Transcriptional regulation of the interleukin-6 gene of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus)

Journal of Virology

Volumn 76, Issue 16, 2002, Pages 8252-8264

  Deng, Hongyu ^a   Song, Moon Jung ^a   Chu, Julia T ^a   Sun, Ren ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RTA; UNCLASSIFIED DRUG;

ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; ARTICLE; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION REGULATION; GENE LOCUS; GENE MAPPING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; NUCLEIC ACID ANALYSIS; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; POLYADENYLATION; PRIMARY EFFUSION LYMPHOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TATA BOX; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TUMOR GROWTH; VIRUS GENOME; VIRUS PATHOGENESIS; VIRUS REPLICATION;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE; CHROMOSOME MAPPING; GENE EXPRESSION REGULATION, VIRAL; GENES, REPORTER; GENES, VIRAL; GIANT LYMPH NODE HYPERPLASIA; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 8, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERLEUKIN-6; LUCIFERASES; LYMPHOMA; MOLECULAR SEQUENCE DATA; PLASMIDS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; RNA, VIRAL; SARCOMA, KAPOSI; TATA BOX; TRANS-ACTIVATORS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0036316347     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.16.8252-8264.2002     Document Type: Article

References (45)

1. Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6
2. Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6
3. Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions
4. Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus
5. Analysis of RNA by Northern and slot blot hybridization
6. Interleukin-6 production in B-cell neoplasias and Castleman's disease: Evidence for an additional paracrine loop
7. Heterogeneity of viral 1L-6 expression in HHV-8-associated diseases
8. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas
9. In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences
10. Open reading frame 50 protein of Kaposi's sarcoma-associated herpesvirus directly activates the viral PAN and K12 genes hy binding to related response elements
11. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
12. Transcriptional regulation of the Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor gene
13. Structure of an extracellular gp130 cytokine receptor signaling complex
14. Auto-activation of the rta gene of human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus
15. Characterization of Kaposi's sarcoma associated herpesvirus/human herpesvirus-8 ORF57 promoter
16. Cytokines and growth factors in the pathogenesis of AIDS-associated Kaposi's sarcoma
17. The role of cytokines in the pathogenesis and management of AIDS-related lymphomas
18. Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line
19. Epstein-Barr virus and its replication
20. Transfection of DNA into eukaryotic cells
21. DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promoters
22. Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells
23. Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells
24. A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit
25. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV
26. Human herpesvirus 8 encodes a homolog of interleukin-6
27. Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6
28. KSHV-encoded viral IL-6 activates multiple human IL-6 signaling pathways
29. Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease
30. TATA element recognition by the TATA box-binding protein has been conserved throughout evolution
31. Autostimulation of the Epstein-Barr virus BRLFI promoter is mediated through consensus Sp1 and Sp3 binding sites
32. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture
33. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)
34. GAL4-VP16 is an unusually potent transcriptional activator
35. Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: Ultrastructural demonstration of herpesvirus in lymphoma cells
36. Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1)
37. Transcription activation of polyadenylated nuclear RNA by Rta in human hepesvirus 8/Kaposi's sarcoma-associated herpesvirus
38. Characterization of interactions between, R. T. A., and the promoter of polyadenylated nuclear RNA in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8
39. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease
40. Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease
41. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus
42. Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression
43. Gp130 and the interleukin-6 family of cytokines
44. Human herpesvirus 8 interleukin-6 (vIL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6
45. The Epstein-Barr virus immediate-early promoter BRLFI can be activated by the cellular Sp1 transcription factor