoS One 2012, 7, e33364.
70. AuCoin, D.P.; Colletti, K.S.; Cei, S.A.; Papouskova, I.; Tarrant, M.; Pari, G.S. Amplification of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 lytic origin of DNA replication is dependent upon a cis-acting AT-rich region and an ORF50 response element and the trans-acting factors ORF50 (K-Rta) and K8 (K-bZIP). Virology 2004, 318, 542-555.
71. Gradoville, L.; Gerlach, J.; Grogan, E.; Shedd, D.; Nikiforow, S.; Metroka, C.; Miller, G. Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line. J. Virol. 2000, 74, 6207-6212.
72. Cousins, E.; Nicholas, J. Molecular biology of human herpesvirus 8: Novel functions and virus-host interactions implicated in viral pathogenesis and replication. Recent Results Cancer Res. 2014, 193, 227-268.
73. Sun, R.; Lin, S.F.; Gradoville, L.; Yuan, Y.; Zhu, F.; Miller, G. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc. Natl. Acad. Sci. USA 1998, 95, 10866-10871.
74. Lukac, D.M.; Renne, R.; Kirshner, J.R.; Ganem, D. Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology 1998, 252, 304-312.
75. Xu, Y.; AuCoin, D.P.; Huete, A.R.; Cei, S.A.; Hanson, L.J.; Pari, G.S. A Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50 deletion mutant is defective for reactivation of latent virus and DNA replication. J. Virol. 2005, 79, 3479-3487.
76. Lukac, D.M.; Kirshner, J.R.; Ganem, D. Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J. Virol. 1999, 73, 9348-9361.
77. Gwack, Y.; Nakamura, H.; Lee, S.H.; Souvlis, J.; Yustein, J.T.; Gygi, S.; Kung, H.J.; Jung, J.U. Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for γ2-herpesvirus lytic replication. Mol. Cell Biol. 2003, 23, 8282-8294.
78. Yu, Y.; Wang, S.E.; Hayward, G.S. The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation. Immunity 2005, 22, 59-70.
79. Bu, W.; Palmeri, D.; Krishnan, R.; Marin, R.; Aris, V.M.; Soteropoulos, P.; Lukac, D.M. Identification of direct transcriptional targets of the Kaposi's sarcoma-associated herpesvirus Rta lytic switch protein by conditional nuclear localization. J. Virol. 2008, 82, 10709-10723.
80. Deng, H.; Song, M.J.; Chu, J.T.; Sun, R. Transcriptional regulation of the interleukin-6 gene of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). J. Virol. 2002, 76, 8252-8264.
81. Song, M.J.; Brown, H.J.; Wu, T.T.; Sun, R. Transcription activation of polyadenylated nuclear rna by rta in human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus. J. Virol. 2001, 75, 3129-3140.
82. Byun, H.; Gwack, Y.; Hwang, S.; Choe, J. Kaposi's sarcoma-associated herpesvirus open reading frame (ORF) 50 transactivates K8 and ORF57 promoters via heterogeneous response elements. Mol. Cells 2002, 14, 185-191.
83. McDowell, M.E.; Purushothaman, P.; Rossetto, C.C.; Pari, G.S.; Verma, S.C. Phosphorylation of Kaposi's sarcoma-associated herpesvirus processivity factor ORF59 by a viral kinase modulates its ability to associate with RTA and oriLyt. J. Virol. 2013, 87, 8038-8052.
84. Rossetto, C.C.; Susilarini, N.K.; Pari, G.S. Interaction of Kaposi's sarcoma-associated herpesvirus ORF59 with oriLyt is dependent on binding with K-Rta. J. Virol. 2011, 85, 3833-3841.
85. Ueda, K.; Ishikawa, K.; Nishimura, K.; Sakakibara, S.; Do, E.; Yamanishi, K. Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) replication and transcription factor activates the K9 (vIRF) gene through two distinct cis elements by a non-DNA-binding mechanism. J. Virol. 2002, 76, 12044-12054.
86. Bowser, B.S.; Morris, S.; Song, M.J.; Sun, R.; Damania, B. Characterization of Kaposi's sarcoma-associated herpesvirus (KSHV) K1 promoter activation by Rta. Virology 2006, 348, 309-327.
87. Sathish, N.; Yuan, Y. Functional characterization of Kaposi's sarcoma-associated herpesvirus small capsid protein by bacterial artificial chromosome-based mutagenesis. Virology 2010, 407, 306-318.
88. Majerciak, V.; Yamanegi, K.; Zheng, Z.M. Gene structure and expression of Kaposi's sarcoma-associated herpesvirus ORF56, ORF57, ORF58, and ORF59. J. Virol. 2006, 80, 11968-11981.
89. Kronstad, L.M.; Brulois, K.F.; Jung, J.U.; Glaunsinger, B.A. Reinitiation after translation of two upstream open reading frames (ORF) governs expression of the ORF35-37 Kaposi's sarcoma-associated herpesvirus polycistronic mRNA. J. Virol. 2014, 88, 6512-6518.
90. 2 glycoprotein activates myeloid-lineage cells to induce inflammatory cytokine production. J. Virol. 2002, 76, 4688-4698.
91. Seaman, W.T.; Quinlivan, E.B. Lytic switch protein (ORF50) response element in the Kaposi's sarcoma-associated herpesvirus K8 promoter is located within but does not require a palindromic structure. Virology 2003, 310, 72-84.
92. Lan, K.; Kuppers, D.A.; Verma, S.C.; Robertson, E.S. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: A potential mechanism for virus-mediated control of latency. J. Virol. 2004, 78, 6585-6594.
93. Ziegelbauer, J.; Grundhoff, A.; Ganem, D. Exploring the DNA binding interactions of the Kaposi's sarcoma-associated herpesvirus lytic switch protein by selective amplification of bound sequences in vitro. J. Virol. 2006, 80, 2958-2967.
94. Chen, J.; Ye, F.; Xie, J.; Kuhne, K.; Gao, S.J. Genome-wide identification of binding sites for Kaposi's sarcoma-associated herpesvirus lytic switch protein, RTA. Virology 2009, 386, 290-302.
95. Liang, Y.; Chang, J.; Lynch, S.J.; Lukac, D.M.; Ganem, D. The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jκ (CSL), the target of the Notch signaling pathway. Genes Dev. 2002, 16, 1977-1989.
96. Wilson, S.J.; Tsao, E.H.; Webb, B.L.; Ye, H.; Dalton-Griffin, L.; Tsantoulas, C.; Gale, C.V.; Du, M.Q.; Whitehouse, A.; Kellam, P. X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency. J. Virol. 2007, 81, 13578-13586.
97. Ye, J.; Shedd, D.; Miller, G. An Sp1 response element in the Kaposi's sarcoma-associated herpesvirus open reading frame 50 promoter mediates lytic cycle induction by butyrate. J. Virol. 2005, 79, 1397-1408.
98. Carroll, K.D.; Khadim, F.; Spadavecchia, S.; Palmeri, D.; Lukac, D.M. Direct interactions of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta protein with the cellular protein octamer-1 and DNA are critical for specifying transactivation of a delayed-early promoter and stimulating viral reactivation. J. Virol. 2007, 81, 8451-8467.
99. Chang, P.J.; Shedd, D.; Miller, G. Two subclasses of Kaposi's sarcoma-associated herpesvirus lytic cycle promoters distinguished by open reading frame 50 mutant proteins that are deficient in binding to DNA. J. Virol. 2005, 79, 8750-8763.
100. Chang, P.J.; Boonsiri, J.; Wang, S.S.; Chen, L.Y.; Miller, G. Binding of RBP-Jκ (CSL) protein to the promoter of the Kaposi's sarcoma-associated herpesvirus ORF47 (gL) gene is a critical but not sufficient determinant of transactivation by ORF50 protein. Virology 2010, 398, 38-48.
101. Persson, L.M.; Wilson, A.C. Wide-scale use of Notch signaling factor CSL/RBP-Jκ in RTA-mediated activation of Kaposi's sarcoma-associated herpesvirus lytic genes. J. Virol. 2010, 84, 1334-1347.
102. Lu, J.; Verma, S.C.; Cai, Q.; Saha, A.; Dzeng, R.K.; Robertson, E.S. The RBP-Jκ binding sites within the RTA promoter regulate KSHV latent infection and cell proliferation. PLoS Pathog. 2012, 8, e1002479.
103. Lan, K.; Murakami, M.; Choudhuri, T.; Kuppers, D.A.; Robertson, E.S. Intracellular-activated Notch1 can reactivate Kaposi's sarcoma-associated herpesvirus from latency. Virology 2006, 351, 393-403.
104. Chang, H.; Dittmer, D.P.; Shin, Y.C.; Hong, Y.; Jung, J.U. Role of Notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expression. J. Virol. 2005, 79, 14371-14382.
105. Gwack, Y.; Baek, H.J.; Nakamura, H.; Lee, S.H.; Meisterernst, M.; Roeder, R.G.; Jung, J.U. Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol. Cell Biol. 2003, 23, 2055-2067.
106. Gwack, Y.; Byun, H.; Hwang, S.; Lim, C.; Choe, J. CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50. J. Virol. 2001, 75, 1909-1917.
107. Gao, J.; Cai, Q.; Lu, J.; Jha, H.C.; Robertson, E.S. Upregulation of cellular Bcl-2 by the KSHV encoded RTA promotes virion production. PLoS One 2011, 6, e23892.
108. Wang, S.; Liu, S.; Wu, M.H.; Geng, Y.; Wood, C. Identification of a cellular protein that interacts and synergizes with the RTA (ORF50) protein of Kaposi's sarcoma-associated herpesvirus in transcriptional activation. J. Virol. 2001, 75, 11961-11973.
109. Yang, Z.; Wood, C. The transcriptional repressor K-RBP modulates RTA-mediated transactivation and lytic replication of Kaposi's sarcoma-associated herpesvirus. J. Virol. 2007, 81, 6294-6306.
110. Yang, Z.; Wen, H.J.; Minhas, V.; Wood, C. The zinc finger DNA-binding domain of K-RBP plays an important role in regulating Kaposi's sarcoma-associated herpesvirus RTA-mediated gene expression. Virology 2009, 391, 221-231.
111. Chang, P.C.; Fitzgerald, L.D.; Van Geelen, A.; Izumiya, Y.; Ellison, T.J.; Wang, D.H.; Ann, D.K.; Luciw, P.A.; Kung, H.J. Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase. Cancer Res. 2009, 69, 5681-5689.
112. Sun, R.; Liang, D.; Gao, Y.; Lan, K. Kaposi's sarcoma-associated herpesvirus-encoded LANA interacts with host KAP1 to facilitate establishment of viral latency. J. Virol. 2014, 88, 7331-7344.
113. Liao, W.; Tang, Y.; Lin, S.F.; Kung, H.J.; Giam, C.Z. K-bZIP of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) binds KSHV/HHV-8 Rta and represses Rta-mediated transactivation. J. Virol. 2003, 77, 3809-3815.
114. Rossetto, C.; Gao, Y.; Yamboliev, I.; Papouskova, I.; Pari, G. Transcriptional repression of K-Rta by Kaposi's sarcoma-associated herpesvirus K-bZIP is not required for oriLyt-dependent DNA replication. Virology 2007, 369, 340-350.
115. Wang, S.E.; Wu, F.Y.; Fujimuro, M.; Zong, J.; Hayward, S.D.; Hayward, G.S. Role of CCAAT/enhancer-binding protein α (C/EBPα) in activation of the Kaposi's sarcoma-associated herpesvirus (KSHV) lytic-cycle replication-associated protein (RAP) promoter in cooperation with the KSHV replication and transcription activator (RTA) and RAP. J. Virol. 2003, 77, 600-623.
116. Wang, Y.; Yuan, Y. Essential role of RBP-Jκ in activation of the K8 delayed-early promoter of Kaposi's sarcoma-associated herpesvirus by ORF50/RTA. Virology 2007, 359, 19-27.
117. Liu, Y.; Cao, Y.; Liang, D.; Gao, Y.; Xia, T.; Robertson, E.S.; Lan, K. Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jκ and a cis-acting RTA responsive element. Virology 2008, 380, 264-275.
118. Chang, P.J.; Wang, S.S.; Chen, L.Y.; Hung, C.H.; Huang, H.Y.; Shih, Y.J.; Yen, J.B.; Liou, J.Y.; Chen, L.W. ORF50-dependent and ORF50-independent activation of the ORF45 gene of Kaposi's sarcoma-associated herpesvirus. Virology 2013, 442, 38-50.
119. Guito, J.; Gavina, A.; Palmeri, D.; Lukac, D.M. The cellular peptidyl-prolyl cis/trans isomerase Pin1 regulates reactivation of Kaposi's sarcoma-associated herpesvirus from latency. J. Virol. 2014, 88, 547-558.
120. Jaber, T.; Yuan, Y. A virally encoded small peptide regulates RTA stability and facilitates Kaposi's sarcoma-associated herpesvirus lytic replication. J. Virol. 2013, 87, 3461-3470.
121. Yang, Z.; Yan, Z.; Wood, C. Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes degradation of the repressors to regulate viral lytic replication. J. Virol. 2008, 82, 3590-3603.
122. Gould, F.; Harrison, S.M.; Hewitt, E.W.; Whitehouse, A. Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway. J. Virol. 2009, 83, 6727-6738.
123. Wang, Y.; Li, H.; Chan, M.Y.; Zhu, F.X.; Lukac, D.M.; Yuan, Y. Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: Cis-acting requirements for replication and ori-Lyt-associated RNA transcription. J. Virol. 2004, 78, 8615-8629.
124. Izumiya, Y.; Kobayashi, K.; Kim, K.Y.; Pochampalli, M.; Izumiya, C.; Shevchenko, B.; Wang, D.H.; Huerta, S.B.; Martinez, A.; Campbell, M.; et al. Kaposi's sarcoma-associated herpesvirus K-Rta exhibits SUMO-targeting ubiquitin ligase (STUbL) like activity and is essential for viral reactivation. PLoS Pathog. 2013, 9, e1003506.
125. Han, Z.; Swaminathan, S. Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production. J. Virol. 2006, 80, 5251-5260.
126. Majerciak, V.; Pripuzova, N.; McCoy, J.P.; Gao, S.J.; Zheng, Z.M. Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8α, and K8.1 and the production of infectious virus. J. Virol. 2007, 81, 1062-1071.
127. Palmeri, D.; Spadavecchia, S.; Carroll, K.D.; Lukac, D.M. Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta protein. J. Virol. 2007, 81, 13299-13314.
128. Malik, P.; Blackbourn, D.J.; Cheng, M.F.; Hayward, G.S.; Clements, J.B. Functional co-operation between the Kaposi's sarcoma-associated herpesvirus ORF57 and ORF50 regulatory proteins. J. Gen. Virol. 2004, 85, 2155-2166.
129. Hunter, O.V.; Sei, E.; Richardson, R.B.; Conrad, N.K. Chromatin immunoprecipitation and microarray analysis suggest functional cooperation between Kaposi's Sarcoma-associated herpesvirus ORF57 and K-bZIP. J. Virol. 2013, 87, 4005-4016.
130. Malik, P.; Blackbourn, D.J.; Clements, J.B. The evolutionarily conserved Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with REF protein and acts as an RNA export factor. J. Biol. Chem. 2004, 279, 33001-33011.
131. Majerciak, V.; Zheng, Z.M. Kaposi's sarcoma-associated herpesvirus ORF57 in viral RNA processing. Front. Biosci. (Landmark Ed) 2009, 14, 1516-1528.
132. Nekorchuk, M.; Han, Z.; Hsieh, T.T.; Swaminathan, S. Kaposi's sarcoma-associated herpesvirus ORF57 protein enhances mRNA accumulation independently of effects on nuclear RNA export. J. Virol. 2007, 81, 9990-9998.
133. Massimelli, M.J.; Kang, J.G.; Majerciak, V.; Le, S.Y.; Liewehr, D.J.; Steinberg, S.M.; Zheng, Z.M. Stability of a long noncoding viral RNA depends on a 9-nt core element at the RNA 5' end to interact with viral ORF57 and cellular PABPC1. Int. J. Biol. Sci. 2011, 7, 1145-1160.
134. Massimelli, M.J.; Majerciak, V.; Kruhlak, M.; Zheng, Z.M. Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA. J. Virol. 2013, 87, 243-256.
135. Sahin, B.B.; Patel, D.; Conrad, N.K. Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways. PLoS Pathog. 2010, 6, e1000799.
136. Majerciak, V.; Uranishi, H.; Kruhlak, M.; Pilkington, G.R.; Massimelli, M.J.; Bear, J.; Pavlakis, G.N.; Felber, B.K.; Zheng, Z.M. Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59. J. Virol. 2011, 85, 1528-1540.
137. Lin, S.F.; Robinson, D.R.; Miller, G.; Kung, H.J. Kaposi's sarcoma-associated herpesvirus encodes a bZIP protein with homology to BZLF1 of Epstein-Barr virus. J. Virol. 1999, 73, 1909-1917.
138. Tang, S.; Zheng, Z.M. Kaposi's sarcoma-associated herpesvirus K8 exon 3 contains three 5'-splice sites and harbors a K8.1 transcription start site. J. Biol. Chem. 2002, 277, 14547-14556.
139. Izumiya, Y.; Lin, S.F.; Ellison, T.; Chen, L.Y.; Izumiya, C.; Luciw, P.; Kung, H.J. Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: Physical association and promoter-dependent transcriptional repression. J. Virol. 2003, 77, 1441-1451.
140. Ellison, T.J.; Izumiya, Y.; Izumiya, C.; Luciw, P.A.; Kung, H.J. A comprehensive analysis of recruitment and transactivation potential of K-Rta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirus. Virology 2009, 387, 76-88.
141. Kato-Noah, T.; Xu, Y.; Rossetto, C.C.; Colletti, K.; Papouskova, I.; Pari, G.S. Overexpression of the kaposi's sarcoma-associated herpesvirus transactivator K-Rta can complement a K-bZIP deletion BACmid and yields an enhanced growth phenotype. J. Virol. 2007, 81, 13519-13532.
142. Wang, Y.; Sathish, N.; Hollow, C.; Yuan, Y. Functional characterization of Kaposi's sarcoma-associated herpesvirus open reading frame K8 by bacterial artificial chromosome-based mutagenesis. J. Virol. 2011, 85, 1943-1957.
143. Lefort, S.; Flamand, L. Kaposi's sarcoma-associated herpesvirus K-bZIP protein is necessary for lytic viral gene expression, DNA replication, and virion production in primary effusion lymphoma cell lines. J. Virol. 2009, 83, 5869-5880.
144. Wu, F.Y.; Wang, S.E.; Tang, Q.Q.; Fujimuro, M.; Chiou, C.J.; Zheng, Q.; Chen, H.; Hayward, S.D.; Lane, M.D.; Hayward, G.S. Cell cycle arrest by Kaposi's sarcoma-associated herpesvirus replication-associated protein is mediated at both the transcriptional and posttranslational levels by binding to CCAAT/enhancer-binding protein α and p21(CIP-1). J. Virol. 2003, 77, 8893-8914.
145. Rossetto, C.; Yamboliev, I.; Pari, G.S. Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 K-bZIP modulates latency-associated nuclear protein-mediated suppression of lytic origin-dependent DNA synthesis. J. Virol. 2009, 83, 8492-8501.
146. Izumiya, Y.; Ellison, T.J.; Yeh, E.T.; Jung, J.U.; Luciw, P.A.; Kung, H.J. Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification. J. Virol. 2005, 79, 9912-9925.
147. Lefort, S.; Soucy-Faulkner, A.; Grandvaux, N.; Flamand, L. Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression. J. Virol. 2007, 81, 10950-10960.
148. Lefort, S.; Gravel, A.; Flamand, L. Repression of interferon-α stimulated genes expression by Kaposi's sarcoma-associated herpesvirus K-bZIP protein. Virology 2010, 408, 14-30.
149. Martinez, F.P.; Tang, Q. Leucine zipper domain is required for Kaposi sarcoma-associated herpesvirus (KSHV) K-bZIP protein to interact with histone deacetylase and is important for KSHV replication. J. Biol. Chem. 2012, 287, 15622-15634.
150. Izumiya, Y.; Izumiya, C.; van Geelen, A.; Wang, D.H.; Lam, K.S.; Luciw, P.A.; Kung, H.J. Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP. J. Virol. 2007, 81, 1072-1082.
151. Sinclair, A.J. bZIP proteins of human γ-herpesviruses. J. Gen. Virol. 2003, 84, 1941-1949.
152. Chen, Y.; Ciustea, M.; Ricciardi, R.P. Processivity factor of KSHV contains a nuclear localization signal and binding domains for transporting viral DNA polymerase into the nucleus. Virology 2005, 340, 183-191.
153. Xiao, Y.; Chen, J.; Liao, Q.; Wu, Y.; Peng, C.; Chen, X. Lytic infection of Kaposi's sarcoma-associated herpesvirus induces DNA double-strand breaks and impairs non-homologous end joining. J. Gen. Virol. 2013, 94, 1870-1875.
154. Nicholas, J.; Ruvolo, V.; Zong, J.; Ciufo, D.; Guo, H.G.; Reitz, M.S.; Hayward, G.S. A single 13-kilobase divergent locus in the Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins. J. Virol. 1997, 71, 1963-1974.
155. Peng, C.; Chen, J.; Tang, W.; Liu, C.; Chen, X. Kaposi's sarcoma-associated herpesvirus ORF6 gene is essential in viral lytic replication. PLoS One 2014, 9, e99542.
156. Deutsch, E.; Cohen, A.; Kazimirsky, G.; Dovrat, S.; Rubinfeld, H.; Brodie, C.; Sarid, R. Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. J. Virol. 2004, 78, 10187-10192.
157. Ford, P.W.; Bryan, B.A.; Dyson, O.F.; Weidner, D.A.; Chintalgattu, V.; Akula, S.M. Raf/MEK/ERK signalling triggers reactivation of Kaposi's sarcoma-associated herpesvirus latency. J. Gen. Virol. 2006, 87, 1139-1144.
158. Lan, K.; Choudhuri, T.; Murakami, M.; Kuppers, D.A.; Robertson, E.S. Intracellular activated Notch1 is critical for proliferation of Kaposi's sarcoma-associated herpesvirus-associated B-lymphoma cell lines in vitro. J. Virol. 2006, 80, 6411-6419.
159. Xie, J.; Ajibade, A.O.; Ye, F.; Kuhne, K.; Gao, S.J. Reactivation of Kaposi's sarcoma-associated herpesvirus from latency requires MEK/ERK, JNK and p38 multiple mitogen-activated protein kinase pathways. Virology 2008, 371, 139-154.
160. Cheng, F.; Weidner-Glunde, M.; Varjosalo, M.; Rainio, E.M.; Lehtonen, A.; Schulz, T.F.; Koskinen, P.J.; Taipale, J.; Ojala, P.M. KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA. PLoS Pathog. 2009, 5, e1000324.
161. Qin, D.; Feng, N.; Fan, W.; Ma, X.; Yan, Q.; Lv, Z.; Zeng, Y.; Zhu, J.; Lu, C. Activation of PI3K/AKT and ERK MAPK signal pathways is required for the induction of lytic cycle replication of Kaposi's sarcoma-associated herpesvirus by herpes simplex virus type 1. BMC Microbiol. 2011, 11, 240.
162. Gregory, S.M.; West, J.A.; Dillon, P.J.; Hilscher, C.; Dittmer, D.P.; Damania, B. Toll-like receptor signaling controls reactivation of KSHV from latency. Proc. Natl. Acad. Sci. USA 2009, 106, 11725-11730.
163. Yu, F.; Harada, J.N.; Brown, H.J.; Deng, H.; Song, M.J.; Wu, T.T.; Kato-Stankiewicz, J.; Nelson, C.G.; Vieira, J.; Tamanoi, F.; et al. Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus. PLoS Pathog. 2007, 3, e44.
164. Li, D.J.; Verma, D.; Mosbruger, T.; Swaminathan, S. CTCF and Rad21 act as host cell restriction factors for Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by modulating viral gene transcription. PLoS Pathog. 2014, 10, e1003880.
165. Lee, H.R.; Doganay, S.; Chung, B.; Toth, Z.; Brulois, K.; Lee, S.; Kanketayeva, Z.; Feng, P.; Ha, T.; Jung, J.U. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) targets expression of cellular IRF4 and the Myc gene to facilitate lytic replication. J. Virol. 2014, 88, 2183-2194.
166. Bi, X.; Yang, L.; Mancl, M.E.; Barnes, B.J. Modulation of interferon regulatory factor 5 activities by the Kaposi sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3 contributes to immune evasion and lytic induction. J. Interferon Cytokine Res. 2011, 31, 373-382.
167. Kuang, E.; Fu, B.; Liang, Q.; Myoung, J.; Zhu, F. Phosphorylation of eukaryotic translation initiation factor 4B (EIF4B) by open reading frame 45/p90 ribosomal S6 kinase (ORF45/RSK) signaling axis facilitates protein translation during Kaposi sarcoma-associated herpesvirus (KSHV) lytic replication. J. Biol. Chem. 2011, 286, 41171-41182.
168. Zoeteweij, J.P.; Moses, A.V.; Rinderknecht, A.S.; Davis, D.A.; Overwijk, W.W.; Yarchoan, R.; Orenstein, J.M.; Blauvelt, A. Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus. Blood 2001, 97, 2374-2380.
169. Pan, H.; Xie, J.; Ye, F.; Gao, S.J. Modulation of Kaposi's sarcoma-associated herpesvirus infection and replication by MEK/ERK, JNK, and p38 multiple mitogen-activated protein kinase pathways during primary infection. J. Virol. 2006, 80, 5371-5382.
170. Sharma-Walia, N.; Krishnan, H.H.; Naranatt, P.P.; Zeng, L.; Smith, M.S.; Chandran, B. ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection. J. Virol. 2005, 79, 10308-10329.
171. Hengge, U.R.; Ruzicka, T.; Tyring, S.K.; Stuschke, M.; Roggendorf, M.; Schwartz, R.A.; Seeber, S. Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 2: Pathogenesis, Castleman's disease, and pleural effusion lymphoma. Lancet Infect. Dis. 2002, 2, 344-352.
172. Haas, D.A.; Bala, K.; Busche, G.; Weidner-Glunde, M.; Santag, S.; Kati, S.; Gramolelli, S.; Damas, M.; Dittrich-Breiholz, O.; Kracht, M.; et al. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pathog. 2013, 9, e1003737.
173. Wang, S.E.; Wu, F.Y.; Chen, H.; Shamay, M.; Zheng, Q.; Hayward, G.S. Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway. J. Virol. 2004, 78, 4248-4267.
174. Xie, J.; Pan, H.; Yoo, S.; Gao, S.J. Kaposi's sarcoma-associated herpesvirus induction of AP-1 and interleukin 6 during primary infection mediated by multiple mitogen-activated protein kinase pathways. J. Virol. 2005, 79, 15027-15037.
175. Cohen, A.; Brodie, C.; Sarid, R. An essential role of ERK signalling in TPA-induced reactivation of Kaposi's sarcoma-associated herpesvirus. J. Gen. Virol. 2006, 87, 795-802.
176. Emuss, V.; Lagos, D.; Pizzey, A.; Gratrix, F.; Henderson, S.R.; Boshoff, C. KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia. PLoS Pathog. 2009, 5, e1000616.
177. Carroll, K.D.; Bu, W.; Palmeri, D.; Spadavecchia, S.; Lynch, S.J.; Marras, S.A.; Tyagi, S.; Lukac, D.M. Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway. J. Virol. 2006, 80, 9697-9709.
178. Cai, Q.; Murakami, M.; Si, H.; Robertson, E.S. A potential α-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1α in normoxia. J. Virol. 2007, 81, 10413-10423.
179. Carroll, P.A.; Kenerson, H.L.; Yeung, R.S.; Lagunoff, M. Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. J. Virol. 2006, 80, 10802-10812.
180. Shin, Y.C.; Joo, C.H.; Gack, M.U.; Lee, H.R.; Jung, J.U. Kaposi's sarcoma-associated herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia-inducible factor-1α to induce vascular endothelial growth factor expression. Cancer Res. 2008, 68, 1751-1759.
181. Gregory, S.M.; Damania, B. KSHV and the toll of innate immune activation. Cell Cycle 2009, 8, 3246-3247.
182. Yu, X.; Shahir, A.M.; Sha, J.; Feng, Z.; Eapen, B.; Nithianantham, S.; Das, B.; Karn, J.; Weinberg, A.; Bissada, N.F.; et al. Short-chain fatty acids from periodontal pathogens suppress histone deacetylases, EZH2, and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication. J. Virol. 2014, 88, 4466-4479.
183. Morris, V.A.; Punjabi, A.S.; Lagunoff, M. Activation of Akt through gp130 receptor signaling is required for Kaposi's sarcoma-associated herpesvirus-induced lymphatic reprogramming of endothelial cells. J. Virol. 2008, 82, 8771-8779.
184. Punjabi, A.S.; Carroll, P.A.; Chen, L.; Lagunoff, M. Persistent activation of STAT3 by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells. J. Virol. 2007, 81, 2449-2458.
185. Burger, M.; Hartmann, T.; Burger, J.A.; Schraufstatter, I. KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway. Oncogene 2005, 24, 2067-2075.
186. Muromoto, R.; Okabe, K.; Fujimuro, M.; Sugiyama, K.; Yokosawa, H.; Seya, T.; Matsuda, T. Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA. FEBS Lett. 2006, 580, 93-98.
187. Cai, Q.; Verma, S.C.; Choi, J.Y.; Ma, M.; Robertson, E.S. Kaposi's sarcoma-associated herpesvirus inhibits interleukin-4-mediated STAT6 phosphorylation to regulate apoptosis and maintain latency. J. Virol. 2010, 84, 11134-11144.
188. Ye, F.C.; Zhou, F.C.; Xie, J.P.; Kang, T.; Greene, W.; Kuhne, K.; Lei, X.F.; Li, Q.H.; Gao, S.J. Kaposi's sarcoma-associated herpesvirus latent gene vFLIP inhibits viral lytic replication through NF-κB-mediated suppression of the AP-1 pathway: A novel mechanism of virus control of latency. J. Virol. 2008, 82, 4235-4249.
189. Lei, X.; Bai, Z.; Ye, F.; Xie, J.; Kim, C.G.; Huang, Y.; Gao, S.J. Regulation of NF-κB inhibitor IκBα and viral replication by a KSHV microRNA. Nat. Cell Biol. 2010, 12, 193-199.
190. Izumiya, Y.; Izumiya, C.; Hsia, D.; Ellison, T.J.; Luciw, P.A.; Kung, H.J. NF-κB serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta by antagonizing the RBP-Jκ coactivator. J. Virol. 2009, 83, 4435-4446.
191. Brown, H.J.; Song, M.J.; Deng, H.; Wu, T.T.; Cheng, G.; Sun, R. NF-κB inhibits γ-herpesvirus lytic replication. J. Virol. 2003, 77, 8532-8540.
192. Grossmann, C.; Ganem, D. Effects of NF-κB activation on KSHV latency and lytic reactivation are complex and context-dependent. Virology 2008, 375, 94-102.
193. Gao, S.J.; Deng, J.H.; Zhou, F.C. Productive lytic replication of a recombinant Kaposi's sarcoma-associated herpesvirus in efficient primary infection of primary human endothelial cells. J. Virol. 2003, 77, 9738-9749.
194. Sadagopan, S.; Sharma-Walia, N.; Veettil, M.V.; Raghu, H.; Sivakumar, R.; Bottero, V.; Chandran, B. Kaposi's sarcoma-associated herpesvirus induces sustained NF-κB activation during de novo infection of primary human dermal microvascular endothelial cells that is essential for viral gene expression. J. Virol. 2007, 81, 3949-3968.
195. Peng, L.; Wu, T.T.; Tchieu, J.H.; Feng, J.; Brown, H.J.; Feng, J.; Li, X.; Qi, J.; Deng, H.; Vivanco, I.; et al. Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances γ2-herpesvirus lytic replication and facilitates reactivation from latency. J. Gen. Virol. 2010, 91, 463-469.
196. Bhatt, A.P.; Damania, B. AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV. Front. Immunol. 2012, 3, 401.
197. Lagunoff, M.; Majeti, R.; Weiss, A.; Ganem, D. Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Proc. Natl. Acad. Sci. USA 1999, 96, 5704-5709.
198. Tomlinson, C.C.; Damania, B. The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathway. J. Virol. 2004, 78, 1918-1927.
199. Martin, D.; Galisteo, R.; Molinolo, A.A.; Wetzker, R.; Hirsch, E.; Gutkind, J.S. PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. Cancer Cell 2011, 19, 805-813.
200. Sodhi, A.; Chaisuparat, R.; Hu, J.; Ramsdell, A.K.; Manning, B.D.; Sausville, E.A.; Sawai, E.T.; Molinolo, A.; Gutkind, J.S.; Montaner, S. The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell 2006, 10, 133-143.
201. Hong, Y.K.; Foreman, K.; Shin, J.W.; Hirakawa, S.; Curry, C.L.; Sage, D.R.; Libermann, T.; Dezube, B.J.; Fingeroth, J.D.; Detmar, M. Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat. Genet. 2004, 36, 683-685.
202. Fu, B.; Kuang, E.; Li, W.; Avey, D.; Li, X.; Turpin, Z.; Valdes, A.; Brulois, K.; Myoung, J.; Zhu, F. Activation of p90 Ribosomal S6 Kinases (RSKs) by ORF45 of Kaposi Sarcoma-Associated Herpesvirus is Critical for Optimal Production of Infectious Viruses. J. Virol. 2015, 89, 195-207.
203. Wang, S.; Wang, S.; Maeng, H.; Young, D.P.; Prakash, O.; Fayad, L.E.; Younes, A.; Samaniego, F. K1 protein of human herpesvirus 8 suppresses lymphoma cell Fas-mediated apoptosis. Blood 2007, 109, 2174-2182.
204. Hideshima, T.; Chauhan, D.; Teoh, G.; Raje, N.; Treon, S.P.; Tai, Y.T.; Shima, Y.; Anderson, K.C. Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6. Clin. Cancer Res. 2000, 6, 1180-1189.
205. Wang, Q.J.; Jenkins, F.J.; Jacobson, L.P.; Meng, Y.X.; Pellett, P.E.; Kingsley, L.A.; Kousoulas, K.G.; Baghian, A.; Rinaldo, C.R., Jr. CD8+ cytotoxic T lymphocyte responses to lytic proteins of human herpes virus 8 in human immunodeficiency virus type 1-infected and -uninfected individuals. J. Infect. Dis. 2000, 182, 928-932.
206. Lang, S.M.; Bynoe, M.O.; Karki, R.; Tartell, M.A.; Means, R.E. Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins down regulate both DC-SIGN and DC-SIGNR. PLoS One 2013, 8, e58056.
207. Weber, K.S.; Grone, H.J.; Rocken, M.; Klier, C.; Gu, S.; Wank, R.; Proudfoot, A.E.; Nelson, P.J.; Weber, C. Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II. Eur. J. Immunol. 2001, 31, 2458-2466.
208. Kledal, T.N.; Rosenkilde, M.M.; Coulin, F.; Simmons, G.; Johnsen, A.H.; Alouani, S.; Power, C.A.; Luttichau, H.R.; Gerstoft, J.; Clapham, P.R.; et al. A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science 1997, 277, 1656-1659.
209. Feng, H.; Dong, X.; Negaard, A.; Feng, P. Kaposi's sarcoma-associated herpesvirus K7 induces viral G protein-coupled receptor degradation and reduces its tumorigenicity. PLoS Pathog. 2008, 4, e1000157.
210. Wang, H.W.; Sharp, T.V.; Koumi, A.; Koentges, G.; Boshoff, C. Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin. EMBO J. 2002, 21, 2602-2615.
211. Burysek, L.; Yeow, W.S.; Lubyova, B.; Kellum, M.; Schafer, S.L.; Huang, Y.Q.; Pitha, P.M. Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300. J. Virol. 1999, 73, 7334-7342.
212. Lin, R.; Genin, P.; Mamane, Y.; Sgarbanti, M.; Battistini, A.; Harrington, W.J., Jr.; Barber, G.N.; Hiscott, J. HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators. Oncogene 2001, 20, 800-811.
213. Foster-Cuevas, M.; Wright, G.J.; Puklavec, M.J.; Brown, M.H.; Barclay, A.N. Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor. J. Virol. 2004, 78, 7667-7676.
214. Rezaee, S.A.; Gracie, J.A.; McInnes, I.B.; Blackbourn, D.J. Inhibition of neutrophil function by the Kaposi's sarcoma-associated herpesvirus vOX2 protein. AIDS 2005, 19, 1907-1910.
215. Brinkmann, M.M.; Pietrek, M.; Dittrich-Breiholz, O.; Kracht, M.; Schulz, T.F. Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus. J. Virol. 2007, 81, 42-58.
216. Wang, L.; Brinkmann, M.M.; Pietrek, M.; Ottinger, M.; Dittrich-Breiholz, O.; Kracht, M.; Schulz, T.F. Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus. J. Gen. Virol. 2007, 88, 1698-1707.
217. Mullick, J.; Bernet, J.; Singh, A.K.; Lambris, J.D.; Sahu, A. Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) open reading frame 4 protein (kaposica) is a functional homolog of complement control proteins. J. Virol. 2003, 77, 3878-3881.
218. Mullick, J.; Singh, A.K.; Panse, Y.; Yadav, V.; Bernet, J.; Sahu, A. Identification of functional domains in kaposica, the complement control protein homolog of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8). J. Virol. 2005, 79, 5850-5856.
219. Spiller, O.B.; Robinson, M.; O'Donnell, E.; Milligan, S.; Morgan, B.P.; Davison, A.J.; Blackbourn, D.J. Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein. J. Virol. 2003, 77, 592-599.
220. Zhu, F.X.; King, S.M.; Smith, E.J.; Levy, D.E.; Yuan, Y. A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation. Proc. Natl. Acad. Sci. USA 2002, 99, 5573-5578.
221. Sathish, N.; Zhu, F.X.; Golub, E.E.; Liang, Q.; Yuan, Y. Mechanisms of autoinhibition of IRF-7 and a probable model for inactivation of IRF-7 by Kaposi's sarcoma-associated herpesvirus protein ORF45. J. Biol. Chem. 2011, 286, 746-756.
222. Gregory, S.M.; Damania, B. Inhibition of the inflammasome response by a viral protein that interacts with NLRs. Commun. Integr. Biol. 2011, 4, 416-418.
223. Inn, K.S.; Lee, S.H.; Rathbun, J.Y.; Wong, L.Y.; Toth, Z.; Machida, K.; Ou, J.H.; Jung, J.U. Inhibition of RIG-I-mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64. J. Virol 2011, 85, 10899-10904.
224. Cesarman, E.; Nador, R.G.; Bai, F.; Bohenzky, R.A.; Russo, J.J.; Moore, P.S.; Chang, Y.; Knowles, D.M. Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma. J. Virol. 1996, 70, 8218-8223.
225. Full, F.; Jungnickl, D.; Reuter, N.; Bogner, E.; Brulois, K.; Scholz, B.; Sturzl, M.; Myoung, J.; Jung, J.U.; Stamminger, T.; et al. Kaposi's sarcoma associated herpesvirus tegument protein ORF75 is essential for viral lytic replication and plays a critical role in the antagonization of ND10-instituted intrinsic immunity. PLoS Pathog. 2014, 10, e1003863.
226. Gunther, T.; Schreiner, S.; Dobner, T.; Tessmer, U.; Grundhoff, A. Influence of ND10 components on epigenetic determinants of early KSHV latency establishment. PLoS Pathog. 2014, 10, e1004274.
227. Borah, S.; Darricarrere, N.; Darnell, A.; Myoung, J.; Steitz, J.A. A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression. PLoS Pathog. 2011, 7, e1002300.
228. Borah, S.; Nichols, L.A.; Hassman, L.M.; Kedes, D.H.; Steitz, J.A. Tracking expression and subcellular localization of RNA and protein species using high-throughput single cell imaging flow cytometry. RNA 2012, 18, 1573-1579.
229. Rossetto, C.C.; Tarrant-Elorza, M.; Verma, S.; Purushothaman, P.; Pari, G.S. Regulation of viral and cellular gene expression by Kaposi's sarcoma-associated herpesvirus polyadenylated nuclear RNA. J. Virol. 2013, 87, 5540-5553.
230. Rossetto, C.C.; Pari, G.S. Kaposi's sarcoma-associated herpesvirus noncoding polyadenylated nuclear RNA interacts with virus- and host cell-encoded proteins and suppresses expression of genes involved in immune modulation. J. Virol. 2011, 85, 13290-13297.
231. Monini, P.; Carlini, F.; Sturzl, M.; Rimessi, P.; Superti, F.; Franco, M.; Melucci-Vigo, G.; Cafaro, A.; Goletti, D.; Sgadari, C.; et al. α-interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononuclear cells. J. Virol. 1999, 73, 4029-4041.
232. Jacobs, S.R.; Damania, B. The viral interferon regulatory factors of KSHV: Immunosuppressors or oncogenes? Front. Immunol. 2011, 2, 19.
233. Jacobs, S.R.; Gregory, S.M.; West, J.A.; Wollish, A.C.; Bennett, C.L.; Blackbourn, D.J.; Heise, M.T.; Damania, B. The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3. J. Virol. 2013, 87, 798-806.
234. Lee, H.R.; Choi, W.C.; Lee, S.; Hwang, J.; Hwang, E.; Guchhait, K.; Haas, J.; Toth, Z.; Jeon, Y.H.; Oh, T.K.; et al. Jung Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein. Nat. Struct. Mol. Biol. 2011, 18, 1336-1344.
235. Molden, J.; Chang, Y.; You, Y.; Moore, P.S.; Goldsmith, M.A. A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. J. Biol. Chem. 1997, 272, 19625-19631.
236. Arvanitakis, L.; Geras-Raaka, E.; Varma, A.; Gershengorn, M.C.; Cesarman, E. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature 1997, 385, 347-350.
237. Montaner, S. Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: Emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma. Cell Cycle 2007, 6, 438-443.
238. Matsuo, T.; Itami, M. Seropositivity of human herpesvirus-8 in patients with uveitis. Ocul. Immunol. Inflamm. 2002, 10, 197-199.
239. Lee, B.S.; Lee, S.H.; Feng, P.; Chang, H.; Cho, N.H.; Jung, J.U. Characterization of the Kaposi's sarcoma-associated herpesvirus K1 signalosome. J. Virol. 2005, 79, 12173-12184.
240. Prakash, O.; Swamy, O.R.; Peng, X.; Tang, Z.Y.; Li, L.; Larson, J.E.; Cohen, J.C.; Gill, J.; Farr, G.; Wang, S.; et al. Activation of Src kinase Lyn by the Kaposi sarcoma-associated herpesvirus K1 protein: Implications for lymphomagenesis. Blood 2005, 105, 3987-3994.
241. Feng, P.; Park, J.; Lee, B.S.; Lee, S.H.; Bram, R.J.; Jung, J.U. Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. J. Virol. 2002, 76, 11491-11504.
242. Brulois, K.; Jung, J.U. Interplay between Kaposi's sarcoma-associated herpesvirus and the innate immune system. Cytokine Growth Factor Rev. 2014, 25, 597-609.
243. Coscoy, L.; Ganem, D. A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation. J. Clin. Investig. 2001, 107, 1599-1606.
244. Neipel, F.; Albrecht, J.C.; Ensser, A.; Huang, Y.Q.; Li, J.J.; Friedman-Kien, A.E.; Fleckenstein, B. Human herpesvirus 8 encodes a homolog of interleukin-6. J. Virol. 1997, 71, 839-842.
245. Russo, J.J.; Bohenzky, R.A.; Chien, M.C.; Chen, J.; Yan, M.; Maddalena, D.; Parry, J.P.; Peruzzi, D.; Edelman, I.S.; Chang, Y.; et al. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc. Natl. Acad. Sci. USA 1996, 93, 14862-14867.
246. Liu, C.; Okruzhnov, Y.; Li, H.; Nicholas, J. Human herpesvirus 8 (HHV-8)-encoded cytokines induce expression of and autocrine signaling by vascular endothelial growth factor (VEGF) in HHV-8-infected primary-effusion lymphoma cell lines and mediate VEGF-independent antiapoptotic effects. J. Virol. 2001, 75, 10933-10940.
247. Stine, J.T.; Wood, C.; Hill, M.; Epp, A.; Raport, C.J.; Schweickart, V.L.; Endo, Y.; Sasaki, T.; Simmons, G.; Boshoff, C.; et al. KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells. Blood 2000, 95, 1151-1157.
248. Shiratori, I.; Yamaguchi, M.; Suzukawa, M.; Yamamoto, K.; Lanier, L.L.; Saito, T.; Arase, H. Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. J. Immunol. 2005, 175, 4441-4449.
249. Mark, L.; Lee, W.H.; Spiller, O.B.; Proctor, D.; Blackbourn, D.J.; Villoutreix, B.O.; Blom, A.M. The Kaposi's sarcoma-associated herpesvirus complement control protein mimics human molecular mechanisms for inhibition of the complement system. J. Biol. Chem. 2004, 279, 45093-45101.
250. Spiller, O.B.; Blackbourn, D.J.; Mark, L.; Proctor, D.G.; Blom, A.M. Functional activity of the complement regulator encoded by Kaposi's sarcoma-associated herpesvirus. J. Biol. Chem. 2003, 278, 9283-9289.
251. Spiller, O.B.; Mark, L.; Blue, C.E.; Proctor, D.G.; Aitken, J.A.; Blom, A.M.; Blackbourn, D.J. Dissecting the regions of virion-associated Kaposi's sarcoma-associated herpesvirus complement control protein required for complement regulation and cell binding. J. Virol. 2006, 80, 4068-4078.
252. Mark, L.; Proctor, D.G.; Blackbourn, D.J.; Blom, A.M.; Spiller, O.B. Separation of decay-accelerating and cofactor functional activities of Kaposi's sarcoma-associated herpesvirus complement control protein using monoclonal antibodies. Immunology 2008, 123, 228-238.
253. Zhu, F.X.; Cusano, T.; Yuan, Y. Identification of the immediate-early transcripts of Kaposi's sarcoma-associated herpesvirus. J. Virol. 1999, 73, 5556-5567.
254. Sathish, N.; Zhu, F.X.; Yuan, Y. Kaposi's sarcoma-associated herpesvirus ORF45 interacts with kinesin-2 transporting viral capsid-tegument complexes along microtubules. PLoS Pathog. 2009, 5, e1000332.
255. Brousset, P.; Meggetto, F.; Laharrague, P.; Attal, M.; Delsol, G. Kaposi's sarcoma-associated herpesvirus (KSHV) in bone marrow biopsy from patients with multiple myeloma: PCR amplification of orf26 but not orf72 and orf75 sequences. Br. J. Haematol. 2000, 108, 197-198.
256. Konrad, A.; Wies, E.; Thurau, M.; Marquardt, G.; Naschberger, E.; Hentschel, S.; Jochmann, R.; Schulz, T.F.; Erfle, H.; Brors, B.; et al. A systems biology approach to identify the combination effects of human herpesvirus 8 genes on NF-κB activation. J. Virol. 2009, 83, 2563-2574.
257. Gregory, S.M.; Davis, B.K.; West, J.A.; Taxman, D.J.; Matsuzawa, S.; Reed, J.C.; Ting, J.P.; Damania, B. Discovery of a viral NLR homolog that inhibits the inflammasome. Science 2011, 331, 330-334.
258. Rozen, R.; Sathish, N.; Li, Y.; Yuan, Y. Virion-wide protein interactions of Kaposi's sarcoma-associated herpesvirus. J. Virol. 2008, 82, 4742-4750.
259. Campbell, M.; Kim, K.Y.; Chang, P.C.; Huerta, S.; Shevchenko, B.; Wang, D.H.; Izumiya, C.; Kung, H.J.; Izumiya, Y. A lytic viral long noncoding RNA modulates the function of a latent protein. J. Virol. 2014, 88, 1843-1848.
260. Rossetto, C.C.; Pari, G. KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genome. PLoS Pathog. 2012, 8, e1002680.