Transcriptional repression of K-Rta by Kaposi's sarcoma-associated herpesvirus K-bZIP is not required for oriLyt-dependent DNA replication

Virology

Volumn 369, Issue 2, 2007, Pages 340-350

  Rossetto, Cyprian ^a   Gao, Yang ^a   Yamboliev, Irena ^a   Papousková, Iva ^a   Pari, Gregory ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

DNA replication; Herpesvirus; Leucine zipper; Transactivation

Indexed keywords

LEUCINE; LEUCINE ZIPPER PROTEIN; PROTEIN K BZIP; PROTEIN K RTA; REGULATOR PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; DIMERIZATION; DNA REPLICATION; DNA SYNTHESIS; GENE CONSTRUCT; GENE DELETION; GENE MUTATION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; TRANSCRIPTION INITIATION;

ANIMALS; BASE SEQUENCE; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL LINE; CERCOPITHECUS AETHIOPS; DIMERIZATION; DNA PRIMERS; DNA REPLICATION; DNA, VIRAL; GENES, VIRAL; GENETIC COMPLEMENTATION TEST; HERPESVIRUS 8, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; LEUCINE ZIPPERS; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; VERO CELLS; VIRAL PROTEINS;

HERPESVIRIDAE; HUMAN HERPESVIRUS 8;

EID: 36048978977     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2007.08.019     Document Type: Article

References (26)

1. Al Mehairi S., Cerasoli E., and Sinclair A.J. Investigation of the multimerization region of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) protein K-bZIP: the proposed leucine zipper region encodes a multimerization domain with an unusual structure. J. Virol. 79 12 (2005) 7905-7910
2. AuCoin D.P., Colletti K.S., Cei S.A., Papouskova I., Tarrant M., and Pari G.S. Amplification of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 lytic origin of DNA replication is dependent upon a cis-acting AT-rich region and an ORF50 response element and the trans-acting factors ORF50 (K-Rta) and K8 (K-bZIP). Virology 318 2 (2004) 542-555
3. AuCoin D.P., Colletti K.S., Cei S.A., Papouskova I., Tarrant M., and Pari G.S. Amplification of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 lytic origin of DNA replication is dependent upon a cis-acting AT-rich region and an ORF50 response element and the trans-acting factors ORF50 (K-Rta) and K8 (K-bZIP). Virology 318 2 (2004) 542-555
4. Byun H., Gwack Y., Hwang S., and Choe J. Kaposi's sarcoma-associated herpesvirus open reading frame (ORF) 50 transactivates K8 and ORF57 promoters via heterogeneous response elements. Mol. Cells 14 2 (2002) 185-191
5. Chang P.J., and Miller G. Autoregulation of DNA binding and protein stability of Kaposi's sarcoma-associated herpesvirus ORF50 protein. J. Virol. 78 19 (2004) 10657-10673
6. Chang P.J., Shedd D., and Miller G. Two subclasses of Kaposi's sarcoma-associated herpesvirus lytic cycle promoters distinguished by open reading frame 50 mutant proteins that are deficient in binding to DNA. J. Virol. 79 14 (2005) 8750-8763
7. Deng H., Young A., and Sun R. Auto-activation of the rta gene of human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus. J. Gen. Virol. 81 Pt 12 (2000) 3043-3048
8. Fixman E.D., Hayward G.S., and Hayward S.D. Trans-acting requirements for replication of Epstein-Barr virus ori-Lyt. J. Virol. 66 8 (1992) 5030-5039
9. Gradoville L., Gerlach J., Grogan E., Shedd D., Nikiforow S., Metroka C., and Miller G. Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line. J. Virol. 74 13 (2000) 6207-6212
10. Hammerschmidt W., and Sugden B. Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus. Cell 55 (1988) 427-433
11. Izumiya Y., Lin S.F., Ellison T., Chen L.Y., Izumiya C., Luciw P., and Kung H.J. Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent transcriptional repression. J. Virol. 77 2 (2003) 1441-1451
12. Izumiya Y., Lin S.F., Ellison T.J., Levy A.M., Mayeur G.L., Izumiya C., and Kung H.J. Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G(1) growth arrest. J. Virol. 77 17 (2003) 9652-9661
13. Izumiya Y., Ellison T.J., Yeh E.T., Jung J.U., Luciw P.A., and Kung H.J. Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification. J. Virol. 79 15 (2005) 9912-9925
14. Izumiya Y., Izumiya C., Van Geelen A., Wang D.H., Lam K.S., Luciw P.A., and Kung H.J. Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP. J. Virol. 81 3 (2007) 1072-1082
15. Liao W., Tang Y., Lin S.F., Kung H.J., and Giam C.Z. K-bZIP of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) binds KSHV/HHV-8 Rta and represses Rta-mediated transactivation. J. Virol. 77 6 (2003) 3809-3815
16. Lukac D.M., Kirshner J.R., and Ganem D. Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J. Virol. 73 11 (1999) 9348-9361
17. Lukac D.M., Garibyan L., Kirshner J.R., Palmeri D., and Ganem D. DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promoters. J. Virol. 75 15 (2001) 6786-6799
18. Sarisky R.T., Gao Z., Lieberman P.M., Fixman E.D., Hayward G.S., and Hayward S.D. A replication function associated with the activation domain of the Epstein-Barr virus Zta transactivator. J. Virol. 70 12 (1996) 8340-8347
19. Schepers A.D., Pich D., Mankertz J., and Hammerschmidt W. Cis-acting elements in the lytic origin of DNA replication of Epstein-Barr virus. J. Virol. 67 (1993) 4237-4245
20. Schepers A., Pich D., and Hammerschmidt W. Activation of oriLyt, the lytic origin of DNA replication of Epstein-Barr virus, by BZLF1. Virology 220 2 (1996) 367-376
21. Wang S., Liu S., Wu M., Geng Y., and Wood C. Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 ORF50 gene product contains a potent C-terminal activation domain which activates gene expression via a specific target sequence. Arch. Virol. 146 7 (2001) 1415-1426
22. Wang S.E., Wu F.Y., Fujimuro M., Zong J., Hayward S.D., and Hayward G.S. Role of CCAAT/enhancer-binding protein alpha (C/EBPalpha) in activation of the Kaposi's sarcoma-associated herpesvirus (KSHV) lytic-cycle replication-associated protein (RAP) promoter in cooperation with the KSHV replication and transcription activator (RTA) and RAP. J. Virol. 77 1 (2003) 600-623
23. Wang S.E., Wu F.Y., Yu Y., and Hayward G.S. CCAAT/enhancer-binding protein-alpha is induced during the early stages of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic cycle reactivation and together with the KSHV replication and transcription activator (RTA) cooperatively stimulates the viral RTA, MTA, and PAN promoters. J. Virol. 77 17 (2003) 9590-9612
24. Wang Y., Tang Q., Maul G.G., and Yuan Y. Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: dual role of replication and transcription activator. J. Virol. 80 24 (2006) 12171-12186
25. Xu Y., AuCoin D.P., Huete A.R., Cei S.A., Hanson L.J., and Pari G.S. A Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50 deletion mutant is defective for reactivation of latent virus and DNA replication. J. Virol. 79 6 (2005) 3479-3487
26. Yamanegi K., Tang S., and Zheng Z.M. Kaposi's sarcoma-associated herpesvirus K8beta is derived from a spliced intermediate of K8 pre-mRNA and antagonizes K8alpha (K-bZIP) to induce p21 and p53 and blocks K8alpha-CDK2 interaction. J. Virol. 79 22 (2005) 14207-14221