Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency

Journal of General Virology

Volumn 91, Issue 2, 2010, Pages 463-469

  Peng, Li ^a   Wu, Ting Ting ^a,b   Tchieu, Jason H ^a   Feng, Jun ^a   Brown, Helen J ^b   Feng, Jiaying ^a   Li, Xudong ^a   Qi, Jing ^c   Deng, Hongyu ^b,c   Vivanco, Igor ^a,d   Melinghoff, Ingo K ^a,d   Jamieson, Christina ^a   Sun, Ren ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUTE OF BIOPHYSICS   (China)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; TRANSACTIVATOR PROTEIN; VIRUS PROTEIN;

ARTICLE; CELL STRAIN 3T3; ENZYME ACTIVATION; ENZYME INHIBITION; HERPES VIRUS; HUMAN; HUMAN HERPESVIRUS 8; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; VIRUS LATENCY; VIRUS REACTIVATION; VIRUS REPLICATION; ANIMAL; CELL LINE; GAMMAHERPESVIRINAE; GENETICS; HERPES VIRUS INFECTION; METABOLISM; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION; VIROLOGY; VIRUS ACTIVATION;

HERPESVIRIDAE; HUMAN HERPESVIRUS 8; MURINAE; MURINE HEPATITIS VIRUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANIMALS; CELL LINE; GAMMAHERPESVIRINAE; HERPESVIRIDAE INFECTIONS; HUMANS; MICE; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; VIRAL PROTEINS; VIRUS ACTIVATION; VIRUS LATENCY; VIRUS REPLICATION;

EID: 76249099841     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.015073-0     Document Type: Article

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