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Volumn 74, Issue 13, 2000, Pages 6207-6212

Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; CYCLOHEXIMIDE; DEOXYRIBONUCLEASE; DNA POLYMERASE; MESSENGER RNA; PHOSPHONOACETIC ACID; VIRUS DNA; VIRUS PROTEIN;

EID: 0034083471     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.13.6207-6212.2000     Document Type: Article
Times cited : (246)

References (45)
  • 2
    • 0029796383 scopus 로고    scopus 로고
    • Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus
    • Arvanitakis, L., E. A. Mesri, R. G. Nador, J. W. Said, A. S. Asch, D. M. Knowles, and E. Cesarman. 1996. Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus. Blood 88:2648-2654.
    • (1996) Blood , vol.88 , pp. 2648-2654
    • Arvanitakis, L.1    Mesri, E.A.2    Nador, R.G.3    Said, J.W.4    Asch, A.S.5    Knowles, D.M.6    Cesarman, E.7
  • 3
    • 0033597453 scopus 로고    scopus 로고
    • Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen
    • Ballestas, M. E., P. A. Chatis, and K. M. Kaye. 1999. Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science 284:641-644.
    • (1999) Science , vol.284 , pp. 641-644
    • Ballestas, M.E.1    Chatis, P.A.2    Kaye, K.M.3
  • 5
    • 0029069445 scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas
    • Cesarman, E., Y. Chang, P. S. Moore, J. W. Said, and D. M. Knowles. 1995. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 332:1186-1191.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 1186-1191
    • Cesarman, E.1    Chang, Y.2    Moore, P.S.3    Said, J.W.4    Knowles, D.M.5
  • 6
    • 0029121668 scopus 로고
    • In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences
    • Cesarman, E., P. S. Moore, P. H. Rao, G. Inghirami, D. M. Knowles, and Y. Chang. 1995. In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood 86:2708-2714.
    • (1995) Blood , vol.86 , pp. 2708-2714
    • Cesarman, E.1    Moore, P.S.2    Rao, P.H.3    Inghirami, G.4    Knowles, D.M.5    Chang, Y.6
  • 7
    • 0032484487 scopus 로고    scopus 로고
    • Identification and characterization of human herpesvirus-8 lytic cycle-associated ORF 59 protein and the encoding cDNA by monoclonal antibody
    • Chan, S. R., C. Bloomer, and B. Chandran. 1998. Identification and characterization of human herpesvirus-8 lytic cycle-associated ORF 59 protein and the encoding cDNA by monoclonal antibody. Virology 240:118-126.
    • (1998) Virology , vol.240 , pp. 118-126
    • Chan, S.R.1    Bloomer, C.2    Chandran, B.3
  • 8
    • 0032530548 scopus 로고    scopus 로고
    • Human herpesvirus-8 ORF k8.1 gene encodes immunogenic glycoproteins generated by spliced transcripts
    • Chandran, B., C. Bloomer, S. R. Chan, L. Zhu, E. Goldstein, and R. Horvat. 1998. Human herpesvirus-8 ORF K8.1 gene encodes immunogenic glycoproteins generated by spliced transcripts. Virology 249:140-149.
    • (1998) Virology , vol.249 , pp. 140-149
    • Chandran, B.1    Bloomer, C.2    Chan, S.R.3    Zhu, L.4    Goldstein, E.5    Horvat, R.6
  • 9
    • 0032579805 scopus 로고    scopus 로고
    • Reactivities of human sera with human herpesvirus-8-infected BCBL-1 cells and identification of HHV-8-specific proteins and glycoproteins and the encoding cDNAs
    • Chandran, B., M. S. Smith, D. M. Koelle, L. Corey, R. Horvat, and E. Goldstein. 1998. Reactivities of human sera with human herpesvirus-8-infected BCBL-1 cells and identification of HHV-8-specific proteins and glycoproteins and the encoding cDNAs. Virology 243:208-217.
    • (1998) Virology , vol.243 , pp. 208-217
    • Chandran, B.1    Smith, M.S.2    Koelle, D.M.3    Corey, L.4    Horvat, R.5    Goldstein, E.6
  • 10
    • 0031714795 scopus 로고    scopus 로고
    • A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus
    • Dittmer, D., M. Lagunoff, R. Renne, K. Staskus, A. Haase, and D. Ganem. 1998. A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus. J. Virol. 72:8309-8315.
    • (1998) J. Virol. , vol.72 , pp. 8309-8315
    • Dittmer, D.1    Lagunoff, M.2    Renne, R.3    Staskus, K.4    Haase, A.5    Ganem, D.6
  • 11
    • 0030734037 scopus 로고    scopus 로고
    • Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus
    • Kedes, D. H., M. Lagunoff, R. Renne, and D. Ganem. 1997 Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J. Clin. Investig. 100:2606-2610.
    • (1997) J. Clin. Investig. , vol.100 , pp. 2606-2610
    • Kedes, D.H.1    Lagunoff, M.2    Renne, R.3    Ganem, D.4
  • 12
    • 0024582237 scopus 로고
    • Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of the Epstein-Barr virus
    • Knowles, D. M., G. Inghirami, A. Ubriaco, and R. Della-Farera. 1989. Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of the Epstein-Barr virus. Blood 73:792-799.
    • (1989) Blood , vol.73 , pp. 792-799
    • Knowles, D.M.1    Inghirami, G.2    Ubriaco, A.3    Della-Farera, R.4
  • 13
    • 0031813291 scopus 로고    scopus 로고
    • Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus
    • Lee, H., J. Guo, M. Li, J. K. Choi, M. DeMaria, M. Rosenzweig, and J. U. Jung. 1998. Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus. Mol. Cell. Biol. 18:5219-5228.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5219-5228
    • Lee, H.1    J, G.2    Li, M.3    Choi, J.K.4    DeMaria, M.5    Rosenzweig, M.6    Jung, J.U.7
  • 15
    • 0032923621 scopus 로고    scopus 로고
    • Identification and characterization of Kaposi's sarcoma-associated herpesvirus K8.1 glycoprotein
    • Li, M., J. McKey, S. C. Czajak, R. C. Desrosiers, A. A. Lackner, and J. U. Jung. 1999. Identification and characterization of Kaposi's sarcoma-associated herpesvirus K8.1 glycoprotein. J. Virol. 73:1341-1349.
    • (1999) J. Virol. , vol.73 , pp. 1341-1349
    • Li, M.1    McKey, J.2    Czajak, S.C.3    Desrosiers, R.C.4    Lackner, A.A.5    Jung, J.U.6
  • 16
    • 0032978479 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus encodes a bZIP protein with homology to ZEBRA of Epstein-Barr virus
    • Lin, S.-F., D. R. Robinson, G. Miller, and H.-J. Kung. 1999. Kaposi's sarcoma-associated herpesvirus encodes a bZIP protein with homology to ZEBRA of Epstein-Barr virus. J. Virol. 73:1909-1917.
    • (1999) J. Virol. , vol.73 , pp. 1909-1917
    • Lin, S.-F.1    Robinson, D.R.2    Miller, G.3    Kung, H.-J.4
  • 17
    • 0030891412 scopus 로고    scopus 로고
    • Identification, expression, and immunogenicity of Kaposi's sarcoma-associated herpesvirus-encoded small viral capsid antigen
    • Lin, S.-F., R. Sun, L. Heston, L. Gradoville, D. Shedd, K. Haglund, M. Rigsby, and G. Miller. 1997. Identification, expression, and immunogenicity of Kaposi's sarcoma-associated herpesvirus-encoded small viral capsid antigen. J. Virol. 71:3069-3076.
    • (1997) J. Virol. , vol.71 , pp. 3069-3076
    • Lin, S.-F.1    Sun, R.2    Heston, L.3    Gradoville, L.4    Shedd, D.5    Haglund, K.6    Rigsby, M.7    Miller, G.8
  • 18
    • 0032567394 scopus 로고    scopus 로고
    • Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein
    • Lukac, D. M., R. Renne, J. R. Kirshner, and D. Ganem. 1998 Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology 252:304-312.
    • (1998) Virology , vol.252 , pp. 304-312
    • Lukac, D.M.1    Renne, R.2    Kirshner, J.R.3    Ganem, D.4
  • 19
    • 0032830320 scopus 로고    scopus 로고
    • Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells
    • Lukac, D. M., J. R. Kirshner, and D. Ganem. 1999. Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J. Virol. 73:9348-9361.
    • (1999) J. Virol. , vol.73 , pp. 9348-9361
    • Lukac, D.M.1    Kirshner, J.R.2    Ganem, D.3
  • 20
    • 0031596141 scopus 로고    scopus 로고
    • h gene mutational analysis suggests that primary effusion lymphomas derive from different stages of B cell maturation
    • H gene mutational analysis suggests that primary effusion lymphomas derive from different stages of B cell maturation. J. Pathol. 153: 1609-1614.
    • (1998) J. Pathol. , vol.153 , pp. 1609-1614
    • Matolcsy, A.1    Nador, R.G.2    Cesarman, E.3    Knowles, D.M.4
  • 21
    • 10544237674 scopus 로고    scopus 로고
    • Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells
    • Miller, G., L. Heston, E. Grogan, L. Gradoville, M. Rigsby, R. Sun, D. Shedd, G. M. Kushnaryov, S. Grossberg, and Y. Chang. 1997. Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells. J. Virol. 71:314-324.
    • (1997) J. Virol. , vol.71 , pp. 314-324
    • Miller, G.1    Heston, L.2    Grogan, E.3    Gradoville, L.4    Rigsby, M.5    Sun, R.6    Shedd, D.7    Kushnaryov, G.M.8    Grossberg, S.9    Chang, Y.10
  • 24
    • 0031048261 scopus 로고    scopus 로고
    • A single 13-kilobase divergent locus in the Kaposi's sarcoma-associated herpesvirus genome contains nine open reading frames that arc homologous to or related to cellular proteins
    • Nicholas, J., V. Ruvolo, J. Zong, D. Ciufo, H.-G. Guo, M. S. Reitz, and G. S. Hayward. 1997. A single 13-kilobase divergent locus in the Kaposi's sarcoma-associated herpesvirus genome contains nine open reading frames that arc homologous to or related to cellular proteins. J. Virol. 71:1963-1974.
    • (1997) J. Virol. , vol.71 , pp. 1963-1974
    • Nicholas, J.1    Ruvolo, V.2    Zong, J.3    Ciufo, D.4    Guo, H.-G.5    Reitz, M.S.6    Hayward, G.S.7
  • 26
    • 0032786533 scopus 로고    scopus 로고
    • Comparison of genetic variability at multiple loci across the genomes of the major subtypes of Kaposi's sarcoma-associated herpesvirus reveals evidence for recombination and for two distinct types of open reading frame K15 alleles at the right-hand end
    • Poole, L. J., J. C. Zong, D. M. Ciufo, D. J. Alcendor, J. S. Cannon, R. Ambinder, J. M. Orenstein, M. S. Reitz, and G. S. Hayward. 1999. Comparison of genetic variability at multiple loci across the genomes of the major subtypes of Kaposi's sarcoma-associated herpesvirus reveals evidence for recombination and for two distinct types of open reading frame K15 alleles at the right-hand end. J. Virol. 73:6646-6660.
    • (1999) J. Virol. , vol.73 , pp. 6646-6660
    • Poole, L.J.1    Zong, J.C.2    Ciufo, D.M.3    Alcendor, D.J.4    Cannon, J.S.5    Ambinder, R.6    Orenstein, J.M.7    Reitz, M.S.8    Hayward, G.S.9
  • 27
    • 0031878386 scopus 로고    scopus 로고
    • The immunogenic glycoprotein gp35-37 of human hcrpesvirus 8 is encoded by open reading frame K8.1
    • Raab, M. S., J. C. Albrecht, A. Birkmann, S. Yaguboglu, D. Lang, B. Fleckenstein, and F. Neipel. 1998. The immunogenic glycoprotein gp35-37 of human hcrpesvirus 8 is encoded by open reading frame K8.1. J. Virol. 72:6725-6731.
    • (1998) J. Virol. , vol.72 , pp. 6725-6731
    • Raab, M.S.1    Albrecht, J.C.2    Birkmann, A.3    Yaguboglu, S.4    Lang, D.5    Fleckenstein, B.6    Neipel, F.7
  • 28
    • 0032899498 scopus 로고    scopus 로고
    • High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populations
    • Rabkin, C. S., I. J. Su, K. F. Powell, M. Croxson, K. E. Foreman, B. J. Nickoloff, S. Alkan, and G. S. Hayward. 1999. High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populations. J. Virol. 73:4156-4170.
    • (1999) J. Virol. , vol.73 , pp. 4156-4170
    • Rabkin, C.S.1    Su, I.J.2    Powell, K.F.3    Croxson, M.4    Foreman, K.E.5    Nickoloff, B.J.6    Alkan, S.7    Hayward, G.S.8
  • 29
    • 0032708891 scopus 로고    scopus 로고
    • Role of the Epstein-Barr virus rta protein in activation of distinct classes of viral lytic cycle genes
    • Ragoczy, T., and G. Miller. 1999. Role of the Epstein-Barr virus Rta protein in activation of distinct classes of viral lytic cycle genes. J. Virol. 73:9858-9866.
    • (1999) J. Virol. , vol.73 , pp. 9858-9866
    • Ragoczy, T.1    Miller, G.2
  • 30
    • 0030834122 scopus 로고    scopus 로고
    • The 222-to 234-kilodalton latent nuclear protein (LANA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by ORF73 and is a component of the latency-associated nuclear antigen
    • Rainbow, L., G. M. Platt, G. R. Simpson, R. Sarid, S. J. Gao, H. Stoiber, C. S. Herrington, P. S. Moore, and T. F. Schulz. 1997. The 222-to 234-kilodalton latent nuclear protein (LANA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by ORF73 and is a component of the latency-associated nuclear antigen. J. Virol. 71:5915-5921.
    • (1997) J. Virol. , vol.71 , pp. 5915-5921
    • Rainbow, L.1    Platt, G.M.2    Simpson, G.R.3    Sarid, R.4    Gao, S.J.5    Stoiber, H.6    Herrington, C.S.7    Moore, P.S.8    Schulz, T.F.9
  • 31
    • 0029876473 scopus 로고    scopus 로고
    • Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture
    • Renne, R., W. Zhong, B. Herndier, M. McGrath, N. Abbey, and D. Ganem. 1996. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat. Med. 2:342-346.
    • (1996) Nat. Med. , vol.2 , pp. 342-346
    • Renne, R.1    Zhong, W.2    Herndier, B.3    McGrath, M.4    Abbey, N.5    Ganem, D.6
  • 33
    • 0032991715 scopus 로고    scopus 로고
    • A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus
    • Sadler, R., L. Wu, B. Forghani, R. Renne, W. Zhong, B. Herndier, and D. Ganem. 1999. A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus. J. Virol. 73:5722-5730.
    • (1999) J. Virol. , vol.73 , pp. 5722-5730
    • Sadler, R.1    Wu, L.2    Forghani, B.3    Renne, R.4    Zhong, W.5    Herndier, B.6    Ganem, D.7
  • 34
    • 0031883550 scopus 로고    scopus 로고
    • Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1)
    • Sarid, R., O. Flore, R. A. Bohenzky, Y. Chang, and P. S. Moore. 1998. Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1). J. Virol. 72:1005-1012.
    • (1998) J. Virol. , vol.72 , pp. 1005-1012
    • Sarid, R.1    Flore, O.2    Bohenzky, R.A.3    Chang, Y.4    Moore, P.S.5
  • 37
    • 0032899921 scopus 로고    scopus 로고
    • Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's Sarcoma, primary effusion lymphoma, and multicentric Castleman's disease
    • Staskus, K. A., R. Sun, G. Miller, P. Racz, A. Jaslowski, C. Metroka. H. Brett-Smith, and A. T. Haase. 1999. Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's Sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. J. Virol. 73:4181-4187.
    • (1999) J. Virol. , vol.73 , pp. 4181-4187
    • Staskus, K.A.1    Sun, R.2    Miller, G.3    Racz, P.4    Jaslowski, A.5    Metroka, C.6    Brett-Smith, H.7    Haase, A.T.8
  • 38
    • 0017265399 scopus 로고
    • Inhibition of Epstein-Barr virus DNA synthesis and late gene expression by phosphonoacetic acid
    • Summers, W. C., and G. Klein. 1976. Inhibition of Epstein-Barr virus DNA synthesis and late gene expression by phosphonoacetic acid. J. Virol. 18:151-155.
    • (1976) J. Virol. , vol.18 , pp. 151-155
    • Summers, W.C.1    Klein, G.2
  • 39
    • 0029966233 scopus 로고    scopus 로고
    • Polyadenylylated nuclear RNA encoded by Kaposi sarcoma-associated herpesvirus
    • Sun, R., S. F. Lin, L. Gradoville, and G. Miller. 1996. Polyadenylylated nuclear RNA encoded by Kaposi sarcoma-associated herpesvirus. Proc. Natl. Acad. Sci. USA 93:11883-11888.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 11883-11888
    • Sun, R.1    Lin, S.F.2    Gradoville, L.3    Miller, G.4
  • 40
    • 0032167919 scopus 로고    scopus 로고
    • A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus
    • Sun, R., S. F. Lin, L. Gradoville, Y. Yuan, F. Zhu, and G. Miller. 1998. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc. Natl. Acad. Sci. USA 95:10866-10871.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10866-10871
    • Sun, R.1    Lin, S.F.2    Gradoville, L.3    Yuan, Y.4    Zhu, F.5    Miller, G.6
  • 43
    • 0031015210 scopus 로고    scopus 로고
    • Characterization of ribonucleoprotein complexes containing an abundant polyadenylated nuclear RNA encoded by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8)
    • Zhong, W., and D. Ganem. 1997. Characterization of ribonucleoprotein complexes containing an abundant polyadenylated nuclear RNA encoded by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8). J. Virol. 71:1207-1212.
    • (1997) J. Virol. , vol.71 , pp. 1207-1212
    • Zhong, W.1    Ganem, D.2
  • 44
    • 0029957833 scopus 로고    scopus 로고
    • Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma
    • Zhong, W., H. Wang, B. Herndier, and D. Ganem. 1996. Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc. Natl. Acad. Sci. USA 93:6641-6646.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 6641-6646
    • Zhong, W.1    Wang, H.2    Herndier, B.3    Ganem, D.4
  • 45
    • 0001293583 scopus 로고    scopus 로고
    • Identification of the immediate-early transcripts of Kaposi's sarcoma-associated herpesvirus
    • Zhu, F. X., T. Cusano, and Y. Yuan. 1999. Identification of the immediate-early transcripts of Kaposi's sarcoma-associated herpesvirus. J. Virol. 73: 5556-5567.
    • (1999) J. Virol. , vol.73 , pp. 5556-5567
    • Zhu, F.X.1    Cusano, T.2    Yuan, Y.3


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